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4-Amino-5-Imidazolecarboxamide Hydrochloride

    • Product Name 4-Amino-5-Imidazolecarboxamide Hydrochloride
    • Alias AICAR hydrochloride
    • Einecs 207-746-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    638791

    Productname 4-Amino-5-Imidazolecarboxamide Hydrochloride
    Chemicalformula C4H7ClN4O
    Molecularweight 162.58 g/mol
    Casnumber 72-40-2
    Appearance White to off-white crystalline powder
    Meltingpoint 255-257 °C (dec.)
    Solubility Soluble in water
    Storagetemperature 2-8 °C
    Purity Typically ≥98%
    Synonyms AICAR hydrochloride

    As an accredited 4-Amino-5-Imidazolecarboxamide Hydrochloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 4-Amino-5-Imidazolecarboxamide Hydrochloride packaged in a sealed amber glass bottle, labeled with safety and product identification information.
    Shipping 4-Amino-5-Imidazolecarboxamide Hydrochloride is shipped in tightly sealed containers to protect from moisture and contamination. It is packaged according to safety regulations, labeled with hazard information, and transported in compliance with local and international chemical shipping standards, ensuring secure delivery and integrity of the compound during transit.
    Storage 4-Amino-5-Imidazolecarboxamide Hydrochloride should be stored in a tightly sealed container, protected from light and moisture. Keep it at room temperature, ideally between 2°C and 8°C (refrigerated if possible), and in a well-ventilated area. Ensure the storage location is free from incompatible materials, such as strong oxidizers, and restrict access to trained personnel only.
    Application of 4-Amino-5-Imidazolecarboxamide Hydrochloride

    Applications of 4-Amino-5-Imidazolecarboxamide Hydrochloride in Industrial Manufacturing

    As a specialized manufacturer with decades of direct involvement in the synthesis and quality control of 4-Amino-5-Imidazolecarboxamide Hydrochloride, we provide this intermediate for integration into several regulated and performance-critical industrial sectors. Below, we detail real-world application scenarios, focused on the pharmaceutical, veterinary, research, and diagnostic industries. Each segment provides specification on compliance, typical dosing, process step, and end-product utilization founded on industry norms and factual downstream customer practices.

    1. Pharmaceutical Active Pharmaceutical Ingredient (API) Synthesis

    This material plays a pivotal intermediate role in the multi-step synthesis of certain purine-based APIs, particularly within the anti-cancer and immunomodulatory drug classes. Its purity and traceability directly affect API batch quality, requiring close management from raw material reception through each reaction step in GMP-certified plants. We continuously monitor quality specifications to support downstream compliance in regulated drug pathways.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP/NF (United States Pharmacopeia/National Formulary) for ingredient and impurity limits
    • 21 CFR Part 211 (FDA cGMP regulations for finished pharmaceuticals)
    • EDQM CEP (European Directorate for the Quality of Medicines - Certificate of Suitability)

    Typical usage ratio

    • Applied within synthesis at 1.0–2.2 molar equivalents per reaction stage, adjusted precisely based on target yield and stage purity requirements in the final API process specification.

    Downstream process integration

    • Introduced after starting material activation, during nucleophilic substitution or ring construction; commonly enters as a limiting or key ingredient in condensation or cyclization steps of advanced nucleotide analogues.

    Final product types

    • Peginterferon API
    • Nucleotide-based kinase inhibitor APIs
    • Thienopyrimidine-based anti-viral drug substances

    2. Veterinary Pharmaceutical Ingredient Production

    Large-scale veterinary pharmaceutical production utilizes this raw material to access modified purine scaffolds, critical for animal-use active ingredients with strict residue and purity controls. Downstream partners emphasize traceable sourcing and validated process history to assure compliance with animal health authority registrations across different geographies, necessitating precise documentation and consistency.

