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4-Bromo-2-Nitrotoluene

    • Product Name 4-Bromo-2-Nitrotoluene
    • Alias 4-Bromo-2-nitro-1-methylbenzene
    • Einecs EINECS 401-090-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    109996

    Cas Number 6968-90-9
    Molecular Formula C7H6BrNO2
    Molecular Weight 216.03 g/mol
    Appearance Yellow to orange solid
    Melting Point 47-50°C
    Boiling Point 278°C at 760 mmHg
    Density 1.69 g/cm3
    Purity Typically ≥98%
    Solubility Slightly soluble in water, soluble in organic solvents
    Synonyms 1-Bromo-4-methyl-2-nitrobenzene
    Smiles CC1=CC(=C(C=C1)Br)[N+](=O)[O-]
    Inchikey VTTQXSHJUKGFIX-UHFFFAOYSA-N

    As an accredited 4-Bromo-2-Nitrotoluene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle, screw cap, labeled "4-Bromo-2-Nitrotoluene, 99%, 100 grams," hazard symbols, safety information, manufacturer details.
    Shipping 4-Bromo-2-nitrotoluene is shipped in tightly sealed containers, protected from moisture and incompatible substances. It is classified as a hazardous material; handle and transport according to local, national, and international regulations for dangerous goods. Appropriate hazard labeling and documentation are required. Store in a cool, well-ventilated area away from sources of ignition.
    Storage 4-Bromo-2-nitrotoluene should be stored in a tightly sealed container, away from light, heat, and sources of ignition. Keep it in a cool, dry, and well-ventilated chemical storage area, separate from incompatible substances such as strong oxidizers, acids, and bases. Ensure containers are clearly labeled and stored according to institutional and regulatory guidelines for hazardous chemicals.
    Application of 4-Bromo-2-Nitrotoluene

    Applications of 4-Bromo-2-Nitrotoluene in Industrial Manufacturing

    As a specialized chemical manufacturer, we supply 4-Bromo-2-Nitrotoluene directly to industry leaders serving advanced and regulated markets. This intermediate supports key transformations in agrochemical synthesis, pharmaceutical API manufacturing, specialty dye production, and high-performance materials, each with specific requirements for quality, compliance, and process integration.

    1. Agrochemical Active Ingredient Synthesis

    Leading agrochemical formulators use this compound as a building block in substituted aniline and phenyl derivatives for select herbicide and fungicide actives. It enters the nitration or amination stage, enabling selective introduction of functional groups needed for target molecule activity and regulatory approval. Batch-wise and continuous flow processes employ specific ratios depending on downstream yields, with close monitoring for impurity control aligned to international residue limits.

    Industry compliance standards

    • FAO/WHO Pesticide Specifications
    • ISO 9001:2015 Quality Management System
    • REACH Regulation (EC) No 1907/2006
    • OECD GLP for agrochemical testing

    Typical usage ratio

    • Used at 0.8–1.3 molar equivalents per batch in initial condensation.
    • Adjusted based on conversion efficiency and final product purity requirements.

    Downstream process integration

    • Introduced in the electrophilic aromatic substitution or amination steps.
    • Feeds directly into catalytic hydrogenation or coupling for active ingredient finishing.
    • Process includes solvent recovery and purification aligned to target API standards.

    Final product types

    • Benzanilide-based herbicides
    • Triazole fungicides
    • Pyridyl ether weed control products

    2. Pharmaceutical Intermediate Manufacturing

    Major pharmaceutical manufacturers employ this intermediate for the synthesis of nitroaniline and bromophenyl APIs. These transformations demand tight process analytical control, batch-reactor traceability, and full documentation under cGMP. Product use varies based on isomeric purity and regulatory filing status, with attention to pharmacopoeia compliance at every stage of API development and scale-up.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • USP/NF and Ph. Eur. quality monographs
    • 21 CFR Part 211 (US FDA)
    • EMA guidelines for starting material qualification

    Typical usage ratio

    • Applied at 1.0–1.1 equivalents for bromination or nitration reaction stages.
    • Ratio adjusted based on pathway yield and required enantiomeric excess.

    Downstream process integration

    • Charged as a core intermediate in heterocycle formation and ring closure steps.
    • Processed with protective group strategies to control byproduct formation.
    • Purified via crystallization or chromatographic separation for API-grade output.

    Final product types

    • Anti-infective intermediates
    • Analgesic API building blocks
    • Custom pharmaceutical intermediates for CDMO pipelines

    3. Disperse & Reactive Dye Synthesis

    Established textile dye manufacturers utilize 4-Bromo-2-Nitrotoluene for developing disperse and reactive dyes with high color fastness and specific hue targets. The material reacts under controlled diazotization and coupling steps, where minor impurity variations can alter shade reproducibility. Production follows ISO and eco-label certification for responsible supply to textile integrators.

