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HS Code |
636300 |
| Cas Number | 56-91-7 |
| Molecular Formula | C9H10N2O3 |
| Molecular Weight | 194.19 g/mol |
| Synonyms | PAH; Para-aminohippuric acid; p-Aminohippuric acid |
| Appearance | White to off-white powder |
| Solubility In Water | Freely soluble |
| Melting Point | 268-270°C (dec.) |
| Purity | Typically ≥98% |
| Storage Temperature | 2-8°C |
| Chemical Structure | Benzoylglycine derivative with a para-amino substituent |
| Pka | 3.83 (carboxylic acid), 5.27 (amino group) |
| Iupac Name | N-(4-aminobenzoyl)glycine |
As an accredited 4-Aminohippuric Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 4-Aminohippuric Acid, 25g, is packaged in a sealed, amber glass bottle with a tamper-evident cap and clear labeling. |
| Shipping | 4-Aminohippuric Acid is shipped in accordance with standard chemical handling regulations. The compound is securely packaged in sealed containers to prevent contamination and moisture exposure. Shipping is typically done at ambient temperature with clear chemical labeling, and compliance with all relevant safety guidelines for non-hazardous laboratory chemicals is maintained. |
| Storage | 4-Aminohippuric acid should be stored in a tightly sealed container, protected from light and moisture, in a cool, dry, and well-ventilated area. It should be kept at room temperature, away from incompatible substances such as strong oxidizing agents. Proper labeling and secure storage are important to ensure safety and maintain chemical stability. |
Applications of 4-Aminohippuric Acid in Industrial ManufacturingAs the original producer of 4-Aminohippuric Acid, we supply this specialty chemical to established sectors with demanding downstream manufacturing requirements. This material contributes key performance and analytical characteristics in regulated industrial workflows. Explore its precise integrations across the following real-world application domains. 1. Active Pharmaceutical Ingredient (API) Synthesis for Diagnostic Agents4-Aminohippuric Acid serves as an essential intermediate in synthesis routes for contrast agents used in renal function diagnostics. Major global pharmaceutical manufacturers rely on its specificity for coupling reactions to produce injectable diagnostics, supporting quantifiable kidney clearance studies. Product batches must consistently meet international pharma standards, with intake controlled during nucleophilic acylation and purification steps to prevent residual impurities in final APIs. Industry compliance standards
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2. Reference Standard in Clinical Laboratory Assay DevelopmentThis compound functions as a calibration and validation analyte within clinical laboratory systems, ensuring the traceability of quantitative urine analysis for kidney performance markers. Accredited kit manufacturers require high-purity material for validated spike-and-recovery workflows. Standard operating procedures mandate its use at analytically controlled concentrations for reliable external quality assessment (EQA) panel production. Industry compliance standards
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3. Renal Function Assessment in In Vivo Animal Pharmaceutical ResearchIn regulated preclinical contract research, 4-Aminohippuric Acid offers a marker for renal plasma flow when dosed to animal models. Specialty research laboratories include it in perfusate solutions for accurate, noninvasive kidney clearance testing. Strict adherence to research animal ethics and regulatory reporting demands lot-specific documentation, purification, and validated quantification protocols. Industry compliance standards
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4. Analytical Control Marker in Pharmaceutical Process ValidationSpecialty pharmaceutical contract manufacturers deploy 4-Aminohippuric Acid as a process control marker in validation of continuous and batch manufacturing lines. Its unique molecular properties allow for audit-compliant tracking as a surrogate for API and excipient recovery during cleaning validation cycles and process flow troubleshooting. The compound supports system readiness certification and documentation for regulatory audits. Industry compliance standards
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Working day in and day out at the source gives a unique perspective on a chemical like 4-Aminohippuric Acid. We see the batches come together, run the purity checks ourselves, and receive feedback from the clients who use this product in their research and production lines. We know every stage by heart, so we understand more than just the technical formula. The compound, known to chemists as para-aminohippuric acid or PAH, carries the CAS number 61-78-9. What sets it apart is not only its established place in pharmaceutical and diagnostic research, but also the consistency and reliability it brings batch after batch.
4-Aminohippuric Acid is not a showpiece. It doesn’t need fanfare — it delivers. Over decades of optimization, we’ve settled on our current model, bringing the product as a fine, white to off-white powder. Typical purity exceeds 99%, and each drum leaving our plant bears the stamp of a rigorous in-house quality management process. The particle size suits standard lab and industrial demands, and we work closely with partners to ensure solubility characteristics match downstream requirements. Actual moisture content comes within low, verified ranges, ensuring the powder stays free-flowing and stable, especially during longer overseas shipments. No batch comes out without full chromatography and NMR confirmation.
