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4-Methoxy-2-Nitrobenzoic Acid

    • Product Name 4-Methoxy-2-Nitrobenzoic Acid
    • Alias p-Anisic acid, 2-nitro-
    • Einecs 217-661-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    185032

    Productname 4-Methoxy-2-Nitrobenzoic Acid
    Casnumber 870-78-4
    Molecularformula C8H7NO5
    Molecularweight 197.15 g/mol
    Appearance Yellow crystalline powder
    Meltingpoint 182-185°C
    Boilingpoint Decomposes before boiling
    Solubilityinwater Slightly soluble
    Purity Typically ≥98%
    Density 1.57 g/cm³
    Synonyms 2-Nitro-4-methoxybenzoic acid
    Smiles COC1=CC=C(C=C1[N+](=O)[O-])C(=O)O
    Inchikey APAJZQZOCPOLIO-UHFFFAOYSA-N

    As an accredited 4-Methoxy-2-Nitrobenzoic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 25 grams of 4-Methoxy-2-Nitrobenzoic Acid, tightly sealed, labeled with safety precautions and chemical details.
    Shipping 4-Methoxy-2-Nitrobenzoic Acid is shipped in tightly sealed, chemical-resistant containers to prevent contamination and moisture absorption. Packages are labeled according to regulatory requirements and handled as non-flammable, irritant solids. During transit, the chemical is protected from direct sunlight, extreme temperatures, and physical damage to ensure safe delivery.
    Storage 4-Methoxy-2-nitrobenzoic acid should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from incompatible substances such as strong oxidizing or reducing agents. Protect from moisture, heat, and direct sunlight. Store at room temperature and avoid sources of ignition. Proper labeling and secondary containment are recommended to prevent accidental exposure or release.
    Application of 4-Methoxy-2-Nitrobenzoic Acid

    Applications of 4-Methoxy-2-Nitrobenzoic Acid in Industrial Manufacturing

    4-Methoxy-2-Nitrobenzoic Acid serves critical roles in a select group of downstream industrial applications relying on aromatic carboxylic acid intermediates. The following sections outline its specific contributions to high-value synthesis routes, sector-specific compliance, established formulation methods, and typical end-use products.

    1. Pharmaceutical Intermediate for Antihypertensive APIs

    As a nitrobenzoic acid derivative, this material is widely used in the multi-step synthesis of antihypertensive active pharmaceutical ingredients, particularly within the class of angiotensin II receptor antagonists. Its stability under hydrogenation conditions and functional reactivity enable consistent batches in regulated API supply chains. Downstream formulators reference dossier data for compliant conversions, optimizing the yield and purity required for final API standards in solid dosage medications.

    Industry compliance standards

    • Good Manufacturing Practice (GMP, ICH Q7)
    • Current Good Manufacturing Practice (cGMP US FDA 21 CFR Parts 210 & 211)
    • Pharmacopeia standards (USP, Ph. Eur., JP) depending on the target market
    • REACH Annex II SDS compliance for chemical intermediates

    Typical usage ratio

    • Used at 0.07 – 0.15 molar equivalents relative to target API, adjusted based on route selection and scale

    Downstream process integration

    • Introduced during the key condensation or amide coupling stage of API intermediate synthesis
    • Subjected to selective hydrogenation or reduction in subsequent transformations
    • Serves as a functional group donor for subsequent ring closures

    Final product types

    • Active pharmaceutical ingredients such as Angiotensin II antagonists (e.g., Losartan base, analogs)
    • Pharmaceutical intermediates slated for further derivatization

    2. Key Intermediate for Agrochemical Herbicides

    The compound acts as a building block for selective herbicide molecules targeting broadleaf and grass weeds. Its nitro and methoxy substitution pattern supports the synthesis of heterocyclic scaffold systems, improving the efficiency and selectivity required in patented crop protection compounds. Agrochemical manufacturers favor it for its predictable reactivity in multistep, high-throughput production lines.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems for process documentation
    • FAO/WHO Specification for Plant Protection Products (FAO/WHO)
    • EU Regulation 1107/2009 for Plant Protection Product Authorization
    • REACH, OSHA Hazard Communication Standard (29 CFR 1910.1200) for raw materials

    Typical usage ratio

    • Commonly dosed at 1 – 5% w/w in active ingredient synthesis streams, with adjustments depending on target molecule complexity

    Downstream process integration

    • Incorporated at the cyclization or nucleophilic aromatic substitution stage in heterocycle synthesis
    • Participates in controlled reduction or coupling reactions under inert atmosphere
    • Feeds into downstream purification steps yielding technical concentrate

    Final product types

    • Patent-protected herbicidal actives
    • Pre-formulated agrochemical intermediates for emulsion concentrates

    3. Dye and Organic Pigment Synthesis

    The aromatic acid structure supports the construction of complex azo and heterocyclic dye molecules for textiles and high-performance plastics. Downstream formulators value the compound’s ortho-substituted nitro functionality, which directs coupling chemistry resulting in defined color profiles and high fastness. Batch-to-batch color reproducibility hinges on consistent purity and integration at key attachable sites.