    Industry compliance standards

    • ISO 9001:2015 Quality Management System
    • OEKO-TEX Eco Passport (for input chemical screening)
    • ZDL (Zero Discharge of Hazardous Chemicals) Manufacturing Standard
    • GOTS 6.0 (Global Organic Textile Standard) chemical criteria

    Typical usage ratio

    • Incorporated at 1.0–1.15 moles per mole of diazonium compound in key coupling reactions.
    • Adjusted by shade strength and chromophore yield.

    Downstream process integration

    • Engages at azo coupling and naphthol condensation phases of synthesis.
    • Supports direct sulfonation or alkylation, depending on desired dye solubility.
    • QC includes spectral analysis for consistency batch-to-batch.

    Final product types

    • Disperse dyes for polyester textiles
    • Reactive dyes for cotton and cellulose fabrics
    • High-performance textile colorants

    4. Electronic and Specialty Intermediate Production

    Producers in electronic chemical supply chains apply this material to manufacture intermediates for liquid crystal displays, photoresists, and advanced polymers. Detailed integration into halogen substitution and subsequent nitration supports electronic-grade molecule synthesis, with robust trace contaminant controls and documentation aligned with global electronics compliance frameworks.

    Industry compliance standards

    • RoHS Directive 2011/65/EU (Restriction of Hazardous Substances)
    • IECQ QC 080000 (Hazardous Substance Process Management)
    • Sony Green Partner Program
    • ISO 14001:2015 Environmental Management

    Typical usage ratio

    • Used at 0.95–1.05 molar equivalents in halogen substitution or nitration steps.
    • Adjusted to target purity and downstream integration requirements.

    Downstream process integration

    • Processed as a monomer precursor in polymer backbone synthesis.
    • Feeds directly into lithography chemical production for microelectronic fabrication.
    • Includes fine filtration and ion-exchange polish for electronics-grade quality.

    Final product types

    • Liquid crystal mixture intermediates
    • Specialty photoresist components
    • High-purity polymer intermediates for flexible displays

    5. High-Performance Material Additive Synthesis

    Manufacturers in the high-performance coatings and engineering plastics sector formulate using this nitro-bromo aromatic compound for stability and functionality improvements. These applications focus on precise introduction of functional groups to polymer chains, enhancing UV stability, flame retardancy, or mechanical resilience, following strict documentation and regulatory rules for end-use approval.

    Industry compliance standards

    • UL 94 Flame Retardant Standard
    • REACH Regulation (Annex XVII restrictions)
    • ISO 9001:2015 Process Quality
    • ASTM D5207-21 for plastics additives

    Typical usage ratio

    • Added at levels of 0.5–3.0 wt% depending on matrix compatibility and performance target.
    • Adjusted per polymer backbone reactivity and additive dispersion requirements.

    Downstream process integration

    • Introduced during pre-polymerization batch or as reactive chain component.
    • Followed by compounding and extrusion with fine monitoring for residual levels.
    • Includes testing for molecular weight distribution and additive efficiency.

    Final product types

    • UV-resistant engineering plastics
    • Flame-retardant coatings for industrial uses
    • Weather-stable specialty films and fibers
    Free Quote

    Competitive 4-Bromo-2-Nitrotoluene prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

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    Certification & Compliance
    More Introduction

    Introducing 4-Bromo-2-Nitrotoluene: Expertise in Every Batch

    Our Manufacturing Mindset

    4-Bromo-2-Nitrotoluene stands out as a key intermediate in today’s challenging landscape for chemical synthesis. We have produced this compound for years, taking into account every step beginning from raw material traceability to the final packed drum. Through hundreds of production runs, we have learned that close attention to reaction temperature, agitation strength, and feed rate of brominating agents directly shapes purity and yield. There’s no shortcut for experience on a plant floor, and each batch behind our name represents adjustment, measurement, and practical know-how gained across a variety of reactor sizes and conditions.

    The purest form of 4-Bromo-2-Nitrotoluene will often show a bright yellow to pale orange crystalline appearance. Under proper storage, its melting range holds steady and impurities can be kept below demanding pharmaceutical or fine chemical thresholds. We’ve seen grade expectations shift over the years, and our approach centers on robust testing and repeated small-batch trials during any process adjustment. The industry’s needs aren’t static. As newer applications emerge in agrochemicals, dyes, and pharmaceutical intermediates, we redesign filtration and cleaning steps without cutting corners on analysis.

    Specifications Built from Experience

    Over repeated campaigns, certain product features remain top of mind. Typical product output features a minimum assay of 99% by GC or HPLC, residual moisture held under 0.1%, and single-digit ppm levels of common organic byproducts like 2-Bromo-4-Nitrotoluene or unreacted starting toluenes. Every lot transitions through multi-stage filtration and, if necessary, re-crystallization to remove trace colored impurities that could trip up downstream hydrogenations or oxidations.

