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4-Methoxybenzyl Alcohol

    • Product Name 4-Methoxybenzyl Alcohol
    • Alias p-Anisyl alcohol
    • Einecs 224-208-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    434414

    Chemical Name 4-Methoxybenzyl Alcohol
    Synonyms p-Anisyl alcohol, p-Methoxybenzyl alcohol
    Molecular Formula C8H10O2
    Molecular Weight 138.17 g/mol
    Cas Number 105-13-5
    Appearance Colorless to pale yellow liquid
    Boiling Point 258-260°C
    Melting Point 22-25°C
    Density 1.09 g/cm3
    Solubility In Water Slightly soluble
    Flash Point 128°C
    Refractive Index 1.537-1.540
    Pubchem Cid 7632

    As an accredited 4-Methoxybenzyl Alcohol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 4-Methoxybenzyl Alcohol is supplied in a 100g amber glass bottle, tightly sealed, with clear hazard labeling and handling instructions.
    Shipping 4-Methoxybenzyl Alcohol is shipped in tightly sealed, chemically-resistant containers to prevent leaks and contamination. During transport, packages are clearly labeled according to regulatory requirements. It should be stored and shipped in a cool, dry, and well-ventilated area, compliant with safety guidelines to avoid exposure and degradation.
    Storage 4-Methoxybenzyl Alcohol should be stored in a cool, dry, well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizing agents. Keep the container tightly closed when not in use to prevent moisture absorption and contamination. Store at room temperature and protect from light. Use suitable chemical-resistant containers and clearly label all storage vessels.
    Application of 4-Methoxybenzyl Alcohol

    Applications of 4-Methoxybenzyl Alcohol in Industrial Manufacturing

    As an established manufacturer, we supply 4-Methoxybenzyl Alcohol tailored for critical applications across diverse chemical sectors. This raw material serves in regulated specialty synthesis, advanced intermediates preparation, and several downstream value chains. Below, we outline established industry segments using this compound as a key input, with details on compliance, formulation, process, and end products reflected from real customer integration.

    1. Pharmaceutical Intermediates Synthesis

    Production of active pharmaceutical ingredient (API) intermediates employs 4-Methoxybenzyl Alcohol as a protected benzyl group or reactive precursor in multi-step synthesis, especially for selective etherification and protection reactions. Formulators apply it within regulated GMP lines for cardiovascular, anti-infective, and central nervous system drug intermediate pathways, requiring traceable batch control and controlled residues.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.) monographs for registered intermediates
    • FDA 21 CFR Part 211 (US cGMP)
    • Chinese Pharmacopoeia (ChP) intermediate-specific requirements

    Typical usage ratio

    • 4-Methoxybenzyl Alcohol usage typically ranges from 0.8 to 2.5 molar equivalents as a protecting group or precursor in reaction streams, adjusted based on substrate and deprotection yield analysis. Process development may optimize loading as low as 0.7 equivalent in high-purity routes.

    Downstream process integration

    • Incorporated routinely during early to mid-stage synthesis for selective oxygen protection or benzylation before subsequent deprotection under acidic or reductive conditions. The timing depends on target molecule characteristics and regulatory impurity profiles.

    Final product types

    • Key intermediates for beta-blockers (e.g., Atenolol, Metoprolol)
    • Precursors for antihypertensive agents and CNS therapeutics
    • Building blocks for synthetic nucleosides and specialty APIs

    2. Flavors and Fragrance Ingredient Manufacturing

    Aromatic compound manufacturers adopt 4-Methoxybenzyl Alcohol for the preparation of fine fragrance aldehydes and acetals, where its methoxy-substituted structure imparts floral and anisic nuances. Industrial processors employ precise formulation and purification regimes to meet flavor safety and regulatory benchmarks, focusing on trace impurity thresholds.

