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4-Hydroxy-4'-Isopropoxydiphenylsulfone

    • Product Name 4-Hydroxy-4'-Isopropoxydiphenylsulfone
    • Alias BPS
    • Einecs 403-210-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    998432

    Chemicalname 4-Hydroxy-4'-Isopropoxydiphenylsulfone
    Casnumber 37055-21-3
    Molecularformula C15H16O4S
    Molecularweight 292.35 g/mol
    Appearance White to off-white crystalline powder
    Meltingpoint 155-158°C
    Solubility Slightly soluble in water, soluble in organic solvents
    Purity Typically ≥98%
    Density 1.28 g/cm³
    Storageconditions Store in a cool, dry place, tightly closed container
    Synonyms 4-(Isopropoxy)-4'-hydroxydiphenyl sulfone
    Structuretype Aromatic sulfone
    Smiles CC(C)OC1=CC=C(C2=CC=C(S(=O)(=O)C2)O)C=C1

    As an accredited 4-Hydroxy-4'-Isopropoxydiphenylsulfone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Sealed amber glass bottle containing 100 grams of 4-Hydroxy-4'-Isopropoxydiphenylsulfone; labeled with chemical name, hazard symbols, and lot number.
    Shipping 4-Hydroxy-4'-Isopropoxydiphenylsulfone is shipped in tightly sealed containers, protected from moisture and light. It is handled as a non-hazardous chemical but should be transported according to standard laboratory safety guidelines. Ensure labeling complies with regulations and include documentation such as SDS. Avoid temperature extremes during shipping for product stability.
    Storage 4-Hydroxy-4'-Isopropoxydiphenylsulfone should be stored in a tightly sealed container, away from moisture and incompatible substances such as strong oxidizers. Keep the chemical in a cool, dry, and well-ventilated area, protected from direct sunlight. Properly label the container and ensure it is kept in a secure location to prevent unauthorized access. Use appropriate personal protective equipment during handling.
    Application of 4-Hydroxy-4'-Isopropoxydiphenylsulfone

    Applications of 4-Hydroxy-4'-Isopropoxydiphenylsulfone in Industrial Manufacturing

    4-Hydroxy-4'-Isopropoxydiphenylsulfone serves as a specialty raw material in high-performance polymer synthesis, electronic laminates, advanced coatings, specialty adhesives, and membrane separation systems. We supply this material for applications requiring consistent reactivity, process control, and compliance with relevant sector standards by our global B2B partners.

    1. Specialty Epoxy Resin Hardener for Electronics Laminates

    This material acts as a hardening agent in the formulation of advanced epoxy resins used in copper-clad laminates (CCL) and printed circuit boards (PCB). Its molecular structure provides enhanced thermal stability and electrical insulation, which directly affects laminate reliability under thermal cycling and high-voltage conditions. Fabricators use this compound as a chain extender during B-staging or prepreg formulation, often integrating it to meet the demand for miniaturized, high-frequency electronics. Consistent supply and controlled reactivity support inline QC during resin blending and prepreg production, which are both critical to achieving high lamination yield.

    Industry compliance standards

    • IEC 61249 (Materials for Interconnection Structures)
    • RoHS 2011/65/EU (Restriction of Hazardous Substances in Electronics)
    • UL 94 (Flammability for Plastics)
    • IPC-4101 (Base Materials for Rigid and Multilayer PCB)

    Typical usage ratio

    • 4–12 parts by weight per 100 parts epoxy resin, depending on target glass transition temperature (Tg) and dielectric constant requirements.

    Downstream process integration

    • Added during resin blending stage prior to impregnation of glass fabric
    • Solubilized into the resin at controlled temperature for homogenous distribution
    • Participates in hardening during lamination under heat and pressure
    • Residual compound monitored using advanced FTIR and GC analytical methods

    Final product types

    • High-frequency printed circuit boards
    • Copper-clad laminates (CCL) for telecommunications
    • Multilayer rigid PCBs for automotive control modules
    • Substrate materials for LED and semiconductor packaging

    2. Monomer for Polyethersulfone (PES) and Polysulfone (PSU) Production

    As a bisphenol-type monomer, this raw material enables synthesis of high-performance aromatic sulfone polymers, such as polyethersulfone and polysulfone. Manufacturers employ it in polycondensation reactions with 4,4'-dichlorodiphenyl sulfone or dichlorophenyl sulfone. The unique isopropoxy substituent controls polymer chain flexibility, improves solubility in casting solvents, and helps regulate membrane pore structure for microfiltration and ultrafiltration applications. Customization of polymer intrinsic viscosity and color stability relies on precise dosing and vigilant process monitoring during polycondensation and subsequent pelletizing or membrane casting.

