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4-Fluoroacetanilide

    • Product Name 4-Fluoroacetanilide
    • Alias p-Fluoroacetanilide
    • Einecs 210-497-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    438508

    Chemical Name 4-Fluoroacetanilide
    Cas Number 403-20-5
    Molecular Formula C8H8FNO
    Molecular Weight 153.16
    Appearance White to off-white crystalline powder
    Melting Point 152-156°C
    Boiling Point 306-307°C
    Density 1.22 g/cm3
    Solubility In Water Slightly soluble
    Smiles CC(=O)NC1=CC=C(F)C=C1

    As an accredited 4-Fluoroacetanilide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A white, opaque plastic bottle labeled "4-Fluoroacetanilide, 100g," featuring hazard symbols, lot number, and manufacturer's details.
    Shipping 4-Fluoroacetanilide is shipped in tightly sealed containers to prevent moisture absorption and contamination. It is typically packaged in accordance with chemical safety regulations and transported as a non-hazardous substance under normal conditions. Ensure storage in a cool, dry place, and follow all applicable local and international shipping guidelines for safe handling.
    Storage 4-Fluoroacetanilide should be stored in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible materials such as strong oxidizing agents. Keep the container tightly closed and protected from light and moisture. Properly label the storage container and ensure access is limited to trained personnel. Store according to local regulations for hazardous chemicals.
    Application of 4-Fluoroacetanilide

    Applications of 4-Fluoroacetanilide in Industrial Manufacturing

    As a direct producer of 4-Fluoroacetanilide, we support multiple established sectors where this intermediate finds critical use. Below, we outline the major downstream industrial applications, each defined by specific compliance standards, processing practices, precise addition levels, and real-world end products. This structure helps procurement, R&D, and regulatory teams navigate technical usage safely, reducing risk across all stages of the supply chain.

    1. Pharmaceutical Intermediate Synthesis for Active Pharmaceutical Ingredients (APIs)

    4-Fluoroacetanilide plays a vital role as a building block in the multi-step synthesis of certain active pharmaceutical ingredients where the fluoro-substituted phenyl core modulates biological activity or improves bioavailability. Its use is driven by the need to introduce a fluorine atom selectively in specific drug frameworks, especially in analgesics, anti-inflammatories, and CNS agents. Our material supports downstream synthesis runs that demand traceability, consistently low impurity profiles, and compliance with regulated pharmaceutical manufacturing standards.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • US Pharmacopeia (USP) monographs for API process intermediates
    • EU GMP for APIs (EudraLex Volume 4 Part II)
    • FDA 21 CFR Part 211 (Finished Pharmaceuticals – indirect reference under process control)

    Typical usage ratio

    • 0.2–2.0 molar equivalents per target API backbone; the ratio depends on the molecular design and desired substitution level at the aromatic ring during coupling or acylation reactions.

    Downstream process integration

    • Usually introduced after initial aromatic ring formation and before heterocycle closure or amide condensation, often via Buchwald–Hartwig or direct acylation, followed by chromatographic purification.

    Final product types

    • Pharmaceutical intermediates for the synthesis of fluorinated antipyretic agents
    • Key precursors for CNS-modulating pharmaceutical actives
    • Advanced starting materials for generic anti-inflammatory drug APIs

    2. High-Performance Agrochemical Synthesis

    Manufacturers leverage 4-Fluoroacetanilide for the construction of fluorinated aromatic rings in select herbicide and fungicide molecules. Its introduction is critical at designated steps for optimizing efficacy and field stability of the resulting active ingredients. The purity and trace compositional consistency of our material influence downstream yield, crystallization behavior, and compliance with agrochemical regulatory submissions globally.

    Industry compliance standards

    • FAO/WHO Specification for Pesticides (FAO:2017)
    • REACH regulatory conformity (Europe)
    • ISO 9001:2015 (for agrochemical production sites)
    • EPA Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA, USA)

    Typical usage ratio

    • Typically 0.8–1.5 equivalents in relation to the target aromatic crop protection core, with exact levels determined by the synthesis pathway and presence of off-target reactivity in the production batch.

