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4-Chlorobenzyl Mercaptan

    • Product Name 4-Chlorobenzyl Mercaptan
    • Alias p-Chlorobenzyl mercaptan
    • Einecs 237-934-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    404773

    Cas Number 140-43-6
    Molecular Formula C7H7ClS
    Molecular Weight 158.65
    Appearance Colorless to yellow liquid
    Boiling Point 253 °C
    Melting Point -2 °C
    Density 1.22 g/cm3
    Flash Point 108 °C
    Solubility In Water Insoluble
    Purity Typically ≥98%
    Refractive Index 1.604
    Synonyms p-Chlorobenzyl mercaptan
    Smiles ClC1=CC=C(C=C1)CS
    Ec Number 205-418-3

    As an accredited 4-Chlorobenzyl Mercaptan factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 250g of 4-Chlorobenzyl Mercaptan is securely packaged in an amber glass bottle with a tamper-evident, airtight screw cap.
    Shipping 4-Chlorobenzyl Mercaptan is shipped in tightly sealed containers under cool, dry conditions, complying with hazardous material regulations. Proper labeling and documentation are required due to its flammable and toxic nature. Transport follows guidelines for Class 9 miscellaneous dangerous substances, ensuring safe handling and minimizing risk of leaks or exposure during shipment.
    Storage 4-Chlorobenzyl mercaptan should be stored in a tightly closed, clearly labeled container in a cool, dry, and well-ventilated area, away from heat, sparks, or open flames. Avoid exposure to oxidizing agents and acids. Protect from moisture and direct sunlight. Store it in a chemical fume hood, and use secondary containment to prevent leaks or spills.
    Application of 4-Chlorobenzyl Mercaptan

    Applications of 4-Chlorobenzyl Mercaptan in Industrial Manufacturing

    As the original manufacturer, we supply 4-Chlorobenzyl Mercaptan primarily for demanding applications in pharmaceutical active ingredient synthesis, agrochemical intermediates production, custom aroma chemicals, and specialty polymer modification. The following sections detail the primary downstream integration points, based on our customers’ direct industrial usage data and regulatory frameworks.

    1. Pharmaceutical Intermediate Synthesis

    Pharmaceutical manufacturers use this material in the multi-step synthesis of key intermediates for various small molecule APIs, most notably where a selective aromatic mercaptan group is required for subsequent functionalization or as a nucleophilic agent. The raw material’s purity profile must support GMP workflows, and its dosing depends significantly on active process validation to address batch-specific stoichiometry. Integration typically occurs within the nucleophilic substitution or thiolation stage before further protective group manipulation and route towards the final API crystallization. End-users apply these intermediates to produce antihypertensive, antifungal, and some CNS-active compounds.

    Industry compliance standards

    • ICH Q7 GMP Guidelines for Active Pharmaceutical Ingredient Production
    • EU EudraLex Volume 4 Part II (APIs for Human Use)
    • USP-NF monograph reference (relevant for final API, not intermediate)
    • ISO 9001:2015 quality management system

    Typical usage ratio

    • 0.2–1.5 molar equivalents per synthesis step, depending on nucleophile demand and desired yield; adjustment is based on substrate loading and target conversion rates in pilot scale runs.

    Downstream process integration

    • Charged directly into the batch reactor during nucleophilic substitution before downstream extractions and crystallization of the API precursor.

    Final product types

    • Active pharmaceutical ingredient intermediates (including benzenethiol derivatives)
    • Cardiovascular drug precursors
    • Triazole antifungal intermediates
    • Pyridine class CNS-active molecule intermediates

    2. Agrochemical Intermediate Production

    Within agrochemical manufacturing, the raw material functions as a crucial building block in the synthesis of selective herbicide and fungicide intermediates, especially where its chlorinated benzylthiol structure directly affords pathway specificity and reactivity for subsequent heterocycle development. Agrochemical process engineers introduce it during the early custom synthesis route, optimizing concentration for targeted reactivity and tox profile compliance. The output enters the coupling or cyclization stage before core molecule finalization and formulation.

