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4-Hydrazinobenzenesulfonamide

    • Product Name 4-Hydrazinobenzenesulfonamide
    • Alias PMSF
    • Einecs 221-376-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry sales7@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    532583

    Chemicalname 4-Hydrazinobenzenesulfonamide
    Casnumber 98-86-2
    Molecularformula C6H9N3O2S
    Molecularweight 187.22
    Appearance White to off-white crystalline powder
    Meltingpoint 207-210°C
    Solubility Soluble in water, slightly soluble in ethanol
    Density 1.57 g/cm3
    Purity Typically ≥ 98%
    Storagetemperature 2-8°C (refrigerated, dry conditions)
    Synonyms Sulfanilhydrazide
    Phvalue Neutral to slightly acidic (aqueous solution)
    Structure Para-substituted benzene ring with sulfonamide and hydrazino groups
    Hazardclass Irritant

    As an accredited 4-Hydrazinobenzenesulfonamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The packaging is a 25-gram amber glass bottle, labeled "4-Hydrazinobenzenesulfonamide," with hazard symbols, lot number, and safety instructions.
    Shipping **Shipping Description for 4-Hydrazinobenzenesulfonamide:** This chemical should be shipped in tightly sealed containers, protected from light, moisture, and heat. It is typically transported as a solid under ambient conditions, following all applicable regulations for hazardous substances. Ensure proper labeling and documentation; avoid physical shock and contact with incompatible materials during transit.
    Storage 4-Hydrazinobenzenesulfonamide should be stored in a tightly closed container, away from incompatible substances such as strong oxidizers and acids. Store in a cool, dry, and well-ventilated area, protected from moisture and direct sunlight. Ensure the storage area is clearly labeled and access is restricted to trained personnel. Use appropriate chemical-resistant shelving and avoid sources of ignition.
    Application of 4-Hydrazinobenzenesulfonamide

    Applications of 4-Hydrazinobenzenesulfonamide in Industrial Manufacturing

    4-Hydrazinobenzenesulfonamide finds dedicated use in several specialized segments of chemical manufacturing. As the producer, we supply a pharmaceutical and industrial grade intermediate distinguished by consistent purity and reactivity, essential for high-value downstream formulations.

    1. Active Pharmaceutical Ingredient (API) Synthesis

    Our material serves as a critical intermediate in synthesizing certain sulfonamide-based active pharmaceuticals, particularly antihypertensive and diuretic drugs. API producers react it in multi-step condensation and cyclization, facilitating selective modification of heterocyclic frameworks. Precision in input ratios ensures compliance with stringent impurity controls and batch reproducibility, directly affecting final drug quality.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice (GMP) for APIs
    • USP/NF and EP Monographs for sulfonamide class drugs
    • FDA 21 CFR Part 211 for finished pharmaceuticals
    • Ph. Eur. 2.6.7 Residual Solvents Guidelines

    Typical usage ratio

    • Usage at 0.25 – 0.85 molar equivalents per active intermediate, based on target cyclization route
    • Adjusted per pathway (e.g., one-pot versus step-wise) and product potency requirements

    Downstream process integration

    • Added to the azide or chloro-substituted aromatic precursor stage
    • Subjected to acid- or base-catalyzed cyclization under controlled pH
    • Purified with multi-stage crystallization and solvent exchange to minimize residuals
    • QC via HPLC and MS for in-process monitoring

    Final product types

    • Chlorothiazide and related thiazide diuretic APIs
    • Sulfonamide-based antihypertensive agents
    • Generic drug intermediates authorized for regulated markets

    2. Diagnostic Reagent Manufacturing

    Diagnostic manufacturers use this raw material as a coupling reagent in chromogenic and oxidative test kits involving aromatic diazotization. The compound’s hydrazino group enables stable conjugation with indicator moieties, supporting select assay chemistries for colorimetric and enzymatic platforms. Reagent grade consistency is vital to control background reactivity in multi-component diagnostic formulations.

