|
HS Code |
182178 |
| Chemical Name | 4-Chlorophenetole |
| Cas Number | 3234-12-8 |
| Molecular Formula | C8H9ClO |
| Molecular Weight | 156.61 |
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | 221-223 °C |
| Melting Point | -29 °C |
| Density | 1.144 g/mL at 25 °C |
| Refractive Index | 1.533 |
| Solubility In Water | Insoluble |
| Flash Point | 93 °C |
| Smiles | CCOC1=CC=C(C=C1)Cl |
As an accredited 4-Chlorophenetole factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | A 100-gram amber glass bottle, tightly sealed, labeled "4-Chlorophenetole," includes hazard symbols, batch number, and manufacturer details. |
| Shipping | 4-Chlorophenetole is shipped in tightly sealed, chemical-resistant containers to prevent leaks or contamination. It should be stored and transported in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances. Proper labeling and adherence to hazardous material regulations are essential during shipping to ensure safety and compliance. |
| Storage | 4-Chlorophenetole should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from sources of ignition and incompatible substances like strong oxidizers. Keep the storage area free from moisture and direct sunlight. Proper chemical labeling and secure storage, preferably in a flammable materials cabinet, are recommended to reduce risks of fire and contamination. |
Applications of 4-Chlorophenetole in Industrial ManufacturingAs the original manufacturer of 4-Chlorophenetole, we supply this specialty intermediate directly to integrated chemical companies worldwide. Our technical team routinely collaborates with R&D and process teams in regulated industries. Below we present the principal downstream application areas, highlighting their specific regulatory frameworks, standards of material usage, integration points in production, and ultimate commercial products. 1. Pharmaceutical Intermediate SynthesisMany generic and innovative pharmaceutical manufacturers deploy 4-Chlorophenetole in the synthesis of active pharmaceutical ingredient (API) side chains and core scaffolds, particularly for certain antihypertensive and CNS (central nervous system) drugs. Our product is frequently utilized during the etherification or arylation steps in multi-step batch and flow synthesis, often under GMP-controlled conditions. Process chemists select this ether for its favorable reactivity and purity in constructing the phenetole structure within the API’s molecule. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
2. Agrochemical Active Ingredient Building BlockAgrochemical synthesis plants leverage this compound as a core intermediate in the production of phenoxy-ether herbicides and insecticides. Typical manufacturing routes integrate it via O-alkylation or nucleophilic aromatic substitution onto heterocyclic rings during the plant protection product’s construction. Final products then pass for active ingredient formulation and registration under global crop protection regulations. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
3. Aromatic Ether Resin and Polymer ModifierIndustrial resin producers include 4-Chlorophenetole in the synthesis of specialty epoxy and thermoset formulations, where its electron-withdrawing and steric features slightly modify curing rates, flexibility, or molecular weight distribution. It typically serves as a co-monomer or endcapper to tailor polymer chain structure rather than as a main monomer, giving specialty adhesives and coatings enhanced performance in automotive, electronics, or engineered wood markets. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
4. Industrial Dye and Pigment IntermediateLarge-scale dye and pigment manufacturers use this material as a precursor for introducing chlorinated and ethoxylated motifs into complex aromatic dye molecules, particularly in the synthesis of azo and anthraquinone series colorants. Its chemical structure allows for selectivity during coupling and diazotization steps, resulting in tailored absorption spectra or improved fastness for textile, leather, and plastics coloration. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
|
Competitive 4-Chlorophenetole prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.
We will respond to you as soon as possible.
Tel: +8615371019725
Email: admin@sinochem-nanjing.com
Flexible payment, competitive price, premium service - Inquire now!
Every day on the production line, we see chemicals move from raw materials to finished goods, and 4-Chlorophenetole remains one of those products with a reliable track record. This compound, sometimes referred to as 1-chloro-4-ethoxybenzene or p-chlorophenetole, comes to us as a clear liquid. It offers specific reactivity that suits a targeted range of applications, drawing attention from several sectors—especially intermediates for pharma, agrochemicals, and, at times, specialty coatings.
Over years of refining our processes, producing 4-Chlorophenetole requires focus. We rely on skilled teams who understand how careful control over temperature, timing, and purity of starting materials shapes the final product. Careful monitoring keeps impurities below set thresholds that affect downstream yields. From sourcing each raw input to the purification steps that follow, we value predictability.
Our model—labeled as YH-4CP based on internal traceability—is one we've tweaked for consistency batch after batch. The decision isn’t just about scaling up; it comes down to every reaction parameter honed for reliability at kilogram and tonnage scale.
