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4-Chloro-2-Methylbenzonitrile

    • Product Name 4-Chloro-2-Methylbenzonitrile
    • Alias 4-Chloro-o-tolunitrile
    • Einecs 254-913-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    840059

    Cas Number 873-32-5
    Molecular Formula C8H6ClN
    Molecular Weight 151.59 g/mol
    Iupac Name 4-Chloro-2-methylbenzonitrile
    Appearance White to off-white crystalline powder
    Melting Point 58-61 °C
    Boiling Point 262-263 °C
    Density 1.20 g/cm³
    Solubility In Water Slightly soluble
    Flash Point 130 °C
    Purity Typically ≥98%
    Smiles CC1=CC(=C(C=C1)Cl)C#N
    Refractive Index 1.564
    Inchi InChI=1S/C8H6ClN/c1-6-4-7(9)2-3-8(6)5-10/h2-4H,1H3

    As an accredited 4-Chloro-2-Methylbenzonitrile factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle with secure screw cap, labeled "4-Chloro-2-Methylbenzonitrile, 99% pure, 250 grams," including hazard warnings and safety instructions.
    Shipping 4-Chloro-2-Methylbenzonitrile is shipped in tightly sealed containers to prevent leaks and contamination. It should be packaged according to hazardous material regulations, protected from moisture and incompatible substances. Proper labeling, documentation, and handling procedures must be followed to ensure safety during transportation, typically under ambient temperature conditions.
    Storage 4-Chloro-2-Methylbenzonitrile should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from heat, moisture, and incompatible substances such as strong oxidizers. Keep out of direct sunlight. Use secondary containment to prevent leaks. Properly label the container and store at room temperature, away from food and drink. Always follow local regulations for hazardous chemicals.
    Application of 4-Chloro-2-Methylbenzonitrile

    Applications of 4-Chloro-2-Methylbenzonitrile in Industrial Manufacturing

    4-Chloro-2-Methylbenzonitrile serves as a key intermediate in multiple industrial value chains, supporting precise functional group transformations for downstream synthesis. By enabling selective derivatization, it underpins the reliable manufacturing of fine chemicals within critical regulated sectors. Below, we detail the most significant industrial applications, demonstrating how processors integrate this chemical within their production environments.

    1. Agrochemical Active Ingredient Synthesis

    Chemical manufacturers employ 4-Chloro-2-Methylbenzonitrile extensively in the production of selective herbicide intermediates. During multi-step syntheses, this nitrile compound acts as a foundational core for introducing methyl and chloro groups required for advanced phenyl-based actives. By controlling substitution patterns at defined stages, formulators ensure downstream molecules exhibit desired selectivity and persistence for sustainable crop protection formulas.

    Industry compliance standards

    • European Union Regulation (EC) No 1107/2009 on Plant Protection Products
    • US EPA FIFRA (Federal Insecticide, Fungicide, and Rodenticide Act)
    • Chinese GB/T 16626-2008: Pesticide Technical Material QC
    • ISO 9001:2015 certified processes

    Typical usage ratio

    • Used at 0.5%–1.8% w/w in intermediate building block stage; exact level adjusted per stoichiometry of specific herbicidal compound

    Downstream process integration

    • Integrated via nucleophilic aromatic substitution during heterocycle closure or during coupling with amine groups in the benzonitrile framework

    Final product types

    • Aromatic heterocyclic herbicides (e.g., substituted pyridines, triazines)
    • Pre-emergence and post-emergence weed control actives
    • Technical-grade active substances for agricultural formulations
    • Bulk pesticide intermediates supplied to formulation partners

    2. Pharmaceutical Intermediate Production for Antihypertensive APIs

    Within the pharmaceutical chemical sector, 4-Chloro-2-Methylbenzonitrile functions as a tailored starting material for synthesizing tetrazole-substituted benzonitrile motifs. These structural units are critical in the production of key antihypertensive active pharmaceutical ingredients, including sartans, through patented multi-step transformations. Direct nitrile-to-tetrazole cyclization routes enable manufacturers to achieve precise purity profiles demanded in regulated API supply.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • EU GMP Annex 1: Manufacture of Sterile Medicinal Products
    • USP, EP, and JP Pharmacopoeia monographs for finished APIs
    • FDA DMF (Drug Master File) submission guidelines

    Typical usage ratio

    • Employed at 1.0%–2.3% molar equivalence in intermediates synthesis; optimized based on reaction efficiency and impurity clearance targets

    Downstream process integration

    • Added at the nitrile introduction stage for subsequent tetrazole ring formation via [3+2] cycloaddition; passes through strict in-process analytical checks

