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4-Methoxycinnamic Acid

    • Product Name 4-Methoxycinnamic Acid
    • Alias p-Anisic acid
    • Einecs 216-245-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    451303

    Cas Number 830-09-1
    Molecular Formula C10H10O3
    Molecular Weight 178.19
    Iupac Name 4-methoxycinnamic acid
    Appearance White to off-white crystalline powder
    Melting Point 173-175 °C
    Boiling Point 332.7 °C at 760 mmHg
    Solubility In Water Slightly soluble
    Density 1.2 g/cm³
    Smiles COC1=CC=C(C=C1)C=CC(=O)O
    Pubchem Cid 68944
    Synonyms p-Methoxycinnamic acid, 4-Methoxy-trans-cinnamic acid

    As an accredited 4-Methoxycinnamic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 4-Methoxycinnamic Acid, 100g, packaged in a sealed amber glass bottle with tamper-evident cap and clear labeling for safety.
    Shipping 4-Methoxycinnamic Acid is shipped in tightly sealed containers to prevent moisture and contamination. It should be transported at ambient temperature, away from direct sunlight, heat, and incompatible substances. Proper labeling and documentation are required, and handling must comply with local and international regulations for shipping chemicals.
    Storage 4-Methoxycinnamic acid should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from incompatible substances such as strong oxidizers. Protect it from moisture and direct sunlight. Store at room temperature, avoiding extreme heat or cold. Ensure appropriate labeling and safety precautions are in place to prevent accidental ingestion, inhalation, or contact with skin or eyes.
    Application of 4-Methoxycinnamic Acid

    Applications of 4-Methoxycinnamic Acid in Industrial Manufacturing

    Our production of 4-Methoxycinnamic Acid serves as an integral intermediate in multiple advanced fine chemical manufacturing sectors. We supply technical and high-purity grades to leading global formulators, who utilize this compound within precisely engineered process steps. Below, we outline verified industrial applications, with emphasis on process requirements, composition ranges, compliance systems, and corresponding finished products manufactured by our downstream partners.

    1. UV Filter Synthesis for Sunscreen and Personal Care

    In the personal care sector, formulators incorporate 4-Methoxycinnamic Acid as a precursor for the preparation of key UV-absorbing agents through esterification or amidation steps. This compound is processed further to manufacture active sun filter ingredients compliant for use in regulated cosmetics and suncare products, where ingredient traceability and photostability assessment underpin downstream production systems.

    Industry compliance standards

    • EU Cosmetics Regulation EC 1223/2009
    • U.S. FDA OTC Monograph for Sunscreen Ingredients
    • ISO 9001:2015 for quality management in cosmetics production
    • REACH Registration for component traceability

    Typical usage ratio

    • As a synthesis intermediate: 1.0–1.2 molar ratio per target filter molecule (scaled according to end active concentration requirements)

    Downstream process integration

    • Condensation with alcohols or amines under acid catalysis to form cinnamate UV absorbers, followed by purification and incorporation into sunscreen lotions or cosmetic emulsions at the formulation plant

    Final product types

    • UVB/UVA filter actives (e.g., Octyl Methoxycinnamate, also known as Ethylhexyl Methoxycinnamate)
    • Water- or oil-based sunscreen creams
    • Daily personal care moisturizers with integrated UV protection
    • Long-wear facial foundations with SPF claims

    2. Pharmaceutical Intermediate for Anti-inflammatory APIs

    API manufacturers employ 4-Methoxycinnamic Acid in the targeted synthesis of non-steroidal anti-inflammatory drug intermediates and structure-activity analogs in their pipeline. Process and quality control measures ensure that input purity and residual solvents remain within regulatory limits, and traceable batch records are an industry expectation for all pharmaceutical supplies.

