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4-Bromo-3,5-Dimethylphenol

    • Product Name 4-Bromo-3,5-Dimethylphenol
    • Alias 4-Bromo-3,5-xylenol
    • Einecs 259-663-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    774916

    Chemicalname 4-Bromo-3,5-Dimethylphenol
    Casnumber 135-98-8
    Molecularformula C8H9BrO
    Molecularweight 201.06
    Appearance White to off-white crystalline solid
    Meltingpoint 94-96°C
    Solubility Slightly soluble in water; soluble in organic solvents
    Density 1.52 g/cm3 (approximate)
    Synonyms 4-Bromo-3,5-xylenol
    Pubchemcid 8654
    Smiles CC1=CC(Br)=C(C=C1C)O
    Storageconditions Store in a cool, dry, well-ventilated area

    As an accredited 4-Bromo-3,5-Dimethylphenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The packaging is a 100-gram amber glass bottle, tightly sealed, labeled with hazard symbols and the name "4-Bromo-3,5-Dimethylphenol."
    Shipping 4-Bromo-3,5-Dimethylphenol is shipped in tightly sealed containers to prevent contamination and moisture ingress. It should be handled according to standard chemical safety protocols, stored at room temperature, and transported as a non-hazardous material unless otherwise classified. Appropriate labeling and documentation are provided to ensure regulatory compliance during shipping.
    Storage 4-Bromo-3,5-dimethylphenol should be stored in a tightly sealed container, away from light, heat, and moisture. Keep it in a cool, dry, and well-ventilated area, separated from incompatible substances such as oxidizing agents. Proper chemical labeling and access restriction are essential. Follow all relevant safety and regulatory guidelines for safe handling and storage of hazardous chemicals.
    Application of 4-Bromo-3,5-Dimethylphenol

    Applications of 4-Bromo-3,5-Dimethylphenol in Industrial Manufacturing

    4-Bromo-3,5-Dimethylphenol serves as an essential intermediate in several specialized industrial sectors, especially where controlled halogenation and phenolic structures are critical. Our manufacturing expertise enables consistent quality and supply for varied downstream applications. Below are real-world scenarios describing how our material integrates into customer processes and finished goods.

    1. Pharmaceutical Intermediate for Antibacterial Agent Synthesis

    Our 4-Bromo-3,5-Dimethylphenol supports pharmaceutical manufacturers in the synthesis of specific phenolic antibacterial agents. Companies utilize it in the preparation of advanced intermediates, particularly where selective bromination affects compound activity and pharmacokinetics. Production lines incorporate this raw material during the key coupling step for diaryl ether frameworks or related structures. Our technical team provides support in adapting to scale-up parameters, ensuring that purity and trace impurities meet stringent regulatory checks throughout the process.

    Industry compliance standards

    • Complies with current Good Manufacturing Practice (cGMP) as per ICH Q7
    • Ph. Eur., USP, and JP monograph specifications for phenol derivatives (where applicable)
    • Rigorous impurity profile evaluation as required by EMA and FDA guidelines
    • GLP-compliant documentation available for preclinical batch requirements

    Typical usage ratio

    • Used at 0.5 to 1.2 molar equivalents relative to the main pharmacophore precursor; ratio adjusted based on target molecule and specific synthesis route

    Downstream process integration

    • Introduced at the coupling or nucleophilic aromatic substitution step, after core scaffold assembly and before final deprotection or purification

    Final product types

    • Active pharmaceutical ingredients for topical antibacterial formulations
    • Semi-synthetic phenolic antibiotics
    • Key intermediates for finished regulated pharmaceutical products

    2. Specialty Intermediate in Agrochemical Synthesis

    Producers of specialty agrochemicals use this compound in the manufacture of selective fungicides and growth-regulating agents. The halogenated aromatic structure enables targeted synthesis pathways, allowing tight control of molecular substitution patterns crucial for biological activity. We support commercial-scale integration and provide consistent lot-to-lot quality that aligns with downstream process validation requirements.

