|
HS Code |
237787 |
| Chemical Name | 4-Chlorobenzil |
| Molecular Formula | C14H9ClO2 |
| Molecular Weight | 244.68 g/mol |
| Cas Number | 134-85-0 |
| Appearance | White to pale yellow crystalline powder |
| Melting Point | 98-100 °C |
| Boiling Point | N/A (decomposes) |
| Solubility | Slightly soluble in water, soluble in organic solvents |
| Purity | Typically ≥98% |
| Density | 1.275 g/cm3 |
| Inchi Key | GFYIXMAEKVIZPM-UHFFFAOYSA-N |
| Smiles | C1=CC(=CC=C1C(=O)C2=CC=C(C=C2)Cl)O |
As an accredited 4-Chlorobenzil factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The 100g 4-Chlorobenzil comes in a sealed amber glass bottle with a secure screw cap and hazard labeling for safety. |
| Shipping | 4-Chlorobenzil is shipped in tightly sealed containers, protected from light, moisture, and incompatible substances. It should be handled by trained personnel using appropriate safety equipment. Transportation must comply with local and international hazardous material regulations, ensuring clear labeling and secure packaging to prevent leaks or spills during transit. |
| Storage | 4-Chlorobenzil should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from sources of ignition, heat, and incompatible substances such as strong oxidizers. Protect the chemical from moisture and direct sunlight. Ensure appropriate labeling and restrict access to authorized personnel. Follow all relevant safety and regulatory guidelines for storage of laboratory chemicals. |
Applications of 4-Chlorobenzil in Industrial ManufacturingAs a direct manufacturer of 4-Chlorobenzil, we supply this intermediate to leading sectors where performance, traceability, and compliance are mandatory. Below are detailed, verified downstream application areas where users integrate 4-Chlorobenzil into their industrial protocols. 1. Pharmaceutical Intermediate for Benzodiazepines SynthesisPharmaceutical manufacturers utilize 4-Chlorobenzil as a precursor in the synthesis of select benzodiazepine derivatives, especially those containing chlorinated aromatic moieties for improved pharmacodynamics. It serves in the formation of heterocyclic scaffolds by condensation reactions, with subsequent transformations leading to the final clinical compound. Its traceability from GMP sources and consistent purity are crucial for drug registration and supply chain audits. Industry compliance standards
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2. Agrochemical Synthesis (Herbicide and Fungicide Intermediates)Agrochemical formulators employ 4-Chlorobenzil to create active moieties in herbicide and fungicide molecules, particularly for products requiring selective action or resistance management. The material participates in condensation or coupling reactions to introduce a chlorophenyl group, enhancing bioactivity and persistence in field applications. Downstream compliance and material tracking are mandatory for export to regulated markets. Industry compliance standards
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3. Fine Chemical Manufacture (Organic Photoinitiators)Manufacturers specializing in photo-curable resins and inks introduce 4-Chlorobenzil as a core building block for photoinitiator molecules. Its chlorinated aromatic structure is essential in tuning photo-reactivity and solubility parameters. End-users apply these photoinitiators in UV-curable coatings, adhesives, and printing inks, where polymerization speed and product clarity are vital. Industry compliance standards
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4. Specialty Dye and Pigment SynthesisProducers of industrial colorants and specialty pigments use 4-Chlorobenzil to introduce specific chromophore modifications in dye molecules. The precise insertion of the chlorinated moiety alters absorption wavelengths and durability upon exposure to light and solvents. Its high purity supports consistent shade development and batch-to-batch reproducibility, crucial in automotive, plastic, and fiber coloration markets. Industry compliance standards
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5. Custom Synthesis for Chemical R&D OutsourcingContract manufacturers and R&D centers acquire 4-Chlorobenzil for custom molecule construction, especially where selective chlorinated benzil functionality is required for new compound libraries. The material supports SAR studies, preparation of reference materials, and synthetic route scouting across multiple chemical development programs. Batch documentation and chain-of-custody details facilitate full regulatory traceability for multinational customers. Industry compliance standards
Typical usage ratio
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If you’ve spent any time in labs or production floors where specialty organics drive progress, 4-Chlorobenzil stands out as a steadfast performer. We’ve produced this material in bulk for decades, seeing firsthand its value where reliability, purity, and consistency stand front and center. This isn’t just another aromatic intermediate you’ll find stacked on a warehouse shelf only to be repackaged and resold. Our approach is grounded in robust process control, starting from raw feedstock through to the crystalline finished powder, and we know exactly what leaves our site. There’s a direct connection to the chemistry and quality that traders or repackers can’t duplicate. Factories count on this molecule across pharmaceuticals, agrochemicals, and dyes, not because brochures say so, but because our partners have run synthesis after synthesis on real lines and reported back with results.
