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4-Hydroxyphenylethyl Bromide

    • Product Name 4-Hydroxyphenylethyl Bromide
    • Alias 4-(2-Bromoethyl)phenol
    • Einecs 226-500-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    534594

    Name 4-Hydroxyphenylethyl Bromide
    Synonyms p-Hydroxyphenylethyl Bromide
    Cas Number 2056-14-4
    Molecular Formula C8H9BrO
    Molecular Weight 201.06 g/mol
    Appearance White to off-white solid
    Melting Point 79-81°C
    Purity Typically ≥98%
    Solubility Soluble in organic solvents such as ethanol and DMSO
    Smiles C1=CC(=CC=C1CCBr)O
    Storage Conditions Store at 2-8°C in a tightly sealed container
    Ec Number 218-159-9

    As an accredited 4-Hydroxyphenylethyl Bromide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

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    Application of 4-Hydroxyphenylethyl Bromide

    Applications of 4-Hydroxyphenylethyl Bromide in Industrial Manufacturing

    As a direct manufacturer of 4-Hydroxyphenylethyl Bromide, we focus exclusively on established industrial downstream uses where this raw material offers consistent performance and integration reliability. Below, we detail real-world application scenarios in four key sectors, with clear compliance, dosage, process, and finished-product references for each.

    1. Pharmaceutical API Intermediate for β-Blocker Synthesis

    The compound serves as a building block in multi-step chemical synthesis routes for certain β-blocker active pharmaceutical ingredients. Its halogenated benzyl group is essential for controlled substitution reactions, allowing for introduction of hydroxyphenylethyl substructures in proprietary pipeline and off-patent cardiology APIs. Incorporation at this step improves both yield and downstream reactant specificity, minimizing byproduct formation critical for meeting stringent pharma impurity profiles.

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • 21 CFR Part 210/211: US cGMP for Finished Pharmaceuticals
    • USP Monographs for Related APIs
    • ChP (Chinese Pharmacopoeia) and EP (European Pharmacopoeia) API guidelines

    Typical usage ratio

    • Used at 0.8–1.3 molar equivalents relative to the core amine reagent; adjustments based on target batch scale and desired selectivity

    Downstream process integration

    • Added during the early-stage N-alkylation or O-alkylation step in the synthesis line, usually following purification of the preceding core structure in glass-lined reactors under nitrogen

    Final product types

    • Bulk β-blocker APIs (e.g., atenolol intermediates, other arylethanolamines)
    • Pharmaceutical intermediates destined for cardiovascular or CNS drug synthesis

    2. Fine Chemical Synthesis of Functional Monomers

    This material functions as a specialty alkylating agent to introduce hydroxyphenylethyl moieties during the production of tailored monomers and functionalized polymers. It provides a precise handle for integrating controlled aromatic side-chains into vinyl, acrylate, or styrenic monomer frameworks. Formulators use it for designing monomers with improved adhesion, crosslinking or reactivity indices, supporting electronic coatings or specialty plastics with stringent composition control.

    Industry compliance standards

    • ISO 9001:2015 (Quality management systems for chemical production)
    • REACH (EC No 1907/2006) registration for handling and downstream user advisories
    • TSCA in the United States (where used in product lines for export)
    • RoHS (for electronics-grade applications if polymer enters E/E assemblies)

    Typical usage ratio

    • Introduced at 0.5–2.0 wt% in monomer preparation stages; dosage tailored for target functional group density in polymer backbone

    Downstream process integration

    • Participates in the initial alkylation or derivatization reaction in batch or semi-batch reactors, prior to polymerization or co-polymerization steps

    Final product types

    • Functional vinyl or acrylate monomers for specialty resins
    • Precursor materials for electronic coating polymers
    • Sidestream monomers for high-performance adhesives

    3. Agrochemical Intermediate—Herbicide Synthesis

    Producers in the crop science industry integrate this compound as a precision intermediate during the custom synthesis of certain phenylethyl-derived herbicide products. Its chemical profile enables smooth halide exchange and subsequent ring substitution, allowing large-scale process engineers to target specific molecular modifications for activity or degradation stability, which are crucial for modern herbicide development protocols.

