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4-Methylmetanilic Acid

    • Product Name 4-Methylmetanilic Acid
    • Alias p-Toluenesulfonic acid
    • Einecs 240-257-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    114378

    Chemical Name 4-Methylmetanilic Acid
    Molecular Formula C8H9NO2S
    Molecular Weight 183.23 g/mol
    Cas Number 99-51-4
    Appearance Off-white to beige powder
    Melting Point 160-164 °C
    Solubility Slightly soluble in water
    Purity Typically ≥98%
    Storage Conditions Store at room temperature, dry and well-ventilated place

    As an accredited 4-Methylmetanilic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 100 grams of 4-Methylmetanilic Acid, with a secure screw cap and tamper-evident seal, labeled appropriately.
    Shipping 4-Methylmetanilic Acid is shipped in tightly sealed, chemical-resistant containers to prevent contamination and moisture absorption. The packaging is clearly labeled with hazard and handling information. During transit, the product is kept in a cool, dry environment, and handled according to applicable regulations for safe transport of chemical substances.
    Storage 4-Methylmetanilic acid should be stored in a cool, dry, well-ventilated area away from sources of ignition and incompatible materials such as strong oxidizers. Keep the container tightly closed and protected from light and moisture. Store in a chemical-resistant container and clearly label it. Ensure proper secondary containment and follow standard laboratory safety and chemical storage protocols at all times.
    Application of 4-Methylmetanilic Acid

    Applications of 4-Methylmetanilic Acid in Industrial Manufacturing

    4-Methylmetanilic Acid serves as a valuable intermediate in multiple downstream chemical industries, supporting diversified manufacturing sectors with stringent specifications. As the original manufacturer, we supply this raw material for controlled synthesis steps, advanced formulations, and regulated end uses across specialized applications.

    1. Synthesis of Azo Dyes for Textile Printing

    Textile dye manufacturers utilize 4-Methylmetanilic Acid for coupling reactions in the synthesis of azo dyes, notably those providing vivid yellow and orange tones. During diazotization, this acid reacts with diazonium salts under acidic conditions, forming stable colorants suitable for cotton and synthetic fiber blends. Strict process controls manage delivery, handling, and environment for compliance and product reliability. Final formulations align with ecological textile production demands.

    Industry compliance standards

    • OEKO-TEX® Standard 100
    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals Manufacturing Restricted Substances List)
    • REACH Regulation (EC) No 1907/2006 Annex XVII (Azocolourants ban)
    • ISO 105 Series (Textile Testing: Color Fastness)

    Typical usage ratio

    • Used at 10–25% molar equivalent relative to diazonium salt, depending on target dye structure and brightness intensity needs

    Downstream process integration

    • Added in the coupling stage after diazotization, under controlled pH and temperature, prior to isolation, washing, and formulation into dye pastes or powders

    Final product types

    • Azo-based disperse dyes for polyester textiles
    • Reactive dyes for cellulosic fibers
    • Print paste intermediates for digital and screen textile printing

    2. Production of Sulfa-based Pharmaceutical Intermediates

    Pharma manufacturers employ 4-Methylmetanilic Acid as a building block in the synthesis of sulfa drugs. The material participates in sulfonamide formation, offering selective reactivity under mild conditions. It enables controlled derivatization, maintaining strict traceability for batch records, and supports multi-step syntheses in medicinal chemistry pipelines, including small-molecule and API pilot production.

    Industry compliance standards

    • Good Manufacturing Practice (GMP) according to ICH Q7
    • USP/NF Monographs (Sulfonamides applications)
    • EU Pharmacopoeia standards (Ph. Eur.)
    • 21 CFR Part 210/211 (US FDA current GMP)

    Typical usage ratio

    • Optimally charged at 1.0–1.2 stoichiometric ratio to aminobenzenesulfonyl chloride in sulfonamide synthesis, adjusted per formation efficiency and side reaction control

    Downstream process integration

    • Directed into the initial condensation or amidation step, followed by purification, crystallization, and API finishing under validated protocols

    Final product types

    • Sulfamethoxazole and related sulfa API intermediates
    • Bulk active pharmaceutical ingredients (APIs)
    • Formulated antibacterial tablets and suspensions

    3. Intermediate for Dyes Used in Paper and Leather Processing

    Producers of specialty dyes for paper and leather applications use 4-Methylmetanilic Acid as a coupling component where color performance, bath stability, and cost efficiency are required. The raw material’s amino and methyl groups help synthesize specific anionic dyes imparting fastness and vividness to packaging paper, office paper, and high-grade leather goods. Controlled dosing and impurity management are essential for print quality and regulatory compliance.

