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4-Bromo-3-Methylphenol

    • Product Name 4-Bromo-3-Methylphenol
    • Alias 4-Bromo-m-cresol
    • Einecs EINECS 244-710-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    647739

    Cas Number 14348-60-2
    Molecular Formula C7H7BrO
    Molecular Weight 187.04 g/mol
    Iupac Name 4-bromo-3-methylphenol
    Appearance Off-white to pale yellow solid
    Melting Point 84-87 °C
    Boiling Point 259-262 °C
    Density 1.60 g/cm³
    Solubility In Water Slightly soluble
    Smiles CC1=C(C=CC(=C1)Br)O

    As an accredited 4-Bromo-3-Methylphenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle with secure screw cap, labeled "4-Bromo-3-Methylphenol, 25g, for laboratory use," with hazard and safety symbols.
    Shipping 4-Bromo-3-methylphenol is shipped in tightly sealed containers, protected from light and moisture. The package is labeled as hazardous, following all regulatory guidelines. It is transported under controlled temperature conditions to prevent degradation, and handled by trained personnel using appropriate protective equipment to ensure safety during transit.
    Storage 4-Bromo-3-Methylphenol should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances such as oxidizing agents. Protect from moisture and direct sunlight. Proper labeling and secure placement are essential to prevent accidental exposure. Use secondary containment to prevent spills and always follow local regulations for chemical storage.
    Application of 4-Bromo-3-Methylphenol

    Applications of 4-Bromo-3-Methylphenol in Industrial Manufacturing

    4-Bromo-3-Methylphenol serves as an essential intermediate in multiple fine chemical manufacturing processes. Our material supports downstream sectors where precision synthesis and regulatory adherence are mission-critical. Below, we detail prominent applications in real industrial contexts, with technical information relevant to compliant production and finished goods markets.

    1. Pharmaceutical Intermediate for Antibacterial Agents

    Leading pharmaceutical manufacturers employ this compound as a key building block in the synthesis of antibacterial active ingredients, particularly in the preparation of highly selective biaryl ether frameworks. Our production partners optimize its usage to synthesize proprietary molecules used in hospital and veterinary medicines. Reaction steps require careful control of halogen and methyl functionalities for target specificity.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • US FDA 21 CFR Part 210/211 (Current Good Manufacturing Practice in Manufacturing, Processing, Packing, or Holding of Drugs)
    • EU GMP Part II for API production
    • Ph. Eur., USP, JP monograph requirements where applicable to intermediates

    Typical usage ratio

    • Reaction formulas typically apply 1.05–1.15 molar equivalents relative to target coupling species, adjusted based on conversion efficiency and impurity profile.

    Downstream process integration

    • Charged in early-stage Suzuki or Buchwald-Hartwig coupling processes for core antibacterial scaffold assembly, followed by selective functionalization and API isolation.

    Final product types

    • Active pharmaceutical ingredients (APIs) for injectable and oral antibiotic medications
    • Veterinary pharmaceutical compounds
    • Intermediates for specialty anti-infective agents
    • Research-grade biaryl-ether standards

    2. Intermediate in Agrochemical Synthesis

    Agrochemical manufacturers integrate 4-Bromo-3-Methylphenol during synthesis of herbicides and fungicides with phenolic structures. Utilization focuses on introducing the bromo-functional group to fine-tune pesticidal activity or environmental stability. Downstream processing requires careful reactivity management to maximize yield and minimize hazardous by-products.

    Industry compliance standards

    • ISO 9001:2015 for quality management in chemical manufacturing
    • REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals – EU) for raw material registration
    • Integrated Pollution Prevention and Control (IPPC), where chlorinated waste is regulated
    • EPA FIFRA regulatory pathways for pesticide registration (U.S.)

    Typical usage ratio

    • Batch reactions use 0.8–1.2 equivalents depending on the electrophile, often in excess to drive complete coupling for active herbicide or fungicide precursor formation.

