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4-Amino-M-Cresol

    • Product Name 4-Amino-M-Cresol
    • Alias 3-Methyl-4-aminophenol
    • Einecs 219-013-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    522329

    Chemical Name 4-Amino-m-cresol
    Cas Number 2835-98-5
    Molecular Formula C7H9NO
    Molecular Weight 123.15 g/mol
    Appearance Light brown to beige solid
    Melting Point 128-132°C
    Boiling Point Unknown
    Solubility In Water Slightly soluble
    Synonyms 4-Amino-3-methylphenol
    Purity Typically ≥98%
    Density 1.18 g/cm³ (approximate)
    Pka Around 10.1 (phenolic hydroxyl group)
    Smiles CC1=CC(=C(C=C1)N)O
    Inchi InChI=1S/C7H9NO/c1-5-2-3-6(8)7(9)4-5/h2-4,9H,8H2,1H3

    As an accredited 4-Amino-M-Cresol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 4-Amino-M-Cresol is supplied in a sealed 100g amber glass bottle with a secure screw cap and clear hazard labeling.
    Shipping 4-Amino-M-Cresol is shipped in compliance with relevant chemical transport regulations. It is securely packaged in sealed containers to prevent leaks and contamination. The shipping container is clearly labeled with hazard warnings. Handling instructions and safety data sheets accompany each shipment, ensuring safe transportation and handling for all personnel involved.
    Storage 4-Amino-m-cresol should be stored in a tightly sealed container, in a cool, dry, well-ventilated area away from sources of ignition and incompatible materials such as strong oxidizers and acids. Protect from light and moisture. Ensure appropriate labeling, and limit access to authorized personnel. Follow all relevant safety and regulatory guidelines for chemical storage.
    Application of 4-Amino-M-Cresol

    Applications of 4-Amino-M-Cresol in Industrial Manufacturing

    As a direct manufacturer of 4-Amino-M-Cresol with extensive technical expertise, we supply this intermediate for high-value applications across several targeted industrial segments. Our production complies with international quality systems, supporting customers in regulated and innovation-driven markets. Below are dedicated use cases in key downstream industries, showcasing real integration into customer formulation and manufacturing flows.

    1. Oxidative Hair Dye Manufacturing

    4-Amino-M-Cresol serves as a critical primary intermediate in the formulation of permanent oxidative hair dyes, where it participates in the color-forming reaction under alkaline conditions. Professional manufacturers incorporate this material for its ability to deliver controlled color depth and hue stability. Its use requires adherence to strict cosmetic chemical standards and supports the production of finished products aimed at regulated consumer markets in North America, Europe, and Asia-Pacific.

    Industry compliance standards

    • EU Cosmetics Regulation (EC) No 1223/2009
    • U.S. FDA 21 CFR Parts 700-740 (Cosmetic Color Additives)
    • Japan Ministry of Health, Labour and Welfare (Positive List)
    • Good Manufacturing Practice (ISO 22716)

    Typical usage ratio

    • 0.05%–1.0% w/w in cream or emulsion base, depending on the target shade and compatibility with other dye precursors; precise levels are chosen to balance shade intensity and meet regulatory limits.

    Downstream process integration

    • Dye intermediates premixed into aqueous or oil-in-water emulsion bases prior to reaction with hydrogen peroxide at the blending stage, followed by pH adjustment and stabilization with antioxidant agents; batch and inline processing both supported.

    Final product types

    • Boxed permanent hair color creams
    • Salon use oxidative dye kits
    • Dual-component developer/color formulations
    • Professional hair colorants for retail distribution

    2. Specialty Inkjet Dye Synthesis

    In the specialty printing segment, reputable inkjet ink manufacturers use this intermediate to synthesize high-purity azo and anthraquinone dyes for digital printing applications. Its nucleophilic reactivity is exploited to produce dye molecules meeting demanding criteria for colorfastness and photostability, which are key for textile and industrial inkjet inks.

    Industry compliance standards

    • ISO 2846 (Printing Ink Color and Transparency)
    • REACH Regulation (EC) No 1907/2006 (Substance Restrictions)
    • Ecological and Toxicological Association of Dyes and Organic Pigments Manufacturers (ETAD) recommendations
    • SGS RoHS reports for heavy metals

    Typical usage ratio

    • 10%–30% molar ratio (relative to coupling agent) in controlled synthesis of dye intermediates; the exact percentage depends on desired color strength and required purity (adjusted for downstream performance tests).

    Downstream process integration

    • Enters at the initial coupling stage of dye synthesis; intermediates then purified by solvent extraction and filtration; final dyes milled and formulated into water-based ink systems with co-solvents and surfactants.

