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4-Amino-5-Methoxy-2-Methylbenzensulfonic Acid

    • Product Name 4-Amino-5-Methoxy-2-Methylbenzensulfonic Acid
    • Alias 4-Amino-5-Methoxy-o-Toluenesulfonic Acid
    • Einecs 224-173-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    997157

    Product Name 4-Amino-5-Methoxy-2-Methylbenzensulfonic Acid
    Cas Number 88-44-8
    Molecular Formula C8H11NO4S
    Molecular Weight 217.24 g/mol
    Appearance White to off-white crystalline powder
    Melting Point 227-232°C (decomposes)
    Solubility Soluble in water, slightly soluble in ethanol
    Purity Typically >98%
    Storage Conditions Store in a tightly closed container, in a cool, dry place
    Synonyms Sulfanilic acid, 5-methoxy-4-amino-2-methyl-
    Ph Of Solution Approximately 4-6 (1% aqueous solution)

    As an accredited 4-Amino-5-Methoxy-2-Methylbenzensulfonic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The packaging is a sealed, amber glass bottle containing 100 grams of 4-Amino-5-Methoxy-2-Methylbenzensulfonic Acid with hazard labeling.
    Shipping **Shipping Description:** 4-Amino-5-Methoxy-2-Methylbenzensulfonic Acid is shipped in tightly sealed, chemical-resistant containers, protected from moisture and direct sunlight. It is handled as a non-hazardous solid (unless otherwise specified by regulations), with standard labeling and documentation. Ensure compliance with local and international regulations during storage and transport to maintain safety and chemical integrity.
    Storage 4-Amino-5-Methoxy-2-Methylbenzensulfonic Acid should be stored in a tightly closed container, in a cool, dry, and well-ventilated area. Protect from moisture, direct sunlight, and incompatible substances such as strong oxidizers. Keep away from sources of ignition. Store at room temperature and label the container clearly. Always follow appropriate safety procedures and local regulations for chemical storage.
    Application of 4-Amino-5-Methoxy-2-Methylbenzensulfonic Acid

    Applications of 4-Amino-5-Methoxy-2-Methylbenzensulfonic Acid in Industrial Manufacturing

    As the direct manufacturer of 4-Amino-5-Methoxy-2-Methylbenzensulfonic Acid (AMMSA), we supply this specialty raw material for well-defined industrial applications requiring high selectivity in performance and regulatory alignment. We support formulation and evidence-based adoption across several established downstream use sectors, focusing on differentiated scenarios with documented technical demand and quality system oversight.

    1. Organic Synthesis Intermediate for Azo Dyes Manufacturing

    AMMSA is a critical diazo component for synthesizing vivid yellow and orange azo dyes used in textile, paper, and leather coloration. Its electron-donating properties enhance color strength and fastness when coupled with diazonium salts. The compound integrates at the initial sulfonation and diazotization stages, providing consistent batch yields and supporting process repeatability in continuous dye manufacturing units. Downstream processors achieve clear chromatic targets and meet robust ecological discharge criteria.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006 – Substances Registration
    • ZDHC Manufacturing Restricted Substances List (MRSL)
    • OEKO-TEX® Standard 100 – Product Class I-IV
    • ISO 9001:2015 – Quality Management for dye manufacturing

    Typical usage ratio

    • In dye synthesis, 0.8%–2.1% by total batch mass, adjusted based on target color depth and substrate absorbency rate

    Downstream process integration

    • Added directly during the diazotization reaction, followed by coupling to the chromophore base
    • Batch or continuous blending with sulfonation pre-mix for water solubility tuning

    Final product types

    • Reactive, acid, and direct azo dyes for cellulosic and polyamide fibers
    • Liquid and powder dye formulations for textile, leather, and paper finishing

    2. UV-Absorber Intermediate for Industrial Coatings

    AMMSA serves as an aromatic sulfonic acid building block in the synthesis of benzotriazole-based UV absorbers and stabilizers. These UV-absorbers protect coatings and plastic films from degradation under prolonged sunlight. Its role in the condensation sequence enables downstream formulators to produce high-purity absorbers tailored to sector-specific weathering standards, particularly in outdoor architectural and automotive coatings.

    Industry compliance standards

    • EN 927-6:2020 for exterior wood coatings weathering performance
    • ASTM D4587 – UV exposure of coatings
    • ISO 14001:2015 – Environmental management in chemical synthesis
    • RoHS Directive 2011/65/EU for electronics coatings

    Typical usage ratio

    • Used at 1.5%–4.5% by weight in intermediate production step; adjusted according to end-use absorber loading

    Downstream process integration

    • Introduced during the condensation stage with hydrazine compounds for UV absorber backbone formation
    • Neutralization and isolation prior to resin blending

    Final product types

    • UV absorber concentrates for architectural and automotive surface coatings
    • Masterbatch UV stabilizers for polymer films

    3. Cosmetic and Personal Care Colorant Ingredient

    AMMSA is authorized as a precursor for producing certified dyes used in cosmetic and personal care products, particularly hair colorants and semi-permanent tints. Strict identity checks maintain batch compliance with cosmetic ingredient standards, and its well-defined molecular profile ensures reliable shade reproduction and toxicological safety in skin-contact applications. Manufacturers rely on its high purity as part of multi-stage dye syntheses with traceability for regulatory filings.