    Industry compliance standards

    • OEKO-TEX Standard 100 (Textile Safety for Chemical Inputs)
    • REACH Annex XVII (Restricted Substances in Dyes/Pigments)
    • ISO 787/1 for General Methods of Testing Pigments and Extenders
    • GHS (Globally Harmonised System) for labeling and MSDS

    Typical usage ratio

    • Ranges from 0.5 – 2% by mass in dye intermediate synthesis, modifiable by target color intensity

    Downstream process integration

    • Involved at the diazotization and coupling stage for azo pigment synthesis
    • Enters reaction as a precursor to methoxy- and nitro-substituted chromophores
    • Often processed in continuous stirred tank reactors for color consistency

    Final product types

    • Disperse and acid dyes for synthetic fibers
    • Azo pigments for plastic coloration
    • Specialty printing inks with tailored lightfastness

    4. Synthesis of Benzimidazole-based Laboratory Reagents and Reference Compounds

    This material provides a reliable feedstock for benzimidazole scaffold construction, required in many laboratory-scale reference compounds, analytical standards, and specialty reagents. Research-scale and contract synthesis labs favor it for its defined substitution, which allows targeted functionalization and high-purity yields necessary in analytical or diagnostic applications. Its introduction stage and purification demands remain closely monitored for final reference grades.

    Industry compliance standards

    • ISO/IEC 17025:2017 for Testing Laboratories
    • GLP (Good Laboratory Practice) for synthesis records and purity control
    • Reference material production must follow ISO 17034 for quality documentation
    • Relevant regional import controls for chemical reference substances

    Typical usage ratio

    • Added at 0.1 – 0.3 molar equivalents in targeted benzimidazole formation, scaled to reaction design and analytical output requirements

    Downstream process integration

    • Input at initial cyclization stage to form benzene-fused imidazole ring systems
    • Used during controlled reduction or oxidation to yield protected reference compounds
    • Followed by high-purity recrystallization and chromatography

    Final product types

    • Certified reference standards of substituted benzimidazoles
    • Analytical reagents for chromatographic calibration
    • Diagnostic lab screening compounds
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    Certification & Compliance
    More Introduction

    Introducing 4-Methoxy-2-Nitrobenzoic Acid from the Manufacturer’s Perspective

    Building Value Through Practical Chemistry

    In the chemical industry, few substances show such useful versatility as 4-Methoxy-2-Nitrobenzoic Acid. Through years spent developing and fine-tuning its production, we have seen this compound shape research, production, and product development for a range of industries. Our team keeps quality at the center of every batch, handling raw materials with care and maintaining consistency in purity and granule size. This commitment stems not from market play, but from hands-on experience with what scientists and processors require to get reliable results.

    Making the Compound: Manufacturing at Scale

    Making 4-Methoxy-2-Nitrobenzoic Acid begins with carefully selected, high-quality precursors. Our process goes beyond simple synthesis — monitoring at each stage, refining purification protocols, measuring loss, and optimizing yield based on actual factory data collection. The synthesis method we use balances reaction speed with temperature control and accurate dosing of nitration mixtures. Real-world manufacturing experience teaches that even a slight deviation in pH or reagent freshness shows up in final product color and melting point. We pay attention to every detail because customers judge performance with their own tests, not just on paper certifications.

    The Model: Focusing on Consistency and Usability

    Our standard production model for 4-Methoxy-2-Nitrobenzoic Acid relies on lot tracing, tight impurity profiles (almost always below 0.1%), and stability control through antistatic packaging. We settle for nothing less than a purity of 99% and above. Granule habit makes a difference too, so we keep particle size distribution tight to avoid clumping, caking, or uneven dissolution. Every package gets checked for color, homogeneity, and flow. This model emerged from hard lessons testing thousands of kilograms and learning what complaints stem from and what practices fix them.

    What Sets 4-Methoxy-2-Nitrobenzoic Acid Apart

    Chemists care about details many overlook. This nitrobenzoic acid derivative offers unique properties compared to similar benzoic acids: the methoxy group raises solubility in ethereal and organic solvents, pushing reaction flexibility for downstream synthesis. Standard 2-nitrobenzoic acid often stalls in esterifications or yields fouler waste during coupling. We see customers succeed with the methoxy group’s electron-donating effect, influencing selectivity in electrophilic aromatic substitution. As the manufacturer, we’ve even supported direct customizations — tuning impurity profiles for research groups or adjusting drying steps to meet rare chromatography standards.