    Industry compliance standards

    • IFRA (International Fragrance Association) Code of Practice
    • EU Regulation (EC) No 1334/2008 on flavorings
    • US FEMA GRAS (Generally Recognized as Safe) assessments
    • ISO 9001:2015 Quality Management for synthetic ingredient production

    Typical usage ratio

    • Usage rate in formulation typically ranges between 0.1% to 4% w/w depending on the role in fragrance or flavor composition and desired release profile. End-users generally conduct preformulation studies to set safe consumption and olfactory outcome.

    Downstream process integration

    • Substrate for selective oxidation to 4-methoxybenzaldehyde, further reacted into acetals or esters for compounded scent profiles. Most lines perform distillation after transformation to ensure flavor-grade purity.

    Final product types

    • Fine and functional fragrances (perfume, cologne concentrates)
    • Food flavoring compounds (synthetic vanilla, anisic blends)
    • Scented personal care additives (soaps, deodorants, lotions)

    3. Agrochemical Active Ingredient Production

    Producers of crop protection chemicals utilize 4-Methoxybenzyl Alcohol as a bespoke building block during synthesis of select herbicide and insecticide intermediates. Control of feedstock purity, moisture, and trace organics directly impacts quality and field approval of agrochemical actives in global regulatory frameworks.

    Industry compliance standards

    • FAO/WHO Specifications for plant protection products
    • ISO 17025 quality compliance for chemical testing
    • REACH Regulation (EC) No 1907/2006 for industrial chemicals in EU territory
    • China Ministry of Agriculture Standard GB/T 16631

    Typical usage ratio

    • The alcohol loads between 1.0 to 3.5 equivalents for nucleophilic substitution or etherification, customized to synthesis route and specific yield constraints applicable to each active ingredient precursor.

    Downstream process integration

    • Integrated after halogenation of aromatic cores, with subsequent steps including alkylation or oxidation to achieve the desired efficacy and formulation stability. Storage and handling address specific agro-use impurity clearance.

    Final product types

    • Intermediate molecules for selective herbicides (e.g., anilide derivatives)
    • Precursors for pyrethroids and phenoxy-based insecticides
    • Fine-tuned active ingredient intermediates used in cereal, vegetable, and orchard protection formulations

    4. Dye Intermediate Synthesis

    4-Methoxybenzyl Alcohol plays a defined role in the manufacture of high-performance dye intermediates, particularly for azo or anthraquinone-based colorants intended for textiles and industrial coloration. Producers track aromatic purity and reactivity profiles closely to meet shade reproducibility and fastness criteria required in modern dyehouses.

    Industry compliance standards

    • OEKO-TEX® Standard 100 for textile chemical safety
    • REACH Annex XVII (EU) for restricted aromatic amines in dyes
    • ZDHC MRSL (Manufacturing Restricted Substances List) compliance
    • ISO 14001:2015 Environmental Management in chemical manufacturing

    Typical usage ratio

    • Substitution or protective group introduction usually at 0.9–2.2 equivalents depending on aromatic substrate and downstream deprotection requirements for chromophore rigidity and lightfastness.

    Downstream process integration

    • Engaged at pre-condensation or coupling step, followed by oxidation or further derivatization. Removal or transformation typically occurs prior to final chromophore ring closure to guarantee shade uniformity.

    Final product types

    • Reactive dye intermediates for cellulosics
    • Disperse colorants for synthetic fibers
    • High-purity pigment intermediates for coatings and plastics coloration

    5. Specialty Polymer Additives

    Manufacturers of advanced polymers and resins apply 4-Methoxybenzyl Alcohol as a functionalized monomer or chain modifier in engineering plastics and specialty resins. The compound introduces oxidative stability or modulates the flexibility of cured materials, especially in performance coatings and electronic encapsulants.

    Industry compliance standards

    • UL 94 standards for plastics flammability testing
    • RoHS Directive 2011/65/EU for restricted substances in electrical applications
    • ISO 9001:2015 Quality Management for polymeric materials
    • ASTM D256 and D638 for plastics mechanical property evaluation

    Typical usage ratio

    • Incorporated between 0.5–5% by weight relative to polymer backbone, tailored for required degree of crosslinking, thermal resistance, and target melt flow index in end-use applications.