    Final product types

    • Pigment-based inkjet inks for textile printing
    • Lightfast industrial ink formulations
    • Direct-to-garment printing inks
    • High-resolution photographic inks

    3. Pharmaceutical Intermediate for Active Ingredient Synthesis

    Pharmaceutical manufacturers employ this material as a core intermediate in the synthesis of certain APIs, primarily for anti-infective and CNS applications, where amino-phenol scaffolds are required. The stringent requirements for trace metal and nitrosamine residue control dictate tight QC on incoming raw materials, making in-house synthesis or direct qualified sourcing essential for regulatory clearance.

    Industry compliance standards

    • USP–NF (United States Pharmacopeia – National Formulary)
    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • EDQM CEP (European Directorate for the Quality of Medicines)
    • WHO Prequalification standards (for finished medicines)

    Typical usage ratio

    • Stoichiometric amount (1:1 molar ratio) in target condensation or acylation reactions forming API backbone, scale and purification steps strictly controlled based on batch yield calculations.

    Downstream process integration

    • Introduced at core structure construction, often in a closed reaction with acid chlorides or aldehydes; crude intermediates isolated, crystallized, and forwarded for further transformation or direct formulation post-purification.

    Final product types

    • Co-crystal API raw ingredients
    • Bulk intermediates for CNS pharmaceuticals
    • Aminophenol-based antibacterial agents
    • Custom-synthesized actives for CDMO-run pipelines

    4. Advanced Photoresist Systems for Microelectronics

    Leading microelectronics and semiconductor manufacturers have adopted this building block for exacting synthesis of custom photoactive compounds within state-of-the-art photoresist formulations. The controlled reactivity and defined impurity profile meet high-purity standards required during lithography for advanced circuitry.

    Industry compliance standards

    • SEMI C93 (Standard for Photoresist Chemicals)
    • IATF 16949 (Automotive QMS, relevant for electronics supply chains)
    • IEC 62474 (Material Declaration Standards)
    • REACH and RoHS for substance compliance

    Typical usage ratio

    • 0.1%–2% by weight in precursor resin synthesis; ratio determined by matrix formulation to achieve precise light sensitivity and pattern resolution.

    Downstream process integration

    • Reacted in controlled synthesis of diazonaphthoquinone esters or similar functional groups; final photoactive compound blended into polymer resin followed by microfiltration and cleanroom filling.

    Final product types

    • Positive and negative tone photoresist resins
    • Semiconductor wafer coatings
    • Advanced lithography materials for PCB and TFT-LCD
    • Specialty circuit patterning agents

    5. Analytical Reagent Production

    Producers of high-grade analytical reagents incorporate the compound into synthesis kits and colorimetric assays for precise quantitative detection in clinical and industrial laboratories. The reproducibility and defined color yield under reagent conditions underpin its preference for such diagnostic tools.

    Industry compliance standards

    • ISO 9001 and ISO 13485 (Medical device reagent manufacturing)
    • USP Reagent Specifications
    • CLSI Guideline C24 (Statistical Quality Control for Quantitative Measurement Procedures)
    • RoHS compliance for chemical reagents

    Typical usage ratio

    • 0.01%–0.5% in working colorimetric solutions; specific level optimized based on test sensitivity and blank absorbance in the target matrix.

    Downstream process integration

    • Added during the kit preparation stage as a primary reagent or indicator compound; formulated with stabilizers and buffer systems, lyophilized or bottled according to downstream assay format.

    Final product types

    • Laboratory assay color reagent kits
    • Clinical diagnostic panel reagents
    • Environmental monitoring solution sets
    • Industrial process test kits for water or food analysis
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    Certification & Compliance
    More Introduction

    4-Amino-M-Cresol: Our Experience, Commitment, and Practical Value

    Understanding 4-Amino-M-Cresol from the Manufacturer’s Floor

    In the business of chemical manufacturing, where every batch counts and consistency builds trust, 4-Amino-M-Cresol stands out as one of the core specialty products we’ve crafted for over a decade. It’s more than just a chemical entry in a catalog. Every lot that leaves our doors represents years of hands-on process refinement and a steady dialogue with chemists, colorant manufacturers, and researchers who count on predictable performance.

    The backbone of our 4-Amino-M-Cresol offering is attention to purity and reliability. Early on, we saw how sensitive applications, such as hair dye formulation or pharmaceutical intermediates, don’t tolerate inconsistencies. Even a tiny deviation in composition leads to altered reactions or unpredictable colors. Manufacturing this compound—chemically known as 4-amino-3-methylphenol—means carefully controlling not just the final product but every step, from raw material screening to packaging.