    Industry compliance standards

    • FAO/WHO Specification 2022 for Technical Grade Agrochemical Intermediates
    • ISO 9001:2015 certified manufacturer operations
    • Residue and impurity controls meeting OECD TG 501 and 502 testing guidelines

    Typical usage ratio

    • Applied at 10–30% by weight in multi-step reaction blends; optimization based on final compound yield and substitution strategy

    Downstream process integration

    • Added after base-catalyzed phenol activation in heterocyclic ring closures or C–O bond formations for thiophene or pyrazole-based agrochemicals

    Final product types

    • Fungicidal active ingredients used in crop protection
    • Growth regulators for specific fruit and vegetable applications
    • Precursor chemicals for pesticide intermediate manufacturing

    3. Intermediate for Performance Coatings and Resin Additives

    Industrial formulators leverage the compound as a building block for engineered resin systems demanding stability under harsh chemical exposure. It often enters as a substituted phenol monomer to enhance crosslinking density and chemical resistance in specialty epoxy and phenolic coatings. Our product supports batch consistency and precise feedstock characteristics for high-process control environments in coatings manufacture.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006 for raw material registration
    • ASTM D543 for chemical resistance testing on final coatings
    • ISO 12944 for corrosion protection in paint and coatings

    Typical usage ratio

    • Blended at 2–6% by resin weight in advanced phenolic resin formulations; levels varied based on desired thermal and chemical stability of coatings

    Downstream process integration

    • Introduced post-polymerization into resin blends during pre-cure mixing, enabling even incorporation before catalyst or curing agents

    Final product types

    • Chemically resistant tank linings
    • Protective coatings for process equipment and pipelines
    • High-performance circuit board laminates

    4. Synthesis Aid in Specialty Electronic Material Manufacturing

    Manufacturers producing high-purity specialty chemicals for electronic substrates employ this molecule in developing photoactive layers and insulating films. The controlled substitution pattern allows precise tuning of optical and dielectric properties, which is critical in advanced printed circuit board and microelectronic applications. Our facility ensures ultra-low metal content and trace analysis certification for this segment.

    Industry compliance standards

    • SEMI C93 standard for photoresist raw materials
    • IEC 61249 for materials in electronic base substrate production
    • RoHS Directive 2011/65/EU on heavy metal and halogen control

    Typical usage ratio

    • Used at 1.5–4% by solid content in formulated photoresist and insulator blends; specific dosage determined by optical density and breakdown voltage requirements

    Downstream process integration

    • Solubilized in pre-mix solutions prior to final casting or coating on substrates; downstream processes include thermal crosslinking and patterned etching

    Final product types

    • Photolithographic resists for microcircuit manufacturing
    • Dielectric films for multilayer PCBs
    • Insulating varnishes with enhanced stability

    5. Intermediate for Industrial Biocidal Formulations

    Producers of industrial-use biocidal additives employ this halogenated phenol in the design of treatment formulations for material preservation, particularly in water-based systems. Its effectiveness in microbial inhibition arises from the bromo-substituted positioning, providing customers with targeted toxicity profiles and long-term durability within approved use cases. Our process controls ensure minimal impurities that could otherwise compromise downstream antimicrobial performance.

    Industry compliance standards

    • BPR (EU Regulation 528/2012) for biocidal product registration
    • EPA 40 CFR Part 158 Data Requirements for Antimicrobial Pesticides
    • ISO 22196 for measuring antibacterial activity on treated surfaces

    Typical usage ratio

    • Integrated at 0.1–0.25% by weight for industrial water preservatives and 0.05–0.2% in surface protectant formulations; adjusted based on regulatory limits and spectrum of action

    Downstream process integration

    • Dosed in masterbatch or concentrate stage prior to blending with bulk product; homogenization ensures consistent distribution for long-lasting effect

    Final product types

    • Wood preservation agents for industrial timber processing
    • Cooling tower and industrial water circuit biocides
    • Antimicrobial surface coatings for HVAC and building materials
    Free Quote

    Competitive 4-Bromo-3,5-Dimethylphenol prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

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    Certification & Compliance
    More Introduction

    Understanding 4-Bromo-3,5-Dimethylphenol: Experience from the Production Floor

    The Character of 4-Bromo-3,5-Dimethylphenol

    4-Bromo-3,5-dimethylphenol stands out among intermediates we produce here at our facility. Many years of handling similar halogenated phenolic compounds have highlighted the unique touchpoints this compound brings to both specialty synthesis and downstream applications. Skipping technical jargon for the facts that matter, this product’s distinctive profile owes much to its methyl substituents, which tweak reactivity and lead to less side-product formation during synthesis. In practical work, a cleaner profile translates into faster purifications and richer yields, both valuable for manufacturers and end users.