    Downstream process integration

    • Fed into the intermediate coupling stage, particularly for fluorination of aniline derivatives via directed acetylation, prior to downstream oxidation, halogenation, or sulfonation in the active substance synthetic scheme.

    Final product types

    • Broad-spectrum fungicide API intermediates
    • Herbicide actives containing a fluorinated acetanilide moiety
    • Insecticide starting materials for controlled release formulations

    3. Specialty Dye and Pigment Synthesis

    Chemical dye manufacturers utilize 4-Fluoroacetanilide to introduce fluorinated aromatic segments in advanced colorant systems. The compound supports improved lightfastness, resistance to oxidative fading, and specialized electronic or hue effects in finished dyes or pigments. For these downstream customers, batch-to-batch retention of fluorine positional accuracy and low residual aniline content are critical to avoid cross-reaction during diazotization or subsequent azo coupling.

    Industry compliance standards

    • OEKO-TEX® Standard 100 (textile conformance for dyes)
    • ETAD Code of Ethics (Ecological and Toxicological Association of Dyes and Organic Pigments Manufacturers)
    • EU REACH substance registration for intermediates
    • ISO 9001 for specialty chemical dyes

    Typical usage ratio

    • 0.3–1.2 mole per mole of diazotizable amine or coupling partner; adjustments based on target pigment shade and required depth of fluoro-substitution.

    Downstream process integration

    • Enters the pigment or dye manufacturing step prior to azo condensation, typically after initial ring functionalization. It supports further sulfonation, halogenation, or oxidative treatments to finalize the dye.

    Final product types

    • Reactive and disperse textile dyes for synthetic fibers
    • Fluorinated organic pigments offering enhanced UV stability
    • Colorants for high-performance coatings and specialty printing inks

    4. Fine Chemical and Polymer Additive Intermediate

    Certain performance polymer producers and fine chemical firms use 4-Fluoroacetanilide for end-group modification or as a monofluoro-aromatic seed in the preparation of tailored additives or block co-polymer sidechains. The direct introduction of a fluoro substituent governs compatibility with resins, blocks moisture ingress, and enhances thermal or hydrolytic resistance in specialty polymer applications. Our material meets trace impurity criteria suitable for compounding and polymerization enhancement runs.

    Industry compliance standards

    • ISO 9001:2015 (Quality Management in Fine Chemicals)
    • EU REACH (polymer and chemicals registration)
    • ASTM D5630 (Standard Test Method for Ash Content in Plastics)
    • UL Yellow Card for flame-retardant additives (applicable depending on the finished compound)

    Typical usage ratio

    • Typically 0.15–1.0 wt% based on total monomer or additive weight in resin or polymer blends; adjusted according to compatibility testing and target property modification.

    Downstream process integration

    • Incorporated post-polymerization as a functional end group, during melt blending, or fed into solution-phase block copolymer synthesis prior to curing and shaping.

    Final product types

    • Fluorinated block copolymers with tailored chemical resistance
    • Functional polymer additives for electronic encapsulation resins
    • Specialized flame-retardant polyolefin compounds
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    Competitive 4-Fluoroacetanilide prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Introducing 4-Fluoroacetanilide: Inside the Factory Floor

    Building Quality with 4-Fluoroacetanilide

    Every seasoned chemical manufacturer knows that a compound's true value comes from its consistency batch after batch. Our crew has worked with 4-Fluoroacetanilide for years, watching the industry's needs evolve faster than price points. In practical terms, 4-Fluoroacetanilide brings together stability and usability that some alternatives just don’t match. We put forward the model manufactured with high purity, tight control on residual solvents, and traceable raw material sources. This compound appears as a solid with an off-white color, produced for ease in storage and transport, which matches what most of our customers want for further synthesis.

    Working Hands-On: What to Expect

    Every bag and drum of 4-Fluoroacetanilide running off the line here comes straight from thoroughly monitored production runs. We use direct fluorination for the consistency chemists expect, and our teams run regular on-site GC-MS checks as a matter of routine. The chemical formula, C8H8FNO, lines up with the CAS number most labs reference, and the melting point holds up across batches, never drifting enough to cause downstream processing headaches. This matters in reaction planning because you can skip trial-and-error tweaks and avoid those costly surprises that often show up when using lower-grade materials.

