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4-Bromo-3,3,4,4-Tetrafluoro-1-Butene

    • Product Name 4-Bromo-3,3,4,4-Tetrafluoro-1-Butene
    • Alias 1-Bromo-1,1,2,2-tetrafluoro-3-butene
    • Einecs 842-887-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    550423

    Chemical Name 4-Bromo-3,3,4,4-Tetrafluoro-1-Butene
    Molecular Formula C4H3BrF4
    Molar Mass 222.96 g/mol
    Cas Number 67749-22-6
    Appearance Colorless to pale yellow liquid
    Boiling Point 66-68°C
    Density 1.71 g/cm3 (at 25°C)
    Solubility In Water Insoluble
    Refractive Index 1.356 (at 20°C)
    Smiles C=C(C(F)(F)Br)CF
    Storage Conditions Store in a cool, dry, well-ventilated place, away from sources of ignition

    As an accredited 4-Bromo-3,3,4,4-Tetrafluoro-1-Butene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 100-gram bottle of 4-Bromo-3,3,4,4-Tetrafluoro-1-butene arrives in a tightly sealed amber glass container with hazard labeling.
    Shipping 4-Bromo-3,3,4,4-Tetrafluoro-1-Butene is shipped as a hazardous chemical. It should be transported in tightly sealed containers under a dry, inert atmosphere, away from heat and incompatible substances. Shipping requires proper labeling and documentation in accordance with local, national, and international regulations for hazardous materials. Handle with appropriate personal protective equipment.
    Storage Store 4-Bromo-3,3,4,4-tetrafluoro-1-butene in a tightly sealed container under cool, dry, and well-ventilated conditions, away from sources of ignition, heat, and incompatible substances such as strong oxidizers. Protect from moisture and direct sunlight. Use appropriate chemical-resistant containers and ensure proper labeling. Follow all relevant safety protocols, including use of personal protective equipment when handling the chemical.
    Application of 4-Bromo-3,3,4,4-Tetrafluoro-1-Butene

    Applications of 4-Bromo-3,3,4,4-Tetrafluoro-1-Butene in Industrial Manufacturing

    4-Bromo-3,3,4,4-Tetrafluoro-1-Butene serves as a high-value intermediate and reactive monomer in several specialized chemical sectors. Below are established downstream applications implemented by manufacturing clients in distinct industries.

    1. Advanced Pharmaceutical Intermediate Synthesis

    FDA-regulated pharmaceutical manufacturers utilize 4-Bromo-3,3,4,4-Tetrafluoro-1-Butene as a selective halogenated building block in multi-step processes for fluorinated drug candidates. The bromo-fluoroalkene moiety allows controlled coupling and functionalization during the creation of new pharmaceutical APIs targeting CNS and oncological disorders. Its use requires validated protocol transfer runs, extensive analytical trace studies, and custom process adaptations to each API’s synthesis route.

    Industry compliance standards

    • US FDA 21 CFR Part 210/211 (GMP for finished pharmaceuticals)
    • ICH Q7 (Good Manufacturing Practice for APIs)
    • EU EMA Annex 1 & 15 (GMP and validation standards)
    • USP/NF monograph guidelines for process impurities

    Typical usage ratio

    • 5–30% relative to main reactant mass, adjusted according to molecular stoichiometry and target yield in pilot and production batches

    Downstream process integration

    • Charged at the halogenation or vinyl functionalization stage, prior to final API crystallization and purification
    • Incorporated via closed-system reactor feed to prevent cross-contamination and volatilization

    Final product types

    • Fluorinated APIs (oncology, neurology therapeutics)
    • API candidates with bromoalkene functionality for further derivatization

    2. Specialty Agrochemical Synthesis

    Commercial pesticide and herbicide producers incorporate this material in the production of novel fluorinated agrochemical actives. The tetrafluoro substituted alkene structure achieves enhanced metabolic stability in plants, resulting in improved duration of action compared to non-fluorinated actives. The precise reaction conditions demand careful process control and product impurity profiling, particularly due to regulatory tolerances for halogenated residues.

