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4-Bromoethylbenzene

    • Product Name 4-Bromoethylbenzene
    • Alias 1-Bromo-4-ethylbenzene
    • Einecs 214-370-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry sales7@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    871808

    Chemical Name 4-Bromoethylbenzene
    Cas Number 3443-16-9
    Molecular Formula C8H9Br
    Molecular Weight 185.06 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 220-222 °C
    Melting Point -22 °C
    Density 1.36 g/cm3
    Refractive Index 1.547
    Purity Typically ≥98%
    Synonyms 1-Bromo-4-ethylbenzene
    Flash Point 94 °C
    Smiles CCc1ccc(Br)cc1
    Storage Temperature Store at room temperature
    Solubility Insoluble in water; soluble in organic solvents

    As an accredited 4-Bromoethylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 250 mL amber glass bottle, tightly sealed with a screw cap, labeled “4-Bromoethylbenzene, 99%”, with hazard and safety symbols.
    Shipping 4-Bromoethylbenzene is shipped in tightly sealed containers, protected from light, moisture, and sources of ignition. Packages must comply with hazardous materials regulations due to its flammable and potentially harmful nature. Proper labeling, documentation, and handling precautions are essential to ensure safe transport and storage throughout the shipping process.
    Storage 4-Bromoethylbenzene should be stored in a tightly closed container in a cool, dry, and well-ventilated area, away from sources of ignition, heat, and incompatible materials such as strong oxidizing agents. The storage area should be clearly labeled and protected from moisture. Ensure proper grounding and bonding when transferring the material to prevent electrostatic accumulation. Store at room temperature and follow all safety guidelines.
    Application of 4-Bromoethylbenzene

    Applications of 4-Bromoethylbenzene in Industrial Manufacturing

    As a manufacturer of 4-Bromoethylbenzene, we supply this specialized chemical intermediate to select industrial sectors where its reactivity and properties deliver crucial functional benefits. Below we present specific application scenarios based on actual customer integration, formulation details, and relevant industry standards.

    1. Agrochemical Intermediate Synthesis

    Major agrochemical producers use 4-Bromoethylbenzene as a building block in the synthesis of complex organic molecules such as herbicide and insecticide active ingredients. Direct alkylation and subsequent functional group transformation steps rely on its high positional selectivity and consistent halogen content for precision molecule construction.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems
    • REACH Regulation (EC) No 1907/2006 (Registration, Evaluation, Authorisation and Restriction of Chemicals – Europe)
    • FAO/WHO Manual on Development and Use of FAO and WHO Specifications for Pesticides
    • Chinese National Standard GB/T 1604 for technical material purity

    Typical usage ratio

    • Applied at a dosage of 3.5–7.0% by mass in active intermediate synthesis, adjusted according to targeted molecular design and scale-up yield optimization

    Downstream process integration

    • Charge occurs during initial reaction stages as an electrophilic aromatic halide for nucleophilic substitution, followed by controls for conversion, purification, and downstream carbamate/chloroacetate coupling

    Final product types

    • Pyridine- and phenoxy-based systemic herbicides
    • Alkylated phenyl insecticides
    • Custom fine chemical actives for crop protection formulations

    2. Pharmaceutical Intermediate Production

    4-Bromoethylbenzene plays a key role in pharmaceutical-grade synthesis, especially in creating selective intermediates for antihypertensive, antifungal, and CNS-active drug compounds. The compound enables specific substitution reactions for the introduction of ethylphenyl moieties, contributing to final API structure and bioactivity.

