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4-Bromo-2,6-Di-Tert-Butylanisole

    • Product Name 4-Bromo-2,6-Di-Tert-Butylanisole
    • Alias 2,6-Di-tert-butyl-4-bromoanisole
    • Einecs 406-040-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    362406

    Chemical Name 4-Bromo-2,6-Di-Tert-Butylanisole
    Synonyms 4-Bromo-2,6-bis(1,1-dimethylethyl)-1-methoxybenzene
    Molecular Formula C15H23BrO
    Molecular Weight 299.25 g/mol
    Cas Number 39693-47-7
    Appearance White to off-white solid
    Melting Point 95-98°C
    Solubility Soluble in organic solvents such as chloroform and ether
    Purity Typically ≥98%
    Storage Conditions Store at room temperature, keep container tightly closed
    Smiles CC(C)(C)c1cc(Br)cc(C(C)(C)C)c1OC

    As an accredited 4-Bromo-2,6-Di-Tert-Butylanisole factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

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    Application of 4-Bromo-2,6-Di-Tert-Butylanisole

    Applications of 4-Bromo-2,6-Di-Tert-Butylanisole in Industrial Manufacturing

    As the direct producer, we have supplied 4-Bromo-2,6-Di-Tert-Butylanisole (4-BDTBA) to key sectors that require highly pure, function-specific intermediates for fine chemical synthesis. The following application scenarios reflect the principal industrial downstream usage of 4-BDTBA, ensuring traceability, compliance, and technical alignment with contemporary manufacturing needs.

    1. Advanced Pharmaceutical Intermediate Synthesis

    4-BDTBA acts as a bulky, electron-rich arylating agent in the multi-step synthesis of specialty heterocyclic scaffolds. Its performance supports the construction of highly selective building blocks for active pharmaceutical ingredient (API) production, where stringent impurity profiles and batch reproducibility are critical. Integration into targeted aromatic substitution steps enables downstream manufacturers to achieve superior reaction precision while reducing the presence of polar byproducts.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice (GMP) for Active Pharmaceutical Ingredients
    • Ph. Eur., USP, JP monograph references for related pharmaceutical intermediates
    • EMA and US FDA Drug Master File (DMF) submission requirements
    • REACH Registration for pre-registered pharmaceutical intermediates

    Typical usage ratio

    • 0.8–1.1 molar equivalents per aromatic coupling unit, depending on substrate reactivity and desired yield
    • Adjusted according to target compound MW and byproduct minimization in pilot and production scale

    Downstream process integration

    • Charged in the arylation or Suzuki coupling step following initial halide activation
    • Dosed batchwise under nitrogen in high-shear reactors prior to addition of transition metal catalyst
    • Integrated into solvent exchange steps for enhanced crystallization purity

    Final product types

    • Pyridazine and pyrimidine-derived API intermediates
    • Electron-rich aryl ether subunits for antitumor and CNS drug precursors
    • Specialty chiral ligands for advanced pharmaceutical synthons

    2. Polymer Stabilizer Manufacturing

    Our chemical supports downstream producers of high-durability plastics seeking to introduce steric shielding into hindered phenolic antioxidants. By acting as an aryl bromide component in the synthesis of main-chain stabilizers, 4-BDTBA improves oxidative resistance profiles in end-use thermoplastic materials, particularly for prolonged high-heat or UV exposure scenarios prevalent in technical molding operations.

    Industry compliance standards

    • ISO 9001:2015 for Quality Management Systems in chemical manufacturing
    • FDA 21 CFR 177.1520 for polymer additive compliance in food-contact plastics
    • ECHA REACH SVHC (Substance of Very High Concern) non-listing confirmation
    • EN 71-3 for toys and children’s product safety where relevant

    Typical usage ratio

    • 1.0–1.3 wt% in the formulation of antioxidant intermediates per batch polymer weight
    • Adjusted up to 2% for specialty engineering plastics requiring enhanced thermal longevity

    Downstream process integration

    • Introduced during primary antioxidant intermediate synthesis, especially for hindered phenol routes
    • Dosed into solvent phase amid alkylation and condensation reactions, followed by purification and extrusion with base resin

    Final product types

    • Hindered phenolic antioxidants for polyolefins (e.g., PE, PP)
    • Stabilizers for engineering plastics (ABS, PC, PA-6, PA-66)
    • Additive packages for elastomers and polyurethane foams

    3. Specialty Electronic Chemical Precursors

    Manufacturers of organic electronic materials, such as OLEDs and conducting polymers, use 4-BDTBA as an aryl bromide source to introduce bulky substituents, increasing molecular stability and minimizing unwanted cross-linking during device fabrication. Its incorporation in custom synthesis routes supports downstream processes requiring extremely low trace metal contamination, relevant to producing next-generation electronic functional coatings and emissive layer components.

