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4-Methoxy-2(5H)-Furanone

    • Product Name 4-Methoxy-2(5H)-Furanone
    • Alias Methyl 2-furoate
    • Einecs 209-678-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry sales7@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    227389

    Iupac Name 4-Methoxy-2(5H)-furanone
    Cas Number 61135-33-9
    Molecular Formula C5H6O3
    Molar Mass 114.10 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 92-94°C at 19 mmHg
    Density 1.17 g/cm3
    Solubility In Water Soluble
    Smiles COC1=CC(=O)OC1

    As an accredited 4-Methoxy-2(5H)-Furanone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 25 grams of 4-Methoxy-2(5H)-Furanone, tightly sealed, labeled with hazard warnings and chemical information.
    Shipping **Shipping Description for 4-Methoxy-2(5H)-Furanone:** This chemical should be shipped in tightly sealed containers, protected from moisture and direct sunlight. Transport under ambient temperature unless otherwise specified, and comply with relevant local, national, and international regulations for laboratory chemicals. Ensure appropriate labeling, and include safety documentation with the shipment.
    Storage 4-Methoxy-2(5H)-Furanone should be stored in a tightly sealed container, protected from light and moisture. Store it at a cool, dry, and well-ventilated location, away from incompatible substances such as oxidizers and strong acids. Ensure proper chemical labeling and keep the storage area free from sources of ignition or heat to maintain stability and prevent hazardous reactions.
    Application of 4-Methoxy-2(5H)-Furanone

    Applications of 4-Methoxy-2(5H)-Furanone in Industrial Manufacturing

    As a dedicated manufacturer of specialty chemical raw materials, we supply 4-Methoxy-2(5H)-Furanone for consistently validated downstream industrial applications. This lactone derivative, also known as mesifuran, finds specialized use in processing environments where strict compliance, formulation control, and product specificity are critical to end quality. Below, we detail key application segments where our material supports precise downstream formulations.

    1. Food Flavor and Beverage Compounding

    Extensively valued for its intense and stable "sweet burnt sugar" and caramel-like aroma, 4-Methoxy-2(5H)-Furanone functions as a high-impact flavoring compound in food and drink formulations. Major beverage producers use it to reinforce and modify top notes in cola, coffee, chocolate beverages, and bakery flavors, requiring absolute adherence to international food safety and additive purity regulations throughout the supply chain.

    Industry compliance standards

    • Codex Alimentarius (General Standard for Food Additives, Section on Flavourings)
    • EU Regulation (EC) No 1334/2008 — Flavourings Regulation
    • US FDA 21 CFR 172.515 — Synthetic Flavoring Substances and Adjuvants
    • China GB 2760 National Food Safety Standard — Standards for the Use of Food Additives

    Typical usage ratio

    • 0.1–10 ppm in finished beverage and bakery formulations, typically calibrated via sensory panel and GC-MS aroma profiling to avoid overpowering the target flavor profile.

    Downstream process integration

    • Dosed into concentrated flavor syrups, compound flavor bases, or directly into beverage blending tanks post-dissolution. Used prior to pasteurization or aseptic filling to preserve aroma intensity.

    Final product types

    • Ready-to-drink colas and flavored soft drinks
    • Instant coffee and chocolate beverage powders
    • Bakery goods and pre-mixes
    • Confectionery (caramel, nougat, toffee)

    2. Tobacco Flavour System Manufacturing

    Premium and mid-range tobacco processors use 4-Methoxy-2(5H)-Furanone to improve the warm, caramelized background notes of both traditional and reduced-risk tobacco products. Its impact on flavor complexity and aroma roundness makes it integral to both mainstream and flavor capsule cigarettes, as well as heated tobacco units.

    Industry compliance standards

    • ISO 12863: Resistance to ignition of cigarettes
    • US FDA 21 CFR Part 1140 (Tobacco Product Standards)
    • China YC/T 421 tobacco flavor safety standard
    • EU TPD Directive 2014/40/EU compliance for tobacco additives (Annex II)

    Typical usage ratio

    • 0.5–15 ppm in tobacco casing and top flavor preparations, set according to sensory impact and migration studies to prevent excessive off-notes during storage or heating.

    Downstream process integration

    • Added to flavor matrices and spraying solutions during tobacco lamina and cutrag blending, or encapsulated with microencapsulation carriers when applied to flavor capsules or bead inserts.