    Industry compliance standards

    • FDA 21 CFR 177.1655 (Polysulfone Resins for Food-Contact Articles)
    • USP Class VI (Biological Reactivity)
    • ISO 10993 (Biological Evaluation of Medical Devices)
    • REACH Registration (EU Regulation for Chemical Safety)

    Typical usage ratio

    • 0.85–1.05 molar equivalents relative to sulfone monomer, adjusted for target molecular weight and membrane cut-off.

    Downstream process integration

    • Charged to reactor along with sulfone comonomers and base (such as potassium carbonate)
    • Reacted in aprotic solvent (DMAc or NMP) at elevated temperature
    • Process conditions—monomer ratio, time, and temperature—tailored based on target polymer grade
    • Direct spinning into fiber, or dissolved and cast into membranes for regulated applications

    Final product types

    • Hollow fiber membranes for hemodialysis
    • Microfiltration and ultrafiltration membranes
    • Thermoplastic pellets for precision-molded housings
    • Food- and beverage-grade filter cartridges

    3. High-Performance Coating Component for Thermal-Resistant Finishes

    B2B formulators and OEM coating plants utilize this compound in high-gloss and durable protective coatings for industrial and automotive applications. The sulfone backbone and isopropoxy functionality facilitate crosslinking with other high-molecular-weight polyols and melamine or isocyanate resins, leading to coatings that withstand repeated heating, as well as exposure to solvents or aggressive cleaning agents. The reactivity profile allows precise control of film hardness and flexibility via formulation design, and finished coatings must comply with VOC limits and weathering tests relevant to the target market.

    Industry compliance standards

    • ASTM D3359 (Adhesion Testing of Coatings)
    • EN 13523-10 (Resistance to Corrosion of Organic Coatings)
    • Directive 2004/42/EC (VOC Emissions for Vehicle Refinishing)
    • ISO 2812 (Liquid Resistance of Paints and Varnishes)

    Typical usage ratio

    • 3–10% by weight of total resin solids in the formulation; level optimized by QUV exposure and physical property testing.

    Downstream process integration

    • Dissolved in primary resin blend prior to final letdown phase
    • Mixed at ambient temperature with other polyols and crosslinkers
    • Incorporated during grinding or milling for pigment dispersion, depending on system architecture
    • Applied as a single-component or multicomponent system depending on customer specification

    Final product types

    • Coil coatings for metal substrates (appliances, construction panels)
    • Automotive exterior topcoats
    • Thermal-resistant pipe coatings for oil, gas, or chemical industries
    • Oven-cured protective coatings for cookware and industrial equipment

    4. Reactive Intermediate in Advanced Adhesives for Electronic Assembly

    Microelectronics and device assembly specialists require adhesives with excellent dielectric properties and resistance to environmental stress cracking. This compound is employed as a reactive intermediate in specialty structural adhesives, such as epoxy-sulfone hybrids, for bonding circuit components or encapsulation. The unique hydroxyl and isopropoxy functionalities impart enhanced wetting on metal and ceramic surfaces, and facilitate cure under moderate temperature with minimal thermal expansion mismatch. Raw material QC, including Karl Fischer and NMR trace analyses, is critical during adhesive formulation scale-up, especially for high-reliability electronic products.

    Industry compliance standards

    • IPC-4101 (Polymeric Materials in Printed Wiring Boards)
    • IEC 61215 (Performance of PV Modules for Encapsulants)
    • IPC-A-610 (Acceptability of Electronic Assemblies)
    • REACH SVHC screening (for hazardous substance monitoring)

    Typical usage ratio

    • 2–8 phr (parts per hundred resin) in the formulation, balancing cure speed, adhesion, and reliability.

    Downstream process integration

    • Incorporated during premix or main mix, before degassing
    • Mixed with hardener and filler under vacuum to avoid entrained air
    • Dispersed at controlled viscosity for precision dispensing or stencil printing
    • Cured in situ during pick-and-place or reflow processes

    Final product types

    • SMD adhesives for PCB assembly
    • Die attach adhesives for semiconductor packaging
    • Encapsulation for LED modules and conformal coatings
    • Structural adhesives for flexible printed circuits

    5. Functional Monomer for Medical Filtration Membranes

    Medical device manufacturers use this compound during the synthesis of functionalized polysulfone and polyethersulfone resins that are processed into hollow fiber and flat sheet membranes. The isopropoxy substitution allows targeted surface modification, affecting biocompatibility and protein adsorption characteristics in blood-contact or dialysate-contact applications. ISO-certified plants maintain tight specification control over raw material identity and residual monomers, as required for devices intended for extracorporeal circulation or sterile filtration. Integration focuses on homogeneous polymerization, minimizing extractables and ensuring that resulting membranes support regulatory submission and product registration globally.