    Downstream process integration

    • Reacted during resin formation or melt mixing, entering either as a co-monomer or as a terminal chain modifier compatible with bulk and solution polymerization methods. Final content verified by GPC or NMR analytical control.

    Final product types

    • Epoxy and urethane resins for electronics and adhesives
    • High-durability engineering polymers for automotive and aerospace
    • Optical-grade plastics requiring enhanced weatherability
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    Certification & Compliance
    More Introduction

    4-Methoxybenzyl Alcohol: A Closer Look from the Manufacturing Floor

    Understanding 4-Methoxybenzyl Alcohol Through Years of Production

    Manufacturing 4-Methoxybenzyl Alcohol provides a window into how a well-made intermediate can unlock possibilities in both research and industrial chemistry. In the daily activity of our plant, we watch batches move from raw input to distilled product, always keeping an eye on things like purity, consistency, and reliability. Over years of poured concrete and humming glassware, feedback from partners who rely on our product has given us experience you cannot pick up from a textbook.

    The Chemical: Formula, Features, and Consistency

    The molecular structure of 4-Methoxybenzyl Alcohol carries the designation C8H10O2 and a CAS number of 105-13-5. Workers in the plant get familiar with its appearance—clear liquid, faint aromatic odor, no visible particulate. Boiling point and melting point are set; in a scale-up facility, these play back into reactor temperature control and distillation design. Experienced operators pay attention to slight color changes and monitor GC trace tightly, knowing trace impurities can throw off downstream synthesis.

    Our typical output runs with purity at 99% or higher, judged by gas chromatography. This isn’t only an internal matter of pride; small differences in purity can become big headaches for those working at the next step, especially pharmaceutical researchers or specialty polymer producers. We’ve seen what happens when a fraction of percent variation creeps in—reaction times shift, yields slip, or isolation gets messy. Over time, even the best-rehearsed lab protocol can’t compensate for an inconsistent raw material.

    Making 4-Methoxybenzyl Alcohol Work for End Users

    On the production line, we handle a range of requests, from kilo-scale up to multi-ton batches. Smaller lots go straight to fine chemical and pharma clients; volume orders head to fragrance, flavor, and agrochemical factories. The versatility comes from the molecule’s functional groups—a primary alcohol tweaked by a methoxy substituent. Our technicians have learned to anticipate the impact this pattern brings to reactivity. The alcoholic group remains reactive for protecting group strategies, reduction, oxidation, and ether formation, and it slips into more functionalized scaffolds without much fuss, as long as the feedstock meets the right standards.

    For those in flavor and fragrance manufacture, the mild aroma and relative safety often compare favorably to more volatile or pungent alcohols. On the other hand, our pharma partners tune in closely to trace metal analysis, looking for reproducibility at every run. Custom requests—anhydrous prep, special packaging, or even tailored impurity profiles—show up every month. Factory life means always keeping records from every batch, since a recurring solvent line or an off-grade drum can point to a necessary process change.

    Comparing with Close Relatives in the Benzyl Alcohol Family

    Anyone deep into aromatic alcohols turns the beaker toward comparisons. 4-Methoxybenzyl Alcohol sits firmly apart from unsubstituted benzyl alcohol; the presence of the methoxy group changes both reactivity and solubility, shifting uses away from the classic solvents and into more specialized synthetic territory. Laboratory teams who run reductive aminations, for instance, see different yields when the para position offers electron donation versus a simple hydrogen.

    The story gets more interesting when you look at other isomers—take 3-methoxybenzyl alcohol, for example. The position of substitution changes electron density and influences selectivity in multi-step synthesis. Over the years, synthetic chemists have let us know their results differ when they swap one isomer for another—sometimes dramatically. It's our job to avoid cross-contamination and mix-ups. Matching the correct isomer every time has more practical impact than a lot of people outside the plant realize.

