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4-Chloro-2,6-Dimethylaniline

    • Product Name 4-Chloro-2,6-Dimethylaniline
    • Alias 2,6-Dimethyl-4-chloroaniline
    • Einecs 221-868-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    416165

    Chemical Name 4-Chloro-2,6-Dimethylaniline
    Cas Number 87-63-8
    Molecular Formula C8H10ClN
    Molar Mass 155.63 g/mol
    Appearance Light yellow crystalline solid
    Melting Point 66-69°C
    Boiling Point 255°C
    Density 1.15 g/cm³
    Solubility In Water Slightly soluble
    Purity Typically ≥98%
    Flash Point 118°C
    Synonyms 2,6-Dimethyl-4-chloroaniline
    Refractive Index 1.598
    Storage Conditions Store at room temperature, protected from light and moisture
    Ec Number 201-754-1

    As an accredited 4-Chloro-2,6-Dimethylaniline factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 100g package features a sealed amber glass bottle, labeled "4-Chloro-2,6-Dimethylaniline," with safety symbols and hazard warnings.
    Shipping **Shipping Description for 4-Chloro-2,6-Dimethylaniline:** Ships in tightly sealed containers, protected from light and moisture. Store in a cool, ventilated area away from incompatible substances. Classified as hazardous; handle with proper labeling and documentation according to local and international regulations. Use personal protective equipment and adhere to UN packing group and transport guidelines.
    Storage **4-Chloro-2,6-Dimethylaniline** should be stored in a tightly sealed container, away from light, heat, and sources of ignition. Keep it in a cool, dry, well-ventilated area, separate from incompatible substances such as oxidizing agents and acids. Clearly label the container, and ensure proper spill containment measures are in place. Store at room temperature and follow all relevant safety protocols.
    Application of 4-Chloro-2,6-Dimethylaniline

    Applications of 4-Chloro-2,6-Dimethylaniline in Industrial Manufacturing

    4-Chloro-2,6-Dimethylaniline plays a vital role in the formulation and synthesis processes of key downstream industries. Our material supports precise requirements in chemical manufacturing where regulated standards and end-product performance are critical. Below, we detail verified application fields, specifying compliance benchmarks, formulation guidance, integration steps, and resulting finished products for each industrial segment.

    1. Agrochemical Synthesis: Herbicide Intermediates

    Our 4-Chloro-2,6-Dimethylaniline is widely utilized in the synthesis of selective herbicide active ingredients, notably as a primary amine source in the pre-condensation stage for various aniline-based active esters. This intermediate participates directly in the key amide formation and provides the structural backbone needed for achieving desired weed selectivity and crop safety profiles. Strict residue control and impurity spec analysis are required due to downstream environmental and toxicological registration needs in global markets.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • OECD Guidelines for the Testing of Chemicals
    • US EPA FIFRA (Federal Insecticide, Fungicide, and Rodenticide Act)
    • EU Plant Protection Product Regulation (EC) No 1107/2009

    Typical usage ratio

    • Used at 0.9–1.1 molar equivalents relative to the acid chloride or isocyanate in target syntheses; batch adjustments depend on stoichiometry, yield optimization, and impurity control requirements.

    Downstream process integration

    • Feeds into the amination or condensation tank after intermediate purification; dosed directly with the acid chloride or coupling agent prior to solvent reflux and controlled-temperature reaction for active ingredient formation.

    Final product types

    • Herbicide technical concentrates (e.g., chloroacetanilide herbicides)
    • Emulsifiable concentrates for row crops
    • Wettable powder herbicides for agricultural field spray

    2. Dye and Pigment Manufacturing: Azo Coupling Component

    In dyes and pigments production, 4-Chloro-2,6-Dimethylaniline serves as an essential diazo component for the generation of specialized mono- and bis-azo colorants used in plastics, textiles, synthetic fibers, and inks. The material’s precise substitution pattern enables manufacturers to control lightfastness, heat stability, and shade intensity in high-value pigment dispersions. Good batch traceability and conformance to heavy metal and aromatic amine impurity specifications are required to meet brand owner and regulatory demands for colorant safety.

