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HS Code |
840059 |
| Cas Number | 873-32-5 |
| Molecular Formula | C8H6ClN |
| Molecular Weight | 151.59 g/mol |
| Iupac Name | 4-Chloro-2-methylbenzonitrile |
| Appearance | White to off-white crystalline powder |
| Melting Point | 58-61 °C |
| Boiling Point | 262-263 °C |
| Density | 1.20 g/cm³ |
| Solubility In Water | Slightly soluble |
| Flash Point | 130 °C |
| Purity | Typically ≥98% |
| Smiles | CC1=CC(=C(C=C1)Cl)C#N |
| Refractive Index | 1.564 |
| Inchi | InChI=1S/C8H6ClN/c1-6-4-7(9)2-3-8(6)5-10/h2-4H,1H3 |
As an accredited 4-Chloro-2-Methylbenzonitrile factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle with secure screw cap, labeled "4-Chloro-2-Methylbenzonitrile, 99% pure, 250 grams," including hazard warnings and safety instructions. |
| Shipping | 4-Chloro-2-Methylbenzonitrile is shipped in tightly sealed containers to prevent leaks and contamination. It should be packaged according to hazardous material regulations, protected from moisture and incompatible substances. Proper labeling, documentation, and handling procedures must be followed to ensure safety during transportation, typically under ambient temperature conditions. |
| Storage | 4-Chloro-2-Methylbenzonitrile should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from heat, moisture, and incompatible substances such as strong oxidizers. Keep out of direct sunlight. Use secondary containment to prevent leaks. Properly label the container and store at room temperature, away from food and drink. Always follow local regulations for hazardous chemicals. |
Applications of 4-Chloro-2-Methylbenzonitrile in Industrial Manufacturing4-Chloro-2-Methylbenzonitrile serves as a key intermediate in multiple industrial value chains, supporting precise functional group transformations for downstream synthesis. By enabling selective derivatization, it underpins the reliable manufacturing of fine chemicals within critical regulated sectors. Below, we detail the most significant industrial applications, demonstrating how processors integrate this chemical within their production environments. 1. Agrochemical Active Ingredient SynthesisChemical manufacturers employ 4-Chloro-2-Methylbenzonitrile extensively in the production of selective herbicide intermediates. During multi-step syntheses, this nitrile compound acts as a foundational core for introducing methyl and chloro groups required for advanced phenyl-based actives. By controlling substitution patterns at defined stages, formulators ensure downstream molecules exhibit desired selectivity and persistence for sustainable crop protection formulas. Industry compliance standards
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2. Pharmaceutical Intermediate Production for Antihypertensive APIsWithin the pharmaceutical chemical sector, 4-Chloro-2-Methylbenzonitrile functions as a tailored starting material for synthesizing tetrazole-substituted benzonitrile motifs. These structural units are critical in the production of key antihypertensive active pharmaceutical ingredients, including sartans, through patented multi-step transformations. Direct nitrile-to-tetrazole cyclization routes enable manufacturers to achieve precise purity profiles demanded in regulated API supply. Industry compliance standards
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3. Advanced Dye and Pigment Intermediate ManufacturingSpecialty dye and pigment plants employ 4-Chloro-2-Methylbenzonitrile as a key aryl nitrile precursor, vital for introducing reactive aromatic moieties in the synthesis of high-purity azo dyes and phthalonitrile pigments. Its controlled reactivity allows precise coupling and condensation, supporting batch-to-batch chromatic consistency in colorant value chains meeting tight customer hue and intensity specifications. Industry compliance standards
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4. Fine Chemical Intermediate for Electronic Material SynthesisManufacturing facilities in the electronics industry use 4-Chloro-2-Methylbenzonitrile as a functionalized intermediate in the tailored synthesis of liquid crystal monomers and other advanced organic materials. Its defined substitution pattern enhances the molecular alignment properties, supporting downstream electronic-grade formulation with consistent dielectric and optical performance for specialized display components. Industry compliance standards
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5. Intermediate in Fragrance and Aroma Chemicals ProductionSelect aroma chemical producers deploy 4-Chloro-2-Methylbenzonitrile in the synthesis of nitrile-derived musks and specialty aromatic accents for fragrance manufacturing. Its molecular rigidity and defined structure contribute to downstream derivatives delivering unique olfactory characteristics, often required in premium functional fragrance compounds for both fine perfumery and household care formulations. Industry compliance standards
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Producing 4-Chloro-2-Methylbenzonitrile has taught us plenty about the expectations of specialty chemical users. Our daily focus is on generating a compound that bridges high purity and consistent yield, which customers in various industries expect and rely on. Through years of hands-on production, the details stand out — temperature control, catalyst choices, process timing. These don’t just influence output; they define what arrives at your dock. Here, the transition from raw input to the final product is not just a technical journey; it’s a commitment to reliability, lot after lot.
