4-Chloro-3-Nitrobenzoyl Chloride
- Product Name 4-Chloro-3-Nitrobenzoyl Chloride
- Alias 4-Chloro-3-nitrobenzoyl chloride
- Einecs 244-886-0
- Mininmum Order 1 g
- Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
- Price Inquiry admin@sinochem-nanjing.com
- Manufacturer Sinochem Nanjing Corporation
- CONTACT NOW
- Characterized by its high reactivity, it functions as an intermediate in pharmaceutical synthesis and conforms to industry purity specifications.
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HS Code |
272096 |
| Cas Number | 2140-61-6 |
| Molecular Formula | C7H3Cl2NO3 |
| Molecular Weight | 236.01 |
| Appearance | Yellow crystalline powder |
| Melting Point | 72-75°C |
| Density | 1.65 g/cm³ |
| Solubility | Reacts with water, soluble in organic solvents |
| Purity | Typically ≥98% |
| Storage Temperature | Store below 30°C, keep dry |
| Synonyms | 4-Chloro-3-nitrobenzoyl chloride |
| Smiles | O=C(Cl)C1=CC(=C(C=C1)[N+](=O)[O-])Cl |
| Inchi | InChI=1S/C7H3Cl2NO3/c8-5-2-1-4(7(9)11)3-6(5)10(12)13/h1-3H |
As an accredited 4-Chloro-3-Nitrobenzoyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle, 25 grams, with secure screw cap and tamper-evident seal; labeled with hazard warnings and chemical information. |
| Shipping | 4-Chloro-3-Nitrobenzoyl Chloride is shipped in tightly sealed, corrosion-resistant containers under dry, cool conditions. Due to its hazardous nature (corrosive, irritant), it is packed with proper labeling and protective measures compliant with DOT, IATA, and IMDG regulations. Avoid contact with moisture and incompatible substances during transit. |
| Storage | 4-Chloro-3-nitrobenzoyl chloride should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from direct sunlight, moisture, and incompatible substances such as strong bases, alcohols, and amines. Store in a designated corrosives cabinet. Avoid exposure to heat and protect from physical damage. Handle under a fume hood using appropriate protective equipment. |
Applications of 4-Chloro-3-Nitrobenzoyl Chloride in Industrial ManufacturingAs an established manufacturer of 4-Chloro-3-Nitrobenzoyl Chloride, we supply this compound to specialized sectors where its unique reactivity supports the synthesis of advanced intermediates and specialty products. Below, we detail key industrial end uses, focusing on specific compliance frameworks, formulation benchmarks, integration into downstream production, and the end products our material helps produce. 1. Pharmaceutical Intermediate for Active Ingredient SynthesisPharmaceutical manufacturers engage our product as an acylating agent in the synthesis of advanced intermediates, especially for 3-nitro-4-chlorobenzoyl-linked building blocks in APIs targeting anti-inflammatory and oncological therapies. Our technical support ensures that our material meets impurities and trace-metal thresholds, sustaining uninterrupted regulatory audit trails during contract manufacturing. Synthesis engineers dose the compound precisely to drive direct benzoylation without excess by-product formation, in line with established pharmacopeial statutes and traceability for validation documentation. Industry compliance standards
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2. Agrochemical Synthesis: Herbicides and FungicidesAgrochemical formulators utilize our compound for the manufacture of benzoylated agro-intermediates, which function as core scaffolds or activating groups for selective herbicides and systemic fungicides. Compliance with local chemical control, worker safety, and residue standards drives careful tracking and titration, as batch QA records must align with authorized field application levels downstream. In plant-scale synthesis, operators meter it during the formation of amide or ester linkages, prioritizing substrate conversion to control active ingredient output specification ranges. Industry compliance standards
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3. Specialty Dye Intermediate ProductionThe fine chemicals sector leverages this reagent as a pivotal building block in the synthesis of azo, anthraquinone, and disperse dye intermediates where both nitro- and chloro-substitution are essential for chromophore generation and shade adjustment. Dye masters rely on precise addition rates since impurities directly affect finished color intensity, fastness, and compliance with lead and heavy metals restrictions imposed by downstream textile brands and exporters. During multi-stage batch synthesis, it is introduced directly preceding coupling with aromatic amines or phenols to lock in chromophore structure and ensure spectral predictability. Industry compliance standards