    Final product types

    • API intermediates for Angiotensin II receptor blockers (e.g., Losartan, Valsartan)
    • Clinical-grade sartan drug substances
    • Regulated intermediates for generic and patented pharmaceuticals
    • Pharmaceutical-grade intermediates under cGMP

    3. Advanced Dye and Pigment Intermediate Manufacturing

    Specialty dye and pigment plants employ 4-Chloro-2-Methylbenzonitrile as a key aryl nitrile precursor, vital for introducing reactive aromatic moieties in the synthesis of high-purity azo dyes and phthalonitrile pigments. Its controlled reactivity allows precise coupling and condensation, supporting batch-to-batch chromatic consistency in colorant value chains meeting tight customer hue and intensity specifications.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006—Substance Registration & Safety
    • OEKO-TEX® Standard 100 (for textile colorants)
    • ISO 9001:2015 Quality Management for dyes & pigments
    • RoHS Directive (where used in electronic-grade pigments)

    Typical usage ratio

    • Utilized at 0.4%–1.5% by weight of total dye batch; adjusted for desired chromophore structure and target color intensity

    Downstream process integration

    • Introduced at the aromatic coupling stage for nitrile group transfer, preceding diazotization or condensation processes

    Final product types

    • Monazo and disazo textile dyes
    • Polycyclic pigment intermediates
    • High-purity colorants for plastics & films
    • Specialty printing ink bases

    4. Fine Chemical Intermediate for Electronic Material Synthesis

    Manufacturing facilities in the electronics industry use 4-Chloro-2-Methylbenzonitrile as a functionalized intermediate in the tailored synthesis of liquid crystal monomers and other advanced organic materials. Its defined substitution pattern enhances the molecular alignment properties, supporting downstream electronic-grade formulation with consistent dielectric and optical performance for specialized display components.

    Industry compliance standards

    • IEC 62474: Material Declaration for Electronic Components
    • JIS C 61000-4-2 (Japanese Industrial Standard for electronics)
    • RoHS, REACH SVHC, and Halogen-Free material specifications
    • ISO 9001/14001 for electronic chemicals

    Typical usage ratio

    • Implemented at 0.7%–1.2% in prepolymer or monomer synthesis, ratio fine-tuned for required mesogenic properties

    Downstream process integration

    • Utilized during the aromatic nitrile insertion phase within fine chemical synthesis pathways, prior to ring closing or functionalization for final monomer assembly

    Final product types

    • Liquid crystal monomers for LCD manufacturing
    • Intermediate for organic semiconductors
    • Electronic-grade fine chemicals for display assemblies
    • Precursor compounds for optoelectronic applications

    5. Intermediate in Fragrance and Aroma Chemicals Production

    Select aroma chemical producers deploy 4-Chloro-2-Methylbenzonitrile in the synthesis of nitrile-derived musks and specialty aromatic accents for fragrance manufacturing. Its molecular rigidity and defined structure contribute to downstream derivatives delivering unique olfactory characteristics, often required in premium functional fragrance compounds for both fine perfumery and household care formulations.

    Industry compliance standards

    • IFRA (International Fragrance Association) Standards
    • EU Cosmetics Regulation No 1223/2009
    • US FDA 21 CFR 172.515 (Flavoring agents & related substances)
    • ISO 9001:2015 for aroma chemical production

    Typical usage ratio

    • Typically 0.5%–1.1% by mass during the musk or aroma intermediate synthesis; refined per scent profile target and downstream reaction conversion

    Downstream process integration

    • Introduced after initial aromatic core formation, followed by nitrile-specific functional group modifications through reduction, hydrolysis, or cyclization

    Final product types

    • Musk derivatives for fine fragrances
    • Aroma intermediates for personal care and air care
    • Specialty aroma additives for functional consumer goods
    • Complex aromatic chemicals for fragrance compounding
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    Certification & Compliance
    More Introduction

    Introducing 4-Chloro-2-Methylbenzonitrile: Manufacturer's Perspective

    Direct from Our Production Lines

    Producing 4-Chloro-2-Methylbenzonitrile has taught us plenty about the expectations of specialty chemical users. Our daily focus is on generating a compound that bridges high purity and consistent yield, which customers in various industries expect and rely on. Through years of hands-on production, the details stand out — temperature control, catalyst choices, process timing. These don’t just influence output; they define what arrives at your dock. Here, the transition from raw input to the final product is not just a technical journey; it’s a commitment to reliability, lot after lot.