    Industry compliance standards

    • FAO/WHO Pesticide Specifications (JMPS)
    • US EPA 40 CFR Part 158 (Pesticide registration data requirements)
    • ISO 9001:2015 (QA management system)
    • REACH Annex II (chemical safety assessment for agrochemicals)

    Typical usage ratio

    • 10–22% as limiting reactant; specific ratio based on targeted fluorine content and active ingredient design

    Downstream process integration

    • Introduced during the halogen exchange or cross-coupling reaction to attach the tetrafluoro moiety to core molecules
    • Direct process monitoring for residual bromine content prior to formulation steps

    Final product types

    • Tetrafluorinated herbicides and insecticides
    • Active intermediates used in the synthesis of new-generation crop protection products

    3. Electronic Chemicals for Semiconductor Manufacturing

    Fabricators of semiconductors rely on this fluoroalkene as a controlled intermediate in the creation of etching agents and photoresist precursors. The compound supports the formation of ultra-thin, low-defect fluorinated films highly suitable for advanced patterning in integrated circuit production lines. Purity specifications and process batch records require strict alignment with electronics cleanroom production protocols.

    Industry compliance standards

    • SEMI C3 Standard (Specifications for Specialty Gases and Chemicals)
    • ISO 14644 (Cleanroom standards for electronics manufacturing)
    • RoHS Directive (2011/65/EU, hazardous substances restrictions)
    • Customer-specific technical agreements (certificate of analysis and trace metal content)

    Typical usage ratio

    • 0.5–3% by weight within monomer blends and etching fluid formulations, tuned for process selectivity

    Downstream process integration

    • Dosed in vacuum-phase deposition, plasma-enhanced surface treatment, or as a functionalized monomer in photoresist synthesis
    • Filtered and charged via ultra-high-purity delivery systems to maintain sub-ppb metal contamination levels

    Final product types

    • Fluorinated photoresists for semiconductor wafers
    • Etching additives for microelectronic patterning

    4. Polymerization Modifier in Fluoropolymer Production

    Producers of specialty fluoropolymers integrate this raw material as a co-monomer modifier to impart specific molecular characteristics, such as increased hydrophobicity or unique thermal properties. Its reactivity profile enables precise tuning of chain structure in high-performance polymer systems, including those used for chemically inert tubing or insulation in demanding environments. Batch formulation requires full traceability for critical process audits.

    Industry compliance standards

    • ASTM D2116 (Standard for fluoropolymers)
    • ISO 9001 (Quality management for polymer production)
    • REACH (EC 1907/2006) registration requirements
    • UL 94 (flammability for polymeric materials, when relevant to end-use)

    Typical usage ratio

    • 2–8 mole% as a minor component by total monomer input, adjusted to control melt flow and end-group composition

    Downstream process integration

    • Fed to the pre-polymerization reactor during solution or emulsion polymerization steps
    • Continuous monitoring to verify absence of residual monomer and unreacted halogen

    Final product types

    • Specialty fluoropolymers for wire/cable insulation
    • Engineered films and linings for corrosive chemical containment

    5. Fine Chemical Intermediate for Fluorinated Surfactant Production

    Manufacturers in the specialty surfactant industry employ this compound during the controlled synthesis of C4-based fluorinated surfactants with defined chain lengths and head group functionalities. The specific molecular structure allows direct conversion through functional group transformation, producing surfactants with targeted surface tension reduction and stability under harsh chemical use conditions. Each step demands batch-level identity and residual impurity profiling to comply with international safety and toxicity norms.

    Industry compliance standards

    • OECD Guidelines for Testing of Chemicals (surfactant biodegradability)
    • EPA TSCA (Toxic Substances Control Act, notification for new chemicals)
    • GHS/CLP Regulation (EC No 1272/2008 classification and labeling)
    • ISO 14001 (Environmental management for chemical synthesis)

    Typical usage ratio

    • 11–20% basis per batch reaction, tuned for final surfactant yield and targeted fluorine incorporation

    Downstream process integration

    • Charged as an early-chain intermediate during the key step for introducing the perfluoroalkyl group
    • Reacted under controlled conditions with specific chain transfer agents and oxidation catalysts

