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4-Methyl-2-Benzothiazolehydrazine

    • Product Name 4-Methyl-2-Benzothiazolehydrazine
    • Alias 4-Methyl-1,3-benzothiazol-2-ylhydrazine
    • Einecs 402-720-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    155657

    Product Name 4-Methyl-2-Benzothiazolehydrazine
    Cas Number 3131-60-6
    Molecular Formula C8H9N3S
    Molecular Weight 179.24 g/mol
    Appearance Yellow to orange crystalline powder
    Melting Point 137-141 °C
    Solubility Slightly soluble in water, soluble in organic solvents
    Purity Typically ≥98%
    Synonyms 4-Methylbenzothiazol-2-yl hydrazine
    Storage Temperature Store at 2-8°C
    Smiles CC1=CC2=NC=CS2C=N1N

    As an accredited 4-Methyl-2-Benzothiazolehydrazine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 4-Methyl-2-Benzothiazolehydrazine, 25g, supplied in an amber glass bottle with tamper-evident seal and clear hazard labeling.
    Shipping **Shipping Description for 4-Methyl-2-Benzothiazolehydrazine:** Ship in tightly sealed containers under cool, dry conditions. Protect from light and incompatible substances. Handle as a potentially hazardous chemical; appropriate labels and safety paperwork required. Follow all local, state, and international transport regulations for hazardous materials. Avoid exposure to heat, moisture, and direct sunlight during transit.
    Storage 4-Methyl-2-Benzothiazolehydrazine should be stored in a tightly sealed container, kept in a cool, dry, and well-ventilated area, away from heat, ignition sources, and incompatible substances such as strong oxidizers and acids. Protect it from light and moisture. Clearly label the storage area, and ensure access is restricted to trained personnel using appropriate personal protective equipment.
    Application of 4-Methyl-2-Benzothiazolehydrazine

    Applications of 4-Methyl-2-Benzothiazolehydrazine in Industrial Manufacturing

    As a direct manufacturer of 4-Methyl-2-Benzothiazolehydrazine, we support a range of large-scale and specialty chemical industries with consistently engineered material optimized for key process integrations. Our precise control over synthesis and quality enables reliable downstream applications where technical performance and regulatory adherence matter.

    1. Agrochemical Intermediate for Fungicide Synthesis

    Major global crop protection producers use this compound as a core intermediate during synthesis of thiadiazole-based fungicides. It acts as a building block in multi-stage cyclization and condensation cascades, enabling target specificity and improved fungistatic properties for cereals and specialty crops. Formulators monitor hydrazine input closely during batch charging to manage conversion yields and residual control, adhering to strict traceability and impurity thresholds.

    Industry compliance standards

    • ISO 9001:2015 (Quality management systems)
    • Commission Regulation (EU) 1107/2009 (Plant Protection Products)
    • FAO/WHO specifications for pesticides (JMPS)
    • REACH Registration (EC 1907/2006)

    Typical usage ratio

    • 0.9 to 1.2 molar equivalents per targeted fungicidal scaffold, adjusted for downstream purifications and catalyst presence

    Downstream process integration

    • Charged in primary or secondary condensation steps, often after protection/deprotection of precursor amines and prior to ring closure or side-chain functionalization.

    Final product types

    • Thiadiazole-based field fungicides (wettable powders, suspension concentrates)
    • Seed treatment agents
    • Post-harvest protective coatings

    2. Pharmaceutical Intermediate for Antimicrobial API Synthesis

    Pharmaceutical manufacturers integrate this hydrazine derivative in the multi-step synthesis of certain heterocyclic antimicrobial active ingredients. Its reactivity supports formation of benzothiazole-hydrazone substructures, which extend activity spectrum and metabolic resistance. Process engineers optimize reactant ratios and monitor purity through in-line HPLC and controlled crystallization to meet compendial standards.