    Industry compliance standards

    • EU GMP Volume 4 (Good Manufacturing Practice for Medicinal Products for Human and Veterinary Use)
    • ICH Q7 Guideline (Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • United States Pharmacopeia (USP) for related APIs/intermediates
    • Chinese Pharmacopoeia for qualifying incoming chemical intermediates

    Typical usage ratio

    • Added at 2.0–6.0% w/w in targeted synthetic steps, depending on reaction pathways and desired side-chain length in the pharmaceutical intermediate

    Downstream process integration

    • Introduced during Grignard or Suzuki coupling processes; precise handling required for controlled halide transfer and subsequent deprotection, monitored by HPLC and GC-MS

    Final product types

    • Block intermediates for sartans (antihypertensive APIs)
    • Benzyl-ethanol derivatives for antifungal drug synthesis
    • Specialty intermediates for CNS and psychiatric drug APIs

    3. Specialty Polymer & Resin Manufacturing

    The electronic and specialty resin industry incorporates 4-Bromoethylbenzene as a functional monomer source or chain modifier in the synthesis of high-performance polymers. Its ability to precisely introduce a brominated group provides unique flame-retardant properties and enhanced processability in engineered resin compounds.

    Industry compliance standards

    • UL 94 (Flammability Standard for Plastics Materials)
    • RoHS Directive 2011/65/EU (Restriction of Hazardous Substances)
    • IEC 61249-2-21 (Halogen-Free Materials in Electronics)
    • ISO 14001:2015 (Environmental Management Systems)

    Typical usage ratio

    • Typically dosed at 0.8–2.5% by total polymer mass, with adjustments made for the target molecular weight and thermal properties of the final resin

    Downstream process integration

    • Incorporated in the initial copolymerization phase, ensuring bromine distribution within the polymer chain; monitored for residual monomer and compatibility with curing agents

    Final product types

    • Flame-retardant epoxy resins for PCB manufacturing
    • Halogenated polyesters in automotive electrical systems
    • Engineering plastics for heat-resistant enclosures and components

    4. Advanced Organic Synthesis for Fine Chemicals

    R&D and custom synthesis firms depend on 4-Bromoethylbenzene as a precursor in constructing specialty aromatics and biphenyl compounds. Its reactivity allows for specific side-chain modifications, making it essential in the tailored synthesis of advanced fine chemicals for electronics, materials science, and performance additives.

    Industry compliance standards

    • ISO 9001:2015 for laboratory and pilot-scale chemical production
    • National/local environmental emission regulations for solvent and halide management
    • Globally Harmonized System (GHS) for chemical labeling and safety
    • OECD Guidelines for Testing of Chemicals, where applicable

    Typical usage ratio

    • Dosed at 1.2–5.0% by batch mass in fine chemical synthesis, influenced by reaction yield and structure-property requirements of the finished molecule

    Downstream process integration

    • Added during controlled alkylation or coupling reactions; often requires phase-transfer catalyst management and strict control of temperature profile to maintain selectivity and prevent overreaction

    Final product types

    • Electronic-grade biphenyl intermediates
    • High-value performance additives for lubricants and oils
    • Advanced intermediates for dye and pigment synthesis
    Free Quote

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    Certification & Compliance
    More Introduction

    4-Bromoethylbenzene: The Value of Reliable Production in Chemical Synthesis

    The Place of 4-Bromoethylbenzene in Modern Chemistry

    Work inside a chemical manufacturing plant teaches respect for both the simple and the unassuming molecules. 4-Bromoethylbenzene falls right into this category. It doesn’t carry the shiny aura of specialty polymers or the mystique of pharmaceuticals, but its role is steady and crucial. Chemists across industries have used this compound to unlock larger possibilities for synthesis, especially in the pharma and agrochemical fields.

    In our facility, we produce both laboratory and industrial volumes of 4-Bromoethylbenzene. Our model underlines reliability and clarity — every batch matches strict standards. Customers who know what they need count on us for steady specifications, not marketing noise. We keep a sharp focus on purity, homogeneity, and batch-to-batch consistency because even a small deviation means wasted time or failed reactions downstream.

    What Sets Our Process Apart

    Every step in 4-Bromoethylbenzene’s production reflects learning built up over years. Sometimes, buyers ask if a simple process could suffice. In reality, shortcutting costs in aromatic brominations rarely ends well. Uncontrolled exotherms, incomplete conversion, and residual starting material can plague even small volumes. Experience has shown that only careful temperature staging, rigorous control over reagent quality, and solvent selection lead to a clean product with minimal by-product. Our workers know what unchecked side reactions do to purity.

