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HS Code |
548752 |
| Chemical Name | 4-Chlorocinnamamide |
| Molecular Formula | C9H8ClNO |
| Molecular Weight | 181.62 g/mol |
| Cas Number | 22052-06-2 |
| Appearance | White to off-white solid |
| Melting Point | 143-147°C |
| Solubility | Slightly soluble in water |
| Iupac Name | (E)-3-(4-chlorophenyl)-N-methylprop-2-enamide |
| Smiles | C1=CC(=CC=C1C=CC(=O)N)Cl |
| Storage Conditions | Store in a cool, dry place |
As an accredited 4-Chlorocinnamamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 4-Chlorocinnamamide, 25g, supplied in a sealed amber glass bottle with tamper-evident cap and clear hazard labeling. |
| Shipping | 4-Chlorocinnamamide is shipped in tightly sealed containers to prevent moisture absorption and contamination. It is transported under ambient conditions, with labeling following regulatory guidelines for chemical substances. Proper documentation and safety data sheets (SDS) accompany all shipments to ensure safe and compliant handling during transit and storage. |
| Storage | 4-Chlorocinnamamide should be stored in a tightly sealed container in a cool, dry, and well-ventilated area, away from direct sunlight and incompatible substances such as strong oxidizers. The storage area should be clearly labeled, temperature controlled (preferably at room temperature), and protected from moisture to ensure material stability and safety. Handle with proper personal protective equipment. |
Applications of 4-Chlorocinnamamide in Industrial Manufacturing4-Chlorocinnamamide plays an important role across several industrial chemical synthesis tracks. As an original manufacturer, we supply this intermediate to producers seeking reliable integration into fine chemical synthesis, pharmaceutical development, agrochemical formulation, and dye or pigment production. Here we outline specific technical applications with compliance, process flow, and end product details for each sector. 1. Pharmaceutical Intermediate for API SynthesisPharmaceutical API manufacturers use 4-chlorocinnamamide as a structurally defined intermediate within small-molecule drug synthesis. Its electron-rich aromatic system supports targeted amide bond formation steps, especially in the manufacture of anti-infective agents and specialized CNS-active molecules. We ensure specification control for residual solvents and impurities, supporting robust downstream cGMP production environments. Industry compliance standards
Typical usage ratio
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2. Agrochemical Synthesis – Herbicide and Fungicide PrecursorsAgrochemical formulators use 4-chlorocinnamamide as a coupling substrate in the manufacture of selective herbicides and fungicidal agents. The material’s aromatic amide moiety promotes desired field activity in crop protection molecules. Our process supports direct scale-up into multi-ton production, with full traceability required for agricultural regulatory approval and downstream processing controls. Industry compliance standards
Typical usage ratio
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3. Specialty Dye Intermediate ManufacturingDye and pigment producers integrate 4-chlorocinnamamide into synthetic pathways yielding specialty aromatic colorants. Its conjugated aromatic ring with amide functionality supports the building of complex chromophores for dispersion, acid, and reactive dyes. Material is processed under strict impurity and color index control to ensure color yield consistency and regulatory acceptance for textile, leather, and plastic coloring applications. Industry compliance standards
Typical usage ratio
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4. Fine Chemical Synthesis for Research and DevelopmentResearch institutions and specialty labs procure 4-chlorocinnamamide as a reference intermediate for SAR (structure-activity relationship) studies, library synthesis, and new material scaffolds. Our high-purity specification aligns with analytical and pilot-scale downstream experimentation, supporting custom molecule discovery and scale validation in both contracted and internal innovation projects. Industry compliance standards
Typical usage ratio
Downstream process integration
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Long hours in the plant shape 4-Chlorocinnamamide, and with each vessel we run, confidence in the process grows. This isn’t a commodity churned by traders who never caught the scent of acylation or tracked the effect of a tiny impurity on downstream use. At our facility, real people oversee every step—starting from the first drum of 4-chlorocinnamic acid right through to the drying ovens that yield the fine, off-white crystals customers rely on. That’s why each batch can be trusted to deliver the structure, the purity, and the consistency that years of improvement have built.
Input materials come through strict controls. Only precursors meeting our own standards pass into the reactors. Technicians document every stage so the full history of each kilo never gets lost. We monitor temperature and pH tightly, avoiding unwanted side products that end up haunting labs downstream. Filtration, drying, and thorough QA screening wrap up hours of attention. The result: a reliable supply of 4-Chlorocinnamamide, never a mystery powder.
Models, in the chemical world, don’t mean consumer-facing stock numbers. Ours simply means a steady molecular snapshot: C9H8ClNO, appearing as pale solid flakes or powder. We watch melting points and assay percentages because one bit off spec can trouble a lab’s synthesis line or kill the yield for a pharmaceutical route relying on the right amide. Usually, you’ll find a product sitting just above 98% purity, but experience shows some users need 99.5% or higher for more sensitive work. We grew the capability to meet these tighter specs through customer requests, and those conversations pushed us to build in house techniques other suppliers find too costly.