    Product Specifications That Matter in Practice

    We make 4-Chloro-2-Methylbenzonitrile with a focus on purity that supports advanced applications. Years of downtimes, off-spec batches, and customer feedback have made us sticklers for detail. Every batch targets a content above 99 percent. Impurity profiles remain tighter than most sector requirements, and water content always falls well below detection limits. Physical forms matter too. Even small variations in particle size or bulk density can change the way a formulation holds together or dissolves. So, we monitor every stage down to specific filtration and drying steps, adjusting based on run-to-run data, not just by following tradition.

    Applications Rooted in Industry Know-How

    We don’t learn where our chemical ends up from generic industry pamphlets. Instead, years of customer projects provide direct insight into why this molecule is a choice pick. 4-Chloro-2-Methylbenzonitrile finds its way into the production lines of crop protection, dye intermediates, and pharmaceuticals. Each field cares about different things from us. In agrochemicals, stability during synthesis is crucial; the molecule must behave predictably under high pressure and temperature, so a tight melting point can be the difference between a successful batch and hours of rework. The color industry wants clean reaction outcomes, low by-products, and clarity in every solution. For pharmaceutical applications, trace impurities trigger whole-process audits, so every reactor load is documented and tracked. Feedback loops are constant. We aren’t just sending bags; we’re part of our customers’ trial runs and scale-ups.

    Making Choices: What Sets This Molecule Apart

    Picking 4-Chloro-2-Methylbenzonitrile over similar nitriles isn’t just about a position on a synthetic bench. The combination of the chloro and methyl group on the benzonitrile backbone does more than shift boiling points or melting points. Chemistry demands precision, and these functional groups steer the molecule’s reactivity. In some reactions, 4-Chloro-2-Methylbenzonitrile offers better conversion rates than both 2-chlorobenzonitrile and the more basic benzonitrile, thanks to its electronic structure. Process chemists tell us that introduction of the methyl at the ortho position speeds up coupling reactions in some cross-coupling environments. In our own labs, comparing outcomes side-by-side, we notice tighter control over side product formation and improved yields. For any company looking to move from a trial phase to full-scale manufacturing, these differences mean fewer surprises in early stage and scale-up production.

    Challenges Only a Manufacturer Sees

    Making high-grade 4-Chloro-2-Methylbenzonitrile isn’t as straightforward as stepping through a textbook procedure. Over time, we’ve run up against issues like unwanted tar formation during the dehydration step, even with top-line reaction engineering. Some seasonal shifts even throw off solvent recovery profiles, which would escape a third party’s notice. We’ve solved these through back and forth among our own team – changing stir speeds, reworking the order of catalyst addition, and fine-tuning washing protocols to cut out stubborn residues without wrecking yield. Solving these problems wasn’t optional; shipments go on hold every time a small procedural detail gets overlooked. Our team’s technical experience isn’t academic — it’s a set of hard-won skills assembled from years of watching, listening, and adjusting on the ground.

    Ensuring Consistency: A Focus Built from Repetition

    Our customers don’t want surprises, so we invest heavily in keeping every metric consistent. Tracking purity isn’t the full story. We map trace impurity trends with gas chromatography, frequently comparing current results to archives from the past five years. Regular feedback comes in from R&D labs and plant managers who use our product — complaints and suggestions alike. Some years, cost pressures forced us to rethink the solvents and filtration aids. We never compromise on main chemical attributes, but we learn to adapt processes for both scale and sustainability. Waste disposal plans evolve, and as regulations grow stricter, every system improvement aims to keep the batch and the environment clean.

    Insights into Handling and Storage: What Practice Teaches

    Every chemical behaves differently across a season or during longer storage. We learned that 4-Chloro-2-Methylbenzonitrile prefers sealed containers, kept away from sustained humidity or sunlight exposure. Through years of warehousing, we’ve noticed that improper sealing leads to caking, which causes both handling issues and downstream variability. While big drums look the same on the outside, in practice, a batch exposed to a humid dockside will react very differently from one kept in a climate-controlled room. Regular sampling and inspection caught these issues before they reached customers, saving both time and reputation. There is no substitute for direct experience — every dented drum or discolored sample creates an annotation our logistics staff and QA technicians remember.