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4. Synthesis of Liquid Crystal Monomers for Electronic DisplaysSpecialty electronics manufacturers source this reagent for epoxide and ester group functionalization steps during the synthesis of biphenyl-based monomers in advanced liquid crystal display (LCD) applications. Downstream customers require tight lot-to-lot reproducibility, verified by in-house NMR and GC-MS checks, in line with rigorous cleanroom and RoHS protocols. Chemical engineers dose it in a strictly controlled environment during high-purity condensation or substitution steps, with product isolation following extraction and vacuum drying to maintain low-ionic content critical for thin-film performance. Industry compliance standards
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5. Synthesis of Photographic and Imaging ChemicalsPhoto-imaging chemical processors rely on this material as a reactant in the production of sensitizer intermediates and developer stabilizers, benefitting from its dual electron-withdrawing substituents to enhance controlling hydrolysis rates and shelf-life stability. Batch records must satisfy strict analytical purity and performance data as defined by global imaging quality standards, particularly for silver halide process chemicals. The reagent is metered into controlled condensation reactions, directly prior to purification and crystallization, ensuring minimal formation of colored by-products interfering with end-use photochemical sensitivity. Industry compliance standards
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- 4-Chloro-3-Nitrobenzoyl Chloride is manufactured under an ISO 9001 quality system and complies with relevant regulatory requirements.
- COA, SDS/MSDS, and related certificates are available upon request. For certificate requests or inquiries, contact: admin@sinochem-nanjing.com.
4-Chloro-3-Nitrobenzoyl Chloride: Experienced Manufacturing for Advanced Applications
Listening to Our Customers’ Needs in Specialty Chemistry
As a manufacturer with decades in fine chemical production, we’ve seen how precision and quality matter, especially with aromatic acyl chlorides like 4-Chloro-3-nitrobenzoyl chloride. Our facility spends months each year tuning reaction conditions and purification methods to give this compound the consistency and reliability our customers trust for their R&D and production lines. Chemistry has real-world consequences. For those who synthesize key intermediates for pharmaceuticals and advanced materials, our experience with this particular molecule helps teams push projects forward, not sideways.
Product Overview: The Real-World Demands for 4-Chloro-3-Nitrobenzoyl Chloride
We understand 4-Chloro-3-nitrobenzoyl chloride isn’t a commodity material. Our team usually sees orders from scientists and engineers who build foundations for new drug molecules, high-value dyes, and custom monomers. In our hands, this product becomes a versatile acylating agent. It performs with predictability in the lab or at scale—without the guesswork that often comes from inconsistent batches or off-the-shelf intermediates.
The molecule itself brings together the electron-withdrawing effects of both chloro and nitro groups on a benzoyl chloride scaffold. This electron-poor character sets it apart from simpler benzoyl chlorides. The nitro position at the meta (3-) carbon, paired with chlorine at the para (4-) site, offers selectivity not every acyl chloride can match. We see daily how this structure supports regioselective reactions and high conversions, even in challenging syntheses. Several customers rely on this property when other acyl chlorides offer too little reactivity or lead to undesirable side products.
We routinely manufacture this product at laboratory, pilot, and batch production scales. Our process control system allows batch sizes from hundreds of grams to hundreds of kilograms. This flexibility lets us serve both development customers and major manufacturers conducting longer synthesis campaigns.
Model and Specifications from a Manufacturer’s Perspective
Each lot we produce follows an internal system we’ve built over years of experience, not just a generic code. We sample throughout our runs for GC purity, confirm structure by NMR, and recheck chloride content so that downstream teams don’t face unpredictable impurities. Customers report time and again that the little differences—like persistent removal of residual starting material and complete dryness—save them labor in their own QC.
On average, our material exceeds 99% GC purity. Excess acid chloride or hydrolysis products rarely show up above trace levels, which cuts back on workup issues and costly extra purification steps. Melting point and color usually keep in a tight range lot-to-lot—our technical staff can spot an off-spec drum by eye, because we’ve packed and opened so many ourselves.