    Industry compliance standards

    • cGMP ICH Q7 (Good Manufacturing Practice for APIs)
    • USP/NF Monographs (applicable finished APIs)
    • European Pharmacopoeia (Ph. Eur.)
    • 21 CFR Parts 210/211 (U.S. FDA cGMP for finished pharmaceuticals)

    Typical usage ratio

    • 0.95–1.05 equivalents per heterocyclic intermediate, based on process mass balance and endpoint monitoring

    Downstream process integration

    • Reacted during intermediate formation, typically in controlled pH and temperature regimes, before subsequent functional group transformations and salt formation.

    Final product types

    • Broad-spectrum antimicrobial APIs (oral and topical forms)
    • Hospital-grade disinfectant actives
    • API intermediates for combinatorial synthesis

    3. Dye and Pigment Intermediate for Specialty Colorant Manufacturing

    Manufacturers of thiazole-based dyes utilize this material for introducing hydrazino or methylthio substituents, enhancing solubility and bath stability. The compound enters the colorant creation sequence where it couples with diazonium or carbonyl groups, and allows precise hue and fastness adjustments. Quality managers track batchwise addition to avoid overtone shifts and regulate metal salt formation.

    Industry compliance standards

    • OEKO-TEX® Standard 100 (restricted substance requirements)
    • EN 71-3:2019 (Toy Safety for heavy metal content)
    • ISO 105 B02:2014 (Color fastness standards)
    • REACH Annex XVII (Restriction of hazardous substances)

    Typical usage ratio

    • 5–15% w/w of total colorant precursor mass, depending on desired chromatic intensity and substrate

    Downstream process integration

    • Introduced during coupler synthesis or pre-final condensation of pigment structure, before salt washing and drying operations.

    Final product types

    • Reactive and disperse dyes for textiles
    • Organic pigments for plastics and inks
    • Specialty dyes for leather and paper finishing

    4. Corrosion Inhibitor Additive in Oilfield Chemicals

    Producers of oilfield service chemicals use this intermediate as a precursor for tailored benzothiazole hydrazone-based corrosion inhibitors. These molecules form strong complexes on ferrous and non-ferrous surfaces, reducing oxidative attack in downhole and pipeline conditions. Technicians monitor precise dosing during blending to align with expected hydrogen sulfide and water cut variation in target oilfield sites.

    Industry compliance standards

    • API RP 14E (Recommended Practice for Erosional Velocity in Piping)
    • NACE MR0175/ISO 15156 (Materials for use in H2S-containing environments)
    • OSPAR Decision 2000/2 (Offshore chemical notification scheme)
    • ISO 9001:2015 (Quality management systems)

    Typical usage ratio

    • 0.2–2.5% v/v in corrosion inhibitor blends, adjusted to local fluid chemistry and metallurgical factors

    Downstream process integration

    • Reacted or blended during inhibitor core formulation, prior to emulsion stabilization and batch quality release for field application.

    Final product types

    • Pipeline corrosion inhibitor concentrates
    • Drilling mud additive packages
    • Production system cleaning and maintenance fluids

    5. Chemical Research & Development for Advanced Heterocycle Synthesis

    Academic and industrial R&D centers use this compound as a personalized reagent for creating new benzothiazole derivatives, supporting exploratory drug discovery and material science. Synthetic chemists rely on its functional group compatibility to access rare scaffolds and analogs in low to moderate scale batch experiments. Stringent recording ensures compliance with hazardous chemical management protocols.

    Industry compliance standards

    • OECD GLP (Good Laboratory Practice)
    • Local chemical safety regulations (e.g., US EPA, ECHA, China MEE reporting)
    • UN GHS SDS Safety Labeling (Globally Harmonized System)
    • Institutional chemical procurement and tracking systems

    Typical usage ratio

    • 0.1–1.0 g per reaction in laboratory synthesis, scaling based on yield optimization and project requirements

    Downstream process integration

    • Used during the formation of core benzothiazole rings, often as a nucleophile or condensation partner, followed by workup and analytical validation of novel compounds.