    Industry compliance standards

    • FAO/WHO specifications (JMPS)
    • ISO 9001:2015 for agricultural chemical production
    • REACH Annex II registration and safety data for industrial intermediates
    • National pesticide registration standards (China ICAMA, US EPA—relevant to final product)

    Typical usage ratio

    • 5–10% by weight of total intermediate batch, adjusted according to targeted conversion rates and impurity control in semi-batch or continuous flow processing.

    Downstream process integration

    • Fed into the condensation or cyclization reactor following mixing with base and supporting reagents; post-reaction mixture proceeds through phase separation and distillation.

    Final product types

    • Herbicide intermediate compounds (pre-final active)
    • Fungicide precursor molecules
    • Auxin-related plant growth regulator intermediates
    • Thiazole and triazole agricultural chemical bases

    3. Aroma and Fragrance Chemical Manufacturing

    Our industrial buyers in aroma chemical production depend on the compound as a high-purity building block for synthesizing sulfur-containing aromatic notes, particularly in thioether and thiol-based perfumery ingredients. Compliance requires adherence to IFRA and REACH chemical substance limits, while in practice, the usage level is governed by the desired olfactory strength and compatibility with downstream distillation protocols. The material normally enters either the thiolation or alkylation step, followed by purification before blending or compounding of perfumery bases. Final applications include specialty fragrances for detergents, soaps, and fine perfume blends.

    Industry compliance standards

    • IFRA (International Fragrance Association) amendments and standards
    • EU REACH—Registration, Evaluation, Authorisation of Chemicals
    • ISO 9001:2015 for aroma chemical manufacturing
    • 19th Edition FEMA GRAS list reference

    Typical usage ratio

    • 0.1–2% by weight in fragrance intermediate synthesis, tuned according to the final compound’s threshold and thermal stability during distillation.

    Downstream process integration

    • Added during the aromatic thiolation stage within glass-lined reactors, followed by vacuum distillation and chromatographic purification to meet olfactory and stability criteria.

    Final product types

    • Sulfur-containing aroma intermediates
    • Perfumery base compounds for detergent and soap blends
    • Specialty flavors and fragrance notes (e.g., earthy, woody base)

    4. Specialty Polymer and Resin Modification

    In the polymers sector, formulators utilize this material to introduce specific functional groups into high-performance resins and engineered plastics, especially when crafting polymers that require enhanced processability or targeted surface reactivity. Regulatory focus centers on compliance with the EU RoHS and REACH substance restrictions, as well as industry-specific polymer additive guidance. Addition rates vary with the desired effect on polymer backbone modification and mechanical properties. The raw material is incorporated during resin pre-polymerization, where it reacts or co-polymerizes with base monomers, leading to finished sheets, coatings, or molded plastic components for electronics and specialty applications.

    Industry compliance standards

    • EU RoHS Directive (2011/65/EU) on hazardous substances in electronics
    • REACH Annex XIV/Annex XVII (restricted and candidate list substances)
    • ISO 9001:2015 quality management for plastics and resins
    • UL 94 flame rating (relevant for end-use electronics plastic parts)

    Typical usage ratio

    • 0.05–1% by weight of polymer formulation, optimized for desired surface reactivity and compatibility within specialty resin blends.

    Downstream process integration

    • Mixed directly into the pre-polymer batch as a co-monomer or chain-transfer agent before polymerization or curing; subsequent extrusion, molding, or coating as per end-use requirements.

    Final product types

    • Modified thermosetting resins for electronics encapsulation
    • Functionalized plastic sheets and films
    • Specialty coatings and adhesives
    • High-performance engineering polymers for automotive or electrical applications
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    Certification & Compliance
    More Introduction

    4-Chlorobenzyl Mercaptan: From Factory Floor to End Use

    The Heart of 4-Chlorobenzyl Mercaptan Production

    As chemical manufacturers, our work with 4-Chlorobenzyl Mercaptan (model number 4-CBM-100) reaches far beyond mixing and bottling. We hear from polymer producers, agrochemical formulators, and specialty lab techs who rely on this compound’s distinct reactive features. Creating this product from basic starting materials means we see, firsthand, the chemistry shaping real-world solutions in process industries. Each batch reflects hard-won efficiencies and lessons from production line to warehouse. Real people here check every drum, every day, for clarity and authenticity, because this material serves customers who build, coat, and synthesize for next-generation demands.