    Industry compliance standards

    • BS 3260: Colorants for Paper (British Standards)
    • Leather Working Group (LWG) Restricted Substances List
    • REACH Regulation (EC) No 1907/2006 requirements for dyes
    • EN 71-3 (for dyed leather toys and children’s goods)

    Typical usage ratio

    • Applied at 12–20% by weight, relative to final dye product, varying with base structure and application method (direct, acid, or metal-complex dye)

    Downstream process integration

    • Used after sulfonation, introduced into condensation or coupling reactions prior to formulation; finished dyes are spray-dried or processed into concentrated liquids

    Final product types

    • Direct paper dyes for office and décor paper
    • Acid dyes for natural and synthetic leathers
    • Stain-resistant treatments in specialty coated boards

    4. Chemical Reagent Manufacturing for Laboratory and Analytical Use

    Specialized chemical reagent suppliers incorporate 4-Methylmetanilic Acid in synthesis kits and analytical reagents, where high purity, batch consistency, and defined impurity profiles are critical. The compound participates in derivatization protocols, colorimetric testing, and standard reference formulations for academia and analytical laboratories. Rigorous documentation supports compliance with reagent-grade certification.

    Industry compliance standards

    • ACS Reagent Chemicals Specifications (American Chemical Society)
    • ISO 17025:2017 for laboratory quality management
    • DIN EN ISO 6353 (Reagents for chemical analysis)
    • Internal Certificate of Analysis (CoA) traceability

    Typical usage ratio

    • Charged at 0.1–2.0% w/w for chromogenic reagent mixes; amounts depend on sensitivity and linearity of the specific test method

    Downstream process integration

    • Incorporated during reagent formulation or as a derivatization agent, then filtered, standardized, and aliquoted into kit components

    Final product types

    • Chromogenic and diazotization reagent kits
    • Standard analytical solutions for research
    • Reference chemicals for QA/QC labs
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    Competitive 4-Methylmetanilic Acid prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Introducing 4-Methylmetanilic Acid: Consistent Quality From the Source

    Understanding 4-Methylmetanilic Acid and its Role

    Producing 4-Methylmetanilic Acid demands more than just meeting purity numbers. Each batch carries the result of hard-earned process optimization, raw material selection, and skilled supervision. At our plant, we have learned that attention to what might seem a minor impurity often prevents years of downstream headaches for end users. Only through hands-on control over every step—from raw aniline selection to the acid chlorination and handling—can we deliver the reliability that chemists and formulators expect.

    The model we supply is geared for precision. Our standard product specification includes a purity not less than 99.5%, due to careful process adjustments that minimize sulfonic and nitro byproducts. Testing protocols have evolved as customers share new analytical results from their own manufacturing lines. It’s one thing to hit a GC standard panel, it’s another to ensure the next step in a customer’s synthesis runs smoothly, batch after batch. This is where decades working with dyes, pigments, APIs, and specialty chemical makers pay off.

    Specifications That Matter in Daily Use

    Specifications are more than numbers on a report. Moisture content, ash, LOI, and even residual solvents play a direct role in product success. For instance, we saw a cosmetic dye customer struggle with batch variability due to slight increases in residual water that most would have overlooked. By bringing drying cycles under tighter control, and adapting our packaging environment, the downstream complaints vanished. That lesson still guides our approach: customers remember the lot that ruined a kilo of prized API more than they remember the 99 that worked perfectly.