    Industry compliance standards

    • ICH Q7A Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • European Pharmacopoeia Monograph 01/2024:1236
    • U.S. FDA 21 CFR Part 211 (CGMP for Finished Pharmaceuticals)
    • USP <823> for impurities and residual solvents

    Typical usage ratio

    • Starting intermediate: 0.9–1.1 equivalents per active pharmaceutical molecule in the pathway (adjusted based on targeted scaling and yield optimization studies)

    Downstream process integration

    • Loaded as the key building block in condensation, hydrogenation, or coupling reactions on API production lines; further processed through crystallization and filtration before formulation of the finished drug

    Final product types

    • Topical anti-inflammatory creams
    • Oral NSAID tablets and capsules (e.g., various derivatives under clinical development)
    • Prescription combination analgesics
    • Specialty pharmaceutical intermediates for onward modification

    3. Flavor and Fragrance Ester Production

    Downstream aroma chemical houses utilize 4-Methoxycinnamic Acid to manufacture specific esters and derivatives for inclusion in flavor and fragrance bases. The compound undergoes proprietary esterification, giving rise to value-added aromatic ingredients with documented organoleptic profiles as required by food and perfumery standards. Batch formulation records, sensory analysis, and origin documentation form parts of the industry’s compliance framework.

    Industry compliance standards

    • FCC (Food Chemicals Codex) for food-grade esters
    • IFRA Standards for fragrance ingredient safety
    • EU Regulation (EC) No 1334/2008 on flavoring substances
    • ISO 22000:2018 Food Safety Management Systems (applied to food-related applications)

    Typical usage ratio

    • Intermediate in ester synthesis: 1.0 molar equivalent per target ester (scaled for intended fragrance note strength or food/beverage flavor load)

    Downstream process integration

    • Feeding into batch or continuous flow esterification with selected alcohols, followed by distillation and purification; resulting aromatic esters are standardized and incorporated at trace ppm to percent levels in final flavor and fragrance equipment

    Final product types

    • Fine fragrance compositions (perfume bases, colognes)
    • Flavoring additives for beverages (cola base, spice blends)
    • Bakery and confectionery flavor infusions
    • Household care perfumes and detergents

    4. Agrochemical Intermediate for Plant Growth Regulators

    Our technical-grade 4-Methoxycinnamic Acid is supplied to agrochemical formulators for the synthesis of plant growth regulators (PGRs) and related bioactive cinnamic acid derivatives. Quality assurance teams at our customer sites monitor input specification adherence, while batch integration is designed for compliance with regional pesticide/biostimulant regulations and crop safety validation protocols.

    Industry compliance standards

    • FAO and WHO specifications for pesticide/biostimulant actives
    • EU Regulation (EC) No 1107/2009 on plant protection products
    • China GB 2763 for agricultural chemicals residue limits
    • OECD Principles of Good Laboratory Practice (GLP) for efficacy trials

    Typical usage ratio

    • Synthesis feedstock: 1.0–1.05 molar ratio, based on compound conversion rates in downstream processing (tuned per PGR specification and crop coverage)

    Downstream process integration

    • Charged into controlled condensation reactions for production of amino acid-modified or esterified PGR formulations; post-synthesis, the product is granulated or solubilized for field-ready pesticide and biostimulant applications

    Final product types

    • Plant growth regulator active compounds (e.g., cinnamic acid–based auxins)
    • Biostimulant concentrate formulations
    • Seed coating chemicals
    • Foliar spray adjuvants

    5. Polymer Additive for Photoresist and Coating Applications

    Advanced electronics and specialty polymer plants employ 4-Methoxycinnamic Acid as a functional additive to engineer photo-reactive crosslinkers and resin modifiers used in photolithography and protective coatings. Precision dosing and clean-room integration ensure compliance with electronic material purity, while validated supply chain transparency underpins qualification for high-reliability microfabrication.