Ask anyone on the floor, and the strongest feedback often comes from clients working in kidney function diagnostics. 4-Aminohippuric Acid has served as a gold standard marker in measuring renal plasma flow. In our conversations with long-term research partners, they point to how dependable results stem from dependable products. Clinics and research labs rely on PAH’s proven clearance profile in nephrology testing. Outside clinical work, university labs use these same properties in studies around organic anion transport and renal filtration specifics. Working directly with buyers, we see some choose 4-Aminohippuric Acid as a calibration standard in analytical chemistry, and others as a benchmark compound in structure-activity relationship studies. The key isn’t just function — it’s predictability and traceability, supported by continuous documentation and transparent manufacturing records stretching back decades.
We get plenty of questions about the nuts and bolts — what purity, what contamination risk, how the batch-to-batch reliability looks over long-term sourcing. Unlike brokers who can only repeat a supplier’s claims, our team produces, checks, and signs off on every stage. Our own technical staff set the bar high, not just to meet numbers but to protect our partners’ own experimental outcomes. For example, impurities at the micro level can confuse renal diagnostic readings, skew analytical baselines, or introduce unexpected peaks in chromatography. So we lean hard on reproducibility. Every time we release a production lot, quality control staff match results against standards not only on the books, but against our own archives of past production. Over time, the trace-level impurities and moisture profiles tell a honest story of how stable our line remains, and that matters most to project leads who bear much bigger downstream risks.
Each chemical operation works differently, but in this field, differences in manufacturer approach have downstream impacts. Some producers focus squarely on tonnage and price — the outcome is often mixed batches, slow documentation, and very limited traceability. Precision users report erratic behavior in sensitive enzymology or analytical work, often linked back to lots with minimal quality oversight. Our own approach sticks to tight raw material sourcing standards, long-established purification routes, and real-time monitoring during synthesis. That means fewer surprises, pure starting points for multi-step syntheses, and no compromises in biological studies where contaminants can change how a molecule interacts with tissue or protein targets.
Most alternative products offered on the market either float within the pharmaceutical or fine chemical grades, but rarely deliver exact documentation on impurity profiles. Some handlers blend batches or repack without a full view of origin or process detail. On the other hand, our team draws on decades tracking every change in process, confirming not just purity but lot-to-lot reproducibility — something clients running critical medical diagnostic applications or high-stakes synthesis routinely request. Inside the plant, that translates to smaller, tightly controlled manufacturing runs, verified each time through direct NMR and HPLC testing.
People often ask what really changes when using 4-Aminohippuric Acid from a direct manufacturer. We see clear advantages in traceability and response time. Our close relationships with academic departments, diagnostic kit producers, and pharmaceutical R&D teams let us pivot to meet shifting requirements, whether that means rapid supply for a clinical trial, custom packaging to avoid waste, or helping resolve analytical questions before product rollout. One team working on new renal function tests flagged a subtle by-product in off-the-shelf acid sourced elsewhere — our own batch ran free of these issues, allowing their research to publish on schedule and ahead of competitors.
Having control over process means our clients never face a black box. Full Certificates of Analysis, batch histories, and if needed, detailed analytical spectra—these accompany each delivery. Some research teams ask for extended impurity profiling to fit new regulatory requirements, and we respond with real data rather than broad assurances. No two projects face the same regulatory or experimental hurdles, but working with a manufacturer who knows every data point gives partners peace of mind. We keep records stretching back decades, and not only for compliance — feedback cycles let us correct the smallest irregularities before they impact customers. After all, an extra percentage point of trace impurity caught early saves weeks in failed experiments or regulatory cleanup for the end user.
Making 4-Aminohippuric Acid isn’t just about chemistry on paper—it runs on the skills of experienced operators and robust safety practice. The synthesis demands careful management of reaction conditions, neutralization steps, and cleanup, all designed to safeguard both personnel and product. Our operators insist on running pilot trials before scaling a new step, and raw material checks form the backbone of our approach to contamination prevention. Ventilation, personal protective equipment, and strict shelf-life monitoring define the everyday environment. Zero compromise on safety pays off both in staff welfare and in avoiding cross-contamination, which can spell disaster for diagnostic-grade compounds
Direct involvement in manufacturing keeps environmental impact front and center. Chemical operations face real consequences if waste or emissions go unchecked. We continuously review waste streams and engineer reaction pathways to reduce solvent use and by-product volumes. While regulations already demand strict oversight, on-the-ground experience shows that staying ahead of environmental compliance creates long-term business security and keeps local communities safe. What that means for our clients—product untainted by regulatory emergencies or shutdowns, continuity of supply, and the satisfaction of supporting responsible supply chains.
