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4-(Hydroxymethyl)Benzoic Acid

    • Product Name 4-(Hydroxymethyl)Benzoic Acid
    • Alias p-Carboxybenzyl Alcohol
    • Einecs 252-018-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    319035

    Product Name 4-(Hydroxymethyl)Benzoic Acid
    Cas Number 874-90-8
    Molecular Formula C8H8O3
    Molecular Weight 152.15 g/mol
    Appearance White to off-white solid
    Melting Point 200-202 °C
    Solubility In Water Slightly soluble
    Boiling Point 443.3 °C at 760 mmHg
    Density 1.39 g/cm3
    Purity Typically ≥98%
    Pubchem Cid 14638
    Synonyms p-Carboxybenzyl alcohol
    Smiles C1=CC(=CC=C1CO)C(=O)O
    Storage Temperature Store at 2-8 °C
    Ec Number 212-869-5

    As an accredited 4-(Hydroxymethyl)Benzoic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100 g of 4-(Hydroxymethyl)Benzoic Acid is supplied in a sealed, amber glass bottle with a secure tamper-evident cap.
    Shipping 4-(Hydroxymethyl)Benzoic Acid is shipped in tightly sealed, chemical-resistant containers to prevent contamination and moisture absorption. It is packaged according to regulatory guidelines for safe transport of chemicals. Appropriate labeling, including hazard information, ensures safe handling during shipping. The product ships via ground or air, depending on destination and regulations.
    Storage 4-(Hydroxymethyl)benzoic acid should be stored in a tightly sealed container, protected from light and moisture, and kept in a cool, dry, well-ventilated area. Avoid direct sunlight, heat, and sources of ignition. Store separately from incompatible substances such as strong oxidizers and bases. Proper labeling and adherence to local chemical safety regulations are essential for safe storage.
    Application of 4-(Hydroxymethyl)Benzoic Acid

    Applications of 4-(Hydroxymethyl)Benzoic Acid in Industrial Manufacturing

    As an established manufacturer of 4-(Hydroxymethyl)Benzoic Acid, we supply this intermediate to multiple downstream industries where it supports production efficiency, process stability, and product function. Below are distinct industrial applications, highlighting the integration of our material in real-world manufacturing environments.

    1. Pharmaceutical Intermediates for Active Pharmaceutical Ingredients (APIs)

    Our material enters the pharmaceutical synthesis workflow as a key intermediate for building selective COX-2 inhibitors, antihypertensive agents, and antimicrobial drugs. Downstream partners integrate this compound in controlled batch reactions due to its stable carboxyl and hydroxymethyl functionality. During multi-step synthesis, the product supports precision modifications and enables robust API yields. Validation is critical; thus, compliance with rigorous international pharmacopoeias and trace impurity control holds priority throughout all process stages.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.) monographs
    • USP/NF (United States Pharmacopeia)
    • China Pharmacopoeia ChP (2020)

    Typical usage ratio

    • Dosage as an intermediate ranges between 0.5–2.0 molar equivalents relative to the primary precursor, adjustable by reaction scale and API molecular design.

    Downstream process integration

    • Charged in condensation or esterification step based on API route.
    • Incorporated during Suzuki coupling in aromatic substitution reactions.
    • Used in final-stage hydrolysis for high-purity salt formation.
    • Validated for residual solvent and heavy metal profiles per pharmacopeia.

    Final product types

    • COX-2 inhibitor APIs
    • Benzamide antihypertensive intermediates
    • Fluoroquinolone antibiotics precursors
    • Chemical reference standards

    2. Polyester and Polyamide Polymerization Additive

    Polymer producers use this compound as a chain terminator and structural modulator in specialty polyesters and copolyamides. The hydroxymethyl group improves branching and modulates crystallinity, influencing polymer thermal/mechanical behavior. Dosing relies on targeted molecular weight distribution and desired end-use performance. This additive benefits bottle-grade PET and film production, facilitating improved impact resistance and process stability. Production lines with continuous polymerization units benefit from tight QC and material flow monitoring to ensure product uniformity.