Walking through the warehouse, it’s easy to spot this product by its distinctive, faint aroma and clarity. Unlike some phenol derivatives that darken over time, 4-Chlorophenetole remains stable when stored under proper conditions. Stability helps our clients trust that quality lingers from dispatch through delivery.
Comparing it to its relatives—a batch of 4-Chloroanisole or plain phenetole, for example—makes its utility clearer. The chlorine atom at the para position changes chemical behavior in reactions; electrophilic aromatic substitutions proceed differently, offering distinct routes for further functionalization. Process chemists notice these shifts immediately. Cases where an extra methyl group (like in anisole derivatives) cause unwanted by-products, 4-Chlorophenetole shows much cleaner conversions.
Ask any colleague in pharmaceutical R&D about the importance of clean aromatic ethers for building complex active ingredients. The ethoxy group handles mild reaction conditions, avoiding some of the by-products seen in methoxy-chlorobenzenes. Medicinal chemistry teams often approach us with requests for consistent reactivity, minimal side products, and a high level of confidence in what they’ll receive. In many synthesis campaigns, our product becomes a foundation for introducing new side chains or ring substitutions needed for prototype drugs.
In pesticide intermediate production, 4-Chlorophenetole carries its own weight. It acts as a coupling partner or stepping stone to more active compounds, allowing for efficient transformations that would stall with other (especially more electron-rich) ethers.
There’s talk every year about competition and price wars in commodity chemicals. The temptation exists across the sector to shave pennies or loosen standards, but our experience doesn't reward cutting corners. We run each batch of 4-Chlorophenetole through multi-step in-house QC checks: GC-MS for purity, water content tests, sensory observations, and checks for trace organic residues. Some buyers ask for high-performance samples for analytical testing; we provide them with every lot. Where others ship on hope, we only dispatch after every department—synthesis, lab, packaging—has signed off on specifications.
Feedback from repeat clients guided us to reinforce controls that set real benchmarks. For example, we maintain methyl chloride below detectable levels, not because regulations demand it, but because experience shows a cleaner downstream performance. Physical handling remains as important as chemistry—the drums we use have lined interiors to prevent even minor metal-catalyzed degradation.
With a product like 4-Chlorophenetole, consistency should never become an excuse to stop improving. Research teams on our site often explore tweaks—changing process catalysts, adjusting solvent ratios, sometimes even modifying agitation speeds. Our process shifts only after testing and thorough validation, but curiosity never gets stifled. That’s why continual trials pay off in small but measurable efficiency gains, less waste solvent, smoother crystallization, or a purer final fraction.
Having open communication with technical clients helps. Sometimes, a customer’s analytical report highlights trace impurities missed in standard testing. We view those moments as learning opportunities, guiding us to invest in sharper chromatography or new purification resins, even if it means an extra step in the plant. Small changes on our end ripple through our partners’ synthesis, often resulting in better end products or higher yields.
Safety culture never leaves the factory. We have watched operators and engineers gain intuition handling 4-Chlorophenetole. It doesn't show quirks of volatility like some lower boiling ethers, so standard PPE and ventilation practices provide good protection. Still, we reinforce careful transfer routines—no hasty drum handling, no shortcuts in valve cleaning. Facility sensors watch for leaks in storage areas, and teams practice coordinated responses in the rare case of a spill. Training sessions reflect real-world scenarios, not just rulebooks, learning from near misses as much as from textbook guidelines.
As a manufacturer, we take environmental stewardship into account. Our waste streams travel to on-site treatment systems. We maintain not just legal discharge levels but also targets set by our internal safety and sustainability council. Waste minimization, solvent recovery, and energy conservation initiatives began as afterthoughts; experience quickly taught us their significance both for cost and community trust. The chemical industry has a troubled past with waste. Our approach—driven by people on the ground—is practical, not piecemeal. Every year brings tweaks for less impact.
Clients don’t always send glowing letters, but every sample request or troubleshooting call plants a seed for improvement. Several years back, a major customer highlighted recurring trace by-products during their scale-up. This field complaint led us to invest in an extra fractional distillation step, which cut out the interfering compound below a critical detection limit. Repeat business followed.
Process engineers also learn from stories of product transport. Extended delays brought on by poor container sealing have a domino effect, so now we pay much closer attention to closure systems and liner materials. Batch lots always get rechecked after any unusual transit delay to guard against subtle degradation.