    4-Methylmetanilic Acid leaves our plant as a stable, free-flowing crystalline powder with consistent particle size. We don’t chase an artificial “ideal” spec but focus on reducing known pain points in customers’ blending processes. Handling ease, dust control and physical stability under varied humidity made us reconsider packing from traditional fiber drums to lined aluminum bags within cartons. This change, suggested by a technical buyer who visited the plant, drove a measurable drop in humidity-related caking and saved real money for a series of dye intermediate customers.

    Key Applications Backed by Practice

    We manufacture 4-Methylmetanilic Acid mainly for companies operating in azo and anthraquinone dye manufacturing, pharmaceutical intermediates, and specialty polymers. Our product’s amine group and methyl substituent play a vital role in achieving color stability and purity in the finished dye. Ask any dyestuff technical director about lot-to-lot hue drift and you’ll get a story about how minor isomer variations, often sourced from inconsistent raw materials, have hobbled large-volume contracts. Our controls on isomer ratio are stricter than what the national standard requires, shaped by repeated troubleshooting on actual production lines, not just bench-scale simulation.

    In the pharmaceuticals sector, absence of heavy metals and minute colored impurities prevent costly rework. Our QC team works directly with analysts in regulatory-driven industries. Each customer’s feedback has sharpened our methods, especially for those using this acid as a coupling intermediate in molecule assembly. During the past five years, our methods have been audited under multiple supplier qualification projects, each time adding to our know-how and process supervision. For specialty polymers, polymerization consistency starts with the precursor. We support polymer scientists with samples for rapid evaluation, allowing them to assess compatibility in their own labs before full-scale production runs.

    Approach to Quality From Raw Material to Final Shipment

    As a direct manufacturer, every kilogram of 4-Methylmetanilic Acid represents tight integration between sourcing, plant operation, laboratory, and shipping. We don’t just pass through product; we own responsibility for its quality from the first drum of feedstock aniline to the last container of the finished batch. Our teams have learned the cost of ignoring small anomalies. Years ago, a change in upstream supplier methodology changed the minor impurity profile. Although the documentation matched, our plant tests caught a shift in organoleptic properties. That event led to the introduction of in-process gas chromatography even at intermediate steps. Today, every shift technician knows they can halt a batch and call a senior chemist in for atypical test results, without bureaucratic runaround.

    Plant safety plays a part too. Oxidative byproducts aren’t just color issues—they can impact plant health and regulatory compliance. We run HPLC and residue analysis several times per shift, not because regulations require it but because experience taught us what’s at stake. This obsessive attention extends to finished goods storage logistics. A warehouse team handles the transfer and labeling in a controlled area. Containers rotate on a first-in-first-out system, with real-time logging that matches shipment batches back to the source reactor run data. This feedback loop links each drum in the field to the actual operator on the production floor.

    How 4-Methylmetanilic Acid Stands Apart From Similar Products

    There’s always a temptation to treat aromatic acids as a commodity. Many in the market do, until recurring headaches bring a halt to production or result in loss of a valued end customer. What sets 4-Methylmetanilic Acid apart lies in its high reactivity under mild coupling conditions, which avoids side product formation and excessive purification cycles. In our experience, firms that tried substituting close isomers or using mixed-grade input ended up facing out-of-spec colors, wasted energy, and unhappy buyers downstream.

    Compared to unsubstituted metanilic acid or 4-ethyl-derivatives, the methyl group on our product significantly shifts both solubility and reactivity. Dye manufacturers tell us this substitution supports more robust, brighter dye lots, with less fading over time. It boils down to fine differences in electron-donating effects and coupling kinetics—something that only truly matters at scale, during cost-sensitive synthesis. That’s why technical professionals keep pressing for certificates of analysis that cover more than just the basics. Through open shipment records and shared data, customers develop trust overtime that they’re getting reliable input for their own products.

    Unlike general-grade metanilic acids seen from blending houses or multi-product traders, our manufactured acid doesn’t contain traces of other substituted anilines often present in recycled or low-grade sources. This means reduced waste, lower risk of regulatory rework, and better downstream yields. The focus remains on what makes our chemistry predictable and cost-effective over years, not just what passes infrequent lab sampling.