    The Experience Behind Production

    Our team has spent countless hours refining the conditions for reliable, scalable production of 4-Bromo-3,5-dimethylphenol. With its structure, it’s easy to fall into the trap of over-bromination or unintended oxidative byproducts. Years back, we ran into this firsthand. Careful control of reaction temperature and the use of freshly distilled solvents made all the difference. Since then, batch consistency remains solid, and reactivity stays on point.

    Translating lab methods to plant scale always brings surprises. Solubility and handling characteristics change along with volume—it’s not just about repeating a recipe. A small shift in mixing speed or feedstock quality can snowball into more persistent clogs, fouling, or crystallization issues. Our on-site team monitors every run and adjusts technique in real-time. This kind of hands-on experience prevents costly downtime and provides a product that meets the repeatability demanded by research and industrial clients.

    Physical Structure and Model Insights

    This compound, with its symmetrical methyl groups paired against a single bromine, brings a rare sort of stability among comparable bromo-phenols. Crystallization occurs rapidly and forms solid, manageable particles, which allows easy further handling. On the operational end, this contributes to predictable behavior in packaging and shipping, something our logistics crew appreciates. Compared to other phenol derivatives, spill and powder management remains less troublesome with this model—less dusting and minimal static cling during bagging.

    Difference in Specifications: Purity and Form Matter

    Having run a range of phenolic intermediates over the years, quality often traces back to purification technique. With 4-Bromo-3,5-dimethylphenol we’ve found that HPLC consistently detects a lower level of process impurities compared with other bromo phenols. Residual halides and methylated byproducts tend to be more persistent in single-step syntheses used by some market competitors. We prefer a two-stage purification, even though it’s more labor intensive. This discipline keeps batch-to-batch purity fluctuations out of the equation and streamlines the downstream workflow for formulators using our output.

    Another noticeable difference here comes from optimizing particle size and moisture control. Moisture sticks around easily in phenolic products, and we invested in new drying infrastructure to bring moisture levels down by almost a full percent over older processes. Why does this matter outside the lab? Customers working in fine chemical manufacture—or electronics, for that matter—see better reaction yield and avoid cake formation in their feeders. That’s one headache we’d rather eliminate before shipping out.

    Why the Specifications Reflect Real-World Performance

    We’re a company that does its own packing and shipping right on-site. There’s firsthand knowledge of where materials break down in transport, what settles out in a drum, and which products clump over time. Our in-house protocol checks include not just bulk purity but also storage resilience under daily temperature swings—simple, logical steps, but they save the end user major hassle. Experienced engineers here remember early failures when some batches lost flowability in transit, or started picking up atmospheric moisture at the warehouse docks. Every procedural improvement is written in the operating manual, ready for the next production cycle.

    Handling experience tells us that not every end user needs high-purity, food-grade material. Many industrial partners simply want a consistent blend of reliability and cost efficiency. With this product, we dial in for fine chemicals, biocides, or resin intermediates, never losing focus on realistic expectations. Technical data stays transparent; we never fudge the numbers to chase more market share. Honest feedback with our customers sharpened these standards and led to real-world advances that no desk analysis could match.

    4-Bromo-3,5-Dimethylphenol Uses: What the Field Teaches Us

    Over the past decade, our plant has produced thousands of kilograms destined for fields as diverse as specialty polymer additives, microbiological controls, and active pharmaceutical intermediates. Each use case brings its own set of demands. Clients in the resins sector value the precise melting point and clean handling. Their own extrusion steps run smoother, saving cleaning time and waste. Product managers in the agrochemical business focus on consistent reactivity; any lot-to-lot differences ripple through complex synthesis routes, and our tightest-spec lots have reduced their raw material loss margins noticeably.