    Industry compliance standards

    • REACH Regulation (EC) No. 1907/2006 Annex XVII (Aromatic Amines Restrictions)
    • GHS/CLP Regulation (EC) No. 1272/2008 for labeling
    • Oeko-Tex Standard 100 (Textile and Apparel Safety)
    • ISO 9001:2015 Quality Management Systems

    Typical usage ratio

    • Normally dosed at 1.0–1.2 equivalents in relation to the diazotizing agent in coupling tanks; adjusted by desired dye shade and total solids content of pigment paste formulations.

    Downstream process integration

    • Charged into the reaction vessel during the coupling phase after diazotization is achieved under cooled acidic conditions; participates in in-situ precipitation or dispersion steps for pigment paste preparation.

    Final product types

    • Azo dyes for plastics and synthetic textiles
    • Organic pigment dispersions for coatings and printing inks
    • Masterbatch colorants for fiber and polymer compounding

    3. Pharmaceutical Intermediate Synthesis: API Precursor Route

    4-Chloro-2,6-Dimethylaniline is utilized as a regulated starting material and critical building block in the synthesis route of selected pharmaceutical active pharmaceutical ingredients (APIs). Its clean aromatic framework enables direct acylation, sulfonation, or further amination during semi-synthetic drug development. Pharmaceutical manufacturers deploy advanced analytics to verify impurity profiles and ensure compliance with national pharmacopoeia and regulatory filings.

    Industry compliance standards

    • ICH Q7A Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • Ph. Eur. (European Pharmacopoeia) and USP-NF (United States Pharmacopeia)
    • FDA DMF (Drug Master File) submission requirements
    • GMP Certificate for pharmaceutical excipients and APIs

    Typical usage ratio

    • Typically used at 1.05–1.15 molar equivalents per reactant; exact ratio depends on conversion rate targets and calculated API process yield.

    Downstream process integration

    • Fed as a purified intermediate during the primary condensation or substitution steps for core API skeleton construction; added following upstream deprotection or salt formation as required by the route design.

    Final product types

    • Small molecule APIs
    • Pharmaceutical intermediates for further modification steps
    • Bulk drugs for formulation or export

    4. Polymer Additive Production: UV Stabilizer Intermediates

    The compound functions as a foundational aromatic amine in the multistep production of select benzotriazole and hindered amine light stabilizers. These stabilizers protect polymeric materials from UV-induced degradation, extending the operational life and color retention of plastics and coatings. Precautions for migration limits and non-toxic residue levels are critical, especially for applications in food packaging, automotive trims, and outdoor-use polymers.

    Industry compliance standards

    • EU Regulation (EC) No 10/2011 (Plastic materials and articles in contact with food)
    • FDA 21 CFR for indirect food additives
    • EN 71-3 (Safety of Toys – Migration of certain elements)
    • ISO 14001:2015 Environmental Management Systems

    Typical usage ratio

    • Loaded at 1.0 equivalent relative to triazole or functionalized reactants in stabilizer synthesis; can be modulated between 0.95–1.15 equivalent depending on end-user polymer compatibility requirements.

    Downstream process integration

    • Input during the initial amination cycle or condensation phase in the multi-step synthesis of photoprotective additives; incorporated into closed reactors before final purification and particle-size adjustment stages.

    Final product types

    • Light stabilizer additive masterbatches
    • Anti-UV agents for polyolefin, PVC, and engineering plastics
    • Performance coatings for automotive and outdoor furniture

    5. Specialty Chemicals Manufacturing: Aromatic Derivatives

    In the specialty chemicals sector, this material enables the synthesis of functionally substituted aniline derivatives. Its chemical structure is tailored for applications requiring targeted reactivity, including the production of protected amine reagents, corrosion inhibitors, and customized agricultural adjuvants. Producers apply tight control over batch traceability and residual impurity levels to meet diverse customer-specific safety assessments and performance criteria.