    Industry compliance standards

    • FAO/WHO technical guidelines for specification of agrochemical active ingredients
    • ISO 17025 Laboratory Accreditation (for QC of each batch delivering to downstream synthesis stages)
    • Regulation (EC) No 1107/2009: EU Plant Protection Products Regulation
    • US EPA 40 CFR Part 180: Tolerances for Pesticide Residues

    Typical usage ratio

    • Applied at 1.0–1.6 molar equivalents for the aromatic substitution stage based on the nature of the primary halide and the desired end-herbicide isomer

    Downstream process integration

    • Charged to the reactor in the key halide exchange or coupling step, typically after preliminary methylation or ring activation of the base phenylethyl core

    Final product types

    • Technical-grade herbicide active ingredients (phenylethyl-related structures)
    • Agrochemical intermediates for selective and non-selective herbicide formulations

    4. Synthesis of Liquid Crystal Materials for Display Manufacturing

    The compound is a critical raw material in the multi-step synthesis of certain hydroxyphenylethyl-based liquid crystal intermediates, particularly those used in advanced twisted nematic and in-plane switching (IPS) liquid crystal displays. Incorporating its moiety influences electro-optical performance and temperature stability in the final liquid crystal mixtures. Its purity and controlled reactivity allow for reliable composite formation in high-volume display glass and mobile panel manufacturing.

    Industry compliance standards

    • IEC 61747: International LCD industry quality and reliability standard
    • ISO 9001:2015 (for chemical quality and traceability in the electronics supply chain)
    • JIS C 6100 (Japanese Industrial Standards for liquid crystal materials)
    • RoHS (when materials are included in consumer electronics)

    Typical usage ratio

    • Incorporated at 0.2–0.6 molar equivalents per liquid crystal precursor molecule; standard ratios fine-tuned to match viscosity, clearing point, and dielectric property specifications

    Downstream process integration

    • Introduced at the conjugation or substitution stage of the liquid crystal intermediate synthesis, frequently in multi-kilogram scale jacketed glass or stainless-steel reactors under inert atmosphere

    Final product types

    • Specialized hydroxyphenylethyl-based liquid crystal blends
    • Intermediate compounds for TN, IPS, and OLED display material lines
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    More Introduction

    Introducing 4-Hydroxyphenylethyl Bromide: A Versatile Tool for Modern Chemistry

    Understanding the Value of 4-Hydroxyphenylethyl Bromide

    Working in the chemical industry brings certain truths to light about how some tools make research and manufacturing easier, faster, and more reliable. 4-Hydroxyphenylethyl Bromide often fits into this conversation. People who step into any chemistry lab, from the academic side to the pharmaceutical industry, know the edge that comes with a reagent you can trust. A compound like this does not just land in the inventory to sit on a shelf. It carries a purpose and delivers results when quality and consistency count.

    4-Hydroxyphenylethyl Bromide stands out due to its chemical structure, blending a brominated ethyl chain with a hydroxyphenyl core. Anyone curious about its impact sees its role in forming carbon-bromine bonds, and those who have spent days troubleshooting a stubborn reaction know the difference one high-purity reagent makes. It crystallizes clearly and arrives as an off-white solid, easy to weigh and store in the lab. Its melting point and spectral characteristics come crisp and clean—no second-guessing purity levels or batch identity.

    Those familiar with chemical synthesis appreciate how vital a compound like 4-Hydroxyphenylethyl Bromide becomes in the development of active pharmaceuticals, fine chemicals, and new materials. The organic bromide reacts reliably across several transformation routes, whether you are doing simple nucleophilic substitutions or preparing advanced intermediates for polymers or specialty chemicals. In my experience, reproducibility in outcomes separates a productive project from one stuck in repeat. Compounds like this make that difference, as yielding consistent, predictable products gives you the confidence to plan the next step.

    Specifications and Real-World Impact

    The specifics matter, especially when researchers and manufacturers handle fine organic chemicals. Purity sits above 98%. Analysis by NMR and HPLC lines up with expectation, batch after batch. Its chemical makeup, C8H9BrO, means you can calculate quantities precisely for each run. The product remains stable in a dark, cool spot—no need for complex storage or elaborate precautions aside from those you'd expect for reactive bromides.

    Lab workers seasoned with custom syntheses know the hazards and fuss created by untrustworthy materials. Subpar or poorly documented lots waste time and resources. There's no shortage of literature examples where brominated building blocks, like 4-Hydroxyphenylethyl Bromide, have set the stage for new discoveries in medicinal chemistry. The same story repeats across agrochemical development and advanced materials. These fields often push R&D forward, not just through ideas, but by using reliable, consistent building blocks. The cost of a failed reaction or inconsistent yield piles up quickly—those dollars add up when the raw material falls short of its promise.

    Not every bromide deserves the same reputation. Many alternatives similar in structure lack the hydroxyphenyl functionality or deliver unpredictable reactivity due to varying impurity levels. Having used a range of halogenated compounds, I know firsthand that switching between seemingly similar reagents often reveals subtle problems: unwanted side products, sluggish reactivity, or tough-to-purify intermediates. With 4-Hydroxyphenylethyl Bromide, the record speaks for itself—the right design and the expected clean behavior. That means less troubleshooting, fewer workups, and faster project progression.