    Final product types

    • Specialized non-ionic or anionic fluorinated surfactants
    • Low surface energy surfactant concentrates for fire-fighting foams, metal plating additives, and industrial wetting agents
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    Competitive 4-Bromo-3,3,4,4-Tetrafluoro-1-Butene prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Introducing 4-Bromo-3,3,4,4-Tetrafluoro-1-Butene: An Editorial Insight

    In the world of specialty chemicals, few molecules strike the balance between reactivity and selectivity better than 4-Bromo-3,3,4,4-tetrafluoro-1-butene. At plant level, watching this compound move from lab synthesis through scale-up and onto tanks ready for shipment, reveals much about the kind of reliability and forethought that goes into every kilo shipped from our facility. Our direct experience with this material—running from batch synthesis to product finishing—gives us a clear perspective on what sets it apart for downstream producers and formulators.

    Model and Specifications from the Factory Floor

    The typical output of our 4-Bromo-3,3,4,4-tetrafluoro-1-butene boasts high purity, routinely verified by GC and NMR in our on-site analytical labs. From a process technician’s view, each batch targets the practical requirements chemists lay out during project kickoff: minimal hydrocarbon byproducts, clean halogen profile, and well-controlled water content. Orders vary in volume—the process scales elegantly due to the attention paid upfront to raw material traceability and reactor set-up, not just automation.

    Production runs lead to a product that arrives as a clear, colorless liquid, with a boiling range tight enough for precision downstream processing. Both shelf life and container compatibility stem from careful purification: we’ve seen at storage that leaching is negligible with the high-density polyethylene drums in use. There’s often a conversation around trace residuals; ongoing stability testing at elevated temps keeps customers informed about what real shelf-life means away from ideal lab conditions.

    Usage in Modern Chemical Manufacturing

    Chemical innovators count on 4-Bromo-3,3,4,4-tetrafluoro-1-butene to build new carbon backbones where traditional halides fall short. Working with it for years, our staff sees its main pull in the creation of specialty polymers, advanced pharmaceutical intermediates, and certain agrochemical scaffolds where a strong C–F bond and selective bromine reactivity come into play. In synthesis of new functional materials, this molecule steps up as a dependable building block—those tetrafluorinated carbons resist metabolic breakdowns, and the bromo functionality provides a handle for further substitution.

    Lab development teams return to this compound repeatedly during fluorine incorporation trials thanks to both the predictability and flexibility it brings to the table. Real-world examples in our customer base use it for fluorinated elastomer production, where demands for endurance and resistance outpace what most C4 building blocks can deliver. When pressed about real advantages, process engineers highlight reduced byproduct formation during vertical synthesis—a tweak in the structure, a larger payoff in process yields.

    Comparisons with Other Halogenated Olefins

    Competition from more common vinyl bromides or simpler fluoroalkenes crops up yearly. There’s something distinct about 4-Bromo-3,3,4,4-tetrafluoro-1-butene: the dual nature embedded in its structure. From one end, heavy fluorination shrugs off chemical attack, providing durability in both high-performance plastics and chemically resistant coatings. The bromine group, on the other hand, offers a pathway into coupling reactions that unlock variety in the final product.

    Unlike tri- or mono-fluorinated butenes, the full substitution at carbons 3 and 4 means side reactions involving hydrogen abstraction or migration barely register during coupling stages. Processing plants see this translate into tighter control over batch reproducibility. Common halogenated analogs often build up nonvolatile residues, fouling reactors; this molecule, refined to our standards, shows much cleaner reactor turnover with significantly less downtime between runs.

    On-site Handling and Worker Safety

    Direct experience matters most in the conversation around safe handling. Our plant teams—used to the sharp odors and volatility of similar compounds—take extra steps with 4-Bromo-3,3,4,4-tetrafluoro-1-butene due to the balance between vapor pressure and chemical reactivity. From drum transfer to reactor feed, air-monitoring and strict PPE protocols maintain both worker health and product purity. Engineers install dedicated ventilation where this material gets transferred, reducing both downtime and risk. Insights from hundreds of transferred drums highlight the importance of leak-proof fittings and regular training—every new operator works beside a veteran on their first few transfers, picking up best practices from day one.

    The product itself doesn’t create excessive waste streams or hard-to-treat contaminants; with the right recovery protocols, negligible off-gassing reaches the shop floor. Off-gases route to dedicated carbon scrubbing, and we routinely assess those beds for accumulation, maintaining environmental compliance and minimizing fugitive emissions.

