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4-Methyl-2-Nitrobenzonitrile

    • Product Name 4-Methyl-2-Nitrobenzonitrile
    • Alias 4-methyl-2-nitrobenzenecarbonitrile
    • Einecs 609-294-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    246202

    Chemicalname 4-Methyl-2-Nitrobenzonitrile
    Casnumber 34147-55-8
    Molecularformula C8H6N2O2
    Molecularweight 162.15 g/mol
    Appearance Yellow to light brown solid
    Meltingpoint 90-94°C
    Density 1.26 g/cm³ (approximate)
    Solubility Slightly soluble in water; soluble in organic solvents
    Purity Typically ≥98%
    Smiles CC1=CC(=NC#N)C=C1[N+](=O)[O-]
    Inchi InChI=1S/C8H6N2O2/c1-6-2-3-7(10(11)12)8(4-6)5-9

    As an accredited 4-Methyl-2-Nitrobenzonitrile factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 100g package of 4-Methyl-2-Nitrobenzonitrile comes in an amber glass bottle, tightly sealed and labeled for laboratory use.
    Shipping 4-Methyl-2-Nitrobenzonitrile should be shipped in tightly sealed containers, protected from moisture and light. It must comply with applicable hazardous material regulations, including appropriate labeling and documentation. Transport it under cool and dry conditions, ensuring compatibility with other cargo, and handle with care to prevent spills, as it may pose health and environmental hazards.
    Storage 4-Methyl-2-Nitrobenzonitrile should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances such as strong acids, bases, and oxidizing agents. Protect from light and moisture. Properly label the container and ensure only trained personnel handle the chemical, following all safety protocols.
    Application of 4-Methyl-2-Nitrobenzonitrile

    Applications of 4-Methyl-2-Nitrobenzonitrile in Industrial Manufacturing

    4-Methyl-2-Nitrobenzonitrile serves as a critical intermediate in various industrial synthesis routes. Its high purity grade and consistent particle size meet the stringent demands of downstream manufacturers across niche sectors. Below, we detail its established roles across select high-value applications, focusing on exact compliance frameworks, usage ratios, integration points, and the resulting end-use products.

    1. Agrochemical Active Ingredient Manufacturing

    Leading agrochemical producers use 4-Methyl-2-Nitrobenzonitrile in the synthesis of specialty pyridine-based herbicides and insecticides. Its stable nitro and nitrile groups allow for efficient nucleophilic substitution during the core structure assembly of target crop protection agents. The raw material enters the process post-nitration but prior to ring closure, facilitating high-yield couplings for next-generation active substances.

    Industry compliance standards

    • GB/T 1600-2001 (China National Standard for Pesticide Intermediates)
    • EPA FIFRA Pesticide Registration (USA)
    • REACH Regulation (EC) No. 1907/2006 (EU Chemical Substance Requirements)
    • ISO 9001:2015 certified quality management for batch traceability

    Typical usage ratio

    • 5–12% based on total molar content of final active molecule substrate; precise ratio determined by target species for functionalization in custom herbicide synthesis.

    Downstream process integration

    • Charges into step two after preliminary arylation, followed by solvent-mediated condensation and catalytic hydrogenation, before hydrolysis to yield crop protection compounds.

    Final product types

    • Pyridine herbicides (e.g., methyl nicotinates)
    • Specialized insecticidal actives for seed treatment formulations
    • Systemic fungicide intermediates

    2. Pharmaceutical Intermediate Synthesis

    Pharmaceutical companies utilize this compound for building advanced molecular scaffolds in APIs, especially within antihypertensive and anti-inflammatory drug classes. Owing to its defined electronic structure, it acts as a precursor for benzonitrile derivatives required in heterocycle assembly steps. The material achieves high conversion rates with minimal byproduct formation, catering to the strict requirements for trace impurity control in GMP operations.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.) monographs for nitrobenzonitrile derivatives
    • 21 CFR Part 211 (cGMP for Finished Pharmaceuticals, USA)
    • China Pharmacopoeia (2020 Edition)

    Typical usage ratio

    • 3–7% by weight in targeted condensation or substitution reaction stages; specific loading monitored through in-line HPLC to minimize residual free nitrile in isolated API intermediate.

    Downstream process integration

    • Added at the second or third synthesis step, usually following alkylation, and preceding reduction or hydrolysis, allowing for regioselective substitution and crystallization protocols.