    Downstream process integration

    • Used at the step of aromatic ring modification prior to further oxidation or alkylation, enabling synthesis of diverse crop protection agents or seed treatment actives.

    Final product types

    • Phenolic herbicide intermediates
    • Protective fungicide cores for cereal and horticultural use
    • Custom pesticide research samples
    • Seed-coating agent precursors

    3. Raw Material for High-Performance Polymer Production

    Chemical manufacturers specializing in high-performance polymers deploy this compound in the synthesis of engineering plastics and advanced resins, where a brominated methylphenol monomer introduces critical flame retardancy and enhances thermal stability. The material enters resinification or copolymer synthesis steps, requiring precise dosing to achieve specific polymer architecture and physicochemical traits demanded by electrical and electronic component molders.

    Industry compliance standards

    • UL 94 Flammability Standards for Plastics
    • IEC 60695-11-10 Fire Hazard Testing
    • RoHS Directive (Restriction of Hazardous Substances) for electronic material safety
    • ISO 14001 for environmental management in chemical process industries

    Typical usage ratio

    • Copolymer blends contain 5–12% by weight for targeted flame resistance; specific addition rate depends on required V-0/V-1 rating and material compatibility.

    Downstream process integration

    • Integrated into step-growth polymerization or reactive extrusion stages before compounding and molding into electrical or electronic housing parts.

    Final product types

    • Flame-retardant plastic housings for consumer electronics
    • Circuit insulation boards
    • Industrial encapsulation resins for automotive and energy
    • Wire and cable jacketing materials

    4. Intermediate for Dyes and Specialty Pigments

    Our material is utilized by colorant and pigment producers for synthesizing brominated phenol components, which enable the manufacture of high-purity azo and anthraquinone dyes. Its selective halogenation facilitates downstream coupling reactions crucial for labile color formation, especially in textile, leather, and plastics dyeing applications. Production batches require rigorous control over isomer ratio and residual impurities to meet international colorfastness criteria.

    Industry compliance standards

    • OEKO-TEX Standard 100 for textiles
    • EU REACH Annex XVII for restricted aromatic amines
    • ISO 105-E04:2013 (Textile colorfastness)
    • CII (Colour Index International) pigment registration

    Typical usage ratio

    • The applied dosage ranges from 1.3–1.6 molar equivalents relative to diazotized amines, with exact ratios chosen based on target dye series and end-use substrate compatibility.

    Downstream process integration

    • Introduced during intermediate coupling for halogenated dye synthesis, followed by purification and formulation into concentrated pigment pastes or dispersions.

    Final product types

    • High-purity textile dyes
    • Plastic colorants for packaging film
    • Industrial pigment dispersions for coatings
    • Leather treatment dyes
    Free Quote

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    Certification & Compliance
    More Introduction

    Introducing 4-Bromo-3-Methylphenol From Our Plant

    Consistency, Experience, and Real-World Value

    Quality always tells its own story. Over the years, we’ve poured everything we know into producing 4-bromo-3-methylphenol, recognizing its unique role in specialty synthesis and beyond. Our familiarity with this compound runs deep. Each batch reflects our hands-on commitment to tighter process controls, right from the raw materials to rigorous, practical testing. The outcome isn’t only purity and reliable specifications; it’s the confidence that comes with knowing exactly where something comes from and how it behaves beyond the lab.

    Core Specifications and Process Control

    Every process step matters when handling halogenated phenolic compounds, and 4-bromo-3-methylphenol is no exception. With the molecular formula C7H7BrO and a CAS number widely recognized in chemical directories, this compound demonstrates stable behavior under standard storage and transportation. For research, fine chemistry, agrochemicals, and pharmaceutical intermediate applications, a high-purity product reduces variables for the users down the line. We continuously refine filtration and crystallization techniques. In our experience, even minor improvements here can drive yield performance and downstream quality for customers who treat their syntheses as seriously as we treat ours.