Ask anyone with a production background: not all chlorinated benzylic ketones are cut from the same cloth. The chemical structure of 4-Chlorobenzil, with its para-substituted chlorine on the benzil framework, lends it a unique set of reactivity features. Latest lots roll out from our plant with a minimum assay of 99%, supported by in-house GC and HPLC verification. We don’t gamble on untested batches because we know those headaches make it all the way down the process chain.
The distinction in quality appears under scrutiny — actual melting point range, color consistency, and absence of off-odor or residual solvents. Our batches consistently meet a melting point between 88 and 92°C, a narrow spread that signals both purity and repeatability in synthesis. We don’t adjust our specs to cover lazy runs, nor do we ship blended or off-grade stock. This particular attention isn’t an abstract guarantee. We’ve supported fine chemicals plants tasked with producing complex molecules, where one off-spec shipment means weeks lost in investigation and wasted resources. Our in-house testing laboratory brings validation direct from production, not just an outsourced COA (Certificate of Analysis) affixed to an anonymous drum. This hands-on commitment to quality means our clients track fewer rejections and enjoy better downstream yields — a fact any process engineer appreciates after chasing unexplained impurities.
In the pharmaceutical field, 4-Chlorobenzil enables key steps for advanced intermediates. Chemists working on new routes for APIs (Active Pharmaceutical Ingredients) often face challenges with selectivity and conversion rates. Using a pure, uncontaminated 4-Chlorobenzil lot, isolated cleanly and free from over-chlorination, provides superior control during condensation reactions or oxidations. For example, in the synthesis of certain benzilic acids or diaryl ketones, the para-chloro group resists side reactions better than ortho-substituted analogs, channeling transformation towards the main product. The purity we achieve cuts out unnecessary process purification, saving both solvent and time.
Outside pharma, agrochemical formulators pick 4-Chlorobenzil as a robust building block in new pesticide and herbicide candidates. Its oxidative stability makes it a useful point of attachment for synthesizing larger heteroaromatic frameworks. We’ve seen custom dye houses employ this compound to prepare unique colorants, especially where stability under UV and hydrogen peroxide conditions proves necessary. End-users share feedback that off-quality material from less rigorous sources leads to variable shade or poor batch replication. Our clients bring years of practical production experience; we invite and incorporate their feedback, adjusting process conditions at our plant to meet evolving needs. Not many suppliers make those adjustments after a call from the floor — we do, because we know uninterrupted production relies on practical, responsive support.
The journey from chlorination of benzil through isolation and purification is deceptively challenging on industrial scale. Controlling reaction conditions, handling heat management, and minimizing formation of polysubstituted by-products takes skill beyond the textbook. Our plant handles each stage with precise temperature and pH control, ensuring selective chlorination and repeatable yields. Every kilogram produced passes hands-on inspection; our operators measure more than metrics — they spot subtle shifts in crystalline habit and hue with trained eyes. We’ve invested in in-line analytical monitoring long before it became a marketing staple, and we still empower operators to hold back anything that looks off-character, no matter how tight the shipping deadline.