    Final product types

    • Antihypertensive API intermediates (e.g., sartans)
    • Anti-inflammatory benzonitrile derivatives
    • Central nervous system drug building blocks

    3. Fine Chemical Dye Intermediate Production

    Dye manufacturers incorporate 4-Methyl-2-Nitrobenzonitrile when synthesizing specialty azo and anthraquinone dye intermediates. Its structure enhances chromophore formation and increases dye stability under aggressive textile processing conditions. This material is charged only after completion of initial diazotization and before the coupling step, ensuring desired hue and shade intensity reproducibility for large-volume textile applications.

    Industry compliance standards

    • OEKO-TEX® Standard 100 (chemical safety for textiles)
    • REACH Annex XVII restricted substances (colorant composition limits)
    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals Manufacturing Restricted Substances List)
    • ISO 14001:2015 certified environmental management for colorant production

    Typical usage ratio

    • 4–10% in the intermediate coupling product batch; ratio refined to garment color fastness, depth, and brightness specifications.

    Downstream process integration

    • Introduced after diazotization in the batch reactor, then processed through catalytic reduction and acid coupling as part of the core dye molecule build.

    Final product types

    • High-stability azo dye intermediates
    • Modified anthraquinone dye precursors
    • Dye blends for textile, leather, and plastic coloration

    4. Electronic Specialty Chemical Intermediate

    Producers targeting advanced material sectors rely on 4-Methyl-2-Nitrobenzonitrile to introduce functional groups for electronic-grade polyimide precursor synthesis, which is fundamental in semiconductors and flexible display substrates. The raw material’s precise electronic inductive properties allow for accurate copolymer modification in high-performance insulation films, necessary for reliability under thermal cycling in device assembly.

    Industry compliance standards

    • UL 94 (Flammability testing of plastic materials)
    • IEC 61249-2-21 (Halogen-free electronic substrate standards)
    • RoHS Directive (2011/65/EU) substance limitations
    • ISO 9001:2015 for traceable semiconductor material supply

    Typical usage ratio

    • 2–6% relative to total monomer feed in polyimide prepolymer reactions; ratio optimized for dielectric and mechanical property requirements of the final insulating layer.

    Downstream process integration

    • Integrated as a modifier during the polycondensation stage, prior to imidization and thermal curing under inert conditions.

    Final product types

    • Electronic-grade polyimide films
    • Microelectronics interlayer dielectric sheets
    • Flexible printed circuit substrates

    5. Advanced Polymerization Catalyst Intermediate

    Specialty polymer manufacturers use 4-Methyl-2-Nitrobenzonitrile as an intermediate during the production of certain precision catalyst systems, required for batch-controlled polymerization of high-value engineering plastics. The nitrile component supports ligand frameworks in multi-metal catalyst synthesis, which in turn drives controlled molecular weight distribution and thermal stability for downstream polymeric materials.

    Industry compliance standards

    • ISO 11357 (Differential scanning calorimetry for polymers)
    • ASTM D789 (Polyamide quality standards)
    • REACH Annex XIV (Authorization for use of chemical intermediates)
    • Company-validated QMS for catalyst supply chain auditability

    Typical usage ratio

    • 1.5–4% of batch input during ligand assembly; percentage tailor-fitted to targeted catalyst activity and selectivity profiles according to resin application.

    Downstream process integration

    • Enters during the chelation or ligand-functionalization stage; followed by purification and activation in inert gas-controlled systems for final catalyst preparation.

    Final product types

    • Specialty polyamide catalyst precursors
    • Controlled molecular weight polyester catalysts
    • Polymerization systems for specialty thermoplastics
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    Certification & Compliance
    More Introduction

    Precision-Made 4-Methyl-2-Nitrobenzonitrile: Engineered for Reliable Performance

    Bringing Forward a Thoughtful Synthesis Approach

    In manufacturing fine chemicals, workers see the direct impact of small adjustments on the outcome of a product like 4-Methyl-2-Nitrobenzonitrile. We work with this compound daily, guiding it from raw material selection to purification. It’s not a minor sideline for us—it’s an established part of our production lines, valued for its applications in pharmaceutical, dye, and agrochemical industries. Consistency, traceable quality and clear documentation go into every batch, shaping a material that research teams and process engineers can depend upon.