    Industry compliance standards

    • FDA 21 CFR 177.1630 (polyester resins for food-contact articles)
    • EU Regulation (EU) No 10/2011 (plastics intended to contact food)
    • ISO 9001:2015 Certified Quality Management System (QMS)
    • REACH (EC 1907/2006) Registration for polymers

    Typical usage ratio

    • Typical additive dose: 0.05–0.5 wt% based on total polymer feed; precise levels depend on targeted intrinsic viscosity and final product properties.

    Downstream process integration

    • Pre-mixed with terephthalic acid and other monomers prior to melt polymerization.
    • Dosed into reactor at start of batch.
    • In-line addition with feeding systems for continuous reactors.
    • Aligned with dosing of catalysts and chain extenders for copolymer tailoring.

    Final product types

    • High-strength PET bottles
    • Biobased polyester fibers
    • Specialty films with improved tear resistance
    • Copolyamide engineering plastics

    3. Synthesis of UV-Absorber and Stabilizer Additives

    Additive producers rely on this compound as a functional building block in the manufacture of UV-absorbing chemicals for coatings, plastics, and elastomers. The benzoic acid core provides a stable aromatic scaffold, while the hydroxymethyl group permits selective etherification or esterification, maximizing compatibility in polymer matrices. By selecting appropriate conversion steps, formulators tune UV absorption peaks and weathering resistance, critical for outdoor use materials where prolonged exposure to sunlight occurs.

    Industry compliance standards

    • OECD GHS classification for chemical safety
    • China GB/T 23979—Requirements for coating additives
    • ISO 14001:2015 Environmental Management System
    • RoHS (EU 2015/863) compliance for plastic applications

    Typical usage ratio

    • UV absorber synthesis: 1.0–1.3 molar equivalents per coupling partner, customized per additive structure; final additive loadings in end-use materials: 0.05–0.2 wt%.

    Downstream process integration

    • Charged as a reactant in etherification with benzophenone derivatives.
    • Incorporated pre-polymerization or post-polymerization for plastic stabilization.
    • Processed in solvent or melt-phase reactions by additive blenders.
    • QC by UV-Vis spectrometry for absorption profile validation.

    Final product types

    • UV-stabilizer masterbatches for polypropylene
    • Sunscreen coating additives
    • Automotive polymer interior parts
    • Exterior architectural paint stabilizers

    4. Liquid Crystal Intermediate for Display Materials

    Manufacturers of display and electronic films employ this material in the fine chemical synthesis of advanced liquid crystal monomers. Its distinct aromatic-hydroxymethyl structure fits strict purity requirements for electronic applications, with careful attention to trace ionic and metal content. Downstream teams use it in Friedel–Crafts or esterification reactions to build rod-like mesogens, vital for stability and contrast in LCD and OLED applications. This application demands best-in-class trace analysis and batch traceability from upstream suppliers.

    Industry compliance standards

    • IEC 61249-2-41 (halogen content for electronic components)
    • Electronically grade QC per JIS C-5016
    • ISO 14644-1 cleanroom requirements
    • REACH (EC 1907/2006) SVHC monitoring

    Typical usage ratio

    • Intermediate dosage at 1.0–1.2 molar equivalents in mesogen synthesis; loading varies by liquid crystal structural requirements.

    Downstream process integration

    • Introduced in initial condensation reactions in sealed reactors.
    • Batch filtration and recrystallization for high-purity output.
    • Direct transition into phenyl esterification with fluorinated compounds.
    • Chromatographic purification to electronic-/display-grade quality.

    Final product types

    • Twisted nematic (TN) liquid crystals
    • In-plane switching (IPS) LCD fluid blends
    • Organic electroluminescent layered devices
    • Flexible display polymers

    5. Active Ingredient in Specialty Corrosion Inhibitors

    Producers of corrosion inhibitor formulations utilize this compound in waterborne system blends for industrial cooling water, boiler, and metal surface treatments. Formulators leverage its functional group reactivity to bind metal ions and form passivation layers, especially in systems handling high temperature and variable pH. Consistent feedstock quality, low volatility, and traceability for environmental compliance mark critical requirements in this market segment. Material dosing and blend ratios adjust according to metal type and fluid conditions on site.