Novel drug development often pushes the boundaries of what diagnostics and chemistry can achieve. Several clients exploring new uses for 4-Aminohippuric Acid—be it in structure-based drug research, transporter studies, or next-generation filtration systems—rely on consistent material properties. Direct feedback tells us that raw materials riddled with batch idiosyncrasies stall innovation. Our facility’s flexibility, built by direct manufacturer access, allows customization in particle size, packaging, and even analytical support. Working together, researchers and manufacturers don’t just chase current needs, but carve out new possibilities. Our feedback loops between production, QC, and the R&D teams on both sides create a culture where improvement never ends.
Recent years have sharpened the focus on supply chain resilience. As direct manufacturers, we navigate global freight disruptions, raw material delays, and changing international regulations in real time. Unlike intermediaries who lose precious hours tracking sources, our logistics team coordinates directly with production, allowing us to reroute shipments or adjust batch priorities based on near-instant feedback. This agility means our clients avoid the cost and stress of stalled trials or research interruptions. We have built contingency stocks for our key partners, offering them reserved capacity and planned production windows so projects stay on track even in turbulent times. Real-world preparation comes from direct oversight, not outsourced risk management.
Returning calls and emails with firsthand technical answers—not script recitals or repeated platitudes—sets a manufacturer apart. Our technical staff, many veterans from the production line, handle queries involving solubility issues, unusual application parameters, or troubleshooting downstream formulations. We have faced cases where users, frustrated by lab-to-bench translation issues, send details to our support team for cost-effective, practical answers. Since we oversee everything from synthesis to drum filling, we troubleshoot with an insider’s knowledge of how process tweaks ripple through finished goods. Clients looking to push 4-Aminohippuric Acid into new experimental regimes often tap into our on-the-ground expertise to sidestep common pitfalls and fast-track their projects.
Long-term reliability grows from collaboration, not mere supply. Many of our partner businesses and university teams return year after year—not for the lowest price, but for a confidence rooted in history and consistent performance. Detailed batch archives, ongoing technical dialogue, and a shared commitment to transparency foster more than transactional relationships. Research continuity, trusted data integrity, and hassle-free sourcing drive decisions more than any sales pitch. Each container we ship reflects the collective diligence of teams who see the entire product life cycle, from raw material to final application.
Producing an established compound like 4-Aminohippuric Acid is not free from challenges. Occasionally, small shifts in upstream supply or changes in minor reagents can impact consistency or even disrupt scheduled deliveries. Unlike external sellers dependent on supplier updates, we adapt internally, revising purification steps, qualifying alternative sources, or running cross-validation trials to keep output steady. When storage or handling issues crop up—such as rare caking in high-humidity seasons—our operations team investigates, modifies packing environments, and reports findings back to clients. These practical, real-world solutions stem from daily engagement with both product and partners.
Not everything found online tells the full story about a chemical’s real-world performance or provenance. Direct access to on-site analysis, documented process alterations, and flexible manufacturing schedules brings a level of reassurance third-parties simply can’t match. Whether regulatory environments tighten, analytical methods change, or clinical priorities shift, partnership with a manufacturer means always having a back channel to the source. This creates not only more reliable science, but also cost savings and fewer research setbacks over the course of long-term projects.
Routine evaluation, honest feedback, and readiness to upgrade or refine methods keep 4-Aminohippuric Acid quality advancing in small, steady steps. We run post-batch debriefs with production staff, solicit annual feedback from major clients, and engage outside analysts to test for trace-level impurities or new contaminants. Crossing from lab-scale to ton production taught us that excellence doesn’t come from static process descriptions, but from hands-on management and perpetual curiosity. Keep asking what could go wrong; keep hunting for better ways to deliver. Our clients benefit from this outlook, seeing tangible improvements in shelf life, solubility, and batch reproducibility year after year.
Current markets overflow with reassurances. We prefer letting our process records, responsiveness to feedback, and unwavering transparency speak for themselves. Buyers with years of hands-on sourcing know the difference once they work with a real manufacturing team — supported by decades of living logs, not recycled noise. For 4-Aminohippuric Acid, as with any specialty item, this means less risk, truer data, and far smoother project delivery.
Those using 4-Aminohippuric Acid daily in fast-paced labs or research clinics find confidence in product reliability and support. Key advantages — clear traceability, rapid technical troubleshooting, detailed documentation, and environmental stewardship — stem directly from having a hands-on, fully accountable manufacturer partner. Batch by batch, process by process, the result is more robust science, fewer headaches, and a smoother path from experimental idea to real-world implementation. These outcomes matter most when lives or major breakthroughs depend on every gram produced and every analytical reading reported.