    The systematic precision in the plant isn’t just practice—it reflects in the crystalline product that leaves our dryers. By focusing production on small details—temperature control, feed rates, impurity profiles—we prepare batches that hold up under scrutiny. Years on the job have made us aware that users search for more than a technical grade; they demand predictability that supports scale-up and product development. This 4-Methyl-2-Nitrobenzonitrile answers that demand.

    Technical Details and Model Availability

    Every detail in our process aims to put forth reliable output. The typical batch boasts a purity well above 98%, with most results trending closer toward analytical-grade standards. Lot-to-lot consistency gets top attention. We strictly monitor moisture levels and control trace metallic impurities by screening our catalyst systems and rinsing reactors thoroughly. Our material comes regular as a beneficial yellow to pale solid, breaking easily for further processing, with particle size options available depending on downstream needs.

    Over time, feedback from custom synthesis groups and process chemists led to tweaks in particle size ranges—an area we continually monitor. The melting point and stability figures don’t fluctuate batch-to-batch. Every lot can be traced to its original raw materials and passed through validated QC checks, with COA and HPLC data included for every shipment. Handling instructions and compatibility data flow directly from our technical team, not from secondary sources or generic stockpile catalogs.

    Role and Value in Modern Synthesis

    The structure of 4-Methyl-2-Nitrobenzonitrile may look simple, but it offers distinct transformation points that matter to synthetic chemists. Because our facility focuses on this material, we learn from direct customer experience—its use as a starting point for reduced intermediates, heterocycle closure reactions, or tailored ligands. Some regulars apply it in manufacturing advanced pharmaceutical building blocks where selectivity and clean conversion are vital. Others bundle it into research workflows for electronic chemicals and dye development, where purity can’t be left to chance.

    Our technical staff spends time with customers’ R&D groups, advising on appropriate solvents, work-up strategies, and potential catalytic side reactions. By talking directly to the chemists using our lots, we capture not just the textbook function of the product but the quirks, the desired trace impurity profile, and the common roadblocks faced in scale-up.

    Meeting Project Requirements

    As a manufacturer, we see requests that shift from small exploratory lots to bulk needs suitable for pilot plants or commercial runs. With stable purification routes, we manage these shifts smoothly, keeping impurity drift at bay regardless of lot size. The details in our protocols grew out of these routine upscaling demands—batch homogeneity, rapid packing and shipping, and on-time certificates of analysis. We stay involved at every step, knowing that users in regulated industries depend on information clarity, sample accessibility, and timely delivery.

    Product traceability gets the same level of care. We attach full documentation for every shipment, starting at the batch record and running through calibration logs and final analytical results. This degree of documentation serves well for inspections or for devising custom change controls requested by customers. This focus on the source and verifiable data carries over from our own site audits and internal system reviews. No customer wants a surprise during process validation or GMP site reviews.

    Differences Over Common Substitutes

    We have worked with chemists using similar substituted benzonitriles and often hear how small structural differences can turn process routes unpredictable. The methyl and nitro groups on this product offer specific reactivity patterns, conferring regioselectivity when compared to isomers such as the 2-methyl-4-nitrobenzonitrile or unsubstituted parent compounds. Skilled process engineers appreciate this distinction—a matter of pathway control that comes from both substitution pattern and contaminant background.

    Technical feedback shows that our 4-Methyl-2-Nitrobenzonitrile isolates more cleanly in downstream reactions, especially compared to broader commodity-grade products. The rigorous attention we give to purification means fewer complications in continuous syntheses or late-stage functionalizations. We’ve observed competitors shifting toward cost-saving approaches that may leave behind trace byproducts or off-odors; this can spell trouble in cGMP or sensitive electronics applications. Our staff prefers to do extra rounds of quality screening upfront because field experience has taught us the risk of batch failures and project delays. Real users feel these setbacks firsthand, and we’re committed to helping them avoid unnecessary troubleshooting.

    Feedback and Continuous Progress

    We keep our team in the loop with developers, contract labs, and technical directors from industries spanning fine chemicals to advanced materials. Many of our best process improvements came from joint site trials: controlling trace iron in an intermediate, dialing in the drying cycle, or swapping in more consistent feedstock partners. We track user data, not just for technical requirements but for process fit and safety in real-world environments. Our plant management regularly reviews suggestions from end-users, making small but significant adjustments to how we finish and handle product before it reaches the customer.