    Industry compliance standards

    • ISO 9001:2015 and ISO 14001:2015 certified quality/environmental management systems
    • Custom documentation compatible with specific downstream industry protocols
    • Chemical Registration according to TSCA (US) and REACH (EU)
    • Customer-specific audit requirements for specialty raw materials

    Typical usage ratio

    • Dosed at 0.95–1.1 equivalents as dictated by the synthetic pathway; often fine-tuned per process optimization studies and desired derivative yield.

    Downstream process integration

    • Added to reaction systems for nucleophilic aromatic substitution, reductive amination, or functional group protection; can take place under inert atmosphere in jacketed glass-lined reactors for specialty projects.

    Final product types

    • Corrosion inhibitors for metalworking fluids
    • Protecting group reagents
    • Custom aromatic intermediates for contract R&D
    Free Quote

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    Certification & Compliance
    More Introduction

    Introducing 4-Chloro-2,6-Dimethylaniline: Experience from the Production Floor

    Our Perspective on 4-Chloro-2,6-Dimethylaniline

    Every batch of 4-Chloro-2,6-dimethylaniline that leaves our site represents hard-earned experience and careful execution. Over the years, we have refined the process, and the differences show in the consistency and reliability. We make this isn’t just because demand is growing in various industries, but also because we know how crucial purity, color, and controlled specifications are to downstream applications—especially where tiny deviations can derail an entire run.

    4-Chloro-2,6-dimethylaniline, also known in some circles as 2,6-Dimethyl-4-chloroaniline, emerges as a core intermediate in organic synthesis. Our team often sees requests for this material in fields as varied as dyes, pharmaceuticals, agricultural chemicals, and polymers. In each case, users stress the importance of clear, defined characteristics: a bright appearance, minimal contaminants, and tight control of physical properties. We track these metrics rigorously, appreciating how time spent in the lab translates to ease-of-use for process engineers down the line.

    Specifications: What We Deliver and Why It Matters

    For us, model numbers don’t matter nearly as much as what’s inside the drum. 4-Chloro-2,6-dimethylaniline produced on our lines features a high assay—consistently above 99%—with low moisture and trace impurities below actionable thresholds. We stick to these numbers because we’ve seen too many complaints hit the market due to variable supply quality. Even minor contamination affects catalyst performance or product color, which comes back as rework or, worse, line shutdown.

    Our experience says that material quality is far from trivial. Experienced purchasers tend to run incoming controls on melting point, purity by HPLC or GC, and organochloride content—habits we encourage because they let both sides catch issues before they become losses. This attention to detail raised our supply standard, but it protected customers with tight tolerance needs, such as pigment makers or drug synthesis outfits.

    Consistency Across Batches: Lessons from Repeated Runs

    It’s easy to make a good batch in a lab, but running at scale week after week shows where a supplier’s process really stands. We bring every lot through a proven route, using refined temperature control and staged additions that deter off-spec isomers and unwanted side products. Technicians sample in real time, keeping an eye on color, odor, and any hint of change. Problems often begin subtly—a faint shift in the initial charge, minor contamination in a feedstock—but after years on the floor, we learned to detect issues while they’re still easy to solve.

    Hot weather can threaten color integrity, and holidays stress maintenance routines. Failing to prepare for such cycles can mean material arrives outside customer targets. We schedule extra QA checks after plant shutdowns or during supply chain shifts, because it’s in these windows that most suppliers run into trouble. The habits built over years proved their worth: customer complaints about hue or purity dropped, and long-term partners began to rely on us for their priority runs, not just gap orders.

    End Uses: Beyond the Catalog Listing

    In the dye and pigment sector, 4-Chloro-2,6-dimethylaniline acts as a backbone for key intermediates. The color industry expects material at the required brightness, so we run UV-vis and visual inspections, not just chromatography. Pharmachem users require ultra-pure lots, since residual halides or other aromatics may interrupt downstream reactions. Agrochemical formulators often check not only purity but the nature of trace organics, aiming to avoid off-target crop effects or compliance failures.