    Industry compliance standards

    • ASTM G170 (evaluating effectiveness for metal corrosion inhibitors)
    • ISO 8044:2020 (Corrosion of metals and alloys—Terms and definitions)
    • China GB 50050-2017 (industrial circulating cooling water control)
    • US EPA TSCA inventory listing

    Typical usage ratio

    • Formulated at 0.01–0.2 wt% in aqueous working solutions; adjustment based on system volume, dissolved oxygen, and water hardness.

    Downstream process integration

    • Blended into water-soluble concentrate in industrial mixing tanks.
    • Pumped into recirculating water systems.
    • Combined with chelating agents and other inhibitors as multi-component solutions.
    • Performance validated by metal coupon immersion testing.

    Final product types

    • Copper and steel corrosion inhibitor concentrates
    • Closed-loop cooling water chemicals
    • Surface passivation rinse solutions
    • Power plant water treatment blends
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    Certification & Compliance
    More Introduction

    Introducing 4-(Hydroxymethyl)Benzoic Acid: A Reliable Choice from a Dedicated Manufacturer

    Understanding the Product

    In the realm of specialty chemicals, 4-(Hydroxymethyl)Benzoic Acid stands out for its clear role in advancing fine chemical applications. We have honed our approach toward producing this compound, identified by its chemical formula C8H8O3, with a sense of practical responsibility. Known for its consistent purity and white crystalline nature, our material reflects our compliance with industry standards and thorough, transparent quality control.

    Each batch of our 4-(Hydroxymethyl)Benzoic Acid reflects years of continuous improvement. The product shows a melting point typically around 143-146°C, and its structure contains both a carboxyl group and a benzylic alcohol. Through this combination, it provides a flexible synthetic handle for chemical transformations, serving both established and emerging needs in pharmaceutical intermediates, photographic chemicals, and polymer modifiers.

    The Manufacturing Perspective: Quality and Consistency

    Tight control over production means fewer worries about batch-to-batch variability. The facility maintains closed-systems during synthesis and handles the substance in ways that safeguard both the environment and downstream users. Our technicians rely on validated methods, such as HPLC and NMR, to check for byproducts and confirm purity. Each kilo provides a reliable starting material for downstream chemical syntheses, because we control every stage, from raw benzoic acid checking to thorough purification of the final solid.

    Years of working with 4-(Hydroxymethyl)Benzoic Acid have taught us it can demand patience. Synthesis requires precise conditions during the hydroxymethylation step—temperature, pressure, and reagent quality all leave their mark. The end product rewards this patience. When used as a building block for pharmaceuticals, protective groups attach easily at the hydroxymethyl position. When entering polymer science, the benzylic alcohol gives useful cross-linking potential. Researchers have found it especially helpful for preparing benzyl ethers and esters that need stability and selective cleavage.

    Why Customers Keep Returning to Manufacturer Supply

    Nothing replaces the value of direct knowledge gained during every production run. Every customer order carries reminders of the practical challenges in laboratories and production plants: needs for reproducible purity, clear origin traceability, and dependable response to technical questions. Distributors and resellers sometimes obscure these details—or even introduce delays as simple questions pass through too many hands. Manufacturers have to offer more: secure material that supports customers’ ability to meet regulatory milestones, pass audits, and formulate with confidence.

    Large energy and process investments go into reliably producing specialty benzoic acid derivatives. That’s why our direct communication with chemists and formulators sharpens our attention to potential process issues. If a customer suspects a contamination risk, samples from our retained lots come under scrutiny to answer these questions directly, not through intermediaries. This approach minimizes downtime and gives researchers and manufacturers direct insight when scaling up or troubleshooting.

    Common Uses: Supporting Scientific and Industrial Progress

    Every shipment of 4-(Hydroxymethyl)Benzoic Acid leaves our facility with a set of intended roles in mind. The primary use appears in pharmaceutical R&D, as teams design active ingredients, prodrugs, or stable intermediates based on its structure. Our product often enters into condensation reactions or selective oxidations, supporting the synthesis of more elaborate molecules. Academics and industrial chemists both demand material that reacts predictably and withstands storage.