    Final product types

    • Lead compound libraries for pharmaceuticals
    • Prototype specialty materials for electronics studies
    • Analytical standards for structure-activity relationship models
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    Certification & Compliance
    More Introduction

    Introducing 4-Methyl-2-Benzothiazolehydrazine: A Reliable Step Forward in Synthetic Chemistry

    Our Commitment as a Manufacturer

    Day in and day out, our team focuses on one priority: making consistently high-quality intermediates for the chemical industry. Over the years, we’ve seen the market shift with changing standards, new discoveries, and evolving needs from every corner of research and manufacturing. Among the many compounds we manufacture, 4-Methyl-2-benzothiazolehydrazine stands out. This product reflects years of experience, diligent process control, and a clear understanding of the demands faced by scientists and industrial users who work with thiazole derivatives.

    Refining this molecule is no straightforward task. We have worked by trial, continuous feedback from global end-users, and constant attention to detail. Making chemicals isn’t just pushing numbers through a reactor — it's about living up to expectations every time a shipment leaves our facility. Our longstanding direct relationships with research chemists and process engineers guide every improvement on the production line.

    Details That Matter: Model and Specifications

    The way we manufacture 4-Methyl-2-benzothiazolehydrazine, from batch selection to purification, stems from real-world usage. This material is often supplied in high-purity solid form, usually as a light to pale yellow powder. Users rely on its reliable melting point and its ready solubility in organic solvents. Trace metal content, residual solvents, and lot homogeneity all reflect careful quality assurance protocols on each batch. No shortcuts, no substitutions. We document and verify purity by HPLC and NMR, but the final judge is always how the product performs in your process.

    Years ago, customers often accepted broader variances in non-critical intermediates. As research and analytical methods improved, those same customers came to expect better. We invested in new analytical tools and redefined our criteria for batch release. Now, if there’s a difference in color, particle size, or trace contamination, it isn’t just noted—it’s addressed at the source, before packaging. This is the kind of assurance that makes a difference for R&D chemists who can’t afford variability, and for scale-up chemists who need reproducibility to translate data from bench to pilot scale.

    For those seeking specifics, we provide thorough documentation of each lot, full analytical data, and clear, readable certificates. Our purity standard typically meets or exceeds 98%, with most lots reaching purity above 99% by HPLC. Users who require special handling or documentation can work directly with our technical support team—there’s no wall between production and application science here. We know who our customers are, and we listen.

    Usage in Industry and Research

    4-Methyl-2-benzothiazolehydrazine often serves as a pivotal intermediate in organic synthesis. Its core structure, featuring both a methyl group and a hydrazine moiety on the benzothiazole ring, gives it reactivity that chemists favor for building diverse heterocycles. One common application involves the preparation of pharmaceuticals, where this material can act as a key step toward crafting innovative therapeutic candidates. We collaborate with process development teams to share relevant handling tips and lessons learned from hundreds of kilo-scale campaigns.

    Synthetic utility isn’t defined by catalog listings or theoretical yields — it’s proven with every actual run. Our customers have used this compound to develop agrochemicals, fluorescent dyes, and advanced materials. Some want single kilos, others seek hundreds. We accommodate both, understanding that requirements shift with new projects, funding cycles, and regulatory demands. Our flexibility isn't a slogan—it comes from the agility we've built up over years of rolling production changes to fit real timelines.

    Every so often, requests come in from university groups or industrial labs who have hit a wall with an off-spec material from another source. Sometimes the issue lies in particle size control, moisture sensitivity, or trace residues inhibiting downstream reactions. Having run a full spectrum of scalability trials, we share lessons right from the reactor floor. It isn’t just about filling an order: it’s about helping people push their science forward, free from the kind of setbacks that waste precious time and budget.

    Setting Ourselves Apart — What Makes Our 4-Methyl-2-Benzothiazolehydrazine Different

    Not every lot of 4-Methyl-2-benzothiazolehydrazine on the market is created equally. Many resellers and trading companies source materials from fluctuating suppliers, with minimal control over upstream manufacturing or analytical practices. Bags change hands five times before reaching the lab. By contrast, every gram of our material comes directly from our own reactors. We develop and refine synthesis processes in-house, improving yield, safety, and waste reduction with each iteration.