    Application Insights Rooted in Production

    Demand for 4-bromo-3-methylphenol comes mainly from laboratories and industrial workshops where curiosity meets purpose. Our product supports teams developing new crop protection agents, pharmaceutical building blocks, and colorants. It’s used as a starting point for Grignard reactions, Suzuki coupling, and other halogen-based transformations. We’ve seen how predictable melting point and solubility profiles help operators set up downstream reactions with fewer surprises. Our technical team tracks every production run, logging subtle differences in batch viscosity or color that only seasoned eyes recognize. These details build a body of knowledge, helping us make modifications that tight-lipped specification sheets might miss.

    What Sets Us Apart From Blanket Resellers

    Lab-scale chemists and large manufacturers visit us because we don’t only ship product. Our technical exchange starts far before the drums hit the dock. Years of producing halogenated aromatics have taught us how solvent selection influences residue content and how a slightly altered crystallization temperature can lead to mixed isomers if not carefully controlled. First-time buyers often ask for generic comparisons. We answer with process logs, not generic claims. Many providers push 4-bromo-2-methylphenol or 2-bromo-4-methylphenol as functionally similar, but reaction outcomes often hinge on those precise substituent positions. Even a shift from the para to the meta position can affect reactivity in electrophilic substitutions or subsequent coupling reactions. Our manufacturing notes, enriched by routine feedback from front-line lab workers, reflect the compound’s real-world behavior.

    Purity and Traceability Aren’t Afterthoughts

    OEM partners regularly ask about trace metals, residual solvents, and impurities that would never appear on a casual “specification” flyer. To us, those questions are familiar and valid. We track impurity profiles batch by batch. Raw material origins, tracing of brominating agents, and heat kinetics are documented for every lot we ship. The difference for production chemists can be night and day: fewer unexplained side products, less downstream cleanup, greater yield accuracy. Our facility hosts a regular rhythm of process audits—not as a regulatory checklist, but as a way to teach new team members and refine old habits.

    Lessons From Daily Production

    Taking shortcuts with phenolic intermediates always leads to trouble. We’ve learned this on the floor, not from text. For 4-bromo-3-methylphenol, incomplete bromination sneaks up as off-color material and unpredictable HPLC profiles. We incorporated multi-stage filtering rigs after early problems appeared, and we integrated inline detection systems to spot isomeric drift before the product leaves the crystallizer. Open process logs let us compare seasonal or supplier variations in precursor quality, and years of working with local analytical labs means we respond to contamination or inconsistency reports fast—not waiting for end user feedback before acting.

    Addressing Needs the Right Way

    Procurement officers and R&D teams seek more than introductory QC reports—they look for process assurances rooted in daily practice. For 4-bromo-3-methylphenol, we document strict segregation of brominated and non-brominated lines to avoid cross-contamination. Regular column chromatography and GC-MS checks flag low-level impurities nobody wants to address in late-stage synthesis. Material safety assessments come straight from the shop floor, with our operators logging air quality and personal exposure on site. Our customer feedback doesn’t disappear into filing cabinets. We forward questions or complaints to our production supervisors, and those updates inform maintenance or process changes on the next cycle.

    Differences That Matter—Structure, Reactivity, and Practical Use

    Many buyers explore similar phenolic derivatives—like 2-bromo-4-methylphenol or non-brominated 3-methylphenol—as options when a single supplier quotes an impossible lead time. The reality we share is concrete: the position of the methyl group and bromine atom drives both physical and reactive profiles. In Grignard formation, for instance, the meta position on our 4-bromo-3-methylphenol product stabilizes intermediate species in a way that others don’t. That creates smoother product handling, especially in processes where fine-particle filtration is involved. Our experience backs up textbook statements; minor molecular shifts can cause headaches, even in seemingly peripheral characteristics like melting behavior, boiling onset, and solubility against common solvents.