    Final product types

    • Flavored cigarette blends
    • Heated tobacco sticks and capsules
    • Tobacco flavor reconstituted sheets

    3. Fine Fragrance and Perfume Production

    Perfumery houses and aroma chemical blenders incorporate this lactone for its radiant, caramel-amber note, enhancing gourmand accords and bolstering sweet base blends in fine fragrance compositions. Used predominantly by compounding facilities targeting high-stability, long-wearing fragrance concentrates.

    Industry compliance standards

    • IFRA (International Fragrance Association) Standards and Amendments
    • EU Regulation (EC) No 1223/2009 on Cosmetic Products
    • US California Proposition 65 for listed fragrance ingredients
    • ISO 9235 (Aromatic Natural Raw Materials — Vocabulary)

    Typical usage ratio

    • 0.02–0.5% by weight of concentrate, with upper end reserved for gourmand-intensive formulations. Benchmarked through olfactory panels for harmonization with aldehydic or lactonic notes.

    Downstream process integration

    • Added during the fragrant oil blending stage, before ethanol dilution or encapsulation into microbead delivery forms for body spray and fine fragrance lines.

    Final product types

    • Fine fragrances (EDP, EDT, EDC formats)
    • Body sprays and home air fresheners
    • Cream perfumes and scented personal care bases

    4. Dairy Flavor, Process Cheese and Non-Dairy Creamer Formulation

    Specialists in dairy analogs and cheese flavor technology apply 4-Methoxy-2(5H)-Furanone to replicate the caramelized lactose notes found in cooked milk and processed cheese. Its ability to provide brown, toasty nuances is crucial for masked flavorings in convenience cheese blends and UHT dairy analogs.

    Industry compliance standards

    • US FDA 21 CFR Part 133 (Cheese and Related Cheese Products)
    • Codex Alimentarius Standard 262-2006 (Processed Cheese)
    • EFSA Guidance on Flavourings in Food
    • China GB 2760 and GB 25191 (Food Additive Use for Dairy)

    Typical usage ratio

    • 1–20 ppm total dosage, adjusted based on matrix composition and degree of heat treatment in final blending, with periodic recalibration against sensory benchmarks during pilot and scale-up batches.

    Downstream process integration

    • Dispensed into flavor pre-mix tanks or directly into cheese mass before homogenization/thermal treatment. In non-dairy creamers, integrated in the spray drying step after carrier solution preparation.

    Final product types

    • Processed cheese slices and blocks
    • Convenience cheese powders for snacks
    • Non-dairy creamer powders and base liquids
    • Ready meals and dairy-flavored sauces

    5. Specialty Pharmaceutical Flavor Masking

    Certain oral pharmaceuticals and nutraceuticals require advanced flavor masking to ensure patient compliance. 4-Methoxy-2(5H)-Furanone is utilized for its caramel-masking properties in direct compression flavor blends and liquid suspensions, particularly for pediatric and geriatric drug products with bitter APIs or minerals.

    Industry compliance standards

    • US FDA cGMPs for Pharmaceuticals (21 CFR Parts 210, 211)
    • Ph. Eur./USP/NF Monographs for excipient usage
    • ICH Q3C Guideline for Residual Solvents
    • China Pharmacopoeia excipient approval lists

    Typical usage ratio

    • 0.05–2.0 mg per tablet or per 5 mL oral suspension, set by in-process taste masking studies and API compatibility assays.

    Downstream process integration

    • Blended into wet granulation or dry blend stage for tablet presses; for liquid forms, pre-mixed into syrup base before final solubilization and homogenization steps.

    Final product types

    • Chewable and orally disintegrating tablets
    • Oral liquid suspensions and syrups
    • Pediatric flavor sticks (granules, powders)

    6. Pet Food and Animal Feed Palatability Enhancers

    Premium pet food blenders include this compound to simulate roasted or cooked-meat notes, aiding in masking synthetic amino acid or vitamin off-flavors, especially in high-nutrient formulations where acceptability drives product success and repeat purchase rates.