    We have supplied 4-Bromo-2-Nitrotoluene in both granular and powder forms, depending on the charging and handling needs of each customer’s process. Sometimes particle size demands change as the production line scales. We’ve seen the frustration that comes from clumping or caking during summer shipping or long-term storage, so we refined our drying methods. Product stability depends on careful packaging selection, and we learned early that triple-layered high-density polyethylene bags inside sealed steel drums hold up best for transport across continents. Not every lot sees the same journey, so we tailor logistics with an eye on shelf life and climate resilience rather than simply ticking boxes.

    Reliability for Reactions Where Outcomes Matter

    Much of what separates reliable 4-Bromo-2-Nitrotoluene from untrustworthy shipments comes down to consistency. We look beyond the typical melting point or assay readouts: our years producing this compound have taught us to run parallel NMR and mass spectroscopy checks every campaign, and we monitor bromine distribution closely. Even small fluctuations can leave users with significant off-spec in reductive or substitution chemistry. We keep a watchful eye on trace halide residues, as these can poison catalytic systems or cause color issues in sensitive dye intermediates. Our team blocks out time every month to revisit root cause investigations for any deviation, even non-conforming odor or packaging complaints.

    Large pharmaceutical and agrochemical clients, in our experience, want more than paperwork—they want to see plant audit trails and the willingness to adjust campaigns based on their unique catalyst or solvent environments. We share analytical packages, and our door is open for customer audits. Real partnership grows from transparency, not slogans.

    Differences That Add Up Over Time

    Although many manufacturers can offer a product matching the chemical formula of 4-Bromo-2-Nitrotoluene, the day-to-day production experience—not just the lab synthesis—separates those who rely on real process feedback from those copying generic prep routes. We have worked through fugitive dust issues, repetitive batch failures, and the domino effects of minor impurity carryover from shared plant lines. Our scale-up team collaborates directly with the chemists in charge of downstream hydrogenation and coupling steps, identifying pitfalls before they land in plant reactors halfway around the world. This boots-on-the-ground knowledge makes a difference when pure technical details don’t tell the whole story.

    Other suppliers take a black-and-white approach: if a material passes “spec,” the job is done. We follow up on how our lots run in actual use—reaction kinetics, yield drift, unexpected solidification in tanks, or gas evolution. By staying in touch after delivery, we learn root causes fast and adjust future production months before problems could reappear. We help solve problems and improve processes, not just fill purchase orders.

    Product Applications: The Real Drivers

    Usage of 4-Bromo-2-Nitrotoluene goes far beyond spreadsheets of chemical reaction steps. We see creative uses in core organic syntheses, particularly as a halogenated intermediate for C–C and C–N bond forming reactions. Research teams leverage its orthogonal reactivity for regioselective couplings and selective reductions. In dye and pigment development, our clients look for high-clarity chromophores and demand transparency around trace impurities that might muddy or dull finished colors.

    High-purity grades find their way into the world’s most rigorous pharmaceutical pipelines, where even ppm-level contamination means lost months or scrapped campaigns. Agricultural chemical innovators depend heavily on predictable impurity profiles to keep their downstream regulatory submissions on track. In both cases, we see the value in simple, painstaking documentation: each drum tracked, each certificate tied back to a batch controlled in-house, not from a broker’s warehouse.

    Traditional catalog suppliers and trading companies may not worry about end-use context. We routinely conduct customer process simulations before shipping new lots to novel applications. These predictive checks let us adjust drying or particle sizing in months where ambient humidity rises. Chemical innovation does not happen in isolation, and product quality emerges both from how it’s made and how it’s handled throughout its lifecycle.

    Why Process Matters Beyond Numbers

    Many users encounter trouble by assuming a single CAS matches every lot called “4-Bromo-2-Nitrotoluene.” Our experience says otherwise. Nitro compounds can develop surprising trace impurities based on temperature ramp, mixing methods, or repeated equipment use. Unlike batch traders, we dive into trouble calls together with clients: discoloration, clumping, and melting point drift often lead to a change in drying times or grinders, or a deeper equipment cleanout between campaigns.

    From day one, analytical details tell an incomplete story. We learned the hard way during customer pilot trials that filtration methods or unique byproduct spectra hidden at sub-percent levels can completely change reaction performance in downstream pharmaceutical synthesis. That is why we monitor for trace polynitro, dibromo, or unreacted starting material—even when the final output looks fine by simple tests. We routinely see our materials outperform those from short-lived brokers because our chemists stay engaged with every campaign, not just the order round.