    Production Challenges: Scaling and Quality Control

    Any chemical manufacturer will tell you scale-up isn’t just a matter of bigger tanks and longer reaction times. For this compound, success at scale relies on real-time monitoring of reaction kinetics. Technicians and chemists worked side-by-side developing protocols for initiating, tracking, and quenching bromofluorination in precisely controlled steps. Having access to in-house analytical labs—right beside the production line—lets our crew pivot mid-run, adjusting feed rates or temperature without the lag of off-site results.

    Long-term stability of shipments arises from this on-site discipline. Containers ship out only after a combination of NMR, GC, and water assays pass repeatedly. Our tech team has spent years refining the drying process to prevent hydrolysis, avoiding any loss in shelf life downstream; the resulting product stays within spec for months in the warehouse. Field feedback from users usually focuses on the product’s reliability, pinpointing the value in a supply chain where inconsistency can derail downstream processing or create expensive unplanned downtime.

    Sourcing of precursors remains an ongoing hurdle—supply chain shocks ripple through any molecule requiring both fluorine and bromine inputs. We work directly with raw material producers, lock in forward contracts, and develop alternate syntheses to lessen dependence on any single supplier or shipping route. Every time a storm or trade closure threatens global feedstock, these relationships pay off, allowing us to honor commitments despite turbulence outside the plant gates.

    Experience with Product Customization and Collaboration

    Customers drive development at every turn. Demands for bespoke material property, alternate purity, or custom packaging land in our technical service inbox regularly. Working through these requests face-to-face with formulators goes beyond simple product tweaks—it often shifts how our chemists approach batch production. Custom-tailored lots exist because collaboration starts at the bench and continues through scaling and documentation.

    One notable instance involved a client’s request for a specific boiling range fraction. Rather than force the material into a rigid spec, our operations team set up a pilot distillation and correlated fraction purity with downstream yield in the client’s process. This type of back-and-forth, rooted in practical pilot-scale manufacturing, keeps science honest and production nimble. The result wasn’t just a modified batch, but a lasting process improvement and closer partnership that kept us agile.

    End Markets and Practical Applications

    Users often take 4-Bromo-3,3,4,4-tetrafluoro-1-butene in directions far beyond our original forecasts. Several coatings manufacturers have adopted it for novel anti-corrosion agents. Others blend it into performance elastomers, combining both chemical resistance and flexibility. Synthesis of advanced intermediates in pharmaceutical pipelines has increased as regulatory pressures mount on more hazardous halogenated intermediates; our compound, with a cleaner profile, supports efforts to streamline hazard communications.

    The push for high-performance materials in automotive and electronics sectors has reached a place where anything less than robust, versatile building blocks can’t pass muster. Having watched customer applications mature over several years, we track which product aspects tie most closely to success: reliable supply, assured batch consistency, and full transparency into production and testing. The quantifiable benefits customers cite—shorter lead times, fewer non-conforming lots, and consistent reactivity—arise directly from granular process control and technical know-how on our side.

    Global Supply and Long-term Availability

    We keep a close eye on shifts in the global regulation of fluorine-containing molecules, particularly as European and North American regulations evolve. By overseeing every step from precursor sourcing to the last valve turn, we sidestep many problems others face: product recalls, out-of-spec drumming, regulatory limbo. That production stability matters most to downstream plants, where even a weeklong hiccup can cascade into larger losses. Investments in real-time data analytics and batch-by-batch traceability support this long-term vision.

    We’ve seen volatility in global logistics, from container shortages to abrupt regulatory changes at ports. Experience has taught us to build in flexibility at every step: holding buffer stock in key regions, pre-positioning drums near major customer hubs, and investing in dedicated compliance staff who track every shipment against the latest standards. Reliability wins business, but anticipation preserves it—no one wants a production line running at half speed due to an unexpected delay, and our logistics crew works behind the scenes to prevent that.