    Labs and plants looking to synthesize fluoroaromatic compounds, pharmaceuticals, or advanced intermediates usually ask us about this material first. In our experience, customers in custom synthesis appreciate the ease in handling—real stability in regular lab air, and no need for elaborate containment or fast consumption once opened. One chemist we work with explained that their main reason for using our 4-Fluoroacetanilide was simple: workers could handle it without complicated PPE, so training time goes down and throughput goes up.

    Setting Ourselves Apart

    The difference comes in how we approach every stage, starting right from storage of precursors through to how finished product is packed. Newer companies often focus on packaging appearance. We care about the inside of the drum: each one gets individually weight-checked and lot-tested. End users mention that our lots dissolve more cleanly in common solvents, such as ethanol or acetone, in direct side-by-side trials. In routine production, a chemist’s worst enemy is a batch that leaves behind residue after recrystallization. Many generic versions can contain unreacted anilines or persistent moisture, both of which hurt the next step in a custom synthesis route.

    We sometimes get questions comparing 4-Fluoroacetanilide to straightforward acetanilide or to 2-fluoroacetanilide. The main difference is reactivity and selectivity in further transformation — 4-fluoro substitution lets downstream processes occur at a better pace or with cleaner yields, especially if you’re catalyzing arylation or working on making fluoro-containing pharmaceuticals. Some clients ran parallel setups using analogous non-fluorinated compounds and found higher impurity profiles as well as less predictable exotherms. For the pharma sector, this translates to more wasted solvent and energy use. For agrochemicals, you end up running more TLCs and struggling to get that final API approved with the regulator the first time.

    In the Trenches: Technical Observations

    Each of us on the line shares a similar story: new users often start with a test batch and notice fewer incidents of run-away reactions, easier filtration, and less yellowing during prolonged heating. From time to time, an R&D chemist will ask for tighter particle size or small test quantities. Our setup makes it possible to tweak the milling stage, achieving custom sizing when projects demand it, while keeping dust to a minimum. We do not mix packages or refill bulk drums, which keeps cross-contamination in check. It might sound old-fashioned, but this discipline comes from watching what works and what angers customers. Consistency saves everyone time down the road.

    Our first-hand reports also show one recurring point: customers facing long supply chains need to know shelf life and resistance to degradation. We’ve seen bags stored for over a year without clumping or breakdown, even in warehouse corners lacking tight humidity control. Newer clients find this reassuring when they ship materials overseas. Traceability is another key—each lot carries exact batch records, which auditors and QA managers have reviewed over the years. If a discrepancy pops up, we track it back through digitized logs instead of expecting users to piece together mystery root causes.

    Health, Safety, and Precautions in Practice

    On a busy production day, worker safety always comes to mind. We have kept incidents low by limiting exposure and automating dust-heavy steps. 4-Fluoroacetanilide does not create strong odors and holds a low vapor pressure, making the plant floor more comfortable for workers. Tight control over equipment maintenance further reduces accidental releases. In our production notes, we see cases where competitors’ batches failed due to higher residual solvents, which led to customer complaints around skin irritancy. Each step of our manufacturing runs at moderate temperatures, with built-in fail-safes against overheating. PPE guidelines focus mainly on minimizing dust inhalation and contact with open cuts. Waste handling remains straightforward—with neutralization tanks placed directly at filtration points, and old batches processed as chemical rather than general waste.

    Environmental Considerations and Responsibility

    Looking at public conversations these days, people expect more than just compliance. Our environmental crew spends every quarter reviewing solvent usage, water discharge, and emissions tied to 4-Fluoroacetanilide. Over the last five years, we have cut industrial solvent losses by switching to a semi-closed loop, and now recover over 80 percent of our acetone and ethanol. This is not just for cost; the push came after local agencies flagged big rises in solvent-related runoff from other plants. We realized quickly that focusing on product purity could go hand-in-hand with emission reduction. Batches now pass tests for low chlorinated solvent residues, and our internal tolerances run tighter than those listed by regulators.