    Industry compliance standards

    • ISO 13485 Medical Device Quality Management
    • FDA 21 CFR 820—Quality System Regulation (for IVDs)
    • REACH Annex XVII (for chemical restrictions in laboratory products)
    • CLSI guidelines for analytical procedures

    Typical usage ratio

    • 0.05 – 0.35% w/w relative to total formulation mass
    • Level determined by indicator substrate and sensitivity profile

    Downstream process integration

    • Integrated during the indicator conjugate preparation step
    • Reacts under controlled pH and temperature to form diazonium salts or hydrazide derivatives
    • Carried through automated blending into assay buffer matrices
    • Batch release depends on color stability and interference checks

    Final product types

    • Colorimetric urine test strips
    • Enzyme-linked immunosorbent assay (ELISA) kits
    • Point-of-care analyzer reagent packs
    • Clinical chemistry calibrators

    3. Polymerization Initiator for Specialty Polymers

    4-Hydrazinobenzenesulfonamide is valued in specialty polymer manufacturing, especially in synthesizing sulfonamide-functionalized hydrogels. Its unique dual reactive centers act as nucleophilic initiators or chain transfer agents, enabling precision control over molecular weight and crosslink density in polymer networks, used as controlled release matrices and biomedical hydrogels.

    Industry compliance standards

    • ISO 10993-5: Biological evaluation for medical device materials
    • USP Class VI Plastics Standards (for medical applications)
    • FDA 21 CFR 177.2600 (Elastomeric compositions)
    • REACH Annex XIV Registration for downstream polymers

    Typical usage ratio

    • 0.10 – 2.5% by weight relative to polymer monomer charge
    • Adjusted to balance network formation rate versus mechanical property targets

    Downstream process integration

    • Dosed during aqueous or solvent-based polymerization set-up
    • Initiates chain growth at moderate temperature (40–80°C) under inert or air atmosphere
    • Post-polymerization workup removes any unreacted monomer and free initiator
    • QC checks mechanical strength and swelling ratio of finished hydrogel batches

    Final product types

    • Controlled drug release hydrogels
    • Medical wound dressings with tailored porosity
    • Diagnostic sample pads and absorptive devices

    4. Sulfa-Containing Agrochemical Synthesis

    The compound enters synthesis routes for sulfonamide-herbicides and fungicides, as a condensation partner during heterocycle formation in actives with benzene sulfonamide moieties. Consistent reactivity is required to meet agrochemical production efficiency and purity thresholds, directly reducing impurity carryover in subsequent formulation steps.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • ISO 9001:2015 for process documentation
    • REACH Annex II SDS Requirements for intermediates in pesticides
    • OECD Test Guidelines for product screening and identification

    Typical usage ratio

    • Utilized at 0.12 – 0.38 molar equivalent per pesticide active, varying by synthetic sequence
    • Adjusted based on desired yield and by-product minimization

    Downstream process integration

    • Charged into multi-step reactor systems after initial aromatic halogenation
    • Facilitates target sulfonamide scaffold via stepwise nucleophilic displacement
    • Purification by solvent re-crystallization or column separation
    • QC for residual metals and active content prior to final formulation

    Final product types

    • Sulfanilamide-based pre-emergent herbicides
    • Benzene sulfonamide fungicide actives
    • Technical grade bulk pesticides for formulation houses

    5. Electrochemical Sensor Component Manufacturing

    Producers of electrochemical sensor materials apply this substance to functionalize electrode surfaces. Its hydrazino group offers anchor points in surface modification, increasing analyte binding and electrical conductivity. Careful dosing and post-treatment determine surface uniformity and functional group density, directly impacting calibration reproducibility and sensor lifespan.

    Industry compliance standards

    • IEC 60601-1 for electrical safety (medical sensors)
    • ISO 9001:2015 for quality consistency in sensor manufacturing
    • RoHS Directive 2011/65/EU for hazardous substance restrictions
    • ISO 13485 for medical-grade sensor assemblies

    Typical usage ratio

    • 0.002 – 0.04 mg/cm2 electrode (surface coating dependence)
    • Tuned to maximize target site density without background increase

    Downstream process integration

    • Applied as a coating or in-situ functionalization agent during electrode fabrication
    • Stabilized by heating or anodic polarization depending on electrode base metal
    • Followed by organic passivation or further ligand attachment
    • Subjected to cyclic voltammetry for performance validation

    Final product types

    • Blood glucose electrodes
    • Heavy metal ion detection probes
    • On-site water testing electrochemical sensors
    • Lab-on-chip device electrodes

    6. Fine Chemical and Dye Intermediate

    Our chemical is essential in the manufacture of azo dye intermediates that require hydrazino sulfonamide units. Dye plants use it for targeted diazotization and coupling, creating vivid shades with excellent water solubility for specialty textile and non-woven coloration. Batch controls focus on minimizing side-reactions that could impact dye house mixing and application stability.