Clients often share their end-use stories, either during technical audits or industry conferences. These conversations shape our understanding of new routes to agrochemicals or the development of niche intermediates that cumulatively enlarge our outlook. If a downstream partner points out a bottleneck created by impurity drift from starting materials, we go back and attack the source in our operation—whether that means tougher in-process cleaning or sourcing a more reliable upstream input.
4-Chlorophenetole doesn’t compete with basic aromatic ethers or generic chloro compounds on a cost-per-kilo basis alone. Direct competitors usually appear as para-substituted or ortho-chloro compounds, which sometimes display similar reactivity but miss key selectivity traits. Where para-chloro offers clean coupling with fewer rearrangements or tar formation, the ethoxy backbone gives slight hydrophobicity and improved solubility in specific organic reaction mixtures.
Synthesizing 4-Chlorophenetole builds on well-understood routes, but containment and clean conversion make all the difference at scale. Our long-haul tanker operators, control room staff, and lab technicians have years of collective experience responding to the quirks that pop up at different atmospheric or ambient humidity levels.
From the earliest pilot runs years ago, we faced hard lessons about how even low ppm levels of residual starting material can lead to rejected batches for our customers. Many manufacturers don’t want to admit that not every process step always goes as planned, but truth on the floor shows that constant vigilance brings the best outcomes. Each run gets evaluated for aromatic byproduct residues that can derail advanced coupling steps in precision organic synthesis.
Key testing tools—GC, HPLC, and IR spectroscopy—aren’t just buzzwords on a spec sheet here. They’re trusted tools, each with their quirks and blind spots. Our team holds weekly ‘deep dives’ on outlier batches, realigning protocols and double-checking reference standards. This environment for scrutiny means that our clients get reports they rely on, plus direct access to our QC staff if a question ever comes up.
Long-term storage stability also features in many buyer’s lists. We keep samples of every lot and deliberately age portions to judge long-term shelf life. These stability bottles tell the real story—if color or odor shifts, we take corrective action in formulation or packaging. The cost of holding inventory like this proves worth it, especially when years down the road, clients request legacy batch information with full traceability.
The foundation of good 4-Chlorophenetole sits in raw material integrity. Our procurement team partners directly with producers, not middlemen. The ethanol derivatives, chlorobenzene sources, and catalysts all get specified for high-performance end use. Long-term supply contracts, regular in-person audits, and shared testing protocols anchor our confidence. Stress-testing raw inputs before full-scale introduction shields us from production upsets or unforeseen drift in batch results.
We have spent time building relationships with upstream suppliers, working alongside their technical people to craft controls that mean true reliability—not just paperwork. Occasionally, this means absorbing a bit of extra cost or delay, but experience keeps proving that unplanned downtime and batch failure cost more.
Inside our labs, the next generation of 4-Chlorophenetole isn’t just about incremental tweaks. We pay attention to signals from regulatory environments, watching for shifts in allowable solvents, by-products, or product handling. As green chemistry trends grow, our process engineers look for mild, cleaner synthesis methods—not by listening to industry hype but by testing each step for practicality at scale.
Customers in pharma or crop science bring requests for bespoke specifications—sometimes ultra-low residual solvents, sometimes custom packaging sizes. Meeting these challenges takes more than theory. Team members from synthesis, packaging, and dispatch huddle over customer feedback and field reports, weighing risks and plotting a realistic path forward.
Supply chain resilience has gained new urgency in recent years. We worked through shipping delays, abrupt changes in border requirements, and global shortages of key raw materials. Every close call has driven us toward building more local storage and nurturing a true partnership approach with logistics providers.
Field engineers and customers share ideas about future modulation of the compound’s structure, and sometimes we begin pilot campaigns together. Not every idea pans out, but each small run sharpens our appreciation of how the market thinks and how we need to adapt. This hands-on approach means that instead of trailing innovation, we walk alongside our clients.
Trust doesn’t grow from ad campaigns or trade show booths. Every shipment reflects thousands of small choices made by workers who know what’s at stake. By welcoming both praise and criticism, investing in skills, and tuning processes based on what actually works, we stick to a straightforward philosophy: every customer deserves confidence in their 4-Chlorophenetole.
Experience shows that over-promising leads to real setbacks. We avoid them by keeping lines of communication open and solving problems from the ground up. Future challenges will change forms, but our approach stays rooted in honesty about what goes right—and what could go better.
In the end, every drop of 4-Chlorophenetole moving from our plant to a research bench or industrial reactor tells a story of people, process, and the quiet push for better chemistry. The journey is never finished, and with each batch, our knowledge grows. Our door remains open—for audits, questions, and every new project that makes this industry what it is.