We make 4-Chloro-2-Methylbenzonitrile with a focus on purity that supports advanced applications. Years of downtimes, off-spec batches, and customer feedback have made us sticklers for detail. Every batch targets a content above 99 percent. Impurity profiles remain tighter than most sector requirements, and water content always falls well below detection limits. Physical forms matter too. Even small variations in particle size or bulk density can change the way a formulation holds together or dissolves. So, we monitor every stage down to specific filtration and drying steps, adjusting based on run-to-run data, not just by following tradition.
We don’t learn where our chemical ends up from generic industry pamphlets. Instead, years of customer projects provide direct insight into why this molecule is a choice pick. 4-Chloro-2-Methylbenzonitrile finds its way into the production lines of crop protection, dye intermediates, and pharmaceuticals. Each field cares about different things from us. In agrochemicals, stability during synthesis is crucial; the molecule must behave predictably under high pressure and temperature, so a tight melting point can be the difference between a successful batch and hours of rework. The color industry wants clean reaction outcomes, low by-products, and clarity in every solution. For pharmaceutical applications, trace impurities trigger whole-process audits, so every reactor load is documented and tracked. Feedback loops are constant. We aren’t just sending bags; we’re part of our customers’ trial runs and scale-ups.
Picking 4-Chloro-2-Methylbenzonitrile over similar nitriles isn’t just about a position on a synthetic bench. The combination of the chloro and methyl group on the benzonitrile backbone does more than shift boiling points or melting points. Chemistry demands precision, and these functional groups steer the molecule’s reactivity. In some reactions, 4-Chloro-2-Methylbenzonitrile offers better conversion rates than both 2-chlorobenzonitrile and the more basic benzonitrile, thanks to its electronic structure. Process chemists tell us that introduction of the methyl at the ortho position speeds up coupling reactions in some cross-coupling environments. In our own labs, comparing outcomes side-by-side, we notice tighter control over side product formation and improved yields. For any company looking to move from a trial phase to full-scale manufacturing, these differences mean fewer surprises in early stage and scale-up production.
Making high-grade 4-Chloro-2-Methylbenzonitrile isn’t as straightforward as stepping through a textbook procedure. Over time, we’ve run up against issues like unwanted tar formation during the dehydration step, even with top-line reaction engineering. Some seasonal shifts even throw off solvent recovery profiles, which would escape a third party’s notice. We’ve solved these through back and forth among our own team – changing stir speeds, reworking the order of catalyst addition, and fine-tuning washing protocols to cut out stubborn residues without wrecking yield. Solving these problems wasn’t optional; shipments go on hold every time a small procedural detail gets overlooked. Our team’s technical experience isn’t academic — it’s a set of hard-won skills assembled from years of watching, listening, and adjusting on the ground.
Our customers don’t want surprises, so we invest heavily in keeping every metric consistent. Tracking purity isn’t the full story. We map trace impurity trends with gas chromatography, frequently comparing current results to archives from the past five years. Regular feedback comes in from R&D labs and plant managers who use our product — complaints and suggestions alike. Some years, cost pressures forced us to rethink the solvents and filtration aids. We never compromise on main chemical attributes, but we learn to adapt processes for both scale and sustainability. Waste disposal plans evolve, and as regulations grow stricter, every system improvement aims to keep the batch and the environment clean.
Every chemical behaves differently across a season or during longer storage. We learned that 4-Chloro-2-Methylbenzonitrile prefers sealed containers, kept away from sustained humidity or sunlight exposure. Through years of warehousing, we’ve noticed that improper sealing leads to caking, which causes both handling issues and downstream variability. While big drums look the same on the outside, in practice, a batch exposed to a humid dockside will react very differently from one kept in a climate-controlled room. Regular sampling and inspection caught these issues before they reached customers, saving both time and reputation. There is no substitute for direct experience — every dented drum or discolored sample creates an annotation our logistics staff and QA technicians remember.