Our team maintains rigorous cleaning and segregation practices for equipment used in 4-Chlorobenzil preparation. Cross-contamination compromises both quality and regulatory compliance. Staff training on specific product lines ensures everyone understands the unique failure modes and risks associated with chlorinated aromatic manufacturing. Years ago, we eliminated cross-batch contamination events by instituting specialized reaction vessels and isolated storage areas for chlorinated intermediates. The end result is reliable output, with batch records spanning process data, operator logs, and real-time analytical feedback.
Clients aiming for cost control frequently find themselves balancing price against the headaches of raw material risk. The true price of a less-controlled source often emerges later — escalated clean-up costs, analytical investigations, and even regulatory action from inconsistent material. For pharmaceutical and agrochemical producers, any deviation in the profile of starting materials alters impurity profiles in the final products. Regulatory submissions rely on repeatable, documented processes; unexpected variance in raw materials means extra documentation, delayed launches, or even entire campaign losses. Once, a client switched to a cheaper lot from an overseas reseller only to face recurring issues with off-odor and greenish tint, both clear signs of incomplete separation. After returning to our supply, process downtime disappeared and the end-product met specifications again. It’s not marketing hype; it’s daily production reality.
We ship our 4-Chlorobenzil only once all data align: purity above 99%, moisture content traceable to below 0.2%, and no residual solvents above 100 ppm, confirmed by direct sampling and analytical data retention for customer review. These standards arise from user need, not mere regulatory compliance. Some customers have requested higher-purity or specialized grades, such as extended control of heavy metals or ultra-low halogen content. We handle such requests with a production cycle tied to customer R&D timelines; several industrial partnerships have started with a phone call from a plant engineer looking for a solution, not just another catalog item.
Real manufacturing means real logistics. Our product packaging isn’t chosen by a marketing department or imported off a shelf. We use UN-certified containers, double-lined with inert plastics to prevent contamination or chemical interaction. All packaging lots come with traceable identification and tamper-evident seals. We’ve learned from hard experience how exposure during bulk transit affects product stability and downstream results. That’s why shipments go out with climate-resilient wrapping during hot season runs, and desiccant packs protect against ambient moisture, no matter the route. Shipping documentation tracks storage recommendations based on empirical data gathered from retained samples stored under varying temperature and humidity. For clients storing stock for several months, we provide guidance on re-testing protocols and shelf-life assessments developed through our own stability studies.
We encourage customers to schedule periodic re-testing and routinely share the methodology honed from our own stability evaluations. Our teams maintain a retained sample archive for each batch shipped, available for any follow-up testing or process troubleshooting. Batch-specific data are supplied upon request. This transparency, rooted in years of supporting practical manufacturing, builds trust — not hollow promises or boilerplate statements, but direct action. Our after-sales support includes real engineers and chemists, not chatbots or sales reps reading from scripts. Many clients connect with our technical staff well after initial deliveries, working together on analytical challenges, process improvements, or new product development. Knowledge from these exchanges informs future manufacturing cycles, so every lot moves a little closer to the process reality of our customers.
The market knows a range of benzylic ketones, but each variant — ortho, meta, para substitutions, different halides — performs differently. Some users have attempted switching to unsubstituted or differently chlorinated benzils in pursuit of modest savings or available inventory. Over years of troubleshooting and lab-scale evaluation, we’ve observed how unintended side reactions multiply and purification steps stretch out for users straying from pure 4-Chlorobenzil in those key steps. Ortho-substituted analogs often bring steric hindrance, slowing reaction rates and increasing demand for catalysts or more aggressive solvents. Meta variants stray off course in reactions designed for selective electrophilic substitutions or nucleophilic attacks. Our para-chloro configuration ensures the right balance between reactivity and downstream chemical behavior — a tangible asset for many process flows.
We have seen careless substitutions create unnecessary work. Mixed halide content, off-ratio isomers, or poorly identified side products balloon out analytical and purification budgets. This is not academic theory, but the kind of real-world lab headaches that slowly erode production margins and delay intellectual property filings. Uniformity batch-to-batch isn’t just about the numbers on a COA. It’s about achieving that same desired outcome — day, night, shift after shift. Customers who tried bulk lots from traders with no documentation saw variable melting points and color, even after repeated requests for clarification or replacement. Process chemists reported repeat contamination with traces of dibenzil or polyhalogenated side products, tied directly to less stringent batch separation in offshore facilities cutting corners to pump volume. Our high consistency means fewer surprise investigations and steadily lower reprocessing rates.