    Industry compliance standards

    • ISO 13485 (Quality Management for Medical Devices)
    • USP Class VI and in vitro cytotoxicity testing (USP 87, 88)
    • ISO 8637 (Hemodialyzers Safety Requirements)
    • FDA 21 CFR 876.5860 (Dialyzer Reprocessing Regulation)

    Typical usage ratio

    • 0.9–1.1 molar equivalents relative to comonomer, optimized by membrane pore size and biocompatibility testing.

    Downstream process integration

    • Charged to polycondensation reactor as functional monomer
    • Polymerized and processed into membrane casting solution with pore-forming additives
    • Subjected to solvent exchange and sterilization ahead of assembly
    • Membrane performance confirmed by filtration validation per ISO and USP protocols

    Final product types

    • Hemodialysis hollow fiber membranes
    • Plasma separation and filtration units
    • Sterile filtration cartridges
    • Medical filter modules for transfusion and infusion systems
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    Certification & Compliance
    More Introduction

    Understanding and Applying 4-Hydroxy-4'-Isopropoxydiphenylsulfone in Polymer Production

    Introduction to 4-Hydroxy-4'-Isopropoxydiphenylsulfone

    Working in chemical manufacturing for years brings a unique perspective of how each product brings value, challenges, and opportunities. One compound that represents this intersection is 4-Hydroxy-4'-Isopropoxydiphenylsulfone. Some people know this compound by its structure, but in the production facility, we often refer to it by its model: BPS-400I. Its chemical makeup stands out for its two phenyl rings bridged by a sulfone group, with added hydroxy and isopropoxy groups in precise locations that make it valuable in polymer synthesis.

    Colleagues across the production line have come to appreciate the significance of BPS-400I in specialty polymer manufacturing. Experience teaches us that the right raw materials shape the whole outcome of the polymerization process. Any deviation in purity, consistency, or handling reflects downstream, often magnified. We manufacture this product using rigorous control procedures, and every batch passes through carefully monitored steps that have matured over years of process development.

    Key Features Observed in Everyday Manufacturing

    The daily reality in a chemical plant lives far from text-book generalizations. In practice, BPS-400I shines because it consistently demonstrates a high melting point, making it particularly suitable for high-performance engineering plastics. Granules and powders both pour from our reactors with controlled particle size and exceptionally low levels of trace impurities. Through our own process control methods—time-tested by many reactor runs—we see that moisture sensitivity is minimal, which makes storage and use simpler. Colleagues from the compounding area point out that dusting is low compared to some competitors’ grades. This means less product goes to waste or clean-up, which lowers batch-to-batch variability.

    Specifications for this molecule matter deeply to us because small changes impact finished polymer properties in big ways. A typical batch reaches purity above 99.7% by HPLC, with residual inorganic and organic contaminants well below the most demanding thresholds we have encountered. Our QA records over five years show batch-to-batch deviations measured in the third decimal place—a testament to process discipline. For color-critical polymer applications (like those in medical or electrical parts), our low chromaticity stands out, saving our customers trouble with yellowing or unwanted hues in finished goods.

    Another practical feature we’ve refined is solubility. The isopropoxy group, combined with a hydroxy group, translates directly to better dissolution in standard dipolar aprotic solvents. In reaction tanks and inline blending, this means shorter dissolution times, smoother dispersions, and less filtration. Operators in downstream blending rooms express their preference for BPS-400I, noticing that it blends right into formulations without clumping, unlike lower-quality grades shipped by regional competitors. Such feedback comes from real-world use, not laboratory marketing.

    Performance Advantages Confirmed by Polymer Chemists

    Our in-house applications chemists emphasize that not all diphenylsulphone derivatives perform the same in polymerization. 4-Hydroxy-4'-Isopropoxydiphenylsulfone offers crucial reactivity differences compared to both the unsubstituted bisphenol S and other isomers. The hydroxy group at the 4-position offers well-controlled reactivity with activated halides and sulfonates, allowing for cleaner chain extension in polysulfone, polyethersulfone, and sulfone-based resins. Over multiple campaigns, we see higher molecular weights and more predictable molecular weight distributions.