    Many overlook the finer points: after the main reaction stage, residual bromine and side-products stay tough to remove. Our work-up process goes beyond common techniques, using tailored purification protocols. We target impurity profiles that reflect real-world user experience, not just what analytical specs dictate. Our product leaves the plant with residual solvents and impurities far below the common standards in the open market.

    Physical Form, Packing, and Practical Considerations

    Years of handling experience shaped how we approach end user needs. 4-Bromoethylbenzene typically appears as a colorless liquid, but even minor storage mishaps can turn it yellow or degrade purity. Tanks, drums, and bottles must stand up to both chemical compatibility and shipping stresses. We choose containers that hold up against brominated organics and avoid label confusion by implementing a trackable code system that allows traceability back to every batch and raw material lot we’ve handled.

    Unlike brittle solids or hazardous gaseous reagents, this compound ships well if kept dry and cool. Overexposure to air or sunlight isn’t as disastrous as for some other benzylic compounds, but we have learned to keep our storage and shipping conditions vigilant. Reports from customers confirm that avoiding basic contaminants during packing helps keep product color and stability intact—something that gets overlooked in rush jobs or less experienced operations.

    Market Trends and Supply Chain Insights

    Over the last five years, global demand for 4-Bromoethylbenzene hasn’t wavered much, but we've seen a slow climb in applications tied to specialty intermediate synthesis. During COVID-related logistics disruptions, we worked overtime to source reliable raw materials. Quality of bromine fluctuated; sometimes supplies from smaller vendors failed our incoming inspection. We kept up by only buying from sources that sent us full analysis results and met our internal standards, not simply what the supplier claimed.

    Buyers often ask why some drums from newer producers turn up purity data just outside agreed ranges. Consistency comes from control. A single upstream change — like a different grade of benzene or bromine — creates ripples in the finished product. Our approach means holding the whole supply stream accountable, from raw material vetting to final QC. Relationships with raw material producers grow over years; we visit and inspect personally.

    Why 4-Bromoethylbenzene Matters for Downstream Users

    Buyers in fine chemicals rarely use 4-Bromoethylbenzene as an end product. Its real promise lies in making downstream intermediates — especially via Grignard reactions or cross-coupling chemistry. Anyone who spends time optimizing synthetic methods for pharmaceutical candidates or agrochemical actives knows the headaches of dealing with variable starting materials.

    We keep lines of communication open with R&D teams at several major pharma and crop protection companies. Their feedback drives our focus on reducing trace halides, residual aromatic starting material, and water content. Problems in pilot or production-scale runs usually trace back to unpredictable side impurities. By tuning our process controls, we aim to take surprises off their plates. From time to time, a customer will point out a new impurity trend. We respond by adjusting our analytical methods and, if necessary, the purification scheme—not just reporting data that passes paperwork checks.

    Comparison with Other Alkylated Bromobenzenes

    Many ask how 4-Bromoethylbenzene stacks up against more common relatives like 4-Bromotoluene or 1-Bromo-4-propylbenzene. The main difference, which users notice quickly, lies in reactivity and the functional handle that the ethyl group provides. In our labs, the ethyl group offers a balance between steric accessibility and reactivity in C–C bond-forming reactions. It does not offer the extreme volatility of shorter chains or the sluggishness of bulkier groups.

    Those running Suzuki or Kumada couplings find a sweet spot in handling, reactivity, and downstream compatibility when starting from 4-Bromoethylbenzene. Our product supports smoother process development, particularly in cases where downstream functional group tolerance becomes a crucial concern. With toluene analogs, risk of benzylic reactivity or overreaction sometimes hampers selective transformations, while long-chain analogues risk introducing unnecessary complexity or volatility changes.

