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4-Chloro-M-Xylene

    • Product Name 4-Chloro-M-Xylene
    • Alias 4-Chloro-1,3-dimethylbenzene
    • Einecs 202-735-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    799071

    Product Name 4-Chloro-m-xylene
    Cas Number 626-24-6
    Molecular Formula C8H9Cl
    Molecular Weight 140.61 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 211-213°C
    Melting Point -19°C
    Density 1.08 g/cm3
    Flash Point 79°C
    Refractive Index 1.521
    Purity Typically ≥98%
    Solubility Insoluble in water, soluble in organic solvents

    As an accredited 4-Chloro-M-Xylene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 250 g of 4-Chloro-M-Xylene, sealed in an amber glass bottle, labeled with chemical name, hazard symbols, and handling instructions.
    Shipping **Shipping Description for 4-Chloro-M-Xylene:** 4-Chloro-M-Xylene should be shipped as a hazardous chemical, packed in tightly sealed, chemical-resistant containers. It must comply with relevant regulations (e.g., DOT, IATA, IMDG), with appropriate hazard labels and documentation. Store and transport it away from heat, ignition sources, and incompatible substances. Handle with proper protective equipment.
    Storage 4-Chloro-m-xylene should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from sources of ignition. Keep it away from strong oxidizing agents and acids. Protect from direct sunlight and moisture. Clearly label the storage container and handle only in areas with appropriate chemical safety measures, including spill containment and fire protection.
    Application of 4-Chloro-M-Xylene

    Applications of 4-Chloro-M-Xylene in Industrial Manufacturing

    As the direct manufacturer of 4-Chloro-M-Xylene, we supply this intermediate to operational plants across various chemical sectors. The following application overview addresses its established roles in industrial processes, regulatory framework, and technical inclusion within downstream operations, supporting compliance and value addition from synthesis through to finished goods.

    1. Agrochemical Synthesis: Herbicide Intermediate

    Production of phenoxy herbicides and secondary plant protection agents frequently involves 4-Chloro-M-Xylene as a building block for active ingredient synthesis, particularly in the formation of substituted benzoic acids and derivatives. Operators select this molecule for its reactivity profile in controlled alkylation and chlorination steps, demanding close management of purity and trace-level haloalkyls to meet product specifications and agricultural legislation.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • REACH Annex XVII (EU) for pesticide intermediates
    • US EPA 40 CFR Part 180 – Tolerances and exemptions for pesticide chemical residues
    • Chinese GB/T 1600-2001 pesticide technical requirements

    Typical usage ratio

    • Applied at 0.12–0.28 molar equivalents in core ingredient coupling reactions; ratio varies per target compound and process yield curve.

    Downstream process integration

    • Introduced in early-stage alkylation reactors; participates in Friedel-Crafts or chloromethylation steps prior to hydrolysis and subsequent downstream functionalization.

    Final product types

    • Systemic herbicides (e.g., phenoxyacetic acid analogues)
    • Pre-emergence weed control granules
    • Commercial crop spray formulations

    2. Dye Intermediate Manufacturing: Azo and Disperse Dyes

    Aromatic intermediates based on 4-Chloro-M-Xylene underpin the synthesis of high-strength azo, anthraquinone, and disperse dye classes used in textile and fiber coloration. The chemical’s dual methyl and chloro substitutions improve coupling efficiency in diazotization and sulfonation pathways, reducing byproduct formation and ensuring batch-to-batch shade reproducibility for fiber-grade dye production.

    Industry compliance standards

    • OEKO-TEX® Standard 100 restricted substance list
    • EU Regulation (EC) No 1907/2006 (REACH)—Annex XVII for aromatic amines
    • ZDHC Manufacturing Restricted Substances List (MRSL)
    • ISO 9001:2015 for dye and pigment manufacturing

    Typical usage ratio

    • 0.18–0.42 wt% relative to final dye mass, adjusted based on targeted chroma/intensity and fiber compatibility.

    Downstream process integration

    • Supplied to batch reactors at diazotization stage, participating as an aromatic substrate prior to sulfonation, condensation, and purification. Process timing influences final color strength.