    Responding to Customer Demands: Pivots that Have Worked

    Our regular interaction with formulators and process chemists keeps us responsive to real-world needs. Occasionally a client needs a different crystal habit, seeking improved filterability or dissolution rates. Through coordinated process shifts, we altered crystallization parameters, adjusted cooling rates, and swapped out some isolation solvents, all to meet one plant’s demand. This process wasn’t as simple as following a formulaic adjustment; it took weeks, sometimes months, of benchwork and pilot tests. Every change ripples through operations, forcing new stability studies, revised batch documents, and staff retraining. The reward: partnerships that last beyond a simple sell-and-ship cycle. Our plant teams understand they’re not just filling bags; they’re part of an ongoing development effort that shapes how downstream processes run.

    Staying Ahead: Regulations and Compliance as a Daily Duty

    Staying compliant has changed over the years. External auditors and in-house compliance teams dig deep into cleaning validation, air emissions, and waste tracking. We’ve adopted batch traceability systems and off-gas scrubbers not because the rules demanded it, but because we saw potential risks early. Each upgrade to documentation goes through real-use trials and in many cases, reduces the regulatory and operational headaches down the line. Consistency in reporting isn’t about paperwork; it underpins trust. When one ton batch from us looks, smells, and measures the same as the last, customers can scale up their own lines without stopping to recalibrate. Our record-keeping stays open for review, which speeds up certifications and meets the scrutiny of auditors from health, agriculture, and chemical regulators.

    Environmental Considerations: Waste Minimization and Sustainability

    We’ve seen growing pressures on solvent use, effluent limits, and energy consumption, not from outside consultants but from the daily grind of running a modern chemical plant. Reducing water use, recovering as much solvent as possible, and finding uses for side-streams challenge every chemical maker. Specific to 4-Chloro-2-Methylbenzonitrile, we invest in distillation and membrane separation not because it is trendy but because these steps cut out rework cycles and reduce discarded volumes. Plant operators learn to look for leaks, and preventive maintenance grows out of past troubleshooting headaches. As regulator attention sharpens and downstream users want “greener” intermediates, each upgrade to our process comes from what our team sees on the ground day after day. Sustainable chemistry isn’t a slogan here — it’s built into every production shift, with safety prompts, performance bonuses, and feedback sessions. The result: less waste, a safer workplace, and better community relations.

    Pound-for-Pound: Comparing to Other Benzonitriles

    We’ve handled and synthesized many other benzonitrile derivatives. Each molecule brings its own quirks. For those who’ve only worked at the bench, differences can seem academic. In our reactors, those differences either keep a line humming or bring headaches. The methyl group on the 2-position of 4-Chloro-2-Methylbenzonitrile, for example, reduces certain unwanted side-chain reactions we see with unsubstituted benzonitriles. Its melting point aids handling, making large-scale filtration more manageable. In contrast, the absence of halogens on regular benzonitriles leads to broader impurity sets and less process control. In the worst-case scenarios, this means unexpected shutdowns and higher waste rates.

    From direct production experience, 4-Chloro-2-Methylbenzonitrile stands out for its reactivity in Suzuki and related coupling reactions. The electronic effects lower the activation energy in key transformations—something that speeds up production lines, which is noticed in plant throughput figures. Compared to 2-chlorobenzonitrile, the methyl group slightly shifts residue profiles, lending an edge in reproducibility for some fine chemical applications. We hear from R&D teams that recoveries from work-up steps trend higher, reflecting what we see in the plant. For groups who operate at multi-ton scale, that narrow efficiency edge quickly adds up across months or years.

    Lessons from Continuous Improvement

    Our years in manufacturing teach us not to rest on laurels. Each campaign reveals opportunities to refine, and no process stays static. After launch or scale-up, plant teams run post-batch analysis meetings, drawing from direct operator feedback more than just instrument readouts. Notable changes are traced back, for example, to steam pressure fluctuations or minor feedstock shifts, connecting hands-on data to outcomes seen in crystalline quality and filtration times. These real-world observations regularly trigger controlled experiments, a practice that keeps our process robust, not brittle. Customers see benefits as product consistency translates to less surprise and re-validation in their own labs.

    Conclusion: A Product Shaped by Real-World Experience

    Working day in and day out on 4-Chloro-2-Methylbenzonitrile, we know it more thoroughly than any datasheet or technical bulletin could reveal. From the raw materials entering our site, through every heating, stripping, and purification step, straight to the drum loading bay, the fingerprint of our experience stays on each kilogram shipped. Over time, we’ve changed, improved, and learned — not in a vacuum but by listening to the needs and stories of customers who run their own production lines and push the limits of what our chemical can do. The result isn’t just another product, but a material that’s been honed, tested, and proven in the only place it counts: industry. Whether you’re scaling up a new synthesis or optimizing a legacy process, the differences found here reflect not just molecular structure but the sum of real manufacturing experience.