    Industry compliance standards

    • AAFCO Official Publication (Flavouring Agents Regulation)
    • EU Regulation (EC) No 1831/2003 on Additives for Use in Animal Nutrition
    • China Feed Additives Catalogue
    • FAMI-QS Code for Specialty Feed Ingredients

    Typical usage ratio

    • 0.5–10 ppm in compounded feed mixes; dosages are trialed in palatability studies using companion animal taste panels and palatant microencapsulation efficiency testing.

    Downstream process integration

    • Introduced during liquid palatant application at post-extrusion coating step or into aqueous flavor slurries prior to kiln or oven drying for uniform surface adherence.

    Final product types

    • Dry pet foods (kibble, pellets)
    • Moist and semi-moist snacks
    • Protein-fortified animal treats
    Free Quote

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    Certification & Compliance
    More Introduction

    Introducing 4-Methoxy-2(5H)-Furanone: The Difference Genuine Manufacturing Makes

    What Sets 4-Methoxy-2(5H)-Furanone Apart in Real-World Production

    Working on the production floor, our team doesn’t just see a chemical—4-Methoxy-2(5H)-Furanone as a batch number or a warehouse SKU. We see a specialty molecule with a history and a future, a compound that plays a distinct part in shaping flavors, fragrances, and the advanced formulations that fill the shelves of modern markets. Daily, the practical story of this furanone unfolds at our site. Staff watch fermentation tanks foam, smell the nuanced, sweet aroma as reactions complete, and monitor filtrate clarity. Each observation brings its own set of lessons, and the pursuit of higher purity, consistency, and improved safety.

    A Model That Reflects Practical Needs in Flavor and Fragrance Chemistry

    4-Methoxy-2(5H)-Furanone carries with it a reputation rooted in sensory impact. Specialists in flavor creation turn to this molecule for its ability to deliver rich caramelized notes and creamy, slightly nutty undertones. Natural strawberries owe much of their signature scent and taste to the presence of furanones in trace amounts, and the addition of 4-Methoxy-2(5H)-Furanone in a controlled, pure form lets formulators achieve depth and nuance that simpler substitutes never reach. Nowhere is this more evident than the baseline comparison between synthetic strawberry and blends that include authentic furanone derivatives. The difference isn’t subtle; it’s subtlety itself—the fine shading that turns a generic taste into something recognizably true.

    The core model we produce focuses on high assay, low-residual solvent, whiteness (or clarity, in solution), and a reliably narrow melting-point spread. We’ve seen firsthand, batch after batch, that these core targets mean fewer off-notes and more predictable behavior in finished applications. Clients report fewer bottlenecks downstream, less product rework, and a notable reduction in quality complaints—data we welcome through routine feedback sessions and field visits. Formulators alike reach for our 4-Methoxy-2(5H)-Furanone during critical NPD projects where the risk of off-flavors or allergen carryover remains a constant enemy.

    Moving Beyond Commodity: The Impact of Purity and Impurity Profiles

    Years ago, sourcing bulk furanones meant tolerating uncertain impurity levels and ambiguous paperwork. Today, production decisions rely on hard numbers—chromatograms, impurity cutoffs, and in-process analytics. In our plant, efforts start well before raw materials reach reaction vessels. Quality teams screen lots with a sharp eye for non-conforming color, odor, and reactivity. Vendor audits and repeated chromatographic checks ensure we’re not pulling unwanted or problematic volatiles along for the ride.

    Purity doesn't stop at a number on a certificate of analysis. The unique challenge with 4-Methoxy-2(5H)-Furanone lies in minimizing unwanted positional isomers and trace acetals—byproducts that dull the characteristic, almost creamy aroma the molecule can offer. Direct experience teaches that even minor contaminants, which elude routine detection, muddy the waters in critical flavor applications. Strict process control and fine-tuned crystallization protocols, as well as careful solvent selection, produce a grade that commands respect in finished goods, with reliable stability and reproducibility.

    Specifications Built on Practical Knowledge

    Standard specifications for 4-Methoxy-2(5H)-Furanone often hide behind technical jargon. Living through hundreds of production cycles, we see the real-world impact of exceeding minimum standards. Our specification limits come not just from regulatory compendia but from solvent compatibility studies, customer shelf-life trials, and, crucially, our own analysis of stability at various temperatures and humidities, both in bulk and in finished product formats. The reason for this isn’t theoretical; we field questions daily from clients facing storage and bottling hurdles. Their feedback shapes the boundaries we set—and the tolerances we’re willing to guarantee.