    Building in Quality from Sourcing to Drum

    The quality of 4-Bromo-2-Nitrotoluene we deliver traces directly to raw material control. We source brominating and nitrating agents from trusted partners, with every drum tested for identity and stability before charging reactors. Tank farm records, in-house batch logs, and continuous upgrades to filtering lines help us spot and stop trends that might lead to out-of-spec output.

    As staff rotate through shifts, we stress training on cross-checking meters, glassware, and finished product storage. Practical training leads to fewer surprises in tank cleaning or sudden pressure spikes during a run. Small changes in feed rates or agitator RPMs, which sometimes get overlooked in batch syntheses, make a major difference at plant scale—especially for thermally sensitive steps such as nitration. We cross-train teams on purification as well, so a surge in orders never means a rushed product with hidden contamination.

    Supporting Innovation in Downstream Use

    Our customers increasingly push 4-Bromo-2-Nitrotoluene into routes that demand more than chemical identity. In specialized pharmaceutical work or custom catalysts, our engineering and technical support team respond in real time with extra analytical data or process recommendations. Having supported both classic and cutting-edge organic syntheses, we know which process tweaks matter for scaled downstream coupling or hydrogenation, and which minor changes could save days in a high-stakes production campaign.

    Software and automation won’t replace plant experience. We sit with users to transfer lessons on drum heating, inerting, or proper drum-opening under local safety requirements. Sometimes a customer inquires about an off-spec lot from another supplier that’s derailed yield or produced mystery precipitates. Walking that problem through, often down to how sample bottles were filled, lets us prevent the same mistakes in future orders. We aren’t shy about sharing lessons from failed runs—in plant chemistry, learning from failure creates true reliability.

    What Sets Our Product Apart

    Over the years, we’ve fielded questions about generic versus manufacturer-quality 4-Bromo-2-Nitrotoluene. Data driven approaches matter, but so does the human element of accountability. Every product drum we ship bears our batch number because every campaign is run under our own roof, with staff who take pride in their craft. Recalls, plant shutdowns, or lost batches aren’t just spreadsheet events—they’re major setbacks that can ripple through partners’ business plans.

    Buyers often ask what makes our process different from competitors: for us, it is the transparency in both production and follow-through. By controlling every stage of the process—not farming out purification, not relying on third-party storage, not pushing “mixed” inventories—we avoid the cross-contamination and sampling errors that have troubled global chemical supply over the past few years. This means we don’t just sell a label, we deliver a finished product that matches what truly matters to chemical engineers and researchers under genuine use conditions.

    Challenges and How We Overcome Them

    Producing and delivering 4-Bromo-2-Nitrotoluene isn’t always smooth sailing. As global logistics have faced disruptions, we have worked closely with freight teams to reroute shipments and monitor environmental conditions that might affect product performance. Our in-house chemists continue to refine reaction conditions as upstream raw materials shift in the broader market. We have lived through large swings in demand, and we stay flexible by monitoring every campaign’s outcomes and keeping an experienced eye on byproduct specifications.

    Technical difficulties during complex syntheses have forced us to pause and change methods. We altered filtration protocols after a run of clumping incidents downstream, and shifted from certain drying regimes after discovering minor yield losses at scale. Feedback from customer technical teams has allowed us to spot edge cases quickly—letting us design new analytical protocols or tweak equipment cleaning before the next production run.

    Proving Our Value One Drum at a Time

    In a business where trust is earned over years and not simply bought on the spot market, our reputation rests on consistency, technical support, and every shipment’s traceable data. Whether it’s an R&D program seeking a consistent new lot for a test campaign or a plant-scale partner preparing for multi-ton coupling, we deliver 4-Bromo-2-Nitrotoluene rooted in genuine process experience.

    Client relationships won’t be sustained by certificates alone. Being responsive to late-stage feedback, standing behind unexpected performance claims, and being available to troubleshoot tricky downstream reactions set us apart. In the ever-evolving world of chemical manufacturing, we believe real knowledge grows through daily practice, careful listening, and a focus on delivering performance beyond just a name on a chemical drum.

    Looking Ahead: Continuous Improvement

    We invest in new analytics, ongoing operator training, and regular feedback sessions with users pushing the boundaries of what 4-Bromo-2-Nitrotoluene can do. Each process change, each new filtration material or alternative reactor configuration, is built on the experience of hundreds of production runs. Process automation goes hand in hand with staff judgment, which only grows through real-world troubleshooting and repeated success under tight deadlines.

    As regulatory standards tighten and downstream requirements become more demanding, we stand ready to adapt. We see every interaction with users, every process update, as a chance to build greater clarity and reliability into every drum—so that each batch of 4-Bromo-2-Nitrotoluene does more than check a spec sheet. It supports chemical innovation where it counts.