    Industry compliance standards

    • SEMI C93 Standard for Materials Used in Photolithography
    • IEC 62474 for hazardous material reporting
    • ISO 14001 Environmental Management for chemical production
    • RoHS Directive for restricted substances in electronics

    Typical usage ratio

    • Photoresist compositor: 0.2–2.5% by weight of resin solids, optimized for polymer performance and exposure characteristics

    Downstream process integration

    • Incorporated through solution blending with polymer matrices, followed by casting, curing, and patterning steps within photoresist or coating preparation lines; purity and reactivity tests precede final resin application

    Final product types

    • Photoresist formulations for semiconductor manufacture
    • UV-cured coatings for optical components
    • Specialty resin composites
    • High-performance protective films for electronics and displays
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    Certification & Compliance
    More Introduction

    Introducing 4-Methoxycinnamic Acid: A Manufacturer’s Perspective

    Understanding the Substance by Experience

    Working daily with 4-Methoxycinnamic Acid, the hands-on familiarity with its solid, crystalline form and the subtle, almost vanilla-like aroma stands out. The material flows well through standard processing equipment, avoiding complications from clumping or residual moisture, which often plague similar organics. Granule size impacts both dissolution rate and ease of mixing in downstream operations, something many overlook until they're elbow-deep in production line troubleshooting.

    Chemically, this compound, also known as p-anisic acid with the CAS number 830-09-1, boasts a structure rooted in the cinnamic acid family. By introducing a methoxy group into the para position, its behavior shifts, especially under high-heat synthetic routes. Our team has tested a variety of batch sizes, confirming stability up to 250°C, which safeguards reproducibility across applications. The white crystalline powder remains easy to identify and handle, supporting repeated measurements without skew or drift—an asset in labs where speed and reliability buy more time than any line on a spec sheet.

    Model, Quality, and Specifications from the Floor

    Our batches–labelled under our standard code MOC-98–show a consistent assay of not less than 98% by HPLC testing. Even small impurities, like ortho- or meta-isomers and organic solvents, receive scrutiny in our daily operations. Staff members rely on modern chromatographic equipment to track purity, watching for any drift between thermal cycles. Quality tests often cover melting point (173–175°C) and loss on drying below 0.5%, ensuring every kilogram matches the assurances on the outbound drum.

    Packaging, too, gets constant review. Standard drums hold 25 kg net to minimize handling risks and ease hoisting during transfer, with liners offering chemical protection. Sometimes calls come in for smaller lots—5 or 10 kg—and we tailor those with the same attention. Factory experience has proven that cross-contamination risks rise when switching between similar aromatic compounds, so cleaning cycles follow a documented checklist that stems from painful lessons, not just regulatory necessity.

    Every production run includes a real-world sample archive, so we can revisit shipments at a customer’s request. Documentation rarely substitutes for physically pulling a past production lot off the shelf and re-analyzing for shelf life or long-term stability—those repeat checks sharpen our quality control far more than paper-based audits ever could.

    Applications in Practice

    Our engagement with customers reveals a demand for 4-Methoxycinnamic Acid in fragrance intermediate production, especially where mild floral and balsamic notes provide subtlety to finished goods. In flavor chemistry, its role as a precursor builds complexity in many synthetic vanillin derivatives; perfumers and flavorists comment that this precursor’s trace residue can shape perception at even low ppm levels. The cosmetics segment routinely integrates this acid as a UV absorber precursor, with solubility in both ethanol and minimal amounts in water allowing direct feeding into creams and lotions.

    Recently, we worked with a laboratory researching new sunscreen agents. Their feedback mirrored our own assessments: the structure allows for the generation of esterified derivatives that block UV-B light without rapid breakdown under light exposure, adding real shelf-life to finished sun-protection products. In pharmaceuticals, research groups synthesize amide and ester derivatives, exploring anti-inflammatory and antifungal properties. Having run test reactions onsite with these labs, our staff sees fewer bottlenecks when the incoming acid dissolves cleanly and withstands base-catalyzed transformations—a mark of purity they confirm not only with documents but by direct reaction yields.

    As a synthetic intermediate, 4-Methoxycinnamic Acid offers a straightforward path to more complex target molecules—flavonoids, fine chemicals, and photo-reactive components. Users value reproducibility over theoretical yields; feedback from scale-up trials often focuses on how our product shortens purification steps, lowering solvent usage and total batch time.

    Working With 4-Methoxycinnamic Acid: Real Lessons

    Chemists and plant operators notice differences immediately when substituting this product for related cinnamic acids. The methoxy group at the para position causes the material to melt smoothly and reduces dustiness when charging reactors, making the environment safer for operators. Trials with alternative grades from market sources sometimes lead to caking or inconsistent melting, which halts operations—a lesson traced back to microscopic moisture content and particle shape. We pursued drying and sieving procedures to minimize these effects, learning through each iteration.