Moisture matters as much as purity. Even a fraction of percent water gets tracked, since downstream processes often demand a completely dry reagent. No coagulated lumps, no unpredictable rehydration. Our dryers and packaging lines kept giving us headaches early on—regular measurements and better controls cut that down, and our leanings from those years now keep the lot-to-lot variation down.
At its core, 4-Chlorocinnamamide acts as an intermediate—shaping other chemicals, giving researchers options for functionalizing molecules, bringing that halogenated twist to structures in pharma or agrochemical development. Many teams saw success in developing fungicides or exploring new anti-inflammatory drug leads. Synthetic chemists reach for it to build libraries of amides for structure–activity studies—you refine a core, measure results, repeat. That’s where reproducibility from the manufacturer isn’t just marketing. It spares endless headaches and keeps budgets from ballooning on wasted runs.
The chlorinated backbone offers subtle electronics and binding properties that make certain synthetic routes possible—structures built with our amide find their way into the world as biological probes, specialty resins, and seed compounds for new patents. As original manufacturers, we hear about the quirks faced in downstream reactions via direct feedback. Lessons from one project—like byproducts popping up from a contaminant—feed right back to our process tweaks. Tweaks rarely come from written standards; they grow from calls and emails, the reports users send, and the letters we get describing success or trouble with purity or solubility.
Because of these partnerships, we keep application notes around. For example, one collaborative pharma development required a low-micron, easy-dissolving grade for rapid blending. Batch size, washing protocols, and packaging all had to shift. Lab-scale talk with the end users steered us away from shortcuts that would have set bigger challenges later.
Manufacturers see the real splits between similar products—places where small molecular changes lead to big shifts in performance. Many outsiders might mix up 4-Chlorocinnamamide with other cinnamamide derivatives, like the unsubstituted variant or the para-fluoro version. The 4-chloro group steers reactivity for coupling reactions, giving chemists a chance to tune selectivity or add downstream handles for further halogen exchange. It can promote different binding modes, leading to sharper results or new biological actions.
From direct comparison, chlorinated versions often perform better in applications needing electron-withdrawing groups. Where an unsubstituted cinnamamide might yield fuzzy results, our 4-chloro builds in predictability and sharper outcomes. In some cases, the para-fluoro cousin brings much lower yields and can introduce instability in harsher reaction conditions. From the production side, our team tracks not just the molecular structure but how each tweak in precursor or reaction profile shifts by-products. Chlorine brings new handling requirements—controlled conditions prevent contamination or unwanted reduction. Working at source means we intervene when issues start, not after a problem batch blocks a synthetic step at a customer’s lab.
Other differences stand out in more practical details. Packaging choices, for instance, are guided by hands-on experience rather than theory. We learned early that the 4-chloro substituent, though stable, reacted unexpectedly with certain plastics in bulk storage. So, we developed tailored containers and lined drums, sending out small-scale pilots to partners before rolling out at scale. These incremental changes, missed by resellers, only come from actual repeated manufacture and from dealing with the real-life results of what happens days and weeks after delivery.
Years of supplying 4-Chlorocinnamamide taught us that glossing over small inconsistencies can ripple out—resulting in failed reactions, missed milestones, or even product recalls. Auditors arrive asking about ISO standards and reproducibility, but we find the more valuable knowledge in problem-solving chats with end users. The checks before release aren’t just paperwork protocol. Real-world stories—like one pharma partner who pushed the edge of formulation tolerance—keep our team focused on what matters in the field, not just in the spec sheet.
We charge our team with regular review beyond the minimum. Each batch gets tested by application, not just by technique. We grind, we dissolve, we stir the product into likely solvents, tracking color shifts and scum lines. Does it flow or remain caked in the packet after transport? Simple questions, but ones that rooted out a faulty dryer element in a way that no certificate of analysis would catch. If anything goes off, we’re back on the lot map, tracing original inputs—notifying customers before trouble hits. These habits cut costs at the user end and keep projects on track.
Chemicals like 4-Chlorocinnamamide take focus to manufacture safely. Solvent recovery, waste minimization, and on-site air and water treatment anchor our operations. Chlorinated byproducts pose special challenges. We built containment and separation steps from early on to prevent accidental releases. Every production run goes through safety checks tailored to each batch’s specifics—especially for handling, storage, and final transport.
We’ve invested in lower-energy drying, using process waste heat to cut down our carbon footprint. Because we oversee the whole supply route, downstream customers benefit from accurate records, full material traceability, and the flexibility to trace the process all the way back to the original feedstock. Sustainable packaging matters as much as the contents—streamlining all logistics to minimize handling risks.