    Industry compliance standards

    • EU Regulation (EC) No 1223/2009 – Cosmetics Products Regulation
    • U.S. FDA 21 CFR Part 73 – Color Additives in Cosmetics
    • ISO 22716 – Good Manufacturing Practices (GMP) for cosmetics
    • China National Cosmetic Hygiene Standard (GB 7916)

    Typical usage ratio

    • As a dye intermediate, 0.2%–1.3% of dye batch mass; inclusion adjusted per targeted intensity and formulation chemistry

    Downstream process integration

    • Undergoes controlled diazotization and subsequent coupling to form stable cosmetic-grade azo dyes
    • Purification by recrystallization or ion exchange prior to blending with emulsifiers and dispersants

    Final product types

    • Hair dye concentrates and semi-permanent color gels
    • Temporary body art inks and colored rinse-off lotions

    4. Analytical and Diagnostic Reagent Manufacturing

    AMMSA is valued for its precision in producing colorimetric reagents, including diazonium salt-based analytes used in clinical and environmental analytical kits. These intermediates function as reaction components in biochemical assays and water testing systems, where color change indicates analyte presence. Tight batch traceability, low byproduct profile, and purity documentation support global reference laboratories and regulatory-cleared diagnostic supply chains.

    Industry compliance standards

    • ISO 13485:2016 – Medical Devices Quality Management (for diagnostic reagents)
    • Clinical Laboratory Improvement Amendments (CLIA) regulations
    • RoHS for laboratory consumable manufacturing
    • EN ISO 9001:2015 for analytical reagent supply

    Typical usage ratio

    • Utilized at 0.05%–0.4% in analytical reagent synthesis, depending on target detection threshold

    Downstream process integration

    • Reacted in-situ during diazonium salt formation for later coupling to indicator substrates
    • Employed in solid-phase or liquid reagent preparation under sterile conditions

    Final product types

    • Colorimetric test strips for water quality
    • Clinical diagnostic kits for blood and urine analysis

    5. Sulfonamide Pharmaceutical Intermediate

    AMMSA acts as a targeted intermediate during the multi-step synthesis of selected sulfonamide drugs, providing a high-purity, amine-functionalized aromatic backbone. Combined with other pharmaceutical-grade reagents, it supports efficient amide coupling reactions and offers regulatory traceability for drug substance manufacturers subject to cGMP protocols and pharmacopoeial audit requirements.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • United States Pharmacopeia (USP) General Chapter <1058>
    • European Pharmacopoeia (Ph. Eur.) compliance for intermediates
    • China GMP (2020 Edition) for chemical APIs

    Typical usage ratio

    • Intermediate input: 1.2–3.7 g per mole of target sulfonamide; quantity depends on the final active structure and yield optimization

    Downstream process integration

    • Participates in directed sulfonation and amide bond-forming steps during API synthesis workflow
    • Subjected to in-process controls for identity and purity prior to downstream coupling

    Final product types

    • Sulfonamide active pharmaceutical ingredients for anti-infective and diuretic therapies
    • Pharmaceutical-grade intermediates supplied to cGMP-compliant formulators
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    Certification & Compliance
    More Introduction

    Introducing 4-Amino-5-Methoxy-2-Methylbenzensulfonic Acid: Purpose-Built Chemistry for Modern Applications

    Few materials earn the loyalty of seasoned chemical engineers and production managers as quickly as 4-Amino-5-Methoxy-2-Methylbenzensulfonic Acid. Over decades of manufacturing, our team has watched changes in markets, upgrades in quality expectations, and new regulations push specialty chemicals into ever more demanding niches. Through it all, this compound has steadily gained attention from our partners seeking clean reactions, consistent batches, and specialty functionality in colorants, pharmaceuticals, and high-end intermediates. After working on numerous production runs and seeing the compound evaluated side-by-side with analogs, there is plenty to say beyond textbook summaries on why experienced chemists often place their confidence in this molecule.

    What Sets Our Material Apart

    At the plant floor, we don’t just watch analytics tick by in the QC lab. We learn, batch after batch, which chemicals really behave. There are dozens of sulfonated aromatic compounds available, but few match the performance or reliability of 4-Amino-5-Methoxy-2-Methylbenzensulfonic Acid in critical dye scaffolds and sulfonamide synthesis. The p-methoxy and methyl substitutions finely tune the reactivity, giving formulation chemists direct access to controlled chemical modifications.