    Gauging difference also involves physical handling—4-Methoxybenzyl Alcohol boasts greater solubility in organic solvents compared to its parent alcohol, which makes it blend more easily in certain applications. Both shelf life and storage conditions matter less, since its chemical stability counters the need for constant climate monitoring that some other sensitive intermediates demand.

    Handling, Packaging, and Day-to-Day Practical Matters

    From manufacturing to drumming, our process streamlines delivery. We typically use high-density polyethylene or fluorinated containers to resist any seepage or chemical attack. Colleagues at the shipping dock insist on good quality seals; after a few reports years ago of minor leaks—always from poor drum capping—we redoubled checks. Our system now signs off on labelling and lot tracking for every shipment.

    On-site storage safety depends on tight, dry, cool conditions. 4-Methoxybenzyl Alcohol behaves quite predictably in terms of vapor pressure and flammability—less demanding than more volatile solvents, but no holiday from good chemical hygiene. Forklift operators and warehouse staff don't want sticky drum residue or vapor; so spill management is trained, and everyone from maintenance to QC rotates through annual refresher courses. Customers appreciate clear labeling and paperwork, especially for customs clearance and national registration.

    If a customer ever notes an off-odor, discoloration, or uncharacteristic phase separation, it leads right back to a complete review. Line managers take these reports seriously—one contaminated batch 12 months ago led to an overhaul of the transfer lines between intermediate storage and final bottling. In real production, no quality system is static; feedback from the field constantly feeds tweaks and corrective actions.

    Supporting Diverse Industries with a Reliable Core Product

    As technology shifts, many sectors find new needs for established building blocks. API research sometimes takes advantage of our alcohol both as a protecting group and as a synthetic precursor to more complex molecules. Peptide coupling, nucleoside chemistry, and certain photochemical applications all create short-term spikes in demand. Because our product’s versatility covers such a range, we counsel research partners on batch size, likely yield, and integration into ongoing production streams, not just a one-off order.

    Agrochemical innovators have also found a niche for 4-Methoxybenzyl Alcohol derivatives. The functionalized benzyl chain enables them to build targeted compounds for pest resistance or plant-growth regulation. In these cases, timing and supply chain reliability take precedence over trivial price cuts. If a planting or spraying window closes, lost time cannot be regained, so we focus on clear delivery commitments matched by process stability.

    Flavor and fragrance formulators prefer this alcohol for its gentle scent as well as the ease of modification into ethers, esters, or more complex aroma chemicals. Our technical service group can suggest storage, blending, or even certain scale-up tricks—lessons from production line experience, not just theory. We document feedback on performance and take time to check every complaint or suggestion, since no two clients use 4-Methoxybenzyl Alcohol quite the same way.

    Sourcing, Verification, and Supply Chain Confidence

    The raw materials for our batches get checked not just for origin but for trace-by-trace composition. Any deviation in anisole, formaldehyde, or reducing agent grades quickly results in a flagged purchase order. Suppliers visiting our facility see the analytical labs in action; every incoming drum gets run through GC, IR, and sometimes NMR, depending on client audits.

    Securing a stable supply means not only reliable deliveries, but active substitution plans in the case of natural disasters, export barriers, or sudden regulatory change. Our procurement team maintains relationships with backup partners on three continents, and reports monthly to management about risk flags or market price shifts. This attention to readiness paid off during logistics disruptions—production kept moving without interruption, and customers experienced no delay in scheduled shipments.

    Regulatory Requirements, Compliance, and Quality Mindset

    Since our clients operate in strictly regulated sectors, our internal documentation must withstand inspection at any moment. We maintain batch records for years, connect every product sample to its batch, and back up electronic lab notebooks for traceability. Both ISO and Good Manufacturing Practice audits focus on clean transitions, cleanliness, and real data—not only SOP checklists. We emphasize training operators to report even potential non-conformance, preferring an honest early alert over a quiet cover-up. This cycle encourages openness, reinforcing team commitment to a safe, repeatable process.