    Polymer applications reflect a different side of the product. Here, the introduction of a hydroxymethyl group not only adjusts molecular weight and crystallinity but also enables specific compatibility for performance plastics. The carboxylic acid group, alongside the benzylic alcohol, means resin formulators can tune crosslink density to a degree not found in other benzoic acid variants.

    Another set of end-users turns toward our 4-(Hydroxymethyl)Benzoic Acid for its role in producing high-performance esters and photosensitive intermediates. These applications demand trusted analytical support: consistent melting range, transparent impurity data, and responsive answers to all technical questions. As a firm producing at the source, we are able to align our analytical release criteria with customer-specific application needs.

    Comparing with Other Benzoic Acid Derivatives

    4-(Hydroxymethyl)Benzoic Acid enters the landscape among a family of para-substituted benzoic acids. Compared to simple benzoic acid, the hydroxymethyl group contributes reactivity, allowing for further substitution or modification by standard organic synthetic steps. Alternate derivatives, such as 4-methylbenzoic acid (p-toluic acid), lack the accessible alcohol function, limiting their value as building blocks in many target molecules. Others, such as phthalic acids or more complex aromatic alcohols, introduce challenges with steric hindrance, solubility, or unmanageable side reactions.

    Our experience working with these related compounds has highlighted the nuanced differences in downstream chemistry. With 4-(Hydroxymethyl)Benzoic Acid, the polarity and mild nucleophilicity of the alcoholic group allow selective protections or functionalizations. The molecular weight of 152.15 g/mol fits well for both small-scale and industrial protocols, and its crystalline solid form simplifies handling compared to viscous or hygroscopic analogs. This matters not just for bench chemists but for plant operators tasked with weighing out and dissolving the substance day after day.

    Quality control routines go further with this compound than with more basic benzoic acids. Water content or trace metal impurities, which might be negligible in bulk chemicals, become essential data points. As a manufacturer, we provide these details up front, saving time for partner labs by eliminating downstream surprises. This readiness stands in contrast to material from resellers, where supporting data may not align with the requirements of regulated processes or custom synthesis work.

    Refining Production: Challenges and Learnings

    Chemicals like 4-(Hydroxymethyl)Benzoic Acid reward careful process engineering. We have encountered bottlenecks from hydroxyalkylation steps and learned to favor a more gradual approach—slower addition, tight thermal management, finer filtration. Direct observations in our plant have shown that even slight changes in temperature ramp rates or catalyst selection can produce different impurity patterns, leading us to adapt monitoring protocols.

    Handling and packaging require special consideration. Crystalline integrity affects dissolution rates during customer’s formulations. Agglomerates or fines can trouble both laboratory balances and industrial feeders. Our technicians manage this by controlling humidity and static during the filling process, using lined drums or sealed bags as needed. Shipment histories indicate that attention to bulk density and tamper evidence reduce risks of storage-related quality drift.

    Regulatory, Environmental, and Safety Focus

    A chemical’s value involves more than its synthetic versatility—compliance demands increase each year. Researchers and manufacturers in all regions expect supporting documentation: REACH registrations, clear GHS labeling, up-to-date SDS, and lot-level traceability. Every batch leaving our gates comes with these supports, prepared not by template, but by people directly involved in production. This instills confidence across technical, commercial, and regulatory teams at our customers’ sites.

    Our site teams manage waste and emissions streams with the same thoroughness applied to product quality, capturing every step and minimizing risks to health and safety. Staff receive continuous training on handling benzoic acid derivatives, so daily plant routines and emergency response drills reflect current best practices. We carry decades of embedded knowledge, so customers know the human stories and technical vigilance that stand behind every pallet or drum.

    In recent years, inquiries about product carbon footprint and lifecycle data have placed new expectations on manufacturers. We recognize these priorities. Where possible, we have substituted greener reagents or energy sources, publishing updates as improvements become validated. Open sharing of environmental metrics reflects genuine partnership with researchers focused on sustainable chemistry.