    In practical terms, the 4-amino group brings downstream functionalization opportunities that open doors in both dyes and medicines. Extracting high purity from each run requires experience with both temperature management and raw material control. We have learned through operational improvements how to deliver tight specification ranges without surprise colors or byproduct contamination that would complicate customer handling or downstream synthesis.

    Consistent Quality from Control to Container

    Manufacturers build a reputation on reliability, not just lab-scale purity claims. Production requires months of planning, the right process chemistry, and the discipline to match tonnage volumes with the same attention as kilogram runs. Our synthesis team starts by verifying initial aromatic building blocks from trusted sources. Small things matter—pH drifts, reaction timing, and filtration efficiency all add up. Through trial, error, and steady optimization, our engineers shaped a production method that holds contaminants to low ppm levels, avoiding trace metal residue or unreacted starting material in the final product.

    We keep a close watch on crystal morphology. Butterfly-shaped crystals may look pretty, but they clump and complicate weighing and dissolution during customer handling. Our batches lean toward well-formed plates for easy handling and fast wetting—minor in theory, but a major advantage on the shop floor. Moisture content control is another area where experience shows its value. Even robust sulfonic acid derivatives can take up water from the air, turning free-flowing powder sticky and hard to dose. Process adjustments and careful packaging keep product flowing, not caking.

    Applications: Building Blocks for Innovation

    Our product’s story comes to life in the hands of industrial chemists. In dyes, 4-Amino-5-Methoxy-2-Methylbenzensulfonic Acid gives access to colorfast, vivid shades that maintain their integrity during finishing or sunlight exposure tests. We have partnered with manufacturers searching for tougher, more light-stable dyes for textiles, plastics, and specialty inks. Feedback from the ground says these applications constantly face new audit pressures to drop impurities and meet increasingly tight limits on heavy metals, byproducts, and amines. Each shipment from our facility comes with full characterization, so clients stay audit-ready and avoid scrambling for compliance documentation.

    In pharmaceutical development, the molecule does more than support drug candidate synthesis. Its clean substitution pattern supports structure–activity investigations, giving chemists a stable intermediate that rarely causes headaches during purification. Polar sulfonic acid groups, paired with defined aromatic substitution, simplify stepwise modifications while safeguarding batch-to-batch reproducibility. Over the years, our technical staff has worked closely with R&D teams scaling up from grams to metric tons, helping them adjust process trains while preserving the sensitive groups that give their molecules unique activity profiles.

    Why Experience in Manufacturing Pays Dividends

    Anyone with a flask and access to standard reagents can make a few grams. Scaling to hundreds or thousands of kilograms draws a sharp line between laboratory curiosity and viable industrial material. Process engineers here sweat over thermal control, side-reaction suppression, and product isolation not because these challenges are glamorous but because they decide the difference between a triumph and a recycling headache. Our best batches come from repeated feedback between synthesis, purification, and customer application. Each cycle helps us recognize new pitfalls: stubborn filtration clogs, small shifts in viscosity during washing, and the way certain lots behave in pilot plant trials.

    This vigilance comes through in the analytical profiles. High-performance liquid chromatography and mass spectrometry tell one story; customer anecdotes add invaluable detail. We learned not to ignore subtle signs—a faint off-odor or a dusty side-fraction points toward process tweaks that later secure a stable, reliable output. Those paying attention in the chemical industry know that consistency wins contracts and supports long-term partnerships far more than a rock-bottom price or a quick shipment ever could.

    Comparisons with Similar Compounds: Fine Lines that Matter

    Some might assume that most sulfonated aromatic acids are interchangeable or that an extra methyl or methoxy group is a minor detail. Daily practice tells otherwise. Trace impurities, slight solubility shifts, and secondary side reactions add up quickly in production. For example, the 2-methyl substitution we maintain in synthesis makes a significant difference in dye coupling reactions and in avoiding unanticipated redox activity. Swapping out for a plain benzensulfonic acid or an isomerized variant leaves customers exposed to batch inconsistencies and extra purification cost down the line.

    Other variants sometimes offer marginally lower raw material costs, but side by side, final product analyses regularly show volatility in dye tone, incomplete reactions, or low crystallization yields. Our 4-Amino-5-Methoxy-2-Methylbenzensulfonic Acid walks the tightrope—reactive enough for coupling, resistant to overreaction or rearrangement—and this edge shows up each time our customers feed it into their reactors. These nuanced distinctions are hard-won and built from dozens of scale-up projects in both established and emerging markets.