    Some laboratories prefer the particle size as it helps in accurate weighing and rapid dissolution in nonpolar solvents. Colleagues from life sciences appreciate that chromatic and unknown organic impurities—often present in less carefully produced alternatives—barely register compared to the more typical, broad-spectrum bromophenols. This single benefit has led several QA technicians to switch suppliers after experiencing fewer re-filtration steps in their own pilot labs.

    Fine chemical synthesis often leans heavily on minor differences others overlook. The ortho/para methyl pattern plays a quiet but profound role, giving this molecule a reactivity edge in Suzuki coupling or selective halogenation. That’s not a sales pitch; that’s the practical verdict of experienced bench chemists. Downstream, these subtleties return dividends in lower by-product ratios and easier post-processing, whether in pharmaceuticals, polymers, or niche dyes.

    What Sets it Apart from Other Bromo-Phenols

    Several competing intermediates have similar melting points and room-temperature stability, but their chemical nuances show up during handling and conversion. Consider 4-bromophenol: while widely used, it sometimes triggers oxidative browning if stored too long. More heavily methylated phenols trade off solubility for increased hydrophobicity, complicating downstream formulation. Our staff have tested rows of alternatives across pilot scale-ups. The bromo substituent on our product yields high selectivity during coupling reactions, reducing clean-up time and improving overall throughput for industrial partners.

    Operators on our lines note that dusting levels are more manageable during dispensing. This might not stand out in a datasheet, but anyone who has operated filling and weighing equipment knows lost yield adds up over the months. Simple process changes, noticed only through hands-on work, ensure the product lands safely and completely – not stuck in filters, not dumped as sweep-up.

    Core Value for Downstream Manufacturing

    Engineers who run continuous flow equipment tend to praise the consistent melting and resolidification qualities of this phenol. Unwanted foaming or caking has dropped since our shift to more precise process control two years ago. Material loss during reworking almost vanished; each hour saved gets fed right back into more consistent plant uptime. This isn’t an abstract benefit either—it lowers overtime, reduces shift overruns, and ultimately cuts costs for everyone further down the chain. Less cleanup, less waste, less stoppage.

    Technicians in the field give prompt feedback on clogging, solution stability, and filter-blinding, and every batch documentation loop completes with those notes in mind. With other phenols, subtle differences in crystal habit can lead to headaches during solvent transfer or filtration; here, we track everything from lot granularity to re-solubility, based on customer outcomes and our own practical runs. 4-Bromo-3,5-dimethylphenol rarely fails to meet those process-driven needs.

    Reasons for Growing Adoption Across Industries

    The use of 4-Bromo-3,5-dimethylphenol increased not because of a marketing push but through genuine, user-driven demand. Across our own production history, this results from learning through setbacks along with successes. Real-world supply chain disruptions tested our capacity, and years of close work with raw material partners have led to robust procurement routines. Whenever spot shortages hit, we keep backup lots on hand and communicate openly with customer operations staff. In a field where price swings and logistics headaches are difficult to avoid, a steady hand and transparency earn more trust than any sales push ever could.

    Complex syntheses in the fine chemical sector, as well as electronic applications, often demand stronger process control and higher reproducibility. Colleagues at synthesis plants have commented that switching to our product simplified their yield calculations and quality checks. Downstream regulatory compliance checks become easier too, as batch certifications match reality, not optimistic best guesses. We track every lot by both analytical result and production run history, and this accountability forms the real backbone of customer confidence.

    How Feedback Drives Process Changes

    Shop floor feedback helped iron out early kinks in product consistency. Maintenance staff pointed to certain pieces of legacy equipment—dryer faults and screen blockages caused by insufficient temperature ramping or cooling. These minor issues can escalate quickly, and sticking to tight process parameters ensures each batch comes out within the defined moisture and particle limits. Problem-solving here involves everyone from dispatchers to shift supervisors, not just lab analysts poring over batch sheets.