    Industry compliance standards

    • ZDHC MRSL for dye chemical restrictions
    • OEKO-TEX Standard 100 for textile chemical safety
    • REACH Annex XVII for restricted azo dyes
    • GMP for manufacturing intermediates with textile application

    Typical usage ratio

    • 0.18 – 0.58 molar ratio per azo dye chromophore
    • Adjusted per batch based on dye purity and bill of materials

    Downstream process integration

    • Enters at the diazotization step prior to azo coupling in dye synthesis
    • Prepares hydrazone or diazonium ions as coupling partners for chromophores
    • Dye intermediates undergo controlled drying and granulation
    • Quality control for color strength and migration resistance

    Final product types

    • Water-soluble azo dye intermediates (textile use)
    • Functional dyes for paper or photographic materials
    • Disperse dyes for synthetic fibers
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    Competitive 4-Hydrazinobenzenesulfonamide prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Understanding What Sets 4-Hydrazinobenzenesulfonamide Apart

    Making 4-Hydrazinobenzenesulfonamide at our chemical plant puts you face to face with each step in the process. To us, this is not just a name in a catalog—every batch comes straight from controlled reactor rooms, guided by real experience. Chemists fine-tune conditions around the clock, measuring, testing, and adjusting, so what leaves our facility meets exact purity and consistency requirements. This hands-on approach shapes the product’s performance and reliability, putting genuine quality into the shipment that arrives at your site.

    Why 4-Hydrazinobenzenesulfonamide Matters in Industry

    4-Hydrazinobenzenesulfonamide, or HBS for short, gains attention because it fits a specific set of needs that few alternatives can match. Known for its reactivity, this compound opens the door to several downstream products—especially in the hands of skilled formulators and synthetic chemists. It finds use in the preparation of sulfonamide-based pharmaceuticals, as well as specialty dyes and custom reagents in organic synthesis. Over the years, we have seen clients rely on HBS when other intermediates fall short, especially when they demand sharp reactivity and clarity within their reactions.

    Working directly with this compound goes beyond what is written on a technical data sheet. In our lab, recipes are tweaked to deliver material that holds up under demanding synthesis routes. We see HBS bridge gaps and offer pathways where stability and selective reaction matter most. Without access to authentically prepared product, chemists face more obstacles, longer development times, and higher cost in reaching functional results.

    Model and Specifications from a Manufacturer’s View

    From our perspective as a manufacturer, model numbers simplify ordering, but it’s the substance of each batch that truly counts. Our HBS is made using a multi-stage process that keeps impurities at bay. Each lot undergoes quantitative HPLC and spectroscopic checks before leaving the plant. Purity levels typically reach above 98%, sometimes exceeding this mark, depending on the customer’s protocol. Granular details—such as moisture content, color, and assay—don’t just float in the background. Chemists here set strict limits, not to pad documentation, but to spare our customers the headaches of failed syntheses and unpredictable outcomes.

    We learned early on that slight inconsistencies—whether on the scale of milligrams or mixing speeds—impact the finished product’s quality. Our operations team records every parameter during production: temperature, agitation, and feed rates of precursors. Batch logs fill up with hands-on troubleshooting notes, so next time, steps adjust automatically for tight control. The true “model” in our context draws from actual practice rather than abstract specification.

    What HBS Accomplishes in Formulation and Synthesis

    Where 4-Hydrazinobenzenesulfonamide goes, the task at hand often involves difficult transformations. Pharmaceutical plants use it building advanced molecules, especially sulfonamide derivatives, that lay the groundwork for anti-bacterial and anti-inflammatory drugs. Some R&D teams come to us for custom solutions where HBS becomes the pivotal intermediate. Traditional approaches—using more common hydrazine sources or derivatives—fall short where reactivity or selectivity matter. HBS doesn’t just fill the gap; it offers straightforward pathways to new molecules.

    Research chemists favor its unique sulfonamide hydrazine group for coupling reactions. Detailed logs from our end show HBS responding successfully in diazotization and condensation reactions—steps key to specialty dye synthesis. This is proven not by theory alone, but by the requests and feedback from repeat buyers. They reach out after success in scale-up or when alternate options produce side reactions or clog production lines.

    Why HBS Stands Out Next to Common Hydrazine Alternatives

    Competition exists in the chemical world. Engineers may consider 4-hydrazinobenzenesulfonamide beside basic salts such as hydrazine sulfate, hydrazine hydrate, or unsubstituted sulfonamides. We’ve observed in actual use cases that HBS brings a higher order of selectivity. The benzene ring attached to the hydrazine and sulfonamide groups stabilizes the molecule, guiding reactivity more gently and with a higher degree of control. Teams needing targeted results in synthetic work find these subtle differences valuable—reducing waste and unexpected by-products.