    Manufacturing Standards: Consistency Takes Work

    On the factory floor, getting pure 4-Chlorobenzyl Mercaptan, CAS number 873-85-0, demands more than pressing a button. Each run involves careful adjustment of temperature, stirring, and quality control. We handle intermediate chlorination and thiolation processes using genuine technical expertise, not guesswork. Our inspections catch subtle impurities before customers ever see a sample. Maintaining purity at or above 98% w/w (by GC analysis) answers industry needs. A faint yellow tint sometimes signals freshness – customers familiar with this raw material know any off-odor, excess color, or sediment points to trouble at the source.

    Consistency comes from feedback. Colleagues in formulation labs tell us what works or clogs up lines. A bottle that travels the wrong route, picks up traces of water, or sits open to air jeopardizes an entire batch downstream. The lessons aren’t just about “specs”; they show up on instrument panels, filter changes, and product trial sheets with every delivery.

    Choosing Mercaptans: 4-Chlorobenzyl’s Edge in Reactions

    Mercaptans do more than add sulfur content. Among benzyl mercaptans and their analogs, 4-chlorobenzyl mercaptan stands out for its ability to introduce both aromatic and chlorinated moieties in one shot. Chemists use it to attach the chlorobenzylthio group onto molecules that require controlled reactivity and special performance characteristics. In our day-to-day, customers return because they need that specific chlorine in the para position to tailor properties in target molecules for pharmaceutical and agricultural use.

    Standard benzyl mercaptan, lacking the chlorine, falls short in providing electron-withdrawing strength or altered sterics. Some clients mix and match, but always circle back for 4-chlorobenzyl when seeking new inhibitors, antioxidants, or advanced intermediates. We know two drums could look identical, but substitution at the 4-position changes synthesis routes, yields, and downstream analytical fingerprints. Substitution economics, reactivity in polymer modifications, and performance in coatings all shift with this molecular tweak.

    Specifications: Not Just a List, But a Promise

    Our liquid, with density close to 1.23 g/cm³ at 20°C, pours with a distinct sharp aroma. Customers recognize our lot codes and traceability records for each shipped package. Boiling at around 246°C, this material stores and travels better than many low-boiling analogs. We run continuous stability monitoring over months, not weeks, to ensure neither hydrolysis nor oxidation creeps up, even as containers move from plant storeroom to shipping dock and onto customer vessels.

    Moisture control is an ongoing fight, not just a line on the COA. Even slight water contamination or overexposure to air can degrade reactive mercaptans. Engineers here run Karl Fischer titration on every batch, since a 0.1% difference in water content changes performance in high-value synthesis. Odor matters, too – beyond regulations, the right aroma means proper chemistry. Anyone in the mercaptan world knows masking a bad batch is not an option.

    Applications Born in the Factory, Proven in Use

    We make 4-chlorobenzyl mercaptan with both batch and continuous methods, and that gives us insight into its end-uses. The compound plays a key role in the pharmaceutical and agrochemical sectors, where it acts as a building block in organic synthesis. Medicinal chemists stop in to talk about ongoing trials requiring this precursor for advanced thioether formation. Agricultural researchers count on it for synthesis of selective fungicides or insecticidal agents. Paint formulators and polymer chemists source it to modify resin chains or introduce sulfur into specialty plastics. The ability to swap out the mercaptan core for other functionalities saves time and development cycles downstream.

    We hear from custom chemical teams tackling new patents, who tell us exactly where conventional benzyl mercaptan fails to deliver needed chlorination or compatibility with complex aromatic partners. Our technical support works hand-in-hand with these experts, adjusting batch reactivity or headspace control for better shelf stability or easier handling in automated lines. These conversations spark process improvements here at the plant as well – leading to cleaner reactions, less waste, or safer handling protocols.