    Final product types

    • High-washfastness azo dyes
    • Polyester and acetate disperse dyes
    • Reactive dyes for blended fiber applications

    3. Pharmaceutical Intermediate: Sartan APIs

    The pharmaceutical sector uses this compound as a key intermediate in the synthesis of certain angiotensin receptor blocker (ARB) APIs, such as the tetrazole-functionalized antisartan molecules. Its chlorinated aromatic ring supports regioselective substitutions or conversions critical for maintaining impurity profiles and facilitating downstream heterocycle formation, demanding documentable traceability and validated analytical protocols.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice (GMP) for Active Pharmaceutical Ingredients
    • US FDA 21 CFR Part 211—Current Good Manufacturing Practice for Finished Pharmaceuticals
    • European Pharmacopoeia (Ph. Eur.) monographs—General Chapter 5.4
    • China Pharmacopoeia (ChP) API registration standards

    Typical usage ratio

    • Variable: typically 0.10–0.20 molar equivalents, with adjustment based on target synthesis route and impurity minimization strategies; formal DoE studies support batch scale-up.

    Downstream process integration

    • Charged to stepwise reaction vessels in N-alkylation, halogen exchange, or tetrazole ring-forming routes, followed by crystallization and pharmaceutical grade purification.

    Final product types

    • Angiotensin II receptor blockers (e.g., valsartan, candesartan intermediates)
    • Tetrazole substituted intermediates
    • Regioisomer-controlled pharmaceutical precursors

    4. Polymer Additives: Modifying Agent for Specialty Resins

    Producers of thermoset and thermoplastic resins utilize 4-Chloro-M-Xylene as a molecular modifier to tune polymer branching and glass transition temperatures in select specialty formulations. Its reactivity helps regulate molar mass and achieve desirable crosslink density during condensation or copolymerization, impacting downstream resin performance characteristics in demanding applications where specific molecular architecture is critical.

    Industry compliance standards

    • ISO 9001:2015—Quality management for plastic and resin production
    • REACH registration and evaluation requirements for monomers/additives
    • UL 94 Flammability Standard (for finished resins and polymers)
    • ASTM D638—Standard Test Method for Tensile Properties of Plastics

    Typical usage ratio

    • Range: 0.5–2.2% w/w as a comonomer or chain modifier; optimized during R&D based on mechanical property targets and crosslink density.

    Downstream process integration

    • Metered into polycondensation or radical copolymerization steps; introduced alongside conventional monomers before curing or extrusion; monitored via IR and GPC analysis for incorporation efficiency.

    Final product types

    • Heat-resistant specialty epoxy resins
    • Modified polyester or polycarbonate copolymers
    • High-gloss molded automotive plastics

    5. Fine Chemical Manufacturing: Custom Aromatic Building Blocks

    Specialty chemical companies rely on 4-Chloro-M-Xylene as a customizable aromatic precursor for diversified downstream molecule construction, spanning advanced materials and niche synthesis requirements. Its substitution pattern enables site-selective transformations, including bromination, oxidation, and nitration, facilitating development of functionalized intermediates for use in UV-stabilizers, photoinitiators, or electronic materials. Precision in reaction stoichiometry and byproduct management drive batch consistency and application-specific yield optimization.

    Industry compliance standards

    • ISO 14001:2015 Environmental Management Systems
    • REACH (EC) No 1907/2006—Specialty organic chemicals registration
    • Custom agreements for end-use notification (as per downstream customer regulatory filings)
    • ASTM E260/E697 for chemical analysis and purity assurance

    Typical usage ratio

    • Process dependent; commonly 1.0–1.4 molar equivalents as primary feedstock per target conversion step, adjusted for scale and targeted yield/purity.

    Downstream process integration

    • Serves as starting aromatic ring for site-directed functional group introduction, typically charged at the initial stage with close in-process analytical monitoring for intermediate control.