Our regular interaction with formulators and process chemists keeps us responsive to real-world needs. Occasionally a client needs a different crystal habit, seeking improved filterability or dissolution rates. Through coordinated process shifts, we altered crystallization parameters, adjusted cooling rates, and swapped out some isolation solvents, all to meet one plant’s demand. This process wasn’t as simple as following a formulaic adjustment; it took weeks, sometimes months, of benchwork and pilot tests. Every change ripples through operations, forcing new stability studies, revised batch documents, and staff retraining. The reward: partnerships that last beyond a simple sell-and-ship cycle. Our plant teams understand they’re not just filling bags; they’re part of an ongoing development effort that shapes how downstream processes run.
Staying compliant has changed over the years. External auditors and in-house compliance teams dig deep into cleaning validation, air emissions, and waste tracking. We’ve adopted batch traceability systems and off-gas scrubbers not because the rules demanded it, but because we saw potential risks early. Each upgrade to documentation goes through real-use trials and in many cases, reduces the regulatory and operational headaches down the line. Consistency in reporting isn’t about paperwork; it underpins trust. When one ton batch from us looks, smells, and measures the same as the last, customers can scale up their own lines without stopping to recalibrate. Our record-keeping stays open for review, which speeds up certifications and meets the scrutiny of auditors from health, agriculture, and chemical regulators.
We’ve seen growing pressures on solvent use, effluent limits, and energy consumption, not from outside consultants but from the daily grind of running a modern chemical plant. Reducing water use, recovering as much solvent as possible, and finding uses for side-streams challenge every chemical maker. Specific to 4-Chloro-2-Methylbenzonitrile, we invest in distillation and membrane separation not because it is trendy but because these steps cut out rework cycles and reduce discarded volumes. Plant operators learn to look for leaks, and preventive maintenance grows out of past troubleshooting headaches. As regulator attention sharpens and downstream users want “greener” intermediates, each upgrade to our process comes from what our team sees on the ground day after day. Sustainable chemistry isn’t a slogan here — it’s built into every production shift, with safety prompts, performance bonuses, and feedback sessions. The result: less waste, a safer workplace, and better community relations.
We’ve handled and synthesized many other benzonitrile derivatives. Each molecule brings its own quirks. For those who’ve only worked at the bench, differences can seem academic. In our reactors, those differences either keep a line humming or bring headaches. The methyl group on the 2-position of 4-Chloro-2-Methylbenzonitrile, for example, reduces certain unwanted side-chain reactions we see with unsubstituted benzonitriles. Its melting point aids handling, making large-scale filtration more manageable. In contrast, the absence of halogens on regular benzonitriles leads to broader impurity sets and less process control. In the worst-case scenarios, this means unexpected shutdowns and higher waste rates.
From direct production experience, 4-Chloro-2-Methylbenzonitrile stands out for its reactivity in Suzuki and related coupling reactions. The electronic effects lower the activation energy in key transformations—something that speeds up production lines, which is noticed in plant throughput figures. Compared to 2-chlorobenzonitrile, the methyl group slightly shifts residue profiles, lending an edge in reproducibility for some fine chemical applications. We hear from R&D teams that recoveries from work-up steps trend higher, reflecting what we see in the plant. For groups who operate at multi-ton scale, that narrow efficiency edge quickly adds up across months or years.
Our years in manufacturing teach us not to rest on laurels. Each campaign reveals opportunities to refine, and no process stays static. After launch or scale-up, plant teams run post-batch analysis meetings, drawing from direct operator feedback more than just instrument readouts. Notable changes are traced back, for example, to steam pressure fluctuations or minor feedstock shifts, connecting hands-on data to outcomes seen in crystalline quality and filtration times. These real-world observations regularly trigger controlled experiments, a practice that keeps our process robust, not brittle. Customers see benefits as product consistency translates to less surprise and re-validation in their own labs.
Working day in and day out on 4-Chloro-2-Methylbenzonitrile, we know it more thoroughly than any datasheet or technical bulletin could reveal. From the raw materials entering our site, through every heating, stripping, and purification step, straight to the drum loading bay, the fingerprint of our experience stays on each kilogram shipped. Over time, we’ve changed, improved, and learned — not in a vacuum but by listening to the needs and stories of customers who run their own production lines and push the limits of what our chemical can do. The result isn’t just another product, but a material that’s been honed, tested, and proven in the only place it counts: industry. Whether you’re scaling up a new synthesis or optimizing a legacy process, the differences found here reflect not just molecular structure but the sum of real manufacturing experience.