By keeping our process in-house, we control air and moisture exposure from synthesis to final packaging. Trace water in acyl chlorides quickly forms byproducts, so every drum or bottle is checked before it leaves our packaging room. Each container lands with a batch analysis report that reflects the tests run by people who understand what matters downstream, not just numbers keyed in for database requirements.
Why Chemists Choose this Intermediate: Real Differences in Structure and Performance
We talk with users across the pharmaceutical, agrochemical, and pigment sectors. They tell us standard benzoyl chloride doesn’t offer the same synthetic handles as 4-Chloro-3-nitrobenzoyl chloride. In sulfonamide or amide bond constructions, the electron-poor aromatic ring delivers cleaner acylation, even under milder conditions. Synthetic teams often swap to this molecule when they need reactivity with less brute force or want to introduce both a nitro and a chloro group without longer syntheses.
Our experience suggests several unique features:
- The electron withdrawal pattern accelerates certain nucleophilic substitutions, delivering higher yields of the desired product while minimizing side reactions.
- It enables streamlined protection and derivatization strategies when synthesizing complex APIs or dye precursors.
- It serves as a strong intermediate when teams are targeting molecules for pharmaceutical screening or optoelectronic properties.
We’ve watched teams waste days purifying out ortho or para isomers when they use less substituted benzoyl chlorides. Our ortho-para selectivity means less rework and higher throughput, which brings projects to completion instead of getting bogged down by repeated column chromatography steps.
Handling and Storage: Lessons Learned Over Years of Production
Acyl chlorides demand respect. We learned early on that minor water traces can ruin kilograms of material, so our process avoids open transfers and maintains nitrogen blanketing all the way to bottling. Temperature swings affect volatility and decomposition. We’ve adjusted our storage protocols so even during weeks of shipping or years of warehousing, the product stays in specification and doesn’t become sticky, dark, or acidic.
A user only ever notices the handling differences when something goes wrong. We see the peace of mind that comes from reliable container sizing, quick-opening seals designed for glovebox or fumehood work, and container labeling that never peels under solvents or humidity.
Manufacturing Challenges and How We’ve Addressed Them
Synthesis of 4-Chloro-3-nitrobenzoyl chloride isn’t trivial. Nitration produces significant exotherms, and improper temperature management can yield tarry byproducts. Over-chlorination creates isomeric impurities that complicate purification. We have built our procedure to deliver consistent selectivity at all production scales, balancing reagent stoichiometry with environmental and operator safety.
As environmental expectations evolve, we’ve lowered chlorinated solvent usage and capture excess HCl rather than vent it. Waste from nitration and chlorination undergoes careful treatment. Decades of improvements have brought us into compliance with the strictest regulations, and we keep a record for every drum shipped. Because we prepare this compound ourselves, no one else needs to wonder about hidden process problems or residues usually found in material made through less attentive processes.
Comparisons to Other Acyl Chlorides and Downstream Benefits
Few alternatives offer the combination of electronic and positional effects 4-Chloro-3-nitrobenzoyl chloride provides. Simple benzoyl chloride struggles to deliver the same regioselectivity in biaryl coupling or peptide linkage formation. Some labs attempt to modify unfunctionalized benzoyl chloride, adding extra nitration or chlorination steps—and with that comes increased cost, step count, and impurity risk.
We see chemists in academia and industry order this product for research programs where subtle differences in the acyl component drive solubility profiles in medicinal chemistry or photophysical behavior in new dyes. Tuning electron density on the benzoyl ring makes a difference in outcomes, not just theoretical yields. The chloro group acts as a synthetic anchor for further substitution, and the nitro group supports transformations not enabled by plainer structures.
Safety, Regulatory, and Environmental Insight from Hands-On Practice
Handling acid chlorides brings safety questions to the forefront. Every technician in our plant receives training on PPE for handling and neutralization procedures. Like many reactive compounds, the product releases HCl on contact with water or protic solvents. We maintain all filling lines in closed systems, and we recommend that users run small-scale risk assessments for new reactions—guidance based on accidents we’ve analyzed ourselves.