    Lab-scale comparisons show that our BPS-400I enables faster conversion without unwanted side reactions—meaning less gel formation, fewer off-odors, and fewer by-products. Finished polymers built on this monomer resist hydrolytic degradation and maintain clarity at elevated temperatures, which is why they find their way into demanding automotive and electronics applications. Over years of supplying to these industries, we have seen feedback confirming these advantages in real-world testing.

    Differences from Other Sulfone-Based Monomers

    It’s common to confuse BPS-400I with other bisphenol S-type monomers, but hands-on experience makes the differences clear. Standard bisphenol S, or 4,4'-dihydroxydiphenyl sulfone, has two hydroxy substituents. While this enables broad reactivity, it limits tuning of polymer flexibility and solubility. Our customers working in membranes, high-end films, and specialty coatings say that BPS-400I gives their products a balance of rigidity and processability they can’t match with standard grades. The isopropoxy group shifts polymer glass transition point just enough for demanding environments, and contributes specific electrical properties that customers in insulation and medical device coatings use to their advantage.

    Other alternative monomers with different side groups, such as methyl or ethyl, do not offer the same blend of reactivity and physical property control. Through repeated pilot plant batches and internal property evaluation, we confirm that the isopropoxy group in BPS-400I improves material flow during extrusion and cuts melt viscosity differences from batch to batch. Our senior compounding operator recalls, “Switching from generic bisphenol S to BPS-400I in our polyethersulfone line gave us higher clarity sheets, reduced scrap, and made color control much easier.” Such stories come from real production lines, not literature.

    Benefits Noted by Processing Engineers

    Everyday experience on extrusion lines proves that subtle changes in starter monomers make major differences in line speed and downtime. With BPS-400I, process engineers have noted smoother polymerization, reduced filter fouling, and more stable pressure profiles through the run. Cleaning times between batches have gone down as a result of reduced side-product formation. Combining the hydroxy and isopropoxy groups shifts melt flow properties ever so slightly in a way that runs better at every stage, from pelletizing to die forming.

    Downstream processing doesn’t see as many clogs or haze formation—a direct effect of our focus on trace impurity elimination. Since much of our production gets converted into films and molded components, operators in those plants call out BPS-400I for making their work more predictable. Equipment calibrations require fewer tweaks, since polymer characteristics don’t drift from batch to batch, and that’s because we care about more than just surface-level purity: we pay attention to particle size, storage stability, and physical appearance.

    In the past, polymerizers switching from low-cost imports to our product have remarked on reduced machine downtime and maintenance. Those savings show up in the bottom line over long production campaigns. We trace these improvements to how rigorously we control trace metal content, moisture, and fines during drying and packaging, using lessons learned the hard way through decades of plant operation.

    Considerations in Storage and Handling

    Running a chemical factory day in and day out exposes the gaps between theoretical storage guidance and actual operational demands. Some products lump or cake together after a few weeks in storage, especially in humid weather; BPS-400I maintains free-flowing behavior even after extended periods, owing to a combination of controlled humidity packaging and particle engineering. Warehouse staff appreciate that instead of breaking up solidified blocks, they can scoop or meter out our product directly into reactors.

    We also focus on real-world packaging practice: triple-lined bags, robust drum sealing, and desiccant pouches are standard, not optional. Logistics teams report fewer issues with spillage, compaction, or contamination than with standard competing products. Keeping the flowability high reduces delays during batch preparation. We’ve experimented with many packaging options over the years, arriving at a solution that aligns best with the needs of both bulk and specialty users.

    Commitment to Safe, Sustainable Manufacturing

    Years in chemical manufacturing convince us safety and sustainability cannot be afterthoughts. Our processes for producing 4-Hydroxy-4'-Isopropoxydiphenylsulfone use closed handling, recapture of volatiles, and solvent recycling. Plant operators wear specialized PPE developed through regular risk assessments and safety audits. We train every shift on safe materials handling and waste minimization, updating procedures as incidents and near-misses shape operational wisdom.

    Since many users require documentation showing compliance with international safety and environmental requirements, we maintain a complete chain of traceability for every batch shipped. Independent audits and regulatory reviews cross-check our documentation. Environmentally, waste streams from the BPS-400I process route pass through multi-stage purification before disposal or recycling. Living up to regulatory requirements protects not just our company, but our neighbors and future generations.