    Standardization and Customer Support Through the Lifecycle

    Busy production schedules mean customers want their shipments on time, each run matching the last. At our facility, inventory planning backs up the chemistry, with regularly scheduled campaigns to ensure uninterrupted supply. Orders for 25 kg drums or full container loads receive the same attention to stability and packaging conditions. No one wants to open a container only to find product has caked in transit or picked up enough moisture to alter its flow properties. Our warehouses maintain controlled humidity and temperature year-round to avoid seasonal surprises.

    Much of our work takes place behind the scenes. Technical teams don’t just sell a drum—they solve offbeat handling challenges, guide on optimal solvent systems, and troubleshoot unanticipated side reactions. Feedback loops between process and application support become especially important as customer R&D teams move toward pilot plant scale or regulatory filings. Many times we have worked side-by-side—onsite in customer facilities, or remotely—to help optimize dissolution profiles, support analytical validations, or expedite delivery for tight project timelines.

    Sustainability, Safety, and the Road Ahead

    Chemical production today requires more than just consistent synthesis and timely supply. Environmental limits, community expectations, and long-term stewardship all shape how our factory runs each campaign. Sourcing starts only with partners who can prove clean track records and documented methods. Waste streams and byproduct handling undergo continuous review. Our waste reduction evolves with every campaign, rerouting process streams into secondary value chains whenever technology and economics allow. Lower solvent usage, water-saving steps, and tighter process controls do far more than just trim costs—they secure a future for chemical manufacturing in an increasingly strict regulatory environment.

    On safety, staff at every level take part in regular drills and reviews. Though 4-Amino-5-Methoxy-2-Methylbenzensulfonic Acid handles as a low-volatility solid, all materials protocols reflect the latest best practice standards. Long experience has taught that well-maintained records, clear labeling, and disciplined operating procedures give the best shield against both major incidents and costly downtime from small errors. We constantly audit and review storage, packaging, and logistics to keep each batch secure from our gates to customer’s plants. Our partners count on us to document every step, ensuring traceability and compliance at every handoff.

    Listening to Customers: Adaptation and Improvement

    Our business rarely stands still for long. End customers demand new certifications, want product adaption for different jurisdictions, or look to adjust specs for novel needs. Every major upgrade, every process chemist request, builds a stronger, more adaptive product line. Sometimes the lessons come from late-night troubleshooting—other times from careful, months-long review. After years of dialogue, some of our best process innovations came straight from customer feedback: more robust drying protocols, improved sampling for in-process analysis, even changed crystal form for easier blending. Every batch, every interaction, pushes us toward a higher standard and a wider range of use cases.

    We rarely get the perfect solution on first try. Process changes ripple out and sometimes create new challenges. The most valuable skill isn’t raw technical knowledge, but the ability to listen, adjust, and keep improving. The companies who work with us know that they aren’t getting just a one-time shipment, but a partner willing to learn alongside their teams, accept critique, and strive for ever tighter process control and cleaner chemistry. That’s how we’ve been able to expand supply year after year without sacrificing credibility.

    Integrity in Every Shipment

    Trust is earned, not just in words, but in on-time delivery, clear communication, and zero-compromise analysis. Our team stands behind each shipment of 4-Amino-5-Methoxy-2-Methylbenzensulfonic Acid. Traceability documents, complete batch history, and a full spectrum of third-party analytics leave no gaps. We work directly with auditors and regulatory affairs specialists at the customer’s facilities, providing clear, immediate answers to queries about solvent removal, trace byproducts, or compliance with ever-more-stringent global safety codes.

    Experience teaches that one missed detail, one poorly communicated change, can lose a customer for good. Over the years, we’ve built up a robust system for pre-shipment checklists, post-shipment technical feedback, and ongoing customer check-ins. These practices, grown from direct service and lessons learned, form the backbone of long-term industry relationships. Production specialties like ours don’t scale by cutting corners. They thrive with a disciplined practice, the humility to keep learning, and a shared commitment to quality chemicals for forward-looking manufacturers.

    The Future of Specialty Intermediates

    Markets may switch course, but demand for pure, dependable intermediates only grows. Increasingly stringent regulatory guidelines, new product launches, and changing consumer demands require a base of solid, reliable, thoroughly characterized chemicals. 4-Amino-5-Methoxy-2-Methylbenzensulfonic Acid stands as a testament not just to process chemistry, but to the value of long-term focus and adaptable partnership. As more downstream specialists join the sector, detailed knowledge, transparency, and responsiveness become the new currency. We are committed to staying at the forefront—not by volume alone, but by bringing together skilled hands, open-minded engineering, and a real interest in every application our product reaches.

    Each shipment has a story behind it—a cascade of process trials, lessons learned, and problems solved long before the drum is opened in a customer’s plant. We believe this attention, hard-won as it is, makes all the difference. For critical dye work, for ground-breaking pharma synthesis, and for every customer who depends on their supply chain, our 4-Amino-5-Methoxy-2-Methylbenzensulfonic Acid will continue leading the way: reliable, precisely made, and ready for the challenges ahead.