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HS Code |
208137 |
| Chemical Name | 4-Chlorophenyl Cyclopropyl Ketone |
| Cas Number | 5807-24-7 |
| Molecular Formula | C9H7ClO |
| Molecular Weight | 166.60 |
| Appearance | White to off-white solid |
| Purity | Typically ≥ 98% |
| Melting Point | 43-46°C |
| Boiling Point | Unknown (decomposes before boiling) |
| Density | 1.2 g/cm³ (approximate) |
| Solubility | Slightly soluble in water, soluble in organic solvents such as ethanol and DMSO |
| Smiles | ClC1=CC=C(C=C1)C(=O)C2CC2 |
| Inchi | InChI=1S/C9H7ClO/c10-8-3-1-7(2-4-8)9(11)6-5-6/h1-4,6H,5H2 |
| Storage Conditions | Store in a cool, dry place, tightly closed |
| Hazard Class | Irritant |
As an accredited 4-Chlorophenyl Cyclopropyl Ketone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | A 25g amber glass bottle, tightly sealed with a screw cap, labeled “4-Chlorophenyl Cyclopropyl Ketone,” and safety information. |
| Shipping | 4-Chlorophenyl Cyclopropyl Ketone is shipped in secure, airtight containers compliant with chemical safety regulations. Packaging ensures protection from moisture, light, and physical damage. All containers are clearly labeled with hazard information. Shipping follows local and international guidelines for hazardous materials, with accompanying safety data sheets for safe handling and transport. |
| Storage | 4-Chlorophenyl Cyclopropyl Ketone should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizers. Protect from moisture and direct sunlight. Ensure appropriate labeling and keep the storage area secure to prevent unauthorized access. Use suitable chemical safety protocols when handling and storing. |
Applications of 4-Chlorophenyl Cyclopropyl Ketone in Industrial ManufacturingAs an original manufacturer specializing in 4-Chlorophenyl Cyclopropyl Ketone, we work directly with downstream producers in select specialty chemical sectors that require advanced intermediates with strong structure-activity relationships. Below, we present the key industrial application scenarios where our material plays a critical technical role, each addressed with detailed process, compliance, and formulation information based on real-world plant and QC data. 1. Pharmaceutical Intermediate for CNS Active CompoundsChemical manufacturers engaged in the production of central nervous system (CNS) drug candidates use 4-Chlorophenyl Cyclopropyl Ketone as an advanced intermediate for synthesizing specific substituted phenylcyclopropyl moieties in psychoactive agent pipelines. This intermediate supports the construction of core scaffolds in research and pilot plant settings, especially for the development of monoamine oxidase inhibitors (MAOIs) and related CNS-active substances. Industry compliance standards
Typical usage ratio
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2. Agrochemical Building Block for Crop Protection ActivesManufacturers in the agrochemical sector employ this compound as a structural intermediate in the synthesis of novel cyclopropyl-substituted phenyl herbicides and selective fungicidal agents. Its characteristic aromatic and strained ring system offers unique reactivity, allowing fine-tuning of biological activity and selectivity of agrochemical actives during multistep reactions. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
3. Fine Chemical Intermediate for Photoinitiator SynthesisProducers of advanced photoinitiators integrate 4-Chlorophenyl Cyclopropyl Ketone into their reaction sequences as a ring-functionalized aryl ketone precursor, providing the required photoreactivity or UV-absorbing chromophore in acrylic and styrenic monomer polymerization processes. Industry compliance standards
Typical usage ratio
Downstream process integration
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4. API Intermediate for Specialty Antidepressant ResearchCustom synthesis operations focusing on structure-modified antidepressant scaffolds use this ketone as a feedstock for constructing non-classical cyclopropyl-linked pharmacophores in early-stage R&D studies. This structural unit allows medicinal chemists to diversify lead candidates while maintaining control of physicochemical parameters. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
5. Advanced Intermediate for Specialty Polymer Additive SynthesisChemical processors manufacturing polymer additives turn to 4-Chlorophenyl Cyclopropyl Ketone as a specialized intermediate to impart stability, chemical resistance, and targeted reactivity into haloaromatic-modified polymer additive chains. Its unique fusion of chlorophenyl and cyclopropyl configurations enables integration into monomer units destined for antistatic, flame retardant, or impact-modifying additives. Industry compliance standards
Typical usage ratio
Downstream process integration
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Every batch of 4-Chlorophenyl Cyclopropyl Ketone that comes off our reactor has a story embedded in its molecules. Developing this compound took years of fine-tuning—controlling not only the purity but also the characteristics that our downstream customers count on. We don’t just make this specialty intermediate; we live its challenges and details every day, because how this chemical gets produced on-site shapes every bit of what matters to our clients in pharma, agrochemistry, or advanced materials.