    Applications that Drive Innovation

    Young researchers sometimes learn the hard way that a chemical’s best use sits buried in technical data. The creative edge comes by seeing it do real work. In medicinal chemistry, this bromide core often acts as a key step for coupling reactions, allowing straightforward attachment to amines, thiols, or alkoxides, forming a range of novel entities. The hydroxy group on the aromatic ring opens doors to precise downstream modifications, producing molecules that serve as lead compounds or bioactive scaffolds. Literature reports highlight its use in synthesizing amine-rich compounds showing antimicrobial or anticancer activity. People in that field care not just about making molecules, but about making ones that matter. In that sense, each bottle carries the chance for a breakthrough, and if the chemistry works well, the progress doesn't stall.

    The flavor and fragrance industry also turns to 4-Hydroxyphenylethyl Bromide for specific aldehyde or alcohol syntheses. With its manageable reactivity and selective transformation routes, you can obtain pure, stable end products suited for further processing or direct blending. This edge becomes critical when designing complex, cost-effective routes to valuable aroma chemicals. Each successful batch means a fragrance house reaches the market with new, compelling scents ahead of rivals. From soaps to luxury perfumes, the difference sometimes lies in a single intermediate well-made. Out in the agrochemical world, plant protection and growth regulators often start with molecules like this, and the research pipeline stays open only because raw materials do what they should without surprises.

    Material scientists tap into its brominated backbone for specialty polymers and advanced functionalized surfaces. Self-assembled monolayers and block copolymer syntheses often require reactive sites introduced through sturdy, predictable building blocks. I have witnessed projects that pivoted on the availability of robust compounds with both halogen and hydroxy functionalities—no other option delivering the right balance of reactivity and downstream utility. Undergraduate classrooms might skip these details, but every seasoned scientific team knows the difference when scaling up to larger runs or translating a discovery from bench to pilot plant.

    Why Quality and Traceability Stand Out

    Experience has shown over and over that raw material quality never takes the back seat. One poorly tracked batch will choke a project, forcing investigators to double-check results or dig through process records searching for what went wrong. With the best suppliers, each lot of 4-Hydroxyphenylethyl Bromide comes with a full trace, from lot numbers to analytical results. This trace matters not just for regulatory folks—anyone who deals with patent applications or has faced an audit understands that gapless paperwork is protection. It supports every claim you make about your finished product and keeps research pipelines free of “mystery material” crises. When a project aims for publication or regulatory approval, every synthesis detail requires proof, not promises. Reliable documentation, linked to a rock-solid supply, backs your work in the peer review process and beyond.

    The conversation about supply chain security grows louder each year. With disruptions in global logistics and shifting compliance requirements, labs no longer trust anonymous vendors or poorly documented sources. Trusted brands and suppliers earn their place because they deliver what the label promises, every time. No one with real skin in the game feels comfortable gambling on “almost good enough” raw materials, and end users who farm out custom synthesis pay a premium for a proven track record. In high-value research, the smallest variation in a starting material can mean the difference between a publishable hit and a failed project, or even patient safety issues in pharmaceutical development.

    Safety and Handling: Hard-Won Lessons

    People taking safety lightly with organobromine compounds won’t work long in the chemical business. 4-Hydroxyphenylethyl Bromide, though manageable, calls for gloves, eye protection, and careful storage habits. Breathing dust or letting it touch skin needs to be avoided, as with all reactive intermediates. I’ve seen too many rushed students skip safety data review, only to regret it. In hands that know what they’re doing, this compound fits nicely into standard laboratory practice. Down-the-line users—production workers or formulation chemists—never look for trouble. They pick suppliers whose safety guidance comes clear, who package and ship with accident prevention in mind. Those direct experience stories about mishandled chemicals always hit home. Safe habits, well-informed colleagues, and responsible packaging keep the focus on progress rather than recovery from accidents.

    Careful labeling and routine inventory checks cut down on confusion. Companies with high standards make sure every delivery ships with updated safety instructions, hazard warnings, and clear batch identification. In regulated environments, missing paperwork or ambiguous labeling stalls production or pulls products out of the pipeline for extra review. The difference between a productive day and a lost week sometimes comes down to these details.

    Comparing to Other Brominated Compounds

    Organic chemistry never lacks for choice in halogenated intermediates, but they do not all pull their weight for every task. Some labs use simpler benzyl bromides when a fully substituted aromatic ring is not required, yet this shortcut often shuts out downstream functionalization. On the flip side, highly substituted bromobenzenes might clog up reactions with steric hindrance or offer little in the way of useful follow-up chemistry. In contrast, 4-Hydroxyphenylethyl Bromide balances reactivity and functional options. The hydroxy group sets up for further reactions—like etherification, oxidation, or cross-coupling—allowing a cascade of new products from a single starting point.