Those decisions didn’t bubble up from a CSR report but from real-world pressure: regulatory visits, insurer expectations, and hard conversations with freight partners who refuse questionable paperwork or unstable drums. Over time, these experiences shaped our production rules to protect both our people and those further down the chain.
Open feedback cycles with our users changed the way we produce and package 4-Chlorocinnamamide. Problems pop up from both the routine and the unexpected—a lot that cakes up on arrival, a rare solvent interaction nobody predicted, or a sharp change in flow behavior after long-term storage. Many improvements stem from these specifics and not from theoretical management plans. Small improvements in anti-static liners, batch labeling visible under low light, or anti-tamper seals started as field fixes that became permanent upgrades.
We regularly keep a dialog running with buyers and formulators, not for after-the-fact apologies but for real-time guidance. Facing a new scale-up? We send sample packs, not just literature, so teams get a sense for solubility, handling, and even smell before launching a larger project. This way, teams gain trust that what leaves our plant arrives under the agreed conditions—every time.
Changes in upstream supplies, fluctuations in regulatory requirements, or new downstream use cases all filter back to process design. Most changes are incremental and come not from new tech, but attention to process—the way a filter cleans quicker with less loss, how end users respond to a packaging suggestion, or even tweaks in drying cycle length helping with powder flow. These touches drive the long-term usability of the product, beyond what’s on a label or brochure.
Managing 4-Chlorocinnamamide production throws up challenges that surface nowhere but on the plant floor. One season, the reliability of a feedstock changed overnight after a supplier altered purification steps. By working on tighter supplier partnerships and installing better incoming QC, the team could head off issues before they hit the reactors.
Bulk shipments sometimes face long customs holds, so we prepare double-sealed, moisture-proof liners and staggered inventory. Delivering drums that arrive clumped or yellowed isn’t just a paperwork headache; it’s direct feedback on a storage, shipping, or drying issue. Only those with day-to-day plant involvement feel how small changes in relative humidity inside a container trigger outsized headaches down the supply chain, so we invest time to simulate shipping conditions and hold buffer stock.
Being responsible for product not just up to the gate but through its first use in a customer’s plant changes the standard of care. Training operators to spot off-color batches by eye, then track those lots for QA, adds another safeguard. The “once-manufactured, always accountable” mindset keeps the bar high. We keep records flowing—batch genealogy, corrective action logs, and supply chain mapping—so nobody gets stuck passing blame after the fact. Recalls rarely happen, not because we never err, but because issues get addressed at the source.
A direct manufacturer’s experience with 4-Chlorocinnamamide brings details a reseller never faces. Order forecasting looks different from the plant side. We see the slow buildup toward annual tenders, the scramble to ship for seasonal plantings in agrochem, or the deadline crunch as a clinical trial pushes for a timely batch. Unlike traders, the priority isn’t reselling inventory but synchronizing synthesis runs, packaging, and shipping so the right quality arrives exactly when users actually need it—not just when a warehouse has excess stock to move.
As a producer, choices in the supply chain run deep. Sometimes, a surplus precursor batch gets processed to minimize waste; other times, a shift in demand steers output to smaller, high-spec batches. By controlling the process, manufacturers own the timelines, batch sizes, and allocation, rather than being at the mercy of third-party stock cycles. This responsiveness echoes in successful projects and fewer backorders.
End users get tangible benefits from direct manufacturer partnerships—technical support that includes site visits, pilot-scale testing, and troubleshooting. Users gain direct insight into the “why” behind a change from old to new packaging or a shift in melting point due to an adjusted drying cycle. Each call that comes in—from a procurement manager cross-checking a CoA, to a researcher troubleshooting a synthetic blockage—gets routed to a team that knows not just the paperwork, but the real chemical and process background for that batch.
To us, working in the plant day after day, what counts isn’t fancy branding but making sure every drum, every box, every packet carries years of improvement and care. With 4-Chlorocinnamamide, the proof comes from repeatable, reliable results downstream—whether in small R&D runs or global production. Users deserve feedback-based improvements, reliable specification, and attentive aftercare shaped by genuine field experience. That’s what sets real manufacturers apart in the world of specialty chemicals.
From raw input to delivery, each lot reflects improvements learned on the plant floor, not in a distant boardroom. That’s why feedback flows directly to the operations team. That’s why site inspectors and auditors tour each section and ask not just about black-and-white tests, but about “problem batches” and the “toughest shipping run.” And that’s why customers keep coming back. They know what goes into the process, how glitches get caught early, and who stands behind every kilogram as it leaves the gate—real people, genuine expertise, and a deep bench of day-to-day practical knowledge, always pushing for better.