    Every step—storage, transfer, measurement—relies on handling guidelines refined through post-shift reviews. Open dialogue between operators and the technical team quickly flag batch-to-batch variations, such as shifts in color or odor, that suggest subtle process drift. Addressing these signs early avoids downstream interruptions and lost production hours. We keep a troubleshooting log open in the plant, documenting causes and corrections, because hands-on experience often exposes more about process stability than any external audit.

    Customers engaged in downstream processing value detailed advice more than polished marketing. Our staff routinely advises on solubility and pH adjustment, since slight differences in process water can lead to clouding or phase separation. One cosmetics customer called after introducing the acid into a new lotion blend; the first batch clouded, but tracking their water’s ionic strength, we proposed small buffer tweaks—learned from our own mixing tank mishaps—that corrected the issue immediately. This kind of feedback cycle, from workshop to warehouse, makes technical support more meaningful, especially as regulatory bodies tighten limits on byproducts and residual solvents.

    Differences From Similar Aromatic Acids

    In laboratory pilot runs and plant-scale productions, we’ve directly compared 4-Methoxycinnamic Acid with other hydroxy- and methoxy-cinnamic acids. The para-methoxy configuration changes not just the appearance—brighter powder with fewer yellowish undertones—but also the downstream conversion rates in syntheses for photostabilizers or aromatic esters. Ortho- and meta-substituted analogs, or those with free phenol groups rather than methoxy, show higher reactivity toward oxidation and less stability in ambient storage. Our storeroom doesn’t lie: after a few months under warehouse conditions, color comparison tells the tale.

    Scalability matters too. During continuous syntheses, some alternative cinnamic acids show rapid clogging in feed lines. 4-Methoxycinnamic Acid, in our system, keeps flow stable. The unambiguous scent also alerts us if a batch absorbs too much environmental moisture, helping prevent cross-contamination—an advantage during scaleups or when switching between white and colored product lines in the same facility.

    The para-methoxy derivative demonstrates a distinct reaction profile in the presence of alkali. Our lab teams find improved yields in esterification and amidation steps and less byproduct contamination, letting us achieve higher purity without additional rework. Customers making sunscreen agents or flavor compounds rely on these small differences to hit regulatory and sensory targets. While other aromatic acids may offer similar results in bench chemistry, process engineers discover, often by costly error, that a change in substituent position alters filterability, color, solution behavior, and reaction timelines in full-scale production.

    Quality, Traceability, and Safety Outlined by Years of Manufacturing

    Oversight surfaces not just in finished product but in every drum, package, and process note. We maintain records of each manufacturing cycle, including the lot histories, starting material sources, and equipment status at the time of filling. Customers sometimes inquire about a specific lot from years earlier for regulatory or research purposes. Our physical and electronic archive means a real sample and process record can be pulled within minutes, not hours.

    Batch deviations become teaching moments. Once, a change in upstream solvent purity showed up as a faint discoloration in a finished batch. By reviewing our on-site logs, we tracked the source, adjusted the solvent supplier, and improved inspection frequency—direct feedback that filtered through to staff on the warehouse floor. Lessons like these tighten controls, not out of obligation, but because repeated missteps cost production time and trust.

    Safety always ties into daily practice. Teams receive regular updates on safe material handling. In one incident, an open drum absorbed atmospheric moisture, causing granule clumping. Identifying the root cause led to small, yet effective, changes in sealing methods and warehouse humidity controls. These adjustments, built on actual observed consequences, prove more effective than top-down edicts or third-party recommendations. The team’s daily vigilance, paired with deliberate improvements, lowers risk for both our operation and our customers.

    Technical Support, Collaboration, and Innovation Built In

    Our technical support team fields requests about compatibility, blending, and compliance with shifting industry standards. Recent discussions extended to REACH and other regulatory changes, with documentation prepared by staff who have seen these requirements shift in real time, not abstracted through layers of distribution. The benefit of manufacturing onsite sits in our ability to produce test lots for novel requests. Research partners access specialty particle sizes and purities, even short pilot runs, to validate formulations ahead of scaling—a flexibility sustained by years of hands-on experience in shifting between R&D and high-volume output.