    Final product types

    • UV-stabilizer precursors for polymers
    • Photoinitiator intermediate chemicals (e.g. benzoin derivatives)
    • Precursors for organic electronic materials and specialty fine chemicals
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    Certification & Compliance
    More Introduction

    Understanding 4-Chloro-M-Xylene: Direct from the Manufacturer's Lab Bench

    Getting to Know 4-Chloro-M-Xylene

    Day in and day out, our plant produces 4-Chloro-M-Xylene as both an important intermediate for specialty chemicals and a reliable workhorse for established applications. Behind every batch of this compound, you’ll find rigorous purification — not just to tick a regulatory box, but because the downstream reactions in the labs of our customers truly hinge on a clean, dependable product.

    We've worked with this material for years, and through thousands of kilograms, experience reveals subtle changes in crystal form, distillation curves, and even color over time. Each batch talks. If something's off, it rarely hides for long, and the importance of consistency hits home every week when chemists call asking about our last quality run. 4-Chloro-M-Xylene doesn’t just fill bottles; it can upend or secure an entire synthetic route.

    Product Details Matter in Real-World Scenarios

    The backbone of our 4-Chloro-M-Xylene production comes from carefully selected raw materials and process controls developed with real-world manufacturing and downstream chemical synthesis in mind. We manufacture and purify this compound primarily in bulk form, maintaining a purity often exceeding 99 percent by GC, but this figure doesn’t tell the whole story. For end-users in pharmaceuticals or agrochemicals, trace impurities can poison catalysts or produce side products hard to separate. On the shop floor, our analytical and purification teams understand the difference between a “spec-okay” batch and one that performs under the high stakes of a scale-up reaction or regulatory audit.

    One thing often overlooked by outsiders is the importance of physical consistency, not just chemical purity. In our storage tanks and during filling operations, we monitor temperature, water content, and even light exposure, as 4-Chloro-M-Xylene can yellow under certain storage conditions. Our process engineers track these trends and tweak protocols so that shipments arriving months apart behave the same in the customer’s reactor. Reproducibility supports trust in the chemistry and ultimately the finished pharmaceutical or specialty polymer produced downstream.

    Why 4-Chloro-M-Xylene Holds Its Place in Manufacturing

    Ask anyone who has tried to substitute a similar aromatic compound in a production run. These experiments quickly reveal the quirks of chemical reactivity and handling. Compared to structurally close relatives like 2-Chlorotoluene or 3,5-Dichlorotoluene, 4-Chloro-M-Xylene brings a specific balance of reactivity and steric profile. This makes it especially useful in coupling reactions and as a building block for more complex chlorinated or methylated benzene derivatives.

    In our time making 4-Chloro-M-Xylene, we’ve seen demand surge from pigment makers, fine chemical producers, and polymer chemistry groups. The underlying need nearly always relates to predictable performance in multi-step organic syntheses. The difference between a methyl and a chloro group, and their exact positions on the ring, can make or break yields. While other isomers or related compounds might look similar on paper, anyone running gram-to-kilogram scale reactions knows that even small shifts in electronic properties or boiling points throw off process controls. That isn’t academic: we’ve fielded urgent queries about downstream clogging, coloration, or contaminant profiles due to swapped isomers from other suppliers.

    Handling also sets this compound apart. Despite being an aromatic, 4-Chloro-M-Xylene doesn’t volatilize as aggressively as lighter mono-methylated benzenes. It allows safer large-scale transfers and easier containment. Our customers have fewer issues with vapor exposure or odor complaints, an underrated point during plant audits.

    Beyond the Laboratory: An Operator’s View

    Nothing equals real experience from the production line. Pouring, filtering, distilling — these jobs reward attention to the material itself, not just what’s on the chromatography report. If you work with 4-Chloro-M-Xylene every week, you develop a sense for its staying power and reliability. There’s a satisfaction in seeing clear, stable drums going out, since a small slip can mean setback at our customers’ sites. Anyone who has seen an entire mixer fouled by an off-spec lot understands why we invest so much in sampling and real-time monitoring.

    Fielding calls from process chemists and hearing which runs performed flawlessly, or which required unexplained troubleshooting, sharpens our internal debate about quality thresholds. High-end users, especially those scaling from kilos to metric tons, need manufacturers with a willingness to dig deep into process data — not just ship out “alphabet soup” specs. We document every step, from raw material provenance to final drum inspection.