    Through regular investment in process engineering, we have been able to control impurities at the source. We employ carefully monitored reaction conditions, advanced filtration, and multiple recrystallization steps, not because a catalog demands it, but because our partners in pharma and materials research have shown us how challenging complex syntheses can become due to a stubborn contaminant or a poorly characterized input. When something doesn't work in the application lab, our chemists work with customers to troubleshoot—not with sales scripts, but with actual analytical results and process change suggestions.

    Another difference comes in our batch homogeneity and lot-to-lot reliability. Since everything starts and ends under one roof, we manage variables such as moisture, temperature, raw material origin, and solvent recovery ourselves. Our warehouse doesn’t sit halfway across the world, so inventory bottlenecks and transit environment swings do not complicate matters. Our customers remark on the predictability—whether an order comes 10 times a year or just once, they know performance won’t vary unexpectedly. For teams planning campaigns months in advance, this matters.

    Compared with other benzothiazole derivatives, 4-Methyl-2-benzothiazolehydrazine offers selective reactivity. Some applications benefit from the methyl group, which confers subtle changes in electron density and steric environment, allowing more efficient formation of downstream targets. Alternative intermediates may need extra protective group strategies or milder reaction conditions, introducing cost, process complexity, and more opportunities for error. We help customers choose wisely by sharing our long-running, practical insight — what’s worked, what hasn’t, and where this material shines.

    Sustainability in Chemical Production: Real Progress, Real Accountability

    As a manufacturer, we set aggressive goals for minimizing waste and managing byproducts responsibly. Old habits die hard, and chemical synthesis has always produced some waste. Yet, by investing in continuous process development, we lower the footprint of every batch. Our operations recover and re-use solvents, optimize reaction temperatures, and carefully treat aqueous waste streams. The drive toward greener manufacturing doesn't come from a desire to slap a logo on our shipments, but from having observed over decades how resource management affects both bottom line and environmental impact.

    Feedback from our partners—some of them highly regulated pharmaceutical and electronics firms—keeps us improving. They want materials not only with consistent performance, but also produced with transparent data on origin, impurity profiles, and emissions. We've responded with new protocols for process documentation and regular energy-efficiency audits. None of these changes would have stuck without ownership at every level, from operators on the synthesis floor to the technical staff running analytical checks seven days a week.

    Perhaps the best marker of responsible manufacturing comes from open dialogue. Our customers ask tough questions, and we give real answers. From disposal routes to transport packaging that reduces spillage risk, we regularly make process adjustments based on feedback. Over time, this approach builds mutual trust—a foundation that matters far more than a polished 'green' marketing campaign. Having a product like 4-Methyl-2-benzothiazolehydrazine used in new, high-demand R&D projects reflects more than just compound performance. It shows that reliability, transparency, and willingness to adapt make a difference—batch by batch, year over year.

    Quality Control: Beyond the Basics

    In today’s regulatory climate, basic quality control barely covers the true requirements of academic and industrial research. We test every lot of 4-Methyl-2-benzothiazolehydrazine against detailed specifications drawn from collaborative work with end-users and industry partners. Modern protocol means more than just a melting point and purity reading: we supply full chromatograms, impurity fingerprints, and if the user requests, trace element and residual solvent analysis. Repeatability, both at microgram and multikilogram scale, remains our everyday focus. Each operator understands the critical checkpoints—if an unexpected peak appears on an HPLC trace, the material comes off stream for troubleshooting, even if this means slower output.

    Most chemical producers know that analytical data impresses audit teams and regulatory agents, but the story doesn’t end with a signed certificate. Some impurities that seem trivial in a crude synthetic step become showstoppers when the material feeds into a medicinal campaign or high-stakes material fabrication. We constantly communicate with our biggest users to hear which analytical specs matter. This allows us to pre-emptively adjust our QC pipeline to match advanced project demands—instead of waiting for an urgent complaint to come back from the field.

    We also maintain representative retains for every lot produced. If a client returns months later with a technical question, we don’t scramble to recreate conditions or hunt for old records. Clear retention practices and real batch archives give our technical team the confidence to answer quickly and accurately. This is rarely discussed in glossy product brochures, but it means peace of mind for research organizations staking ambitious projects on reliable intermediates.