    Color, for example, isn’t just monitored for appearances: it's an early warning sign of potentially reactive or unstable batches. We developed a more robust purification protocol after seeing yellowish hues emerge under certain conditions, taking hard data from the lab into the factory setting and, eventually, into our final standards. Specifications come alive on every run, a series of choices leading away from short cuts and toward the reliability that applications demand, whether in luxury perfume, specialty confectionery, or nuanced beverage labels.

    Challenges and Solutions on the Production Line

    Process bottlenecks in the early days forced us to rethink filtration sequences and solvent recovery. Even minor variances in pH or temperature profile could swing yields or generate colored byproducts. Over time, we built a feedback loop that connects operators, lab analysts, and quality managers in real time. Monitoring purity by GC/MS at multiple checkpoints, not just once at the end, let us intercept issues before expensive rework was required.

    The biggest learning curve came from managing the subtle thermal sensitivity of the compound. We learned, often through small setbacks, where to draw the line on distillation temperatures and how to optimize cooling profiles to avoid solidification in pumps and lines. Design tweaks—baffles, agitation rates, and the choice of corrosion-resistant alloys—reduced maintenance stops and downtime. These lessons from years of direct production feed back into every new lot, ensuring we reach the necessary purity without excessive waste or risk.

    Applications Driven by Real-World Feedback

    It’s easy to read marketing about ‘broad applicability’ and ‘multi-industry use.’ What we actually see are clusters of use-cases, each with their own hurdles and rewards. 4-Methoxy-2(5H)-Furanone draws the most attention from formulators in the flavor and fragrance sectors, where analytical sensitivity and creative demands collide. Being able to deliver not just a certificate, but full spectra and stability data under common mixing conditions, builds trust into the supply chain.

    Bakery, dairy, beverage, and confectionery producers come to us looking for more than just an ingredient. They want clean-label potential, allergen disclosures, and multi-batch consistency. In practice, this means investing in segregated production lines and dedicating campaign runs to high-scrutiny lots, overseen by both internal and customer inspectors. The effort pays off. Taste panels and analytical labs show improved top-note intensity and shelf-stability, meaning fewer product recalls and more consistent consumer approval.

    Comparing with Other Furanone Products

    We frequently field questions comparing 4-Methoxy-2(5H)-Furanone to sibling molecules—such as 2,5-dimethyl-4-hydroxy-3(2H)-furanone (commonly called Furaneol) and 2,3-dihydro-5-methyl-4(1H)-pyranone (known in the trade as Maple Lactone). Each member of this family plays a unique sensory role, but our day-to-day work shows how the methoxy group in 4-Methoxy-2(5H)-Furanone gives a more subdued, creamy sweetness compared to Furaneol’s sharper, burnt sugar effect.

    We see the difference at the bench and in production trials. A confectioner may find Furaneol instantly recognizable and bold, but 4-Methoxy-2(5H)-Furanone imparts a roundness that lingers and links with other notes more seamlessly. This absence of harsh edges lets flavorists layer in strawberry, caramel, or dairy notes with fewer balancing acids or buffering agents. The practical outcome: finished goods that don’t just taste ‘good enough’ in a lab, but excel on fast-moving consumer shelves, even after months of storage and shipping.

    Handling, Storage, and Real Production Logistics

    Teams on the ground face the daily task of moving intermediate and final product safely between reactors, crystallizers, drums, and shipping containers. 4-Methoxy-2(5H)-Furanone’s moderate volatility means storage requires a dry, cool, and well-ventilated area, sealed against air and moisture. The compound’s stability profile responds poorly to light, humidity, and prolonged contact with reactive metals. We learned these lessons directly, through real loss events and subsequent investment in anti-static drums, inert gas blanketing, and UV-blocking storage solutions.

    Shipment of fresh lots occurs only after hands-on inspection: teams confirm not only purity but clarity, odor, and freedom from visible contamination. After the adoption of batch-level RFID tracking, traceability improved and error rates dropped. These process improvements grew from years of incremental change, feedback from technical clients, and direct incident reviews, not just from broad directives or paperwork audits.