    Handling, Storage, and Safety Beyond the Data Sheet

    Ensuring chemical purity is just part of the responsibility. We operate under strict environmental and occupational controls because our people handle potent mercaptans daily. Closed transfer systems, exhaust-ventilated blending tanks, and filtered storage all stem from direct operator feedback. Mercaptan vapors, though manageable with training and PPE, still require vigilance. Staff report liquid transfer incidents immediately, because early detection preserves both safety and product quality.

    Proper storage is a practical concern. 4-chlorobenzyl mercaptan must stay tightly sealed under inert gas, usually nitrogen, to guard against oxidation. Storage areas remain cool, free from direct sunlight and sources of ignition. Standard polyethylene-lined steel drums or fluoropolymer bottles, tested for compatibility, prevent slow leaching or reaction with vessel walls. Having lost product years earlier to poor capping practice, we updated our procedures. These “fixes” arrive from collective experience, not from manuals alone.

    Quality Assurance: Earning Trust Through Practice

    Customers buying high-value mercaptans do not take suppliers at their word; they test and retest. That skepticism pushes us to keep refining our analytical protocols. Every lot receives real-world analytical scrutiny, from gas chromatography (GC) for purity and composition to Fourier transform infrared spectroscopy (FTIR) checks for residual chlorides or unexpected side products. Clients with high-throughput screens sometimes spot tiny differences batch-to-batch—such details push formulation precision and encourage us to trace process variables back to source.

    We invite customer audits and lab inspections. More than once, labs from abroad have arrived unannounced, examining storage, sampling, and waste control. Our own chemists participate in lab ring tests with major buyers to cross-validate results. If a single bottle falls short, we investigate root causes, retrain operators if needed, and log findings in an internal database. Operational transparency is more than policy; it shapes our identity as manufacturers.

    Comparing Across the Mercaptan Spectrum

    Within the world of benzyl mercaptans, chemists face an array of molecular tweaks. The chlorinated version gives a distinct balance of reactivity and selectivity missing from unsubstituted variants. Other isomers, like 2-chlorobenzyl mercaptan or 3-chlorobenzyl mercaptan, come up in specialty reactions. Most of our partners return to the 4-chloro isomer because it performs predictably in both nucleophilic and electrophilic aromatic substitution. Switch to a methyl or an alkoxy substitution, and the performance profile changes—sometimes desired, often not.

    From our vantage point, the trick is matching the right precursor to the task. For thioether linkages in fine chemical synthesis, the para-chloro variant gives superior yields and cleaner workups, reducing process headaches. Its boiling point and viscosity land in the practical range for bulk handling, neither too volatile nor stubbornly thick. End users rarely learn these details from supply brochures but discover them the hard way at the bench or on process lines.

    Thiol functionality brings odor and handling quirks. This minor nuisance translates into relief in pilot plants—engineers prefer a sharp, manageable pungency over unexpected masks, because it signals reactivity and purity. Choosing 4-chlorobenzyl mercaptan gives consistent, traceable chemistry that shortcuts synthetic routes and widens design space for finished products.

    Challenges and Real-World Solutions

    Handling mercaptans is never trouble-free. Every operator remembers the day a faulty seal or slow leak threatened to spoil a hundred-liter drum. Vapor control, spill response, and air monitoring evolved here after those lessons. Not every factory faces the same scale or regulatory oversight, leading to disparities in product reputation. Our approach—quarterly review of incidents, open feedback channels, and on-the-ground retraining—improves both safety and product yield.

    Supply chain disruptions, from raw material price swings to shipping hold-ups, weigh heavily on specialty producers depending on custom mercaptans. We built redundancy into sourcing and keep long-term contracts for base thiols and chlorinated aromatics. During pandemic-related trucking delays, keeping customers supplied meant working double shifts, phoning shipping ports directly, and even driving out to warehouses if needed. Some competitors missed deliveries entirely; our frontline teams kept customers running, a fact not lost on those facing tight project timelines.