    Some years back we added scrubber upgrades that pull down volatile fluorinated compounds before they ever reach the stack. The liquids routed into our system get neutralized, minimizing environmental risk—and the system logs every liter. Factory staff take pride in meeting these tougher standards, especially since many have young kids in the same community. We hear straightforward questions during staff meetings: if it hits the drain, will it come back to us? Treating waste with respect gained us local support, and in turn gave bigger customers the peace of mind they needed to keep sourcing from us.

    End-Use Insights: Synthesis, Pharmaceuticals, and Intermediates

    Many of our partner businesses use 4-Fluoroacetanilide as a crucial building block. Synthetic chemists pursuing agrochemical leads or new API candidates need consistent, pure fluoroaromatic rings. The distinction here seems small at first glance but matters most in high-complexity routes. Small difference in fluorine position can steer physical properties and reaction profile, so the 4-position often gives improved selectivity—meaning cleaner reactions without extra purification steps. As a manufacturer, nothing beats feedback where a single change, like switching from 2- to 4-fluoroacetanilide, translates into a measurable yield boost or lower residuals in bioassays.

    It’s become clear in our experience that research divisions value predictability of outcome just as much as cost. Dropping out impurity spikes helps catch early signals that would trip up later scale-up. Down the line, this saves both troubleshooting time and analytical runs. A product that consistently performs as expected lets process chemists plan with confidence. They’ve told us that having the lot paperwork and analysis on tap—without time-wasting requests—helps them justify their choices during internal audits or tech transfers.

    Global Logistics: Experience in Shipping and Handling

    Shipping specialty organics gets tricky with customs and long travel times. We produce in formats meant for both bulk industry (fiber drums, full-pallet loads) and small R&D orders (sealed bottles, accurate weights). Over time, we found many of our customers want peace of mind about the status of the order in transit, especially as cross-border trade faces labor shortages and random customs stops. Each shipment checks out with tamper-proof labeling and documentation tied to that batch, making acceptance smoother at every port. When warehouse operators find a split drum, we investigate it ourselves and send investigators, not just order replacements.

    Transport team feedback taught us how packaging choices affect final delivery. Double-bagged drums keep ambient moisture far from the product, and warning markings help keep loads at the correct stack height. We worked a long time before settling on carton linings that survive the summer heat without breaking down. We also back up those claims with photos and documentation that show up alongside the shipping papers—not just promises in a catalog. Sometimes, repeat customers run their own stability studies, and we accommodate their sampling by pulling material from the actual bulk lots, not demonstration jars.

    Staying Ahead of the Curve: Feedback and Continuous Development

    Any honest manufacturing discussion starts and ends with feedback. Production teams gather input from those on the receiving end—R&D, scale-up labs, and finished goods production planners. We build those comments into every production cycle, and regularly tweak filtration, drying, or QC routines to adapt to evolving requirements. Customers pushing for greener chemistry or better scalability find us open to adjusting our methodology, as long as quality holds steady.

    Technical questions around allergen traces, additional metal content, or cross-reactivity get routed straight to our chemists—no third-party delays. Researchers told us our openness around data builds trust; they rarely have to re-test our material for major contaminants, but each time they do, we offer access to our records. Transparency around specification sheets, COAs, and process modifications helps avoid surprises in the middle of a development run. Keeping this two-way street open works both ways—it alerts our manufacturing team to supply risks and changing market needs well before the next production campaign starts.

    Key Takeaways from Decades in Chemical Manufacturing

    We’ve witnessed fads and hype rise and fall across the chemical space. Through it all, 4-Fluoroacetanilide remained steady for those requiring tight control over input quality and batch reproducibility. Sharp attention to detail—whether in raw material prep, isolation steps, or clean packing—echoes in the trust that processors and researchers place in us to deliver every drum as promised. The difference stacks up over time, where the specification you set on day one remains met on batch fifty.

    Every batch means running through tough internal checks, quick troubleshooting, and ongoing discussion with the professionals who shape their industry standards. From direct feedback and residuals testing, right down to waste handling and closed-loop solvent lines, our job means putting chemical integrity and practical reliability above all. Mistakes cost time and money—so tight control and responsive service mean less downtime and more successful application for the serious user of 4-Fluoroacetanilide.