    Reliability makes a difference. Repeat clients stick around because they found our batches stable year over year, compared with unstable sources from traders who shift suppliers without warning. We never blend in off-spec or technically downgraded product, even though discarding sub-par material raises costs — our experience shows this bit of short-term pain prevents long-term complaints, technical troubleshooting, and possible lost business for the customers formulating sensitive pharmaceutical or electronic intermediates.

    Typical Specifications: Beyond Purity Alone

    Working in the lab, you notice more than what shows up in a standard specification sheet. Sure, the melting point falls reliably in the 170-172 degrees Celsius range. Moisture content reads below 0.3% and heavy metal screening comes in far below regulated limits. What isn’t always captured is ease of handling. There’s no sticky residue, no uncontrolled dusting, and a tap of the jar releases free-flowing pale yellow powder. Packing turns out odorless, and once a seal is broken, there’s no rapid fouling — the product holds up for reasonable periods under capped conditions.

    Our QA team keeps logs on each batch’s performance: consistency in IR spectra, absence of minor byproducts visible on HPLC, and repeat yields in common nitration, reduction, and esterification lab tests. We continually cross-reference these observational records with formal specs because we know customer processes and their variables rely on the interplay between specification limits and the unspoken “feel” of a good compound.

    Where Chemists and Engineers Turn to This Compound

    4-Methoxy-2-Nitrobenzoic Acid fits easily into pharmaceutical intermediate production, specialty dyes, and even some flavor and fragrance ingredient pipelines. From our dialogues with formulating chemists and scale-up engineers, we know they often demand this compound for routes where direct methoxylation or nitration of more expensive intermediates would drive up costs or complicate purification. It can serve as a building block for benzanilides, substituted phenyl hydrazones, and even azo dye backbones.

    We regularly support researchers tracing metabolic breakdown of analogous compounds, and they keep coming back because our material doesn’t introduce unknown analytical “ghost peaks.” Sourcing through multi-step organic transformations, a clean starting point matters. Not every product from outside manufacturers passes this test. Working directly with us lets clients discuss any modification need, from grinding finer powders to providing extra certificates of analysis on lot variations.

    Comparisons With Close Alternatives

    The market features plenty of benzoic acid derivatives. Standard nitrobenzoic acids lack the same solubility in less polar organic solvents and sometimes hinder downstream coupling with bases and amines. Methoxybenzoic acids without the nitro group often fail to deliver the right electrophilic “bite” needed for key condensations. We’ve watched clients trial parallel routes, reporting higher yields and fewer side reactions using our 4-Methoxy-2-Nitrobenzoic Acid than when switching to the simpler 4-methoxybenzoic acid or 2-nitrobenzoic acid.

    Another area of difference lies in color stability and shelf-life. Electronic industry customers periodically test batches for trace iron or copper; certain routes produce unacceptable levels unless strict process controls are present. Our process avoids unwashed glassware steps and screens for trace metal contamination, since over time minor metal content in packed product can darken or catalyze degradation even during normal storage. Not all suppliers scrutinize these aspects, leading to performance gaps in sensitive device fabrication.

    Solving Issues Together: Practical Support From the Manufacturer

    Every year, someone somewhere secures a drum of benzoic acid derivative that fails during a reaction step. Sometimes the solution is obvious — the product absorbed moisture in a humid storeroom, or a supplier cut corners during drying. Sometimes the failure is subtle: a marginal change in residual solvents, an overlooked trace of incomplete reactions, or contamination carried from the last product run in a shared reactor. Over the years, we’ve learned that fielding real issues directly makes every batch better.

    Our team regularly consults on application troubleshooting. We’ve gone beyond merely selling the product, helping a batch chemist identify unexpected TLC-smearing or working with a plant to adjust pH conditions during scale-up to support efficient workup and waste treatment. We can run orthogonal analytical checks, from NMR to mass spec, sharing detailed batch records so end-users aren’t left second-guessing reasons for a process failure.

    Many buyers initially stick with whoever offers the lowest price or quickest delivery, yet frequently circle back after a run of process inconsistencies, clogging, or unwanted color change. As a manufacturer, we don’t just sell molecules— we bring our process insights, hard-earned data, and real-life troubleshooting skills to every delivery.

    The Hidden Work Behind Every Batch

    Most people outside the specialty chemicals sector never see the daily grind behind supplying consistent and clean 4-Methoxy-2-Nitrobenzoic Acid. It doesn’t arrive ready-made; each batch means careful weighing, measuring water content, cleaning glass-lined vessels, and meeting the detailed documentation required for international trade and regulated industry. As we fulfill orders, our top technicians review not just the end product but all the records behind it — logs of every cleaning cycle, maintenance notes, and staff turnover. We understand that seemingly unimportant changes in temperature control or personnel training can echo months later as field complaints.