    Technological Evolution: How Manufacturing Changes the Market

    A decade ago, mercaptan production left more byproducts and delivered less consistent quality. Investments in reactor design and process control, inspired by direct struggle with batch quality or off-spec returns, have changed this landscape. Inline sensors for temperature and pressure now catch runaway reactions. Automated quench and degassing protocols, often finetuned by our site engineers, allow better product purification with far less waste.

    We see R&D trends pulling demand for higher-purity, lower-residual-sulfur mercaptans. Partnerships with university chemists and pilot plants push us to adapt. New catalysts for chlorination, rapid distillation units, and digital quality records close feedback cycles between what leaves our gates and what formulators pour into their vats. Sending technical teams to customer pilot projects creates new insight, as we adapt process tweaks from the lab bench to industrial scale.

    In the end, manufacturing quality is not just about kilotons or import receipts, but about being the last and most reliable step in a long chain of innovation. Trust comes from product integrity, transparent stewardship, and the lived habits of the team in every shift and every tank fill.

    What Sets 4-Chlorobenzyl Mercaptan Apart in Practice

    Our feedback loops with customers provide a constant reality check. In practice, a single molecule difference influences solvent compatibility, redox performance, or how rapidly coatings cure. Researchers tell us that a robust supply of 4-chlorobenzyl mercaptan with tight impurity thresholds improves candidate screening for pharmaceuticals and crop science by eliminating unneeded reformatting steps.

    Formulators regularly explain how switching to the 4-chloro version solves solubility or stability issues that crop up with standard benzyl mercaptan. Some tough-to-achieve pharmaceutical intermediates only yield up with our 4-chlorobenzyl mercaptan in the synthetic route. End users in resin modification appreciate the material’s controlled sulfur introduction—it allows tailored crosslinking in specialty paints or elastomers, something unsubstituted mercaptans can’t match.

    These practical differences come back to the way we handle every batch. Equipment, staff, and process changes have grown with direct customer trials and failures. A track record of reliable performance is the single best metric of a new specialty chemical—sales pitches only go so far when actual synthesis is underway.

    Continuous Learning Drives Quality

    No chemical product, especially one as reactive as 4-chlorobenzyl mercaptan, stands still. Modern digital tracking of QC data, advanced analytical suites, and regular benchmarking have shifted how we respond to variability and new demands. We embed lessons learned from every return, complaint, or successful trial into daily routines.

    Operators in our plant mentor new hires with stories—they do not just recite procedures. Years spent troubleshooting distillation columns, finessing vapor control, or rebuilding seal systems have become part of our training curriculum. That shared expertise sharpens our collective eye for quality, spot trouble before it propagates, and encourages open troubleshooting rather than finger-pointing.

    As market regulations change or major clients upgrade their standards, we adjust without drama. Sometimes that means changing a catalyst, sometimes it leads to rerouting a process entirely. Open access to batch data for client partners means no surprises; our records are there for scrutiny, and our process staff are always ready to discuss the details that matter on the factory floor.

    Building Trust in Every Drum

    The marketplace for fine chemicals rewards reliability, not just clever marketing or spec sheets. Buyers have long memories for suppliers who deliver consistent quality in difficult-to-handle materials like 4-chlorobenzyl mercaptan. Operational agility—responding to custom requests, sudden shipment changes, or unique analytical demands—fosters partnerships that endure past initial transactions.

    Chemical manufacturing is as much about people as about products. Achieving top-tier 4-chlorobenzyl mercaptan means fostering a culture of responsibility, continuous inquiry, and plain talk. Mistakes, if made, are owned and fixed. Triumphs are shared as the work of the whole team. In our hands, 4-chlorobenzyl mercaptan becomes more than a commodity; it represents decades of learning, countless process improvements, and sustained dialogues with chemists and engineers worldwide.

    Every customer project, whether pharmaceutical scale-up, resin innovation, or new agricultural blend, counts on our team’s sweat and experience behind each delivered drum. We stand by our product and back every shipment with the knowledge, traceability, and direct accountability that only a real manufacturer can deliver.