    Manufacturing Challenges and Quality Achievements

    The process starts long before reactors fire up. For 4-Amino-M-Cresol, raw material traceability sits at the foundation. We take the time to screen every input for contaminants commonly seen in regional markets, whether it’s heavy metals, aldehyde traces, or residual solvents. This focus grew out of lessons learned years ago, when a minor impurity in one order led to a cascade of customer issues: off-odors in creams, color shift in dyes, unexpected side-products in fine chemical synthesis. Since tightening controls upstream, these incidents dropped to near zero.

    The manufacturing itself involves a multi-step reaction, carefully monitored at each stage. Our team tracks not just yield, but by-product formation and intermediate stability. Filtration and crystallization parameters were tweaked across dozens of pilot runs. Through patient process engineering, we’ve learned how to minimize dust generation—important for powder-handling safety on larger orders—and how to promote uniform granule size for easier handling by our customers.

    Specifications Informed by Real-World Use

    Each unit we deliver typically shows over 99% content by HPLC, backed by full impurity profiling and residual moisture reporting. The color—often a light brown to tan, with occasional cream highlights—tells part of the story, while the fine crystalline structure enables straightforward weighing and solubilization, important for laboratory-scale and industrial mixing operations. We found that particle fineness affects not only solubility speed but also avoids unwanted clumping in automated feeder systems, especially in dye houses and custom synthesis labs.

    We record every result, because trace data protects both our process and our clients’ outcomes. Over the years, broad-spectrum analyses helped us detect and trace sources of variation, such as minute changes in temperature during the amino-methylation stage or slight shifts in pH that affect end color and stability. The result isn’t just specification-driven; it’s shaped by real-world performance feedback, whether from industrial scale blenders or benchtop trial runs in research labs.

    Putting 4-Amino-M-Cresol to Work: Practical Usage Across Industries

    4-Amino-M-Cresol took off in hair dye and colorant production, where it helps provide rich, lasting browns and acts as a reliable coupler in oxidative dye systems. Its chemistry lets formulators achieve subtle shades that depend on precise amine and methyl positioning, a detail that can only come from consistent manufacturing. We’ve seen this compound used in everything from well-known salon brands to specialist color systems for gray coverage and sensitive-skin products. The expectations in these fields include strict traceability, allergen management, and adherence to regulatory standards, each demanding a transparent supply chain.

    Beyond cosmetic chemistry, 4-Amino-M-Cresol appears in select pharmaceutical syntheses and as a building block for specialty resins and fine chemicals. Many of our larger volume clients blend it into dyes for textiles, where it imparts high colorfastness and resist fading from sunlight or repeated washing. These industrial customers require large, repeatable batches with no surprises in reactivity, since even slight composition drift would disrupt months of process validation.

    The Difference: What Sets Our 4-Amino-M-Cresol Apart

    Several products in the market carry similar labels, but differences in source materials, handling protocols, and care at each manufacturing stage impact reliability. We’ve learned—often through urgent client feedback—how other sources sometimes ship material with inconsistent color, unknown trace metals, or lingering solvent odor. These issues stem from repackers or cut-rate producers focused on volume instead of rigorous process control. Our product takes a different path, shaped by a refusal to cut corners and a direct responsibility for each kilogram produced.

    Batch quality depends on everything from the reactor design to precise temperature control, and what may look like a cosmetic difference—such as off-color or slightly damp cakes—translates into performance issues on the user end. Repeated investments in process equipment, better filtration, and staff training significantly reduced the kinds of minor variations that commonly lead to complaints or lost productivity in sensitive processes.

    How We Identify and Solve Real Issues

    The shift from a generic commodity chemical to a trusted specialty ingredient happened slowly, often through solving our customers’ practical problems. Early hair color formulations ran into haze formation until we improved our washing stage and reduced residual sulfates. Resin manufacturers, wrestling with inconsistent curing rates, worked with us to refine impurity removal. Open feedback channels—sometimes brutal, always honest—taught us more than trade shows or marketing bulletins ever could.

    We found a competitive edge by logging every customer complaint and success for internal review. One textile mill flagged a recurring problem with streaky colors when using competitors’ batches; our testing revealed that subtle pH drift and trace magnesium impurities played a hidden role, which our tighter controls could overcome. This level of detail, difficult to match without proximity to production, helped us partner as problem solvers rather than mere suppliers.

    Industry Standards and Regulatory Insight

    In this manufacturing environment, regulations shape product reality. European and international guidelines on aromatic amines make detailed impurity checks a legal requirement, not just a quality target. Auditors from downstream brands visit and demand traceability for every batch delivered over the last five years. The experience forced us to develop robust documentation systems—batch records, analytical certificates, and chain-of-custody data—readily available instead of buried in archives.