    Industry compliance standards

    • IEC 62474 for declarable substances in electronics
    • RoHS Directive (2011/65/EU) for heavy metal and halogenated compound restrictions
    • ISO 10993-5 for cytotoxicity of electronic medical device coatings
    • Japanese Chemical Substances Control Law (CSCL) for precursor management

    Typical usage ratio

    • 0.9–1.2 molar equivalents for coupling into carbazole and diphenylamine derivatives
    • Dosage tuned by polymer backbone length and specific device performance targets

    Downstream process integration

    • Dispensed in initial coupling steps before cyclization for OELD emitter synthesis
    • Blended into precursor resin solutions for direct functionalization
    • Applied in controlled batch reactors to prevent contamination in high-spec electronics environments

    Final product types

    • OLED (Organic Light-Emitting Diode) small molecule precursors
    • Conductive and semiconductive polymer intermediate resins
    • Specialty chemical components for organic photodetectors

    4. Agrochemical Active Ingredient Development

    Downstream agrochemical formulators employ 4-BDTBA in building advanced aromatic herbicide intermediates, especially those requiring ortho-substituted anisole frameworks to achieve enhanced bioactivity and environmental stability. The raw material’s predictable steric profile facilitates precision in halogenation and subsequent etherification steps, critical to manufacturing consistent and conforming crop protection agents.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • OECD Guidelines for the Testing of Chemicals (Sections 1 and 2)
    • ISO 17025 laboratory quality standards for batch release
    • China GB 2763 pesticide MRLs relevant for exported agrochemicals

    Typical usage ratio

    • 0.7–0.95 weight equivalents based on final herbicide target structure and field stability demands
    • Adjusted within regulatory tolerance for environmental impact studies and market destination

    Downstream process integration

    • Introduced in aryl ether formation after initial halogenation
    • Charged directly in batch or continuous-flow reactors during active agrochemical synthesis
    • Controlled dosing downstream to minimize off-target reactivity with soil matrix simulants

    Final product types

    • Selective herbicide intermediates for cereal crops
    • Bulky aromatic fungicide scaffolds
    • Custom plant growth regulator base compounds
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    More Introduction

    4-Bromo-2,6-Di-Tert-Butylanisole: An Editorial Perspective

    Getting to Know the Compound

    Chemistry has a way of introducing compounds with names that stretch across the page, but sometimes complexity carries a purpose worth paying attention to. 4-Bromo-2,6-Di-Tert-Butylanisole, despite its technical name, finds a spot on lab shelves for good reason. In research and production settings, folks who choose this product recognize its structure as far more than a collection of atoms. It delivers a unique combination of properties that not only gives certain processes a competitive edge, but also illustrates the way modern chemistry responds to new technical challenges.

    Specifications Driven by Practical Needs

    4-Bromo-2,6-Di-Tert-Butylanisole stands out before the first experiment even runs, thanks to a crystal-clear molecular structure: a benzene ring with two tert-butyl groups and one bromo substituent, plus a methoxy group providing extra bulk and subtle electronic influence. Its molecular weight and specific arrangement don’t show up by accident—the tert-butyl groups shield the ring, lending stability against unwanted reactions. The bromo atom, meanwhile, acts as a reliable handle for further modification, whether it’s in academic research or industrial application. Instead of a vague, multipurpose material, this product arrives with clear boundaries and expectations: purity, reproducibility, and traceability, three qualities that come up often in technical conversations and peer-reviewed journals.

    Laboratories searching for consistency expect nothing less than a compound that matches its certificate of analysis batch after batch. Routine quality checks like NMR, GC-MS, and HPLC offer concrete data on purity—no more hoping for lucky results. A good batch of 4-Bromo-2,6-Di-Tert-Butylanisole meets not only purity thresholds above 97% but also low moisture content, which matters when you start pushing synthesis yields to their limits. These details matter: even small deviations can ripple through a multistep process, costing time, money, and peace of mind.

    Applications That Matter on the Bench and Beyond

    Organic synthesis relies on more than just good intentions and clean glassware. Specialty reagents like 4-Bromo-2,6-Di-Tert-Butylanisole come along to solve problems that simpler molecules simply can’t. In my own chemistry days, I learned quickly that some reactions fail without the right activating groups in place. Here, the dual tert-butyl protection wards off side reactions; the bromo group invites precise substitutions via cross-coupling or further functionalization. Academic groups often cite this kind of chemistry when developing new pharmaceuticals, advanced materials, or catalysts. The difference between a theoretically interesting molecule and a scalable process sometimes comes down to whether you’re working with a clean, reliable input.