    Laboratory conversations often drift toward interchangeability—substituting one bromophenol for another or running pilot batches with an available isomer. We’ve witnessed the waste and frustration these “shortcuts” can trigger. Unrelated bystanders rarely account for the subtle shifts in thermal stability or unwanted chlorination patterns that emerge when moving between isomers. For industrial clients planning months ahead, this matters as much to the bottom line as it does to regulatory or EHS teams. Our plant-wide focus on outcome-driven adjustments means we don’t gloss over differences as an inconvenience for the end user. We document, communicate, and incorporate each lesson, making sure our clients operate from a position of certainty.

    Downstream Impact: Safety and Compliance in Practice

    Shipping regulations and local compliance for halogenated organics are only part of the safety equation. Actual on-site handling drives much of our learning. Our material leaves the plant labeled and accompanied by practical handling instructions drafted from years on the shop floor. For 4-bromo-3-methylphenol, safe storage at ambient conditions, away from active oxidizers and in sealed, moisture-free packaging, preserves both product integrity and operator safety. Regular drills and staff education sessions—rooted in our own incident logs—go into shaping the safety culture behind each shipment.

    We’ve worked with field users to develop protocols for accidental spills, waste disposal, and reactive cleanup, all tied closely to the unique properties of this compound. The takeaway always circles back to familiarity: staff who understand the chemistry behind their tools spot problems earlier and handle routine situations with less risk. We share this practical knowledge directly with our partners, recognizing that no two sites operate under identical constraints.

    Meeting Evolving Needs Without Cutting Corners

    Markets change, and so do end uses for intermediates like 4-bromo-3-methylphenol. The drive to formulate more selective pharmaceutical intermediates and biologically active agents has steadily increased demand for high-purity, precisely-structured halogenated phenols. In response, we’ve invested in modernizing filtration setups and adding remote-monitoring for every distillation run. Short-term efficiency gains never justify long-term compromises to product consistency. We favor incremental process tweaks—such as tweaking solvent flow rates or recalibrating temperature profiles—based on running commentary from our production staff. Their feedback identifies trends long before statistical analyses or late-stage QA cycles would.

    Beyond the Bottle: Supporting Practical Innovation

    Customers with the most demanding requirements often bring us their process complications and ask for suggestions. We don’t shy away from sharing what we see in our own production or from passing on cautionary tales. If scaling up exposure windows or ambient storage causes subtle color shifts or batch-to-batch melting point drift, we document it. Sharing our operational notes helps real-world developers avoid setbacks, whether scaling up for process validation or tweaking a research workflow. For the newer breeds of API or precision agricultural compounds, this hands-on experience often outweighs generic “technical support” from arms-length resellers who never set foot in the plant.

    Adapting to Tomorrow’s Requirements

    Sustainability and regulatory oversight have redefined what constitutes responsible chemical manufacturing. Our approach to 4-bromo-3-methylphenol builds on a continuous improvement cycle. We re-examine water usage, solvent recycling, and material handling with each audited shipment. Recent years pushed us to explore alternative brominating agents when supply interruptions hit the market. Our in-house chemists dropped standard one-size-fits-all approaches and piloted new, less hazardous reagents without sacrificing product reliability. This direct experimentation reshaped not only costs but also environmental impact. We don’t insulate process development from the realities of the shop floor. Everyone from the apprentice tech to the shift supervisor has a voice in tools, processes, and safety workflows.

    Our operational improvements stem as much from regulatory encouragement as from site-driven initiative. Familiarity with emerging reporting frameworks helps us remain transparent with customers and auditors alike. We see the benefit: transparent process documentation and hands-on improvement reduce the risks of recalls, shipment delays, or compliance disputes downstream. Every lesson, whether learned through process audits or post-shipment feedback, reinforces our commitment to consistent, reliable delivery and tightly documented provenance.