Handling a molecule like 4-Chlorophenyl Cyclopropyl Ketone starts at the source: the raw materials. Sourcing quality p-chlorobenzaldehyde and ensuring precise control during the cyclopropylmagnesium bromide reaction isn’t about ticking off a checklist. Our production team monitors each charge much like a chef samples each ingredient before cooking. We follow this through, regularly analyzing for purity and tracking side-products. The finished ketone won’t pass through our final QC room unless it consistently meets our minimum 99% GC purity mark. Achieving this purity isn’t a one-step operation; it depends on full control of temperature, solvent ratio, and agitation speed. Every time a solvent top-up happens or conditions change in the reactor, even slightly, we document, adjust, and learn.
Our standard production run yields white crystalline ketone, free-flowing and easy to transfer, with minimal dust formation. RCC-packaged in lined drums, moisture stays out—even during extended storage—while our closed filling set-ups keep product contact limited. You won’t see erratic batches or “mystery” discoloration; our team has learned, sometimes the hard way, what small slip-ups with water levels or impure solvents can cause. We stand behind each drum, because it came right out of our own plant, where traceability starts at the first raw material check-in rather than somewhere downstream.
Specification sheets may list melting points and refractive indices, but seeing the difference between batches cached for months in the warehouse tells a truer story. Some manufacturers skim on drying, or repackage open drums that attract atmospheric moisture. Our own holding trials, stacked against ambient humidity swings, showed us the need for double-sealing and packing at low dew points. Every end-user who needs a sharply defined melting range—especially those coupling downstream—gets exactly what the reaction theory predicts: minimal by-products and no surprises.
Conversations with our partners in process R&D uncovered how trace chlorinated impurities can cause headaches in scale-up. Polishing solvent mixtures in purification systems and extending residence time during filtration means our product leaves barely a trace above background on chlorinated aromatics. We share this data with customers—QC sheets in-hand—not just because it’s required, but because any deviation undermines our own process. More than once, we’ve run pilot studies in-house replicating a customer’s synthetic route downstream, just to catch subtle incompatibilities.
Many clients approach us after struggling to source consistent 4-Chlorophenyl Cyclopropyl Ketone for advanced syntheses. In API building, any contamination makes regulatory filings a maze. Our secure production controls and batch logs let them tie every kilo to not just batch numbers, but production histories, environmental logs, and even personnel on the line. That’s peace of mind when facing regulatory audits or troubleshooting a scale-up hiccup.
In crop science, our ketone routes into key intermediates for broad-spectrum fungicides. We’ve seen usage cases needing not just purity, but also material amenable to extended storage and redissolution. Here, particle size and handling make the difference; third-party sources can often clump on sitting or hydrate over weeks, requiring additional recrystallization. We ship a product that won’t block lines, cause clogs in feeders, or waste a team’s time unclumping drums.
The material’s unique cyclopropyl group lends rigidity and metabolic stability to targets in medicinal chemistry—traits that researchers covet for modulating receptor interaction or improving oral bioavailability in development compounds. The product’s structure influences its reactivity. Unlike more flexible aliphatic ketones, our cyclopropyl ring creates predictable reactivity patterns, giving process chemists the reliability they want in multi-step syntheses.
We’ve trialed competitor samples side-by-side. Material from resellers often travels farther and sits longer in less-than-ideal warehouses. Moisture uptake, color drift, or inconsistent bulk density result. For some customers, these issues translate to slower dissolutions, uneven dispensing, or downstream filtration inefficiencies. We’ve invested in in-house vacuum drying and inert-gas packing to counteract these issues, and our on-site logistics team gets every drum loaded and shipped promptly after QA release.
Other suppliers may offer large-volume pricing, but downstream costs matter—especially when impurities or variability show up during process optimization. We rarely see batch rejections from API makers using our ketone, reflecting not just luck, but the accumulated effort of process tuning and raw material traceability.
Transparency builds trust. Every audit invitation on-site, every shared production run, and every opened logbook means no surprises for partners. Feedback cycles with customers—especially those at the pilot or kilo-lab stage—help us pick up reagent trends early. Several improvements to our crystallization stages came directly from suggestions of those who spent weekends fighting clumped or poorly soluble intermediates. The resulting product avoids those practical headaches by design, not by accident.
Small-molecule intermediates often fly under the regulatory radar compared to finished goods, but a single contaminated intermediate batch can shut down weeks of finished product output. We learned from experience, seeing how one poorly monitored exotherm in the Grignard step led to off-odor and color in a full batch. While the formal impurity level still met the published market spec, our downstream contact flagged it during formulation screening. Ever since, we’ve overhauled temperature mapping and implemented tank-by-tank records for every exothermic addition. Our process logs now stretch years back, tightening our ability to investigate quickly. If an inquiry comes in about a specific lot, we pull records, pull backup samples, and start onsite investigations within hours.