    Safety documentation doesn’t stop at regulatory boxes. Our long-term partners need real insight into allergenic potential and off-target reactivity, especially since consumers have raised risk awareness in specialty dyes and healthcare products. Collaborating with external toxicologists gave us critical guidance on minimizing residues, down to ppm levels, so our product remains compliant and trusted for sensitive end uses. This added layer of transparency goes beyond minimum compliance; it ensures long-term business stability for both customers and ourselves.

    Collaborating on Custom Needs

    Customization rarely appears as an isolated request. Successful partnerships often mean tailoring granule size or residual water to suit specific mixing equipment, or adjusting pack sizes for ease of handling in automated production. A hair dye startup may need a handful of kilograms vacuum-sealed for research, while a global textile brand orders tons with shipment reports tailored for each receiving plant. Instead of one-size-fits-all, we organize internal logistics and packaging teams to match how our customers really use and store the material.

    Sometimes custom specifications mean developing special analytical methods to match a customer’s own downstream QA protocols. Years spent in this business taught us that real trust forms when we demonstrate flexibility under real constraints, not just through sales pitches. Our technical support team—rooted in the same labs where QC and scale-up happen—works hand-in-hand with client process engineers to solve integration hiccups, batch troubleshooting, and unexpected impurities.

    Continuous Improvement and Technology

    Manufacturing isn’t static, and neither is our 4-Amino-M-Cresol process. Investing in chromatography and spectrometry tools allowed better, earlier impurity detection, often identifying shifts invisible to basic methods. Digital data tracking, once a luxury, now provides live insight for production supervisors and QA chemists. These tools helped us tighten specifications, shorten reaction timelines, and reduce material waste.

    Lean manufacturing principles, introduced years ago, still shape our daily routines. Cross-functional teams review not just output numbers, but customer complaint trends and field performance. Regular root-cause analysis means that when an issue crops up—be it a faint off-smell or a slight decrease in solubility—the right people investigate deeply, not just treat surface symptoms.

    The Role of Responsible Sourcing and Sustainability

    Sourcing plays a larger role than many realize. Early experiences with unstable shipments or questionable provenance taught us to build reliable raw material partnerships, supported by periodic supplier audits and long-running contracts. We favor sources with demonstrated environmental controls and transparent labor practices, since supply chain risks can land squarely on our doorstep or our clients’ brands.

    Waste minimization and energy efficiency belong at the forefront of specialty chemical production. Process refinements to lower water use, and careful solvent recovery, all contribute to a more responsible footprint. These changes often introduce subtle but important shifts in operational discipline—operators track yield loss more closely, engineers tweak thermal cycles for energy savings, and the laboratory verifies no new impurities sneak into the final product. Cleaner, safer production pays back in business resilience as much as environmental standing.

    Supporting Knowledge Sharing and Growing Together

    Education remains an underappreciated part of our service. Experienced chemists provide training to partners about proper 4-Amino-M-Cresol handling, storage practices to prolong shelf life, and safe integration into larger mixes. This technical support means fewer surprises downstream, since improper storage or exposure to environmental moisture can quickly spoil an entire order.

    Customers sometimes invite our experts to train their new hires, bridging the gap between chemical theory and everyday manufacturing reality. Sharing field-tested tips—like the effects of temperature swings on solubility, or ways to spot early signs of degradation—saves time and avoids costly missteps before a full production run ever begins. These relationships, older than many companies’ product launches, form the backbone of our business reputation.

    Challenges Faced and Solutions Found

    Problems occasionally emerge, no matter how robust a process may be. Several years ago, a global logistics crunch threatened our delivery timelines; we responded by adding warehouse capacity and creating staggered production schedules to buffer against supply chain shocks. In another case, a lot failed color inspection for a major cosmetics brand. Instead of hiding the issue, we invited their QA team onsite to retrace the anomaly. It turned into a rare opportunity for real process sharing, building trust we couldn’t have earned any other way.

    Where product recall risk arises—a rare but real possibility in the specialty chemicals world—our documentation allows rapid batch trace-back. Rather than delaying response, our team acts quickly to identify root causes and replace affected material, putting transparent communication first. These uncomfortable moments shape durable business ties because we face problems openly, not by shifting blame or hiding behind paperwork.

    Putting Things in Perspective

    Among a wide range of intermediates we make, 4-Amino-M-Cresol illustrates how every detail matters, from reliable sourcing to hands-on process management and transparent customer engagement. It earns its place in sensitive applications not through luck, but through a daily grind of quality assurance, communication, and relentless improvement. Our company stands behind it with a practical, problem-solving mindset sharpened by real-world partnership, not just transactional sales.

    After years in chemical manufacturing, we’ve discovered that real value for customers grows out of direct accountability and open exchange—attributes more powerful than any marketing slogan. 4-Amino-M-Cresol, in our hands, is more than a code or a standard; it’s a continuously improving promise that reflects both our experience and our promise to build lasting reliability together.