    Looking Ahead: Supporting Progress and Innovation

    We have noticed that research on 4-(Hydroxymethyl)Benzoic Acid grows year after year. Innovative medicinal chemists use it for smart drug linkers; material scientists exploit the balance of reactivity and stability in new coatings or sealants. Sometimes requests arrive that challenge what we thought possible—tailored particle size, customized drying, special packaging, or extended stability trials. Direct involvement in the process helps us work alongside customers, not just as suppliers, but as stakeholders in their development projects.

    Extensive technical records let us quickly support novel applications or qualification runs for medical and high-performance sectors. Teams here maintain open channels with customers, reviewing feedback and supporting trouble-shooting. Many customizations originate from such exchanges: a tightened specification, a more robust container for overseas shipment, an adjusted delivery frequency based on a new project’s needs. None of this would emerge from a pure trading operation, only from manufacturer’s continuous investment in capability and relationship.

    In global markets, volatility and uncertainty test the discipline of supply chain management. Our decades of experience in specialty chemical production mean deeper reserves of raw materials, agile scheduling of plant shifts, and plans ready to secure consistent material during interruptions. Direct manufacturer supply insulates end-users from sudden shortages or extended lead times. These supply reliability considerations gain value in regulated industries, where changes in input chemicals can set back projects and increase complexity.

    Practical Storage and Handling Expertise

    Years watching shipments move from plant to lab bench to industrial reactor underscore the importance of product stewardship. Our technical support team offers on-the-ground advice for avoiding cross-contamination, clumping, or unplanned exposure. While 4-(Hydroxymethyl)Benzoic Acid stores stably in cool, dry conditions, subtle factors—ambient humidity, container permeability, or even variation in warehouse temperature—alter shelf life and ease of use. Since every gram we ship flows from line operators and analysts who see the product daily, practical storage and handling tips arrive rooted in direct experience, not theory.

    Plant visits and customer audits provide further learning. Engaged end-users often present unique questions about compatibility with solvents, blends, or dosing systems. Our technical team supports studies on solubility, reactivity with specific process intermediates, or compatibility with commonly used stabilizers, drawing on historical plant data and literature tracking.

    Thoughts on the Future Direction

    The field of benzoic acid chemistry continues to change. New reaction pathways and green technology norms drive a steady evolution of expectations from customers and regulators. While today much discussion centers on medicinal and polymer chemistry, tomorrow’s uses might emerge from electronics, bio-derived plastics, or enhanced adhesives. Our facility adapts as requirements evolve. Years of building in-house expertise and cross-training chemists and operators provide a workforce prepared to fine-tune the product whenever novel synthesis or analysis methods demand different purity or analytical controls.

    Suppliers without direct manufacturing face built-in gaps—longer timelines to adapt, less certainty about the nuances that separate acceptable from exceptional product quality, less flexibility when customers need adjustments. Chemical manufacturing, especially for specialty compounds like 4-(Hydroxymethyl)Benzoic Acid, asks for adaptability and thorough understanding as much as technical skill.

    Every day our manufacturing team reviews new literature, process patents, and application reports. Chemistry never stays still. Direct engagement with product gives us an edge in bringing sustainable, safe, and high-quality 4-(Hydroxymethyl)Benzoic Acid to innovative end-users, whether in pharmaceuticals, advanced materials, or academic research.

    Final Reflection: Commitment to Progress and Partnership

    Manufacturing 4-(Hydroxymethyl)Benzoic Acid reliably is about more than having the right reactors and analytics. It demands responsive and skilled people, experienced in handling the special needs of customers working on demanding projects. Many collaboration and innovation stories begin with a simple request for a certificate or a technical explanation and grow into enduring partnerships built on direct manufacturer access.

    As we look forward, the mindset guiding our work will remain constant—the readiness to answer direct questions, to take feedback into our laboratory and plant, to share lessons learned, and to bring value through more than just a bottle of chemical. From our factory floor to your lab bench, 4-(Hydroxymethyl)Benzoic Acid continues to support the advancement of science and technology, driven by the dedication of experienced hands and the enduring quest for better solutions.