    The Known and the Unknown: Navigating Product Differences

    Anyone sourcing 4-Chloro-M-Xylene directly from a chemical manufacturer should look closely at more than just the designation or CAS number. The finer distinctions — boiling range, color index, trace oxygenate levels, chloride content — grow in importance during process optimization or certification for regulated use. Our teams have participated in customer audits that ask as much about solvent residuals as about metal contamination in the final product.

    This focus arises partly because our way of making 4-Chloro-M-Xylene differs from mass-market approaches. We rely on continuous feedback from our own facilities, not just the “recommended conditions” printed in catalogs. If small batch syntheses run with lower yields than the published literature, or mixed solvent effects create bottlenecks, we experiment and adjust. Factory trials and close work with end-users build the confidence that a change in process or scale won’t undercut downstream reactions.

    If 4-Chloro-M-Xylene disappears from a process stream, a lab may struggle to retrofit or revalidate production. Several colleagues have relayed stories where a supplier switched an isomer, or relaxed a spec, and a multi-thousand-liter reaction crashed overnight. The results cascade — ruined lots, urgent root-cause investigations, lost time, even regulatory setbacks. This is something academic articles rarely capture. Only direct involvement teaches which details separate a usable product from a risky one.

    Pursuing Purity without Compromise

    Cleanliness isn’t a luxury at this scale. Batches with elevated nonvolatile residue or trace halides risk not only yield but safety. Hazard assessments in our own operations flagged that certain classes of impurity amplify exothermicity, raising the possibility of runaways under scale-up. By investing in regular equipment audits, advanced analytical tools, and rigorous operator training, we trap these hidden threats early. Chemists downstream may never know about the hundreds of control points, but they notice when a reaction kicks off smoothly, batch after batch, with no deviation.

    We always aim to exceed the minimum, not just brush up against regulatory limits. This isn’t just corporate-speak: inspectors from both environmental and occupational safety boards have commented on our internal testing programs. By tracking both process and impurity profiles over years, we’ve developed a sense of “batch memory” — knowing when a tiny shift in infrared spectra might predict a future issue.

    Building Enduring Supply Relationships

    Much of the published FAQ-style information skips an important truth: most industrial users aren’t just buying molecules, they’re betting entire supply chains and product launches on their relationships with their raw material manufacturers. We’ve worked with partners who bring decades of institutional memory, asking for more than just purity certs or safety sheets. Before accepting the first shipments, they request detailed breakdowns of process control history, impurity trends, and even logistics protocols during summer heat waves.

    We’ve learned, often the hard way, that even perfect product in the bottle can be waylaid by cracked packaging, improper labeling, or slow response times during urgent resupply. Our logistics managers meet weekly with technical staff, looping in warehouse and shipping teams to spot issues before drums reach client docks. We look for, and act on, feedback beyond the usual tick-box metrics.

    Supporting Complex Synthesis and Scale-Up

    Process chemists in dye manufacturing and API synthesis lean heavily on aromatic intermediates that behave consistently under pressure and heat. 4-Chloro-M-Xylene survives the gauntlet of Grignard reactions, Friedel-Crafts alkylations, and metal-catalyzed couplings, offering a well-defined aromatic core. Each time research teams switch from flask to pilot plant, they ask detailed questions about thermal stability, crystallization properties, and impurity carryover — questions we can answer from firsthand plant experience, not just data sheets.

    Our technical service team frequently works alongside customers troubleshooting scale-up batches, reviewing product handling, and even training end-users on safe and efficient transfer. Most fine-tuned processes depend on minute attention to factors like dimerization potential, water content, and compatibility with other solvents. Over time, these partnerships result in process improvements on both sides — and fewer sleepless nights for everyone.

    The most successful projects arise from open discussion. Our plant engineers have fielded two a.m. calls from overseas partners reporting a color shift or unexplained residue. These conversations drive both process improvements and strengthened commitments. If there’s been a lesson in all this, it's that dialogue and record-keeping offer more solution power than endless product brochures or marketing catchphrases.