    Rarely does a shipment go directly into final production without prior validation. Our technical support group spends much of its time comparing actual samples from different lots against control charts—there’s no generic supply, especially for regulated or reputation-sensitive end markets. This hands-on, high engagement style lets us spot and rectify issues quickly, rather than waiting for feedback through a chain of intermediaries. Direct visibility has driven improvement throughout our facility.

    Comparisons: Standing Apart from Commodity Suppliers

    We get many questions comparing 4-Chloro-2,6-dimethylaniline against other isomers or related anilines. The 2,6-dimethyl groups dampen unwanted side reactions, which pays off during downstream chlorination or diazotization. A straight 4-chloroaniline lacks the double methyl protection, making it more reactive and prone to byproduct formation under harsher conditions. For those who have dealt with sludge in reactors or ambiguous assay reports, the value of high-purity, minimally reactive intermediates becomes clear. We avoid generic offers for price alone—cycles of cleaning vessels and re-qualifying supply cost more in the end than a higher-grade intermediate.

    For us, differences also show up in technical documentation and traceability. Full batch trace, certificate of analysis (COA) with chromatographic details, and measured water content go with every shipment. These documents shouldn’t be afterthoughts—they save days of troubleshooting during a customer’s scale-up. This is not universal in the market, and we frequently receive trial requests from companies frustrated by data gaps from previous suppliers. Openness makes audits easier and shows where improvement is needed.

    Troubleshooting Common Issues: Our Approach

    The most frequent pain points we hear about relate to inconsistent supply quality and packaging failures. Small changes in crystal form or trace contamination can jam automated feeders or produce subtle off-notes, especially in fragrance or pharmaceutical lines. Even seemingly minor mishaps—like a liner shifted during filling or fibers introduced during drum handling—show up fast. We maintain a hands-on team devoted to packaging line audits, as this often catches small issues before they hit a customer’s line.

    Beyond factory checks, feedback loops with users proved invaluable. We treat midstream feedback—about handling, solubility, or color—as a source of process improvement, not just a ticket to close. Sometimes, a run of uncharacteristic clumping reveals a humidity drift in storage or unnoticed carrier contamination upstream. Other times, an unexplained impurity triggers a deeper probe into sourcing practices for key input materials. Solutions arrive through relentless root cause analysis, guided by real-world usage data, not theory. Every incident brings lessons; more than once, improvements inspired by a specific complaint ended up embedded in our plantwide procedure.

    Environmental and Regulatory Considerations

    Strong regulations cover aromatic amines, especially those with halides. Our compliance specialists focus not just on national standards, but also on customer-specific audit requests and rapidly evolving global norms. Batch waste tracks to every shipment, and emissions come under regular scrutiny, with continuous improvement projects targeting both environmental and worker safety metrics. Local community engagement and regulatory site inspections shape ongoing investment in abatement technology and job training.

    Modern procurement teams check not only product specs but also sustainability records. They ask about energy intensity per batch, water use efficiency, and safety performance. We’re forthright about our records, sharing both the successes—energy savings from new heat exchangers, solvent recycling wins—and the setbacks, like lagging on a new air scrubber install. This openness prompts sharper improvements and builds long-term trust.

    Collaborative Development: Working with Customers

    The best suppliers work side by side with development teams at customer sites. Our technical staff join early-stage meetings, listen to new requirements—tighter purity ranges, different packaging sizes, special labeling—and build those adaptations rapidly. We invest in custom filtration and tailored drying steps when a customer’s downstream process reveals specific needs. This isn’t about chasing every request, but about building a feedback-driven pathway from the plant to end-use application.

    Custom runs often begin as trials—a few kilo lots on special grade—moving to full production once the downstream metrics hit target. Our close integration means feedback loops close within the same season, not after a year of waiting and risk. These customizations sometimes translate into new SOPs that benefit even our standard product lines: a sterility wash validated for one client might reduce general contamination risk, or a change in packaging layout can bring added efficiency to other supply chains.