    We track all process batches and keep inventory tightly rotated, using firsthand lessons about product aging and the influence of warehouse microclimate. By investing in staff and equipment and reworking our protocols for transparency, we control all points of variability. If a container ships with even a small blemish or storage deviation, we reach out to clients rather than wait for an issue to develop. Experience teaches that small issues compound quickly if ignored. This way, clients gain more trust in each lot, and we keep our standards where they belong: above regulatory baseline, aimed at the real issues users face in research or industry.

    Addressing Environmental and Safety Requirements

    Modern manufacturing isn’t just about molecule quality. Regulations covering workplace safety, effluent control, and emissions push us to continually upgrade our plant. We collect and treat process water, audit all solvent use, and train operators to spot risks as a matter of routine. Handling substances like 4-Methoxy-2-Nitrobenzoic Acid with nitration and aromatic components means extra attention to powder handling, spill control, and employee protective gear. Our safety data emerge from on-site trials, not templates, so customers get practical guidelines informed by real use cases.

    We also remain open about compliance documentation, supporting our buyers through rapidly changing environmental standards. We make this effort part of our job not to just satisfy auditors, but because cutting corners today often brings bigger problems tomorrow, both for us and for clients using the product in their own plants and labs. We find that openness with customers on compliance matters pays off in smoother regulatory reviews and trust during on-site audits.

    Continuous Improvement: Feedback Loops and Honest Reporting

    No product stays static. Our formulation and production teams run regular retrospectives with the research users and the large-scale industrial buyers. We actively seek out reports of side reactions, unexplained losses, or changes detected in downstream reactions. From these open conversations, we’ve re-tuned filtration rates, improved drying efficiency, adjusted packaging for more humid regions, and updated labeling for traceability. These changes spring not from top-down directives but from the ground-level feedback of actual users sharing what matters to them. Mislabeling, packaging flaws, or variation in process yield, even at less than one percent, gets addressed — no matter how minor it seems.

    We partner closely with established research groups, industrial clients, and contract manufacturers. Over time, this network broadens and deepens the knowledge base behind each batch, leading to improved reproducibility in customer projects and faster troubleshooting if something unpredictable occurs. This organized web of user feedback, rooted in the day-to-day experience of researchers and process engineers, guides our production lines, lab controls, and equipment investments.

    Bringing Clarity to Complex Supply Chains

    The global business of chemical supply can muddy the origins and history of a substance. Traders and brokers often obscure where and how a batch was made. As the manufacturer, we pull away that uncertainty by offering direct visibility into our process and history. Buyers with sensitive applications — from pharmaceutical syntheses to OEM production for electronics — see value in real documentation, lot history, and open technical support. We share what matters so end-users can trust not just the label on a drum, but also the practices and integrity behind it.

    This approach turns each sale from a mere transaction into an ongoing relationship. Our policy is direct: we deliver the same product to every client, regardless of size. No split lots, no handoffs between traders, and no reshuffled inventory. Customers know each delivery matches what they approved in trials or pre-purchase validation, not some lesser offshoot shifted around supply hubs. The difference shows up in fewer returns, less downtime on downstream lines, and more time spent making progress instead of troubleshooting bad material.

    Looking Forward: Meeting Challenges in Advanced Applications

    The next wave of uses for 4-Methoxy-2-Nitrobenzoic Acid already shows up in our client conversations. Custom applications emerge, from advanced polymer backbones to targeted biological probes. We see increasing demand for material with specific isotopic content, finer control on particle morphology, and ultra-low impurity standards for regulated drug intermediates. Our development teams stay close to these shifting requirements, adjusting process chemistry and controls to keep ahead of demands that didn’t exist a decade ago.

    Raw experience still drives our improvements. Each missed target, each customer complaint, and each suggestion becomes the benchmark for future batches. Ongoing research and plant upgrades stem from real-world necessity, and these incremental gains build a record of reliability. This reliability becomes a resource shared by all who depend on our 4-Methoxy-2-Nitrobenzoic Acid for their own innovations.

    Closing Trust Gaps Through Direct Manufacturing Experience

    Every batch of 4-Methoxy-2-Nitrobenzoic Acid carries our fingerprints, shaped by firsthand manufacturing experience and ongoing discussion with end-users. We respond rapidly to questions, provide test samples, and exchange detailed process notes because user needs always evolve. By keeping our focus squarely on how products perform in actual research and industrial settings, we keep things grounded and make the entire supply chain more responsive, from the raw materials down to the smallest screw-cap bottle held in a research lab.

    Buyers partnering directly with an engaged manufacturer enjoy more than a chemical — they gain access to years of troubleshooting wisdom, a track record of batch stability, and a collaborative approach to solving the practical problems that arise from innovation. In an industry where fine details affect both scientific discovery and industrial efficiency, working with those who make the compound, and stand behind every order, proves its worth again and again.