    Research teams have put this compound to work in Suzuki-Miyaura and Buchwald-Hartwig couplings, where its bulky side groups push selectivity in the desired direction. If you’ve ever run a crowded reaction with multiple possible outcomes, you know just how much selectivity matters. At the same time, process chemists in industry lean on these features when scaling up reactions for material science or agrochemical research. Because the methoxy group and tert-butyl arms impact solubility and steric environment, they grant this compound unique behavior in solvents that can be tough to match.

    Everyday Problems, Tangible Solutions

    Science rarely moves forward by accident. I’ve seen too many labs hampered by inconsistent supplies or impurities to overlook the value of a well-characterized starting material. The hard-earned lesson—learned after too many failed chromatograms or inconsistent melting points—is that reactivity profiles can shift with even minor byproducts. In the real world, reproducibility underpins credibility, and companies know their reputation rides on this. With a reliable source of 4-Bromo-2,6-Di-Tert-Butylanisole, projects advance without constant troubleshooting, results become more trustworthy, and teams hit deadlines with fewer headaches.

    One aspect of this compound that often gets highlighted is its shelf stability. Tert-butyl groups discourage oxidation, which means open-bottle uncertainty goes down and confidence in results goes up. In practical terms, it means chemists spend fewer hours checking the blue-tinge of a decomposed sample and more time on the bench learning something new. Whether setting up a new cross-coupling reaction or troubleshooting a stubborn route to a pharmaceutical intermediate, the ability to revisit old aliquots or stock solutions is an unsung advantage that experienced chemists appreciate.

    Comparisons That Shape Decisions

    Markets overflow with reagents that seem interchangeable at first glance, but anyone who has run repeated reactions knows that small changes in substituents lead to big changes in the lab. Direct competitors to 4-Bromo-2,6-Di-Tert-Butylanisole often swap in less bulky groups or different halogens. Fluoro-compounds tend to behave differently under coupling conditions; chloro analogs cost less, but can be less reactive and sometimes less selective during transition metal-catalyzed reactions. Early on in my career, budget constraints nudged me toward less expensive, lesser-purified options. Inevitably, those trials ended with columns that dragged on for hours and yields that failed to impress.

    The unique chemical identity of this compound bridges more than just academic interest. Thanks to those bulky tert-butyl groups, 4-Bromo-2,6-Di-Tert-Butylanisole resists some unwanted side reactions better than simpler anisole derivatives. Even compared to similar bromo-anisoles lacking tert-butyl protection, users report higher conversion and less tar formation in complex coupling conditions. Downstream, this translates to less time spent purifying, more time focusing on what actually matters to a project’s success.

    Scaling Challenges and How Firms Respond

    While breakthroughs in bench-scale chemistry grab headlines, the path to a successful product often runs through thorny production questions. Bulk procurement teams care about things the individual researcher might not—cost per kilogram, batch-to-batch consistency, scalable packaging options, transport constraints, and regulatory documentation. The companies that supply 4-Bromo-2,6-Di-Tert-Butylanisole know this landscape well. Quality assurance teams operate as the first line of defense against unwanted surprises, offering detailed product characterization, clear batch records, and sometimes even full supply chain traceability.

    Routine analysis pairs with transparency here. Firms committed to integrity invest in well-documented protocols—spectroscopy, mass balance, and stability studies—before anyone even opens the first drum. Buyers in regulated industries have grown wise to the difference between a legitimate supplier and a shortcut artist, and the market rewards those who keep safety and compliance visible throughout the process. In the decades since my graduate school days, those standards have only tightened, and chemistry professionals choose partners who share their values.

    Broader Impact on the Scientific Community

    The story of a specialty compound like 4-Bromo-2,6-Di-Tert-Butylanisole stretches far beyond what’s mixed in a flask. Reliable access to high-purity reagents supports innovation, cuts down on irreproducible work, and prevents the sort of wasted effort that can demoralize research teams. In collaborative projects where every member depends on clean, consistent materials, the value delivered ripples through multiple layers of an organization. Research publications that list this compound in their methods can attribute clean spectra and robust results in part to the underlying supplier commitment.

    Between commercial production and academic inquiry, there’s always a need for stewardship—transparent processes, honest reporting, rational pricing. That trust doesn’t form in a vacuum. It grows from a shared outlook that research should be reliable and reproducible, not based on lucky batches or favors pulled from the storeroom. In reviewing recent advances in cross-coupling methodology, it’s clear that reliable input materials make ambitious projects possible. Expanding research targets in organobromine chemistry always circles back to materials that can support complex aims without introducing new problems.

    Addressing Gaps and Weathering Headwinds

    Every product in a lab or industrial process will face stress points: supply chain interruptions, unexpected regulatory shifts, or even abrupt changes in demand. Lessons from recent years underline the importance of diversified sourcing and nimble logistics. A compound like 4-Bromo-2,6-Di-Tert-Butylanisole won’t shield a business from all the surprises out there, but sourcing from transparent, ethical producers does buffer against volatility.