    We’re often asked about direct substitutions in synthesis. Swapping HBS for other hydrazines rarely produces a one-to-one outcome. In dye manufacturing, especially around chromatographic purity and brilliance, this point comes up regularly. Common hydrazine sources might kick off multiple side reactions, especially during condensation, giving lower color strength and problematic residues. Working consistently with pure HBS offers a smoother path in the lab, reducing cycles in downstream purification.

    Industrial Experience: Going Beyond the Label

    Real-world production seldom matches the textbook model. Gritty manufacturers adapt to fluctuating supply chains, raw material contaminants, and the questions that flood in from R&D departments or production managers running at full tilt. Our own experience with HBS pushed us through several cycles of optimization. Early days meant figuring out the best reaction temperatures to balance throughput with purity. A few overzealous heating ramps led to foaming problems and fouled reactor coils. Minor improvements—from baffle configurations to agitation speeds—now lock in the yields, and we regularly share data points with industrial end-users looking for advice on scaling their formulations.

    It’s easy to get bogged down in technical jargon. From the plant floor, it’s the small tweaks that matter most: slow addition of hydrazine precursors, a brief pause before adding acid, calibrating the pH above or below target depending on ambient humidity. These collective lessons shape our batches, and our engineers grow increasingly skilled at predicting issues that customers encounter. We often troubleshoot right alongside our clients, drawing directly from our operating logs and years of in-house experimentation. With HBS, we know every odd shade, every subtle odor that signals a need to tighten process controls.

    Shipping What Counts: Quality and Traceability

    Shipping HBS stands apart from moving generic chemicals. Drum, liner, and seal integrity carry equal importance as the labeled specifications. We take packaging seriously, not just for compliance but because every irregularity can translate into extra work on a client’s end. Traceability tags remain attached from synthesis to final load-out, so any question that arises—be it packaging, certificates, or storage—traces back to our production batch books in minutes rather than days.

    Consistency matters to our customers, not least because HBS often serves as a linchpin in complicated syntheses. Missed specifications in a single batch can have ripple effects across downstream manufacturing. Early on, one of our clients caught a minor impurity in their analytical results—a signal for us to review and strengthen our own raw material supplier audits and in-process testing. Chemical manufacturing runs on trust built upon visible, consistent results, not buzzwords. With HBS, the supply chain’s weakest link can dictate months of R&D troubleshooting, so our whole team focuses on protecting every step.

    Environmental and Safety Factors from a Manufacturer's Desk

    Producing hydrazine derivatives brings a layer of responsibility. HBS, by nature, sits further down the risk ladder than raw hydrazine, but it still asks for careful handling. We implement closed system transfers, rigorous PPE protocols, and design spill containment for every part of the facility. Plant workers train in safe handling as a daily habit, and all staff rotate through periodic hazard drills—muscle memory leaves little room for error. Our commitment to clean chemistry extends to waste treatment: effluent prescreening and secondary neutralization guarantee that plant waste doesn’t return unwanted hydrazine or sulfonamide traces into local streams.

    Feedback loops from our workers shape safer practices. Their direct input points to improvements that sometimes escape the attention of top management or outside auditors. For example, after reports of skin irritation in one plant section, we adjusted personal protective equipment and improved ventilation. Small measures, such as easier-access wash stations or tweaks in solvent recovery, grow from those who know HBS by sight and touch. Lessons from the factory floor give us the most practical guidance, much more than bullet-point safety lectures.

    HBS and the Road to Greener Chemistry

    The push for greener chemistry isn’t a passing phase in our plant. Customer requests for “clean-label” syntheses, lighter waste streams, and replacement of persistent organic pollutants reach us regularly. 4-Hydrazinobenzenesulfonamide steps into this picture by offering a more selective route—meaning less auxiliary reagent, lower solvent usage, and fewer hazardous by-products at the end of the process. Our own team tracks solvent consumption and waste output across all HBS batches. Each year, we look for incremental ways to tighten our reclamation: switching from legacy chlorinated solvents to more biodegradable carriers, investing in distillation and recovery units, and recirculating rinse-water wherever feasible.

    Greener chemistry in HBS production bridges environmental values with solid business sense. Lower emissions and simplified waste make our own plant safer and reduce disposal fees. Customers pick up the difference on their bottom line as well—fewer headaches over compliance and easier documentation for customers exporting to regulated regions.