    Periodic revalidation of test methods and calibration of equipment prevents subtle purity loss over time. Beyond our lab walls, we keep awareness of changing national standards, especially in markets where specification limits keep getting tighter. Our regulatory team reviews every certificate and pushes updates as needed, keeping clients equipped to show their own compliance with local rules.

    Continuous Improvement: Process, People, and Product

    Our experience manufacturing 4-Methoxybenzyl Alcohol stretches beyond what shows up in a catalog. Each process innovation—a more efficient column for distillation, better particle filters, more precise temperature profiles—starts with feedback from daily operators or direct customer remarks. Teams meet weekly to discuss yield records, process upsets, and areas for technical improvement.

    Long-standing employees mentor new lab technicians and production workers on best practices from past incidents—times when an input change caused cloudiness, or batch crystallization drifted off spec. Continuous learning adds up; over years, process yield rose, off-grade material fell, and the incidence of returned lots steadily dropped. We constantly encourage staff to take pride in these wins, because sustained improvement directly benefits everyone using our product down the line.

    Beyond technical upgrades, we listen to customer feedback on documentation and communication. One common request involved more detailed certs with advanced impurity profiling for pharma-grade lots; another wanted bulk shipment tracking in real time. Each solution gets weighed for feasibility, cost, and benefit, then rolled out with proper training. We never treat customer support as a side activity—each concern is another touchpoint for building lasting relationships.

    Troubleshooting and Real-World Solutions

    Small problems become big if neglected. Our quality control team logs every complaint, flags recurring themes, and investigates root causes. Temperature excursions during shipping caused amplified complaint frequency in hot months. We introduced new insulated pallets and temperature loggers, cutting heat-related quality cases to zero. A handful of partners preferred specific bottle sizes, citing easier decanting; we ran a pilot, then made it a standard option for repeat accounts.

    Handling advice from various sectors also shapes our own safety policy. Feedback from warehouse staff at a major customer site revealed that pallet stacking sometimes slipped under certain conditions. Our loading crew worked with them on revised protocols and packaging adjusters, reducing field issues and easing audits. Partnerships with end users, especially ones who are upfront about challenges, keep our family of users, from small start-ups to global enterprises, growing and evolving.

    Responsible Stewardship in Chemical Manufacturing

    Strong stewardship defines the entire life of our product. We invest in closed-system waste handling, minimizing solvent losses and maximizing reclamation. Production of 4-Methoxybenzyl Alcohol generates some process by-products that we reprocess or neutralize according to robust environmental standards. Regulators and local authorities review our waste streams; our in-house environmental group conducts quarterly audits and looks for efficiency gaps.

    In the past three years, plant teams identified solvent recovery improvements that not only cut waste but improved profitability and reputation. These investments matter not just for us, but for downstream customers who demonstrate green credentials to their own partners. We support them with chain-of-custody documentation and open channels for site audits. If a client flags a sustainability concern or asks for a new type of certificate, we work together to find a solution that meets evolving expectations.

    Looking Ahead: Meeting Challenges, Sharing Experience

    4-Methoxybenzyl Alcohol maintains a reputation as a responsive, adaptable product, backed by both solid manufacturing processes and a team ready to solve problems. Our experience delivers more than just barrels and documentation. Every successful lot reflects lessons absorbed from real-world client challenges: easier scale-up, smoother batch processing, and advanced purity requirements. The result is a chemical that stands out in performance, with feedback from users in hundreds of labs and factories informing every adjustment we make. In the context of a competitive marketplace, these practicalities drive why customers stay with us for years.

    For those seeking a strong account of what makes 4-Methoxybenzyl Alcohol reliable, safe, and effective, our perspective from the shop floor sets the record straight. Technical expertise, operational transparency, and respect for the critical work carried out by our customers define each batch we ship. We regard each partnership as a step toward advancing both chemistry and manufacturing progress.