    Supply Chain Reliability: Insights from Years of Operation

    Supply reliability only partly depends on production. We took direct control over sourcing key starting materials years ago, after quality problems during an otherwise smooth period. This vertical integration cut both supply hiccups and pricing shocks, because we see changes upstream before they hit forecasted supply. Sourcing teams keep a steady rotation of secondary suppliers ready, but we favor building robust primary relations with a handful who pass regular audits and traceability checks.

    Logistics remains ever-present in our planning. Packaging lines constantly revalidate weight limits, stacking configurations, and sealing protocols, learning from every near-miss or external recall. Real-time location tracking and temperature monitoring, paired with shipment-level moisture sensors, tell us immediately if an order faces risks. Replacement stock sits staged for loading at peak demand seasons, and we maintain full logistics documentation archives to speed up customs or compliance reviews. Our customers count on real-world shipment schedules and frank updates, even when conditions change.

    Protecting End Products: Downstream Impact

    Chemical intermediates such as 4-Chloro-2,6-dimethylaniline rarely get the spotlight, but their downstream impact is decisive. An error at the intermediate stage can disrupt a whole campaign, with repercussions for end-product compliance, performance, and even finished product recalls. We understand that, for many clients, the difference between acceptable and excellent comes down to how well an intermediate supports process robustness. One run, contaminated by just a few parts per million of an unwanted isomer, might force the rework of barrels of high-value product. We devote significant resources to refining our internal systems to spot and root out such issues before they ship.

    Downstream customers often share details of their challenges. Unusual behavior in a solvent system, viscosity changes, or sluggish downstream yields shed new light on the connections between slight variances in the intermediate and big swings in end-product quality. This long-loop feedback strengthens both our analytical toolbox and our practical response times. Data doesn’t just sit in reports; it returns to inform every round of process optimization.

    Continuous Improvement: Beyond Today’s Standards

    A reliable manufacturer never stands still. Even after reaching a high standard for 4-Chloro-2,6-dimethylaniline, we remain vigilant for better ways to clean reactors, reduce waste, or measure contaminants. Equipment upgrades, method validation, and new test instrumentation drive advances, but the core comes from the workforce’s ideas on what actually works in practice. Operators recommend agitation tweaks and schedule changes that only those hands-on with equipment would suggest.

    Inspection tours—routine and unannounced—find small problems before they spread. A minor filter upgrade recommended by a process tech, a smarter drum sealing method, or a faster cleaning agent have quietly built greater reliability in our output. Kaizen, six sigma, and lean methods all influence our operation, but results flow from listening to what works and discarding what does not. Improvement is a habit, not a project.

    Looking Ahead: The Future of Specialty Intermediates

    Markets evolve. New applications in specialty polymers and advanced agrochemicals linked to 4-Chloro-2,6-dimethylaniline have started to emerge, sometimes with unfamiliar requirements—different solvent handling, unexpected impurity profiles, or demands for faster delivery. We adapt our own standards when these shifts occur, returning often to the basics: Open conversation, deep process knowledge, adaptability to customer constraints, and constant monitoring of our footprint.

    Reputation rests on past delivery, not just on published specs. We collaborate actively with customers as they explore new syntheses, participate in regulatory reviews, and face new environmental or supply chain challenges. This joint approach often uncovers area for improvement even outside our own plant. The focus on real-world outcomes means trial-and-error and human knowledge remain central, guiding the best of what modern chemical manufacturing can offer.

    Summing Up: Commitment in Every Lot

    Every shipment of 4-Chloro-2,6-dimethylaniline represents far more than just a chemical transaction. It’s the product of years of process refinement, joint troubleshooting with users, adherence to ever-tighter regulations, and a commitment to doing the hard work of improvement every single day. Our edge comes from an honest look at what happens between manufacturing and use, and a willingness to keep pushing standards forward. This is what distinguishes makers willing to put their expertise—and their reputation—behind every drum that leaves the gate.