    Partnerships continue to push boundaries. A few years ago, a collaboration tackled odor masking in fragrance applications. We tailored our drying protocols and sieving parameters, trading anecdotes and process samples directly with the client, until both sides resolved the core processing challenge. This shared process built trust and repeat business, not by promoting generic features, but through problem-solving that only manufacturers closely involved with their own material can provide.

    Feedback from regular partners sometimes leads to blending small batches with related acids, supporting the development of new standards in aromatic chemical libraries. Fielding requests for highly pure grades, the team re-engineers process steps, holding pilot trials on production-scale equipment before releasing anything to the market. The iterative nature of this work builds knowledge with each cycle, not only for ourselves but for the industries relying on new materials. This practical know-how turns customer challenges into improvements for both parties, shaping not just the product but the direction of our facility’s investments.

    Meeting Evolving Industry Demands

    Industry regulations never rest, and neither can we. With frequent updates in substances allowed in finished food, fragrance, and pharmaceutical products, sourcing and manufacturing stay under the microscope. We trace each material’s journey from raw ingredients to finished acid, tracking safety and purity at every juncture. Our facility draws on continuous staff education, keeping up with quality benchmarks through both traditional classroom training and direct hands-on coaching. Regulatory compliance rests not only on closed-loop documentation but on real process mastery, reinforced by the team that works intimately with the acid daily.

    Environmental management matters, not as a slogan, but as practice on the production floor. All spent solvents and wash residues undergo treatment in our in-house facility, with run-off tracked and logged per lot. The drive to minimize waste improved our recovery systems for both solvents and reactants, lowering both environmental impact and operating costs. Shifts in regulations, especially for European and North American customers, push for lower levels of trace contaminants and clearer recordkeeping. These standards translate daily into more careful material handling, stricter testing, and deeper transparency in reporting—all practices rooted in reality, not in marketing materials.

    4-Methoxycinnamic Acid: Future Uses and Continuing Innovations

    Researchers worldwide search for new uses for 4-Methoxycinnamic Acid, particularly in materials science and medical chemistry. Our R&D group tracks global literature while maintaining process samples ready for immediate customer trials. Some project groups explore the acid as a building block for advanced polymers, noting that its methoxy group introduces flexibility and light-resistance. Others investigate its bioactivity in experimental therapeutics, sometimes uncovering unexpected stability advantages over less substituted analogs.

    We monitor trends in greener synthesis routes, drawing on real-life trials to optimize conditions—solvent selection, catalyst choice, waste minimization—based on actual process challenges, not just theory. Changes like these translate into higher overall yields, safer working conditions, and reduced emissions, helping the facility stay ahead in competitiveness and compliance. These incremental improvements constantly reshape our daily workflow, proving that innovation means more in practice than in PowerPoint slideshows.

    No process unfolds without its pain points. One production run may reveal a stubborn impurity; another highlights a stubbornly sticky powder that clings to dosing scoops. Each problem propels our team to adjust the process—sometimes batch size, sometimes drying temperature, sometimes filtration mesh micron rating. The quick turnaround, rooted in direct plant experience, often solves customer issues before they even notice. These cycles improve both our product and our operators’ skills, demonstrating the inherent value in working directly with the substance rather than relying only on external input.

    Summing Up from the Manufacturer’s Bench

    Firsthand work with 4-Methoxycinnamic Acid demonstrates its value beyond its chemical description. By personally overseeing everything from raw ingredient acceptance to final product drum, we spot the subtle features—melting behavior, particle size, moisture resistance—that end up shaping both customer satisfaction and plant productivity. Improvements in quality, safety, and customer support don’t come by accident or corporate messaging. They result from daily lessons, open conversations with end users, and a willingness to treat every complaint as both feedback and opportunity. For anyone sourcing this compound, connecting with a manufacturer who knows the material through real-world experience, both good and bad, delivers an advantage beyond the spec sheet.