    Environmental Management and Responsibility

    Years of producing halogenated chemicals breeds a certain realism about environmental impact. It’s not enough to simply check a box for compliance and move on. Our site captures all vented gas through a multi-stage scrubber, monitors wastewater for trace organics, and recycles solvents wherever practical. Several plant improvements come straight from operator observation—such as swapping out older gaskets or engineering out hard-to-clean dead legs—actions based on real trends in maintenance records.

    Waste minimization brings real cost savings, but the drive also comes from what teams see on the ground: nobody wants to run a site with persistent odor complaints or emergency call-outs. Best practices, from regular leak checks to hands-on environmental drills, keep these risks at bay. Our own team doubles down on process improvements, so regulators and neighbors alike have confidence in site safety and stewardship.

    Challenges and Solutions from a Manufacturer’s Perspective

    No batch leaves our premises without facing real scrutiny, and every inefficiency in the process comes back as lost hours or extra maintenance. From sourcing through delivery, every stage brings up potential pitfalls: precursor variability, equipment wear, real-world logistics. Chemicals like 4-Bromo-3,3,4,4-tetrafluoro-1-butene demand attention to detail, not just on paper, but on the factory floor at every shift change. Staff feedback and regular production audits drive early detection of process drift or impurity buildup—preemptive action is the surest way to maintain quality.

    Batch tracking and digital monitoring give us minute-by-minute insight, but we never undervalue hands-on experience. Veteran operators picking up subtle shifts in reaction behavior, or maintenance crews catching leaks before sensors trip—a culture that values both automation and craftsmanship underpins consistent output.

    In responding to unexpected disruptions, our strategy never rests on a single solution. A blend of technical redundancy, direct raw material partnerships, and open channels with downstream users gives us the resilience needed to weather both internal and external shocks. Drawing on years in the business, we respond quickly and learn from every hiccup, refining internal checks and building in extra robustness with every cycle.

    Continuous Improvement: Lessons from the Field

    Innovation can’t rely just on state-of-the-art chemistry; practical process improvements make larger impacts day-to-day. Field reports from customers play a big role in process tweaks: unexpected changes in viscosity, shifts in odor profile, or easier cleaning cycles all inform our long-term development. Regular visits to customer plants, joint troubleshooting sessions, and reviewing field failures in live settings give practical feedback loops much stronger than any theoretical exercise.

    One case involved recurring sticky residue in downstream pumps; after a series of site visits, our technical team tracked this back to a previously negligible impurity fraction. By adjusting purification parameters in-house, we cleared up client issues and improved our own product line. Stories like these run through the company, reinforcing a culture of not just responding but building permanent solutions.

    The Value of Direct Manufacturer Experience

    Direct engagement, from plant tours to regular technical calls, sets us apart from traders or resellers. Every week, production staff sits down with R&D, reviews emerging trends, discusses possible tweaks, and plans new pilot runs based on real application feedback. This hands-on, closed-loop approach means process improvements show up in the next batch, not the next quarter.

    For teams using 4-Bromo-3,3,4,4-tetrafluoro-1-butene, the benefits run deeper than standard product supply. Field engineers pop into our control room, plant chemists drop in to see batch data in real time, and everyone keeps the conversation open. These relationships make problem-solving nimble, so challenges rarely turn into problems for our partners. On-site expertise, built on years learning from both success and failure, stands as the real differentiator.

    Looking Ahead: The Role of 4-Bromo-3,3,4,4-Tetrafluoro-1-Butene

    With demand for specialty fluorinated building blocks rising, keeping production rooted in practical, day-to-day discipline ensures we keep pace with both regulation and innovation. Customers looking for a stable source, responsive support, and measurable quality find that dealing directly with hands-on manufacturers delivers tangible results. Our plant teams remain the backbone of this reliability—testing, adapting, and collaborating, always focused on safe and effective delivery.

    Bringing a new molecule to market takes more than following standard operating procedures. It takes experienced judgment, real communication, and willingness to dive into technical detail from the shop floor upward. Every batch of 4-Bromo-3,3,4,4-tetrafluoro-1-butene we ship carries that legacy of collaboration and technical depth. Working with it over years, we see not just the molecule but the broader shifts in innovation it powers—durable polymers, advanced pharmaceutical intermediates, and sustainable coatings that stand up in tough environments. This ongoing hands-on involvement ensures we don’t simply sell a product; we deliver a solution built for practical progress.