    Efforts to green chemical production also loom larger every year. The push for lower waste and better environmental profiles means both buyers and suppliers must think ahead. Solvent recycling, improved batch yields, and reduced byproduct generation are just some of the ways current producers make a difference. Researchers expecting leadership from their suppliers increasingly ask tough questions about environmental impact, labor standards, and overall transparency. Only those suppliers who have answers backed by data will keep pace with these shifting expectations.

    The Value of Experience in Choosing the Right Product

    A lifetime in and around chemistry labs leaves a clear impression—success depends on choices made before the reaction even starts. The right starting material smooths out project timelines, limits surprises, and keeps collaborative efforts running on schedule. Cutting corners upfront quickly proves shortsighted; once, a team I worked with tried a cheaper, less pure analog, and we spent weeks backtracking. That lesson stuck. In environments where every hour counts and output justifies investment, quality products deliver returns that far outweigh any perceived savings from low-cost alternatives.

    Peer reviews count on careful bookkeeping, clean data, and robust reproducibility. Publications in respected journals go hand-in-hand with transparent sourcing and detailed product histories. When everyone has put in hours toward an end goal, compromised materials drag the whole process down. Recognizing reputable suppliers of 4-Bromo-2,6-Di-Tert-Butylanisole—and demanding their best, batch after batch—builds a foundation for teamwork, trust, and lasting scientific impact.

    Solutions That Move the Field Forward

    Many of the problems and obstacles facing researchers and industry buyers have answers rooted in communication and transparency. Suppliers of 4-Bromo-2,6-Di-Tert-Butylanisole who share batch analyses, offer detailed usage advice, and provide clear storage recommendations demonstrate not only technical expertise but also a real partnership mindset. Beyond the technical paperwork, the best firms encourage ongoing dialogue with their users—taking seriously the feedback that helps refine both product and process.

    Creating spaces—whether at conferences, online platforms, or industry roundtables—puts practitioners together with those who make and distribute these critical chemicals. This cross-pollination improves specifications, safety protocols, and even packaging design. It also puts the focus squarely on responsible stewardship: minimizing waste, maximizing efficiency, and ensuring sustainability across the board.

    Digital tools also play a bigger role each year. From automated ordering to QR code-driven batch traceability, the landscape for specialty chemicals is evolving. Buyers can now check certificate of analysis documents at the scan of a barcode. Regulatory updates or recall notices move rapidly through digital channels, protecting both workers and the broader community. Greater transparency, streamlined logistics, and attention to end-user needs will continue to separate leaders from the rest of the market.

    Points of Consideration for Newcomers and Veterans Alike

    People new to the world of specialty chemicals often approach compounds like 4-Bromo-2,6-Di-Tert-Butylanisole with understandable caution. The product represents more than an investment in glass and reagents—it’s a commitment to robust science, responsible sourcing, and practical problem-solving. Clients who learn the ins and outs of sourcing, storage, and real-world applications position themselves for success across a range of advanced research fields.

    Even veteran chemists have reason to revisit their assumptions. Scientific progress keeps raising the bar for reliability, clarity, and traceability. A few decades ago, tolerance for minor impurities or documentation gaps felt more common. Today, both peer-reviewed journals and regulatory agencies demand more: clean records, robust validation, and honest reporting. In a world of accelerating innovation, no one can afford to rest on old habits.

    Staying current with safety recommendations, regulatory hurdles, and technological resources takes time and attention to detail—but pays off tenfold just in trouble avoided. I’ve seen the cost of shortcuts, and too often those costs land far beyond the initial investment. Transparent sourcing, rigorous quality assurance, and supplier communication remain the best guardrails for any company hoping to compete—and contribute—over the long term.

    Looking to the Future

    Technology, regulation, and user expectations will keep shifting. Advances in analytical instrumentation, process control, and materials science will place new demands on compounds once considered routine. In specialty chemistry, only those compounds with a proven track record—like 4-Bromo-2,6-Di-Tert-Butylanisole—hold the confidence of both legacy researchers and those pushing the boundaries into new areas such as green synthesis, functional materials, and complex pharmaceuticals.

    The landscape for organic syntheses, combinatorial libraries, and specialized functional materials continues to evolve. With so much attention on sustainability and traceability, reputational risk has become a major consideration for both suppliers and buyers. Teams that share information promptly, address problems quickly, and focus on long-term partnerships are best positioned to thrive, even as shifting priorities change the market.

    Taking a step back, it’s clear that a single product can hold real influence well beyond the scale of a single laboratory. Aggregated across universities, corporations, and research institutes, access to high-performance materials will continue to underpin advances in science and technology. Whether working under the glare of industrial lights or the steady focus of a university research microscope, chemists and engineers keep moving the needle forward with the help of robust products that do what they promise—time and again.