Scale exposes flaws in what seems feasible at laboratory bench level. We’ve lived through the issues of scale-up firsthand, investing years and resources in engineering solutions for reaction vessels, agitation patterns, crystallization, and filtration. The precision in our conditions reflects trial, error, and many lessons paid for along the way. We’ve worked side by side with customers scaling from pilot to multi-ton campaigns, refining crystallization controls or fine-tuning work-up and wash phases. Application insight from actual production — not textbook theory — means that our product reliably integrates with a variety of workflow machinery, from jacketed glassware to stainless bulk reactors. Few things frustrate engineers more than an otherwise “high-purity” chemical that clogs filters, fails to dissolve predictably, or forms tenacious dust. Through consistent control of crystal habit and particle size distribution, we help customers sidestep those obstacles. Years of feedback from engineering teams inform every change we implement, directly shaping how we stabilize product properties for broad compatibility.
Technical support stands at the edge of every delivery. Our chemists and process engineers partner with customers not just for the initial product validation, but through changes in synthetic routes, equipment scale-ups, or even regulatory submissions. Rather than a disengaged vendor, our team works with your R&D and QC units, reviewing analytical outcomes, confirming root causes in the unlikely event of a nonconformance, or helping redesign experiments to gain higher recovery rates. In one memorable partnership, a European client faced persistent throughput issues due to the unpredictable behavior of a supplier’s lot. We supplied not only our product but detailed lot history, including crystallization temperatures, trace impurity tables, and extended support for adjusting work-up conditions in their plant. After implementation, turnaround times improved, and complaints about inconsistent performance vanished from their QC logs. That’s the assurance backed by engaged manufacturing — not third-party sourcing with blind phone support.
Every customer faces mounting regulatory expectations. Our systems track each batch, providing documentation aligned with REACH and global transport codes. We maintain full traceability from source lot through processing, warehousing, and final delivery. When registration dossiers or custom documentation are needed, our regulatory specialists coordinate with your internal teams to ensure submissions move without snags. Documentation supplied isn’t pulled out of a generic library copied from the web — it’s tailored to the nuance of your requirements. Our archive covers reaction conditions, analytical method development records, in-process controls, and finalized packaging data, all supported by original operator sign-off. This level of detail secures peace of mind for audits, internal reviews, and regulatory inspections worldwide. Over time, this approach has saved client companies from recalls or compliance investigations caused by incomplete supplier records — something rarely anticipated until it’s the difference between a product launch and a costly delay.
As new research emerges and market demands shift, we engage with partners looking to expand the use of 4-Chlorobenzil beyond traditional sectors. The molecule’s aromatic backbone and chlorinated site bring interesting potential in high-performance polymers, advanced materials, and specialty coatings — areas where repeatability and documented performance determine success. R&D teams visiting our facilities often collaborate on pilot runs for specialty grades, requesting controlled particle size or tighter limits on halogen or oxygenated traces. We welcome the challenge, adjusting reaction and washing protocols, and feed recent process improvements back into standard runs. Field data provided by production chemists, along with analytical trends gathered from our clients’ feedback, prompt us to continuously refine, not complacently rest on established protocols.
Standing behind a product means more than adjusting a database entry or changing a barcode. It means being available to address practical problems: a crystallizer that doesn’t settle right, a filter cake that looks off, a plant manager calling late to confirm documentation matches observed specs. Our long history with 4-Chlorobenzil isn’t about stacking technical superlatives or overpromising; it rests on direct, measured, hard-earned experience managing its manufacture, supply, and performance in challenging conditions. We don’t overstate capabilities — our customers set the bar through challenging projects, insightful feedback, and high standards. Every kilo of 4-Chlorobenzil carries the imprint of skilled hands, thoughtful operators, and a culture where chemical know-how is lived, not just typed into an online system.