Pharma customers often demand not only Certificates of Analysis but also extended documentation tying events and deviations. Our QC system links each batch to monitoring logs, equipment calibration records, and even personnel certifications—providing a living record that meets not only local specs but also global standards demanded by multinational partners who audit us in person.
We keep communication open with our clients and learn from how they actually use the compound. A research group working through new ring-opening methodologies pointed out subtle solvent compatibility issues, prompted by differences in product washing and drying. Rolling these lessons into our SOP, we now always deliver with known solvent residues at trace or absent levels, according to common use cases. This sort of adjustment rarely shows up in a basic product overview. We respond to real life on the production floor and in the user’s lab.
Formulators working on fungicidal actives report the importance of stable bulk density and fine, free-flowing powder for dosing consistency, a lesson learned after an earlier generation of material blocked feeder screws and delayed a full campaign. We built screening and drying adjustments into our production runs to produce not just a pure compound, but a manageable one, avoiding yield and consistency loss at the user’s site.
Running a chemical factory means living the consequences of every material handling choice. Our commitment to enclosed systems, monitored emissions, and targeted solvent recovery didn’t come from external pressure but from hands-on experience with workers and the local community. In the early years, we encountered aromatic odor complaints during certain peak cycles. That prompted a full overhaul of off-gas scrubbing and containment protocols. Batch after batch, we maintain one of the lowest environmental footprints for this class of product, as documented by our third-party environmental inspection reports.
Worker safety goes hand-in-hand with product quality. Training includes recognition of solvent exposure symptoms and proper emergency procedures. We’ve invested in local exhaust, real-world PPE assessments, and rotating shift schedules to avoid fatigue. Each policy reflects our lived experience on the factory floor—where a slip or overlook can carry consequences from both a safety and product standpoint. There’s pride in keeping both our team and product safe from start to finish.
Markets change. End-use demands evolve. A molecule like 4-Chlorophenyl Cyclopropyl Ketone, once a niche item, finds its way into new applications each year. What remains constant is the intense focus on reliability, traceability, and real-world usability at large and small scale. We schedule regular reviews of both market feedback and in-house production records to identify pressure points or bottlenecks before they turn into issues for our clients.
Our chemists, production staff, and logistics handlers all sit at the table when changes come up—whether that’s a new drum design, fine-tuned particle sizing protocol, or adjusted drying regime. We’ve learned that decisions only work when every link from precursor purchase to delivery truck gets considered. Several upgrades to our packaging and shipping routines originated from feedback on how material reached its destination: from broken drums on rough roads to humidity-driven caking in tropical climates. Our packaging upgrades now reflect real journeys, not just internal lab tests.
Delivering 4-Chlorophenyl Cyclopropyl Ketone isn’t only about analytical numbers. Every end user—chemist, plant engineer, or formulator—betting a week’s progress or a product’s success on a drum that arrives on Monday deserves more than just a sales pitch. Real manufacturing credibility comes from sharing process logs, opening audit trails, and accepting that real improvement only follows transparency and genuine feedback. This approach defines our product, day after day, batch after batch.
Each interaction with process scientists opens a new perspective on functionality and handling. A medicinal chemist’s workup may reveal where trace solvents slip in, or how minor crystalline differences impact yield. Agrochemistry customers may need weekly shipments in different packaging arrangements. Every such data point gets added to our routine, not as an afterthought, but as an operating challenge that makes us rethink and improve what we already do well. Over the years, details matter most—the ones that don’t appear in standard paperwork, but which surface during real-time operations.
We see the manufacturer-client relationship as a two-way street. Sharing technical challenges around 4-Chlorophenyl Cyclopropyl Ketone encourages us to run new QA tests and explore better process routes. We’ve worked through supply chain slowdowns, managed alternative sourcing for raw materials, and documented all root-cause investigations—saving our customers costly downtime in their own production flow. Each time we share a yield report, shipment ETA, or deep-dive on trace impurity profiles, the ongoing collaboration strengthens our product and its fit for future work.
Partnership doesn’t stop with product delivery. Post-delivery support, responsive technical input, and openness to modification—in the end, these build working trust. Over decades of hands-on manufacturing, direct product feedback, and attention to every ton and every kilo, we keep refining what it means to supply real-world, plant-made 4-Chlorophenyl Cyclopropyl Ketone. Our product walks the talk—delivering function, reliability, and assurance that only comes from a team rooted in the actual work of chemical manufacturing.