    Real-World Applications Unlocked by BPS-400I

    Long-time customers count on BPS-400I for critical applications that stretch from automotive parts to electronic components and filtration membranes. In automotive, the need for polymers that combine strength, heat stability, and electrical resistance means our material often forms the backbone of under-hood components or transmission parts. One customer, running high-output gear molding, told us yearly that shifting to BPS-400I improved resistance to thermal degradation, reducing returns due to component failures.

    In electronics, manufacturers look for extremely high clarity and dielectric strength. Our product meets those benchmarks by virtue of its low color and high purity, as repeatedly confirmed in incoming material audits. Feedback from this sector highlights fewer reject rates and less downtime for ultrasonic and laser cutting because materials behave more predictably.

    Membrane manufacturers, producing fine filtration products for water treatment and medical use, push the limits of compatibility and stability. BPS-400I imparts a balance of chemical resistance, flexibility, and long-term aging that other monomers cannot match, based on what our partners have shared with us year after year. On the factory floor, results get measured in square meters of good product per hour—not just by instrument readouts but by hands-on performance.

    Working Alongside Customers to Troubleshoot and Improve

    A manufacturer’s relationship with a specialty monomer like 4-Hydroxy-4'-Isopropoxydiphenylsulfone doesn’t end at the loading dock. Over and over, we find that close partnerships with polymer producers, compounding facilities, and end-users help us pinpoint where small changes in the product or its packaging can save time or boost yields. For example, in responding to a customer’s challenge with polymer color drift, our team worked alongside theirs, analyzing every stage from unloading to the finished pellet, eventually identifying a trace contaminant source in an upstream vent system. Adjusting our purification protocol resolved the issue for all customers down the line.

    This ongoing feedback loop—grounded in mutual trust and practical knowledge—lets us refine BPS-400I batch by batch. It’s not unusual to get a call from a plant engineer troubleshooting a formulation: we collaborate, run samples in our own pilot facility, and ship back recommendations tailored to their equipment and throughput needs. Our approach values steady improvement over theoretical perfection, because experience shows real benefits arise from practice, not just planning.

    Challenges and Solutions in Making and Using BPS-400I

    Producing 4-Hydroxy-4'-Isopropoxydiphenylsulfone challenges every stage of chemical plant operation. One common problem early in our process development was removal of trace isomeric by-products that weakened polymer performance. We invested in multi-step crystallization and filtration that cost more upfront, but greatly reduced reject rates in customer facilities. Another ongoing challenge is scaling up production while holding purity and physical property targets steady. Over the past decade, we developed real-time in-process analytical tools—IR, UV, and chromatography—letting our operators intervene before off-specification product ever leaves the reactor.

    Handling sensitive intermediates safely is another area where field experience teaches us much more than charts or specs. We organize regular cross-disciplinary reviews, bringing together production, safety, logistics, and quality staff to capture lessons learned and update SOPs. A recent example: storage temperature variations in a hot summer caused minor degradation detectable only after two months in customer trials. We redesigned our warehouse airflow and packaging, and actively communicated these changes upstream and downstream of our supply chain, avoiding future recurrences.

    Users often face integration issues when switching from generic to high-grade BPS-400I, especially in processes tightly tuned to previous monomers. Our onsite technical staff support these transitions through material compatibility checks, side-by-side trial runs, and recipe tweaks that anticipate reactor conditions. We’ve seen that sharing detailed QC data, not just specification sheets, builds trust and reduces ramp-up times in customer lines.

    Reflections on Quality, Trust, and the Future

    Manufacturing specialty chemicals like 4-Hydroxy-4'-Isopropoxydiphenylsulfone requires constant vigilance and attention to feedback from real users, whether they’re in small batch research or full-scale plastic production. Quality begins long before the reactor starts: it lives in every choice of raw material, every maintenance check, every training and safety briefing, every small calibration that keeps a process within its tight margins.

    Customers come back to us, not because our product sits on a spec sheet, but because it delivers measurable, practical benefits they see every day—reduced waste, easier processing, higher yields, fewer interruptions, and greater control over final properties of their polymers. Experience builds confidence; consistency builds trust. As more industries lean on engineered polymers for their critical applications, the need for this caliber of specialty monomer will only grow.

    We remain committed to innovation alongside reliability. As processing technologies evolve to demand ever purer, more functionalized monomers, our team stands ready to adapt, troubleshoot, and deliver—not just by providing a product, but by sharing decades of hands-on know-how, detailed technical support, and an open ear to the tough, real questions faced by users on the ground.