    The Real Impact of Safety and Environmental Handling

    Batch production plants run best when everyone, from operators to QC, treats aromatic intermediates like 4-Chloro-M-Xylene with respect. While this chemical offers more forgiving handling compared to lower-boiling solvents, it still demands attention: regular drum inspections, vapor leak checks, and containment upgrades. Each year, our EHS teams assess not just compliance but actual workplace comfort and environmental impact. Lower odor, slower volatility, and reliable containment improve plant morale and reduce neighborhood complaints.

    Long before new regulations reach the books, we’ve sought ways to cut residual emissions and minimize waste, running in-plant solvent recovery or implementing better tank venting systems. This isn’t a one-time fix; ongoing monitoring, staff retraining, and infrastructure upgrades feature more and more on our budgets. Industry peers who cut corners on volatile aromatic streams often end up paying later — in fines, bad press, or lost neighbor trust. None of these risks compare well to the incremental cost of safer, cleaner operations.

    Continuous Improvement: Listening, Learning, and Evolving

    If a plant stops learning, that’s when mistakes creep in. Over more than a decade of producing, storing, and shipping 4-Chloro-M-Xylene in bulk and custom pack sizes, we’ve embraced a continuous improvement mindset. We analyze every customer complaint, trace side reactions in real-time, and regularly update process maps. The world of specialty chemicals changes fast, and so do the tools and techniques available to manufacturers. Advanced process controls and digital plant monitoring give new insight into old challenges.

    We invite customer site visits and third-party audits, relying on more than just self-reporting. Years ago, a demanding pharmaceutical client asked for a week’s worth of on-site QC records, cross-referenced with equipment logs and ambient temperature data. At the time, pulling that much documentation felt excessive. Looking back, those scrutiny sessions led to smarter documentation strategies and greater team awareness. Now, site-wide data dashboards give production managers clear views of batch trends, flagging early warning signs and unlocking process tweaks unthinkable a decade ago.

    Serving Niche and High-Volume Applications Alike

    Not every shipment of 4-Chloro-M-Xylene goes to high-profile synthesis projects. Bulk drums support large-scale pigment production, while smaller lots serve research teams developing tomorrow’s materials. The product works reliably as a building block for specialty coatings, certain resins, and even performance lubricants. Each of these end uses teaches something new about the flexibility and limits of our process — from solubility quirks to purification bottlenecks.

    We regularly receive updates from research teams pushing into new reaction space, sometimes onboarding new process parameters that require tweaking oven setpoints or exploring modified solvent systems. These customer-driven trials feed back into our R&D pipeline, helping steer capital expenditures and support requests when new equipment becomes necessary. As a true manufacturer, meeting these challenges goes beyond fulfilling standing orders; it asks a willingness to experiment, troubleshoot, and scale.

    What Sets Our Approach Apart

    We do not just ship chemicals. We track every profile, monitor every batch, listen to every customer’s feedback, and invest in plant capabilities. Certifications and safety assurances matter, but so does the lived experience of chemists, engineers, operators, and logistics support. Every decision about plant upgrades or packaging revisions reflects these stories — from the time a sticky valve nearly cost a shipment to the repeated midnight troubleshooting sessions with international partners.

    Our commitment to quality, reliability, and informed improvement earned us return business and supplier of record status for exacting clients. End-users with sensitive reactions, limited process windows, and regulatory deadlines expect more than a faceless commodity supplier. We deliver by drawing on decades of hands-on operational knowledge, not simply by matching targets on paper.

    Building on Tradition and Looking Ahead

    Chemical manufacturing rewards patience, long-term thinking, and attention to evolving customer needs. 4-Chloro-M-Xylene remains a crucial piece of the specialty chemicals landscape, not just for what it is but how it supports thousands of downstream innovations. Solid, rigorous manufacturing practice underpins every drum we send out — and every challenge we tackle. No two years, or even two quarters, in this business look quite the same, and each day sharpens our focus on getting the details right.

    We remain dedicated to all aspects of production, safety, and customer partnership around 4-Chloro-M-Xylene. As new applications develop, regulations shift, and technologies emerge, we stand ready to adapt, innovate, and deliver with the knowledge that our product’s real value lies not simply in its chemistry, but in the effort, experience, and care behind every shipment.