    Plant upgrades aren’t just about automation or new investments; the root comes from lessons in stumbles and solving them as a team. We learned that operator training makes all the difference. A missed temperature setpoint or slight drift in bromine concentration, caught early, prevents a week’s worth of rework. Every updated standard procedure finds its roots in these operational realities.

    Supporting Sustainable Production

    Sustainability sits as a practical goal for any modern chemical operation. Producing 4-Bromo-3,5-dimethylphenol without excess energy waste or unnecessary reagents means lower operating costs and less environmental load. Not every chemical plant is built the same way, and we inherited older assets that weren’t always efficient. Through regular upgrades and efficiency drives, steam and solvent use dropped, and closed-loop recovery improved. Local environmental controls have grown tighter, and we adjusted venting and scrubbing to keep neighbors satisfied along with compliance inspectors.

    Much of this progress comes from people who have worked the lines for more than a decade. Their practical improvements—improved solvent recovery, heat exchange balancing, and smarter scheduling—help meet the demand for a cleaner footprint. The residue that leaves the plant today is lower in both mass and toxicity compared to earlier years, directly benefiting those living and working near the site.

    Safety and Handling Built From the Ground Up

    Safe handling comes from daily experience, not just safety data sheets. The way this compound interacts with common lab and plant materials—stainless steel, glass, PTFE—has caused fewer headaches in pipework and transfer hoses compared to stickier or more corrosive alternatives. Localized training helps avoid skin or inhalation contact, but practical engineering controls stand as the main defense. Every technician new to the site learns quickly the differences between this product and bulkier, more dust-prone phenols.

    Because we run integrated operations, storage and packing methods adapt to the practical hazards presented. Drying upgrades, improved air handling, and staged bulk delivery cut down exposure risk and product loss. Forklift operators, warehouse staff, and on-shift supervisors all contribute to safe workflow, and recurring review keeps incidents low.

    Partnering in Application Development

    We understand that the true value of 4-Bromo-3,5-dimethylphenol doesn’t end at the plant gate. Development teams on both sides regularly troubleshoot real-world problems—solubility shifts, coupling side reactions, impurity drift—finding ways to reduce post-processing needs or switch to more cost-effective steps. Feedback from small-scale users has sharpened our screening and lot release tests. Issues that slip by standard lab checks often surface in tricky pilot runs; a close working relationship with those customers means we quickly spot and resolve the unexpected.

    Research teams sometimes need tight technical support, and experienced staff step in to share not just specifications but field-tested solutions. This ongoing exchange closes gaps that data sheets alone never catch. Several process tweaks introduced over the years—altered drying temperatures, adjusted filtration rates—came straight from hands-on problem solving by people who both run the plant and engage with users daily.

    Looking Ahead: Meeting New Industry Demands

    The chemical manufacturing landscape does not stand still. Regulatory standards shift, new competitors arise, and every customer spectrum—from seamless, continuous-feed production to precision laboratory applications—expects performance above baseline. As more of our clients push into advanced materials and electronics, consistency, traceability, and reliable performance grow in importance. The trend shows a rising preference for lower-impurity raw materials, better logistics responsiveness, and traceable lot histories that document not just chemistry, but production practice as well.

    We prioritize listening to those who handle, react, and transform our product in their own setting. Scaling up or changing synthesis routes, users count on feedback that is clear and actionable. Our investment in application support and rapid logistics fits directly with the reality on the ground: people crave reliability, and that can’t be delivered by copy-paste product descriptions. Every week, product meetings review field data, and process manuals update to reflect both troubleshooting and new opportunities.

    Conclusion: Decades of Experience, Delivered in Every Batch

    Running a chemical plant teaches respect for both material and people. Each drum of 4-Bromo-3,5-dimethylphenol shipped tells the story of improved safety, practical upgrades, smarter process control, and above all, the power of learning from experience. Suppliers who produce their own material know that every detail, from spec sheet to packaging, matters. The lessons in product handling, customer feedback, and plant upgrades come not just from industry trends, but from hands-on problem solving each day. Our commitment is reflected in every kilogram we deliver to customers who demand quality, transparency, and real-world results—on their own terms, and on ours.