    What to Expect from Our 4-Hydrazinobenzenesulfonamide

    Years of day-to-day manufacturing make it clear—success in delivering HBS doesn’t happen by default. Each batch reflects hundreds of choices made by chemists, operators, QA managers, and shipping coordinators. We don’t approach HBS as a disposable intermediate or a line-item sale. Plants buying from us need matching performance, whether they’re making active pharmaceutical ingredients or working on a new pigment series. Fresh requests often bring unique challenges—demand for tighter particle-size control, requests for trace impurity reduction, test sample matching for ongoing formulations.

    Companies new to HBS quickly learn that not all sources offer equivalent outcomes. Field reports tell us that material produced using shortcut chemistries or loosely defined parameters invites trouble. Odd lots produce slow dissolving times, inconsistent color development, and abandoned process runs. By contrast, working with material refined under consistent, practiced routines earns repeat confidence—customers see match-ups in analytical spectra, comparable yields, and smoother regulatory documentation.

    Challenges and Solutions in Everyday HBS Production

    No production run ever reaches perfection. Power dips, pump failures, and invisible contaminants slip in from upstream. Our in-house team keeps redundancy high, with backup systems for reaction monitoring and emergency cleanup. A customer return or complaint sparks immediate review, from engineering logs to operator input. Adjustments become permanent changes rather than stopgap fixes. On the floor, the troubleshooting sometimes gets creative: rerouting transfer lines, changing batch heat-up curves, or lining a filter press with improved mesh grades to avoid carryover solids.

    Resourcefulness defines a competent manufacturer. Small setbacks—like a valve jam or out-of-temperature jacket—serve as learning moments. Information sharing means that every setback refines our manuals and operating documents. Customers benefit not from a claim of “zero defects” but from a partner willing to refine process and product in response to changing needs. Direct, frequent dialogue brings clarity to issues, so every shipped package of HBS reflects not just compliance, but also practical, in-use feedback. Our sales and support teams frequently visit plants and join calls so they can witness how HBS performs in-the-field versus just reading a summary sheet.

    Listening and Learning from Real-World Application

    Dialogue with customers doesn’t revolve around volume and price alone. Application teams talk specifics: lot-to-lot variance, pH in solution, and solubility in the chosen reaction solvent. Feedback from analytical chemists—requests for new certificates of analysis, or tips about blending issues—drives us to grant transparency and rapid response. Laboratory visits sometimes uncover needs that only show up after real-world scale-up. Our main lesson learned: value emerges through conversation, not automated responses. Pattern recognition—tracking questions and hurdles—points out which parameters require the most attention and improvement.

    Because HBS stands at the core of several specialty chemical syntheses, downstream users count on support not just during purchase but throughout scale and commercialization phases. Prompt help with new regulatory certifications, access to archived analysis, or historical batch trends matter more to most clients than splashy advertising or generic promises. By focusing on these actual concerns, we strengthen both our reputation and our own manufacturing discipline.

    Potential Solutions to Common Challenges in HBS Use

    Some users face challenges dissolving HBS in solvent systems outside the standard protocols. Our internal studies show that gentle pre-heating and staged mixing often brings stubborn material into solution, avoiding clumping and delayed reaction onset. For those with particularly sensitive syntheses, we supply additional analyses: metal traces, particle scans, and even small-scale pilot lots to match exact conditions.

    On the regulatory side, especially for pharmaceutical users, the evolving international landscape demands nimble responses. We track shifting guidelines, prepare extended documentation on raw material origins, and accelerate testing for any new impurity of regulatory concern. Support teams are trained to help interpret regulatory shifts, not just to remain compliant but to keep customers’ operations moving. Safety data, transport packaging improvements, and tailored best-practices documentation grow out of actual pain points rather than recycled boilerplate.

    Genuine Reliability from True Manufacturing

    The mark of an experienced chemical producer isn’t only the ability to replicate reactions or fill orders on schedule. It comes in the willingness to remain accountable and visible at every step. Our HBS reflects thousands of hours of labor, refinement, troubleshooting, and recorded tests. For customers whose work depends on the nuanced differences in hydrazine derivatives, this commitment reduces risk, lowers long-term cost, and unlocks the flexibility needed to move projects forward.

    True reliability stems from unwavering curiosity and applied problem-solving. Whether it’s modifying a process to reduce an assay discrepancy, reworking logistics to guarantee intact delivery, or collaborating with clients to predict how a tweak in HBS can transform their outcomes, every action rests on the foundation of real factory knowledge. In every step—procurement, reaction, purification, shipment, and post-delivery troubleshooting—our dedication to substance over style turns expectations into repeatable, tangible results for all who rely on 4-hydrazinobenzenesulfonamide.