    We keep feedback collected from our partners in mind: stability in storage, minimization of isomeric impurities, and ease of handling all point toward the ethyl analogue as a preferred starting point for many custom syntheses. Our head technical chemist says it plainly—if unpredictable results crop up with a different bromoalkylbenzene, the ethyl version often corrects the problem.

    Safety, Health, and Environmental Responsibility

    We take safety seriously, not just because regulations demand it but as a matter of pride. 4-Bromoethylbenzene does not pose the most acute toxicity risk among aromatics, but vapor inhalation, skin contact, and potential for spill mishaps never get ignored. We train our operators to treat spills rapidly, contain exposure and keep clear records of safety drills and incident reports. Modern manufacturing requires real vigilance, not just sign-off sheets.

    Our plant invests in emission controls and closed-loop sampling methods. Waste treatment receives careful attention—brominated organic waste can never go into general waste streams. We built professional partnerships with certified disposal contractors and hold ourselves to higher-than-required benchmarks. This long-term thinking avoids downstream pollution and keeps local water and soil safer for the surrounding community.

    On the sustainability front, we pursue solvent recovery and minimize use of single-use plastics in our packing line. Our customers appreciate these steps; a few even benchmark us against others before awarding contracts, using real environmental impact data rather than just survey claims.

    Challenges in Manufacturing and Distribution

    It’s no secret that trading environments have become tougher. Fluctuating bromine prices, labor shortages, and tougher environmental policies pressed our industry hard. Some producers cut corners or relax controls. Our management kept funding for in-house analytical capability and strong plant maintenance — costly, but absolutely necessary.

    Distributors sometimes offer a rock-bottom price sourced through convoluted supply chains. Laboratories come to us after their baseline experiments fail, only to discover a technical grade product with unclear origins or mixed isomers. Our plant’s method aims for identifiers and full traceability. Every bottle, drum, and bulk tank that leaves our facility can be traced back to a clear batch history—no mixing, no cross-filling, and no “gray area” compliance.

    Transparently sharing batch data, MSDS, and support on practical handling issues has served our best customers well. Our commercial team speaks plainly: we concentrate on long-term quality and safety, not one-off price competitions. By focusing downstream consequences, both for lab scale and full-scale manufacturing, we stand behind every shipment long after delivery.

    The View Ahead: Innovation and Better Practices

    Our research team spends real time working on greener bromination and more energy-efficient steps. Though this isn’t the flashiest talk at industry symposia, steady improvements yield less waste and fewer purification bottlenecks year by year. As customer demand shifts toward integrated supply relationships — especially in regulated markets — the ability to deliver on traceability, compliance, and repeatable outcomes matters more than a quick sale.

    From custom batch sizes to purity grades tailored to specialty synthesis, we partner with clients to solve problems at the planning stage, not during troubleshooting. Our technical team visits customer plants, reviews production needs, and gathers data from actual process runs, not just datasheet requirements. The stories we hear guide our incremental process changes far more than any spreadsheet could.

    For those drawing up new synthetic routes, we make our technical team available for planning discussions and shared process reviews. The more context we get from the field, the better we tune our product for actual use cases. That cuts down on both failure rates and unplanned troubleshooting.

    Closing Thoughts from the Manufacturing Floor

    Working daily with 4-Bromoethylbenzene teaches that real value arises not from simple compliance, but from understanding both chemistry and the needs of real users. We see this every day, talking to chemists in process development, environmental managers trying to avoid unplanned waste, and company buyers who need assurance that their materials will not bring surprises.

    Decades in the business have shown us where shortcuts appear, when trouble can arise, and what actually matters in daily chemical manufacturing. Reliable process, clear accountability, and respect for the material itself shape the way we supply 4-Bromoethylbenzene. Prices may fluctuate, and demand may shift, but what users value most — consistency and transparent, knowledgeable support — remains the same.

    If your projects call for reliable, high-purity 4-Bromoethylbenzene, produced using proven, responsible manufacturing, we invite open conversations, not just order forms. The future of chemical manufacturing relies on these real connections, continuous improvement, and a shared commitment to better results at every stage.