    Deep Experience With Process Adaptation and Customer Support

    Being a direct manufacturer, we frequently adapt our process flows as industries shift. Fifteen years ago, dye makers set the pace. Today, demand for pharmaceutical intermediates, electronics, and OLED production brings new purity needs and fresh regulatory wrinkles. We regularly visit customer plants, taking samples and problem reports back to the lab so our own process can address specifics—like eliminating trace sodium, improving filterability, or tuning the acid’s flow for large-scale reactors.

    Troubleshooting real-world issues led us, for example, to overhaul one purification step in response to a partner’s feedback about color development in polymer applications. A competitor’s material caused yellowing under low-temperature storage. Ours maintained optical clarity, which gave our customer a lead on the market. That account holds steady because we respect their process as much as our own.

    Customers appreciate more than technical consistency; they want logistics transparency and reliable documentation. Each drum includes full traceability reports, matching batch to reactor, and certificate details that answer specific end-use questions, not just regulatory checklists. We field technical calls directly—no passing problems to faceless resellers—because we know a plant shutdown at a customer’s site impacts their own delivery and trust. Ongoing supply chain disruptions in recent years taught everyone the cost of “repacking” and mid-market trading. Our clients know they get manufacturer insight and direct action when needed.

    Commitment to Responsible Manufacturing

    Sustainable production sits at the core of every plant initiative. Years of running reactors teach the hard truths about waste, energy use, and safety risk. We invested early in closed-loop solvent recovery, improved water treatment on-site, and local community engagement—real steps to ensure that making 4-Methylmetanilic Acid supports both business continuity and environmental stewardship.

    We document solvent and effluent records, not to tick compliance boxes, but to learn over time where we can minimize losses and make cleaner, leaner batches. That mindset shapes every engineering upgrade: condensers that cut VOC emissions, reactor maintenance to reduce downtime, and QA teams empowered to stop production in the face of any anomaly.

    Continuous Learning, Customer Partnership, and Staying Ahead

    The difference with direct production experience lies in handling details that don’t show up in a typical product catalog. Over the years, our teams have learned that even a small shift in raw material origin can influence impurity patterns and, therefore, product performance. Ongoing communication with technical and procurement teams at user facilities brings practical solutions—sometimes changing nothing more than a filter grade or packaging closure prevents thousands in rework costs for a partner halfway around the world.

    As application science inches forward, and regulatory needs multiply, flexibility in process and a willingness to sample new plant technologies becomes crucial. Feedback loops between our lab and client QC departments fuel improvements in both documentation and production runs. Audit teams from the pharmaceutical and electronic materials sectors bring tough questions, and we use every one of these as a springboard to recalibrate both our internal and external standards.

    Direct partnership puts us in the line of fire for troubleshooting, early specification changes, and process updates. This brings a level of responsibility that contract and trading companies rarely experience, but it drives continuous improvement and innovation. Whether a customer seeks batch samples for new dye formulas, purity upgrades for advanced materials, or long-term supply contracts for pharmaceutical lines, we build our documentation, storage, and shipment to fit agreed needs with eyes open to their daily plant realities.

    Conclusion: What Decades of Direct Manufacturing Bring

    Few materials have driven so many lessons about process optimization, plant discipline, and partnership as 4-Methylmetanilic Acid. Its unique place in manufacturing comes both from its versatile chemistry and, crucially, from the minute details learned through decades of direct production. Meeting market needs is not about meeting a set of generic claims; it's about understanding client goals, solving their actual process issues, and building trust batch after batch.

    For every container that leaves our facility, a supply chain expert, a plant operator, and a product developer know the story isn’t just what’s on the label but the collective attention, troubleshooting, and flexibility standing behind it. This gives our customers more than a product—it gives them a partner grounded in real manufacturing, with every technical, chemical, and logistical turn addressed firsthand. That partnership makes all the difference, both in yielding products that achieve targeted results and in supporting the ever-evolving industries that trust 4-Methylmetanilic Acid as a core ingredient.