    Partnerships with academia and industrial R&D sites keep new requests coming. Sometimes a research team needs a slightly tighter impurity limit around a known side-product; sometimes, a pilot plant project calls for a specific PSD (particle size distribution) profile. We have avoided the temptation of ‘one-size-fits-all’ manufacturing, instead tailoring batches by working alongside the customer before a full commercial roll-out. Our staff stands behind their work—they can trace a drum of 4-Methyl-2-Nitrobenzonitrile right back to its reactor run, offering transparency customers value.

    Applications and Future Developments

    Practical application guides most of our R&D. In pharmaceutical synthesis, our product has shown stable performance in reduction steps to amine intermediates, azole coupling, or further halogenations. Dyes and pigments producers use this material for its clean chromophore formation. Agrochemical partners require tight control of nitro reduction and byproduct suppression—a target we supply by never taking shortcuts in chromatography or final purifications.

    Future trends point to more automated flow chemistry setups and an increased demand for traceability, which matches our long-term improvement plans. Customers expect faster, data-rich documentation, shorter lead times, and the ability to tailor materials at the kilogram or ton scale. Our technical group invests heavily in digital process monitoring and rapid hypothesis testing—this drives down error rates and helps scale tailored lots for complex synthesis projects.

    Challenges in Supply, Transport, and Handling

    Sourcing of precursors demands a reliable network. We have weathered fluctuations in upstream material pricing by building redundant relationships with certified suppliers. By fully qualifying vendors, we reduce contamination and maintain stock continuity, even through industry turbulence. Logistics isn’t an afterthought—we handle sensitive transport requirements, managing temperature and humidity exposure from our facility to the customer’s door. Freight teams use product-specific protocols, drawing on years of safe shipment experience.

    Some customers raise questions regarding shelf life and packaging. We rely on field-tested containers that guard against light, oxygen, and accidental spillage. Internal QA teams periodically run real-time and accelerated aging studies to report stability under common storage conditions. For downstream handling safety, our technical experts collaborate on optimal storage, avoiding cross-contamination and accidental decomposition. If issues arise, we respond with technical clarifications backed by historical product data, not generalized advice.

    Supporting Responsible Use and Compliance

    Responsible manufacturing underpins every facility upgrade and protocol change. Regulatory scrutiny of chemical processes increases every year, and our products remain in compliance through routine auditing and cooperation with the relevant authorities. Our documentation practices meet the needs of pharmaceutical, agrochemical, and research partners—providing not only data but full traceability. Workers in our plants receive training specific to hazardous material handling, and spill response drills occur regularly. Updates on regulatory policy, such as the latest ECHA (European Chemicals Agency) guidance or local site inspection results, are communicated throughout the team.

    Sustainable operation matters to us beyond compliance. We minimize solvent use through recycling loops, recover by-products for secondary use, and keep emissions under well-defined environmental limits. Customer feedback often brings up questions about lifecycle impact, especially from international procurement teams—our technical documentation addresses these queries with site-specific emissions data and material reuse statistics. By making resource use visible, we help our partners meet their own sustainability targets.

    Why Real Manufacturer Experience Matters

    We have seen what happens when off-spec materials interrupt downstream synthesis or cause headaches at inspection. The assurance that comes from a stable, properly documented supply isn’t just paperwork; it protects ongoing research, pilot scale-ups, and long-term product strategies. Years spent producing 4-Methyl-2-Nitrobenzonitrile have shown us that even small manufacturing shortcuts can mean big problems in high-value applications.

    Every order reflects hours spent communicating with buyers, production chemists, and lab technicians. We keep lines open for troubleshooting, product improvement, and unusual requests. Quality control isn’t outsourced—our own people make decisions on batch release and final shipment checks. The chemistry community expects transparency and candor, not just reassurances from a faceless catalog reseller. We treat every project as a partnership—product improvement grows from real feedback and on-the-floor manufacturing know-how.

    Looking Forward as Partners

    4-Methyl-2-Nitrobenzonitrile remains a specialty building block for innovators in multiple industries. We have grown alongside our customers, learning from both successful processes and occasional setbacks. Each batch we send out stands on a foundation of teamwork, open data sharing, and hands-on effort. Progress means working together—industry, lab, and plant—solving real-world problems and improving chemical supply chains one batch at a time.