    Compounds lacking the hydroxy group often limit further creativity on the molecule. Trying to retro-fit additional active handles after the fact bogs chemists down with unnecessary steps or risky protecting group strategies. The hydroxy and ethyl bromide groups act together, offering a clean route to both nucleophilic and electrophilic transformations. Having handled reactions with less forgiving bromides, I recognize the wasted time in purification and repeated work-ups. Fewer byproducts or side reactions save hours over months-long campaigns. For research teams working toward patents or scale-up, efficiency means competitive advantage. Customers looking for speed, consistency, and the fewest unknowns stick with solutions that deliver on all counts.

    Building Trust Through Transparency and Consistency

    Modern laboratories—industrial or academic—run not just on experiment but on trust. Consistency in chemicals keeps research plans on course and careers moving in the right direction. As regulatory pressure mounts across pharmaceuticals, electronics, and agricultural work, transparency only grows in value. In my years overseeing several grant-driven projects, I learned that shortcuts with raw materials never pay. The costs show up in stalled projects, failed grant milestones, or rejected journal submissions. A quality supplier provides access to analytical support, full batch histories, and responsive service. You need to know what you’re putting into your flask or reactor. Trust built on this foundation lets research progress stay focused on asking new questions rather than returning to old problems caused by questionable starting points.

    Even in a fast-moving market, no one wins by cutting corners. Sourcing 4-Hydroxyphenylethyl Bromide from well-documented, credible suppliers shrinks risk and builds confidence. End users—small biotech start-ups or established pharmaceutical players—trade on speed and reliability. A chemical that checks all the boxes for purity, documentation, traceability, and consistent performance is more than a raw material; it becomes part of the team. You can budget hours and dollars to real experiments, not patch jobs or damage control.

    Any experienced lab manager knows how one batch of inconsistent reagent can unravel months of work. Early in my career, chasing after unexplained yield losses often led straight back to raw material issues. The lesson—never accept the just-okay option when the best is available. Customers remember that kind of difference, and strong relationships grow around suppliers who make life easier, not harder. Fast, on-time delivery and proactive communication set the tone for everything that follows. These values become habits and filter down through every part of an operation, whether you’re running a start-up or a multinational lab network.

    Potential Solutions to Ongoing Challenges

    Like most sectors, the chemical industry faces growing pressure on cost, oversight, and supply chain security. Cutting-edge research only happens when the basics are locked down. Improving transparency starts with adoption of digital inventory systems that track every batch, every delivery, and every use. Automated notifications help labs keep up with recall notices or formulation updates, without relying on memory or paperwork that might go missing. Building supplier relationships pays off—lines of communication matter when volatility affects global supplies. During recent years, supply disruptions have taught everyone to diversify sources, audit supplier credentials, and maintain a strategic stock of critical intermediates. Resilient operations find creative ways to protect research timelines.

    Training plays a part too. Chemists entering the workforce need to understand more than just reaction mechanisms; they need to grasp why every raw material choice matters. Outreach from experienced researchers, combined with supplier-led seminars and hands-on workshops, closes the gap. Communicating lessons learned across different teams or regions avoids repetition of avoidable mistakes. Combining experience with openness keeps the field dynamic while reducing waste and risk. No one needs another story about a lost project caused by an avoidable raw material blunder.

    Policy pressure and sustainability goals also push innovation. The future of specialty chemicals, including critical intermediates like 4-Hydroxyphenylethyl Bromide, depends partly on greener production routes and improved lifecycle management. Engineers and chemists working on scale-up problems look for reductions in waste, safer processing, and ways to simplify purification. The best suppliers adapt with cleaner, more efficient manufacturing and transparent reporting on environmental impact. Consumers—whether they buy grams or kilograms—prefer options that align with values of stewardship, quality, and social responsibility.

    The Bottom Line: Value, Experience, and Progress

    People who work with 4-Hydroxyphenylethyl Bromide long enough recognize its real value goes beyond the chemical formula or technical specification. It’s the reliability, transparency, and flexibility that matter most in practice. Researchers, production chemists, and product developers all benefit from access to materials they can trust. Years of navigating challenging projects, seeing both successes and failures, underline one principle—every detail counts when striving for excellence in chemistry. Whether supporting major discoveries or smaller process improvements, the right choice in starting materials often sets the pace for long-term progress. Clear communication, rigorous standards, and steady supplier partnerships keep the doors open to innovation, delivering advances not just for individual labs but for industries as a whole.