Air quality controls and waste handling feature prominently in our operations. We adopted in-house scrubbing for off-gases twenty years ago, well before many new guidelines became law. This keeps our teams safe and makes regulatory audits straightforward. For our customer’s documentation, we support REACH and TSCA submissions as needed, coming from records generated during in-house synthesis—not third-party declarations.
Packaging Insights Earned from Decades of Use
Every operator recognizes that material loss during packaging or decanting amounts to lost time and money. Over the years, we’ve moved to tamper-resistant, solvent-resistant plastic or lined steel containers for all acyl chlorides. Lining materials are chosen for compatibility, and filling volumes suit both process-scale and research settings.
In our experience, labeling matters. We design each label to resist ethanol, acetone, and humidity, ensuring secure tracking from our warehouse right to your benchtop. Barcode traceability and color indicators help avoid confusion during on-site receiving or transfer, especially when labs stock multiple similar products.
Supporting Global Supply for Advanced Chemistry
Our global distribution reflects decades spent building a reliable cold-chain and hazardous goods shipping network. Whether a university in Europe, a pharmaceutical R&D center in the US, or an agrochemical pilot plant in Asia, we’ve seen material successfully delivered in climates that range from tropical humidity to arid desert. All documentation, from analysis reports to shipping manifests, travels ahead to ensure quick customs clearance and regulatory acceptance.
Long-term partnerships let us forecast future demand, keeping raw material inventory robust. We’ve seen surges in consumption for vaccine intermediates and then swings back to specialty pigment production—because our synthesis is not outsourced, surge capacity remains within our own plant.
Concrete Examples From Real Manufacturing
Teams synthesizing sulfonamide-based antibiotics have moved to our 4-Chloro-3-nitrobenzoyl chloride due to higher coupling efficiency, judged by NMR endpoint analysis and LC-MS purity. They reported reduced side products, translating to easier purification steps and less time required with preparative HPLC. We routinely hear from organic synthesis labs that choose our material for acylating protected amine groups, where the electron-deficient aromatic ring delivers clean reactions, minimizing N-acyl side products common with less activated electrophiles.
Pigment manufacturers put emphasis on batch color and solubility profile. When using our 4-Chloro-3-nitrobenzoyl chloride in azo coupling steps, they report brighter color and higher process yields compared to unfunctionalized or singly substituted benzoyl chlorides. We take pride in visiting customer sites and seeing these differences under real operating conditions, not just in a catalog entry.
We’ve also assisted polymer and fine chemical firms needing kilogram-scale supply quickly. Surges in demand have put strain on global supply chains, but we’ve filled all confirmed orders from stock or quick turn production runs. This adaptability reflects how tightly our production and planning teams work together under one roof.
Continuous Improvement and Feedback From the Field
Regular feedback loops between our chemists and end users make a difference. Over time, customers asked for more detailed impurity profiles and rapid response to technical questions. In response, we improved our batch documentation and expanded technical support to give more real-world application insight, sharing our expertise transparently with the teams relying on our product.
In one instance, modifications suggested by a downstream API synthesis partner led our operations staff to fine-tune reagent addition rates, resulting in cleaner product and a labor-saving workup for everyone involved. We don’t stop at technical specifications—real-world experience and open channels keep our product aligned with user needs as regulatory and scientific expectations evolve.
What Makes Quality in Specialty Aromatic Acyl Chlorides
A specialty acyl chloride must offer more than purity on paper. Our lot-to-lot consistency helps synthetic teams avoid troubleshooting and improvisation. We focus on quality from raw material selection through terminal filtration and final QC checks. Years of refinement in our processes pay off in less downtime and fewer surprises for labs and plants using our material in scale-up or routine operations.
As manufacturers, we talk daily with scientists trying to solve problems with molecular precision. Our batch history and track record in 4-Chloro-3-nitrobenzoyl chloride supply means users get more than a bottle of chemical—they obtain a reliable step for their creative synthesis. Our personal investment in every kilogram reflects a broader commitment to supporting science and industry, balancing rigorous production standards with the flexibility to respond to the next challenge.