    Traceable Experience Backed by Direct Practice

    One detail distinguishes producers from mere suppliers: living with the consequences of each process adjustment. We’ve spent years revising bromination reaction times and precursor selection precisely because every modification echoes into the product, from stability over time to solubility in field-use applications. Our plant history carries dozens of case studies—what actually worked and what led us back to the drawing board. For partners relying on 4-bromo-3-methylphenol as a cornerstone intermediate, this lived experience doesn’t only mean a safer, more predictable product. It means greater flexibility and real troubleshooting support when a new regulatory requirement or unexpected application reveals a new challenge.

    Practical Solutions to Everyday Problems

    Supply chain shocks, if left unaddressed, disrupt not only pricing but also consistent quality. We’ve faced supplier interruptions and surging demand, forcing us to re-qualify alternative raw materials more than once. Through it all, our answer has always involved granular batch documentation and open communication with our stakeholders. No customer likes unexpected lead times or unexplained property shifts, so we escalate every outlier, relying on a mix of internal checks and outside verification to avoid selling uncertainty. Our ability to stabilize outputs in rough market cycles comes less from algorithm-driven planning and more from practical process memory—getting the batch right, documenting materials, and keeping an eye on both established and emerging sources.

    This approach informs our entire product cycle for 4-bromo-3-methylphenol. We adjust supplier vetting, train plant staff on the chemistry of raw input variability, and keep backup plans in motion. The product that results benefits from every difficult season, every batch that failed to live up to our expectations before being corrected or replaced. Our regular end users know this record, and many of them have visited the plant, watching us troubleshoot issues firsthand. Genuine relationships and open process documentation build real business memory—something off-the-shelf distributors rarely understand.

    Long-Term Partnership Challenges and Our Response

    Large-quantity buyers bring expectations and face risks that differ from the R&D crowd. Sourcing 4-bromo-3-methylphenol by the ton brings new logistical and technical hurdles—container integrity, bulk transfer risk, long-haul transport conditions, and spoilage. We’ve learned—from loading dock accidents to customs delays—that attention to environmental and physical hazards can’t be outsourced. Every training session is born from a past incident. We continue tightening the way we label, pack, and heat-seal drums, and we stay in regular dialogue with bulk transport providers—learning from each overlap where things go smoothly and where they don’t.

    We capture these hard-won lessons in our standard training and safety updates, not as window-dressing, but as tools that protect real people using our materials around the globe. Our clients—formulation chemists, operations managers, and regulatory affairs teams—use these updates to train their own staff about handling and storage risks, translating our decade-plus of production feedback into day-to-day improvements in their own shops.

    Supporting Innovation With Direct Input

    Research partners wrestle with unexpected challenges: regulatory changes, evolving method development, new impurity thresholds. Some innovators circle back to us after building a project around the reliable nucleophilicity of 4-bromo-3-methylphenol, only to run into unforeseen hurdles. We listen, review their data, and—when possible—test scenario tweaks on our own pilot lines. Adjusting solvent ratios, cycling through filtration options, or trialing cleanup protocols are part of our joint toolkit. This collaborative improvisation stems from our own history; we’ve walked the same uncertainty road, logged the setbacks, and learned that practice always trumps theory in the field.

    By continually refining our processes based on these partnerships, we feed improvements back into mainstream production, blurring the line between R&D and commercial-scale manufacture. We advise researchers on optimizing storage, maximizing shelf life, and even choosing compatible initiators for late-stage synthesis. Over time, these small nudges help sharpen the final product—making new therapies, better crop protection agents, and more sustainable chemical tools a step closer to reality.

    Final Reflection: Experience Delivered

    Everything we know about 4-bromo-3-methylphenol stems from getting our hands dirty, working through each challenge, and constantly improving product and processes. Each bag, bottle, or drum shipped carries with it not just a commodity but the daily labor of our staff. It serves the researchers, the industrial chemists, and the developers aiming to make something better—each relying on transparent, adaptable, and predictable building blocks. For us, the mark of a successful product isn’t just meeting an analysis spec; it’s seeing our partners convert that consistency into real progress in their own fields.