    Regulatory and Safety Practices Grounded in Practical Experience

    No credible chemical supplier can afford to overlook safety or regulatory challenges. Our experience runs deeper than simply filling out documentation. We invest hundreds of man-hours in routine hazard analyses, exposure simulation, and spill containment drills. Familiarity with real hazards—slippery floors from minor leaks, solvent headaches, the rare but serious risk from improper mixing—shapes every policy update. Each process upgrade grows not only from incident reports but also from real collaboration with on-site and customer EHS specialists who have faced the same issues in their own facilities.

    The furanone family doesn’t present the acute toxicity risks of many industrial chemicals, which does not mean safety lapses carry minor consequences. Our teams commit to clearly labeled containers, continuous ventilation, and comprehensive PPE use, developed not simply from regulatory compliance but from firsthand review of near-miss logs and hands-on site walkthroughs. These details matter as much to end-users as the finished product’s flavor profile.

    The Ongoing Value of Direct Manufacturing Input

    Looking at the competition, it’s easy to spot a difference between traders who move drums around and manufacturers who adjust, refine, and troubleshoot production every day. Being responsible for each batch means more than simply meeting customer requirements; it means anticipating their next challenge. We have been asked for custom impurity reports, sub-lot blending, even targeted odor re-balancing. Each request extends our capabilities and deepens our understanding. Manufacturing on site puts us in direct contact with the feedback that matters—from the moment a new variant enters the pipeline to the first customer complaint or compliment.

    Technicians and line managers remember the countless tweaks to reaction times, agitation rates, and purification steps, each one backed by shelf-life studies and accelerated aging protocols. It’s thanks to these practical trials—sometimes stretching over months—that we can say with confidence how a given batch will stand up in the real world. Every employee from R&D to final packaging knows that the best measure of our product comes from kitchens, test labs, or consumer panels far from the factory floor.

    Building Relationships Through Transparency and Predictability

    Every call from a technical client, every site visit from a flavorist, brings questions that reflect real-world risks. Will this lot behave like the last? Can it handle a temperature spike during downstream processing? Does it throw unexpected notes in dairy matrices? In practice, the best answer isn’t just “yes” or “no”; it’s walking through spectral data, production records, and current shelf samples together, showing not only what went right but also how we learn from what went wrong.

    Long-term customer relationships develop where suppliers stand behind each lot, answer for discrete technical issues, and welcome constructive criticism. In recent years, we’ve invited partners onto the production floor, offering not just open houses but deep dives into our lab and scale-up protocols. The conversation often reveals new expectations, market shifts, or unforeseen application challenges—each one shaping the next evolution of our 4-Methoxy-2(5H)-Furanone line.

    Looking Ahead: Sustainable Production and Industry Trends

    New sustainability demands require thought beyond yield and cost. Recent advances in biocatalysis, solvent recovery, and waste minimization already change the equation for plants like ours. We source key raw materials with an eye to traceability and minimum-waste extraction, tracing every solvent drum and monitored effluent discharge. As analytical tools improve, so do our options for detecting micro-impurities and fine-tuning separation steps, reducing both environmental impact and sourcing risk.

    Demand from premium natural and clean-label brands continues to rise. These clients bring stringent requests for transparency and a willingness to pay for real traceability—from field to drum, and drum to dose in final product. Our direct experience meets these requests not just by shifting paperwork, but by opening our site, showing real process data, and letting clients work with our teams. We see these shifts not as threats to the business but as opportunities to prove the value of a genuinely controlled, responsible supply chain.

    Conclusion: The Manufacturer’s Perspective on 4-Methoxy-2(5H)-Furanone

    Producing 4-Methoxy-2(5H)-Furanone reflects years of steady improvement, adaptation, and close listening to the practical needs of industry peers. This is not just another item on a long stock list—it is a specialty molecule whose margin for error can make or break sensitive product launches, whose consistency saves money, and whose reliable sensory profile carries real value in a crowded market. Feedback from the field, production incidents, and ongoing lab data combine to make our product distinct.

    Our commitment, as the originators—not middlemen—remains rooted in delivering clarity, safety, and reliability with every lot. Questions from clients today spark process upgrades tomorrow, and no specification remains static under the weight of practical, on-the-ground learning. Every bottle of 4-Methoxy-2(5H)-Furanone shipped bears the signature of this continuous dialogue between production, client, and consumer—a relationship that defines not just a single compound, but the outlook of modern chemical manufacturing.