    Supporting Innovation—Our Perspective From the Production Floor

    Laboratory-scale innovation often outpaces what’s possible in kilo-labs or production plants. Bridging that gap takes a manufacturer’s patience and hands-on know-how. This is especially true for compounds like 4-Methyl-2-benzothiazolehydrazine, where minor tweaks in process design or purification yield significant improvements downstream. Partnering with innovators, we’ve run custom campaigns to support scale-up, process transfer, and regulatory approvals.

    Direct experience guides us more than any manual ever could. For instance, some users need a changed particle size to suit novel reactor designs or minimize dust. Over dozens of optimization rounds, we have fine-tuned milling, sieving, and drying steps. Others report trouble with cold-storage stability or time-dependent color changes. Our extensive internal archives, backed by real shipping and storage data, offer practical solutions. Instead of treating every new request as an exception, we see it as part of building better processes and a broader skill base.

    Innovation doesn’t always mean the most complicated chemistry. Much of our progress has come from basic improvements—better packaging practices to minimize clumping or moisture ingress, or tighter feedback cycles between analytical and production teams. Lessons travel quickly on our floor. Many of us have worked with the same material, on the same equipment, for years. This familiarity allows for rapid troubleshooting, collaborative improvements, and knowledge sharing across teams. These incremental advances shape the value our 4-Methyl-2-benzothiazolehydrazine brings to market.

    Risks, Challenges, and Real-World Solutions

    Every compound carries specific risks and hurdles. Manufacturing 4-Methyl-2-benzothiazolehydrazine, especially as demand grows, means strong attention to safe hydrazine handling and control of hazardous emissions. Regulations grow tighter—rightly so. Adhering to these standards, our teams regularly train in hazard mitigation, emergency response, and compliant transport. This isn’t just box-checking; several times, prompt action during production has prevented accidents and saved material, thanks to on-the-ground expertise.

    Supply chain shocks can complicate sourcing of specialty raw materials. We address this by maintaining close ties with several vetted suppliers, regular stock reviews, and forward purchasing strategies. Having lived through global disruptions, we know it’s never a single component that derails production—it’s the interplay between people, process, and logistics. Our response balances keeping excess inventory for critical reagents with lean operations practices.

    Perhaps the greatest challenge is growing demand from new sectors. We see cross-disciplinary requests—in electronics, advanced polymers, natural products, or diagnostics. Each field asks new questions about trace impurities, solvent choices, or end-use documentation. We invest in open technical dialogue and employ an integrated support model. The answers come from our own senior chemists, not an outsourced call center.

    Some challenges come from regulatory changes. We keep active watch for changes in safe handling, labeling, and permissible levels of byproducts. Compliance isn’t simply a one-time training: our chemists and safety teams refresh skills regularly, sharing new protocols as they emerge from global industry forums or regulatory publications. These internal routines keep us ready for shifts, no matter the region or application.

    For clients with high-sensitivity uses, such as pharmaceutical manufacturing, we understand the need for drug master files, GMP documentation, or shipment with full traceability. Even though not every project requires this level of oversight, we’ve invested in the systems to meet it. This way, innovative projects can progress without long delays or uncertainty about material credentials.

    Looking Toward the Future—Listening and Learning

    As a manufacturer, we recognize that today's standard process may be tomorrow’s starting point for something better. The demands on materials like 4-Methyl-2-benzothiazolehydrazine continue to evolve. Our customers push boundaries and set new benchmarks for what this chemistry can do. We respond by keeping our teams close to the ground, reviewing technical feedback, and investing in incremental improvement.

    This means welcoming plant tours, open audits, and technical exchanges. No secrets, just a continued drive to serve researchers and production chemists genuinely interested in advancing their own goals. Our story with this compound is shaped not by catalog pages, but by the ongoing conversations that drive better science and industrial progress.

    Every batch goes out with the lessons and pride of our manufacturing teams. Reliable, transparent, and ready to meet new challenges—this is how we see the value of 4-Methyl-2-benzothiazolehydrazine in today’s world. We look forward to every new question, knowing each one pushes us further and strengthens our partnership with the true engine of progress: the global scientific and industrial community.