    Industry compliance standards

    • VICH GLs (International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal Products – Quality Guidelines)
    • EU Regulation (EC) No 470/2009 on veterinary drug residues
    • China Veterinary Pharmacopoeia
    • US FDA CVM (Center for Veterinary Medicine) guidance for API manufacturing

    Typical usage ratio

    • Used at 0.8–1.5 molar equivalents per synthesis, adjusted depending on batch scale and downstream intermediate purity specifications as per veterinary drug master files.

    Downstream process integration

    • Integrated during the synthesis of animal-use prodrugs and nucleotide analogues, often as part of a key condensation or amination stage in custom synthesis protocols for large-volume veterinary actives.

    Final product types

    • Veterinary antimetabolite drugs
    • Livestock growth promoters (purine-based)
    • Animal-specific immunomodulator actives

    3. Nucleic Acid Derivatives for Molecular Biology Reagents

    Advanced molecular biology labs and reagent formulators utilize this intermediate in the chemical synthesis of modified nucleotides for PCR, DNA labeling, and sequencing reagents. Purity, metal ion profile, and batch reproducibility are crucial, with strict control over contaminant and byproduct levels to avoid interference in high-sensitivity downstream bioassays.

    Industry compliance standards

    • ISO 9001:2015 quality management system for reagent manufacture
    • ISO 13485:2016 where molecular diagnostics components are intended for medical device use
    • REACH Registration for lab chemical supply in the EU
    • OECD Principles of Good Laboratory Practice (GLP) for lot release

    Typical usage ratio

    • Applied at 0.5–1.0 equivalent to starting ribose or deoxyribose units, depending on desired modification level in custom nucleotide synthesis batches.

    Downstream process integration

    • Employed in the formation of the imidazole-containing rings during the chemical assembly of modified nucleoside triphosphates or fluorescently labeled analogues, typically under anhydrous conditions at pre-activation or cyclization stages.

    Final product types

    • qPCR probe nucleotides
    • DNA/RNA synthetic analogues
    • Fluorescent dNTPs/analogues for sequencing and detection kits

    4. Biochemical Diagnostic Enzyme Substrate Synthesis

    Manufacturers for clinical biochemical test kits incorporate this intermediate for the construction of enzyme substrates used in diagnostic assays, especially for metabolic function panels. Regulatory and technical demands require documented absence of interfering residue substances, and consistent reactivity to ensure accuracy of patient test results in global clinical settings.

    Industry compliance standards

    • ISO 13485:2016 for in vitro diagnostic (IVD) reagent manufacturing
    • 21 CFR Part 820 FDA QSR for medical device components (US market)
    • EN ISO 18113 for diagnostic kits in the European Union
    • CLSI (Clinical and Laboratory Standards Institute) protocols for reagent consistency

    Typical usage ratio

    • Used at 0.3–0.9 equivalents relative to parent nucleoside or substrate precursor, with adjustment based on final substrate reactivity specification and kit scale production batch size.

    Downstream process integration

    • Added during the ring modification step or final substrate coupling process, often immediately before crystallization or purification of diagnostic substrate compound.

    Final product types

    • Enzyme-coupled detection substrates (e.g., for xanthine oxidase tests)
    • Clinical diagnostic panels for purine metabolism
    • Blood analyte detection reagents
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    Certification & Compliance
    More Introduction

    4-Amino-5-Imidazolecarboxamide Hydrochloride: A Closer Look at Our Specialty Product

    Dedication to Purity and Reliability

    Producing 4-Amino-5-Imidazolecarboxamide Hydrochloride takes more than following a recipe—it demands steady focus and consistent quality control at every single stage. From raw materials entering our plant to that last, oddly satisfying moment the finished compound is sealed up for shipment, every batch is a reflection of our team’s experience and the standards we set for ourselves. This isn’t an anonymous white powder churned out by a nameless factory. The material that comes out of our reactors directly influences crucial research and production lines worldwide, including high-stakes fields like pharmaceuticals, specialty reagents, and fine chemical intermediates. The responsibility never feels abstract to us, because we know research timelines, cost savings, and patient outcomes often depend on exactly what we send out our doors.

    We work with 4-Amino-5-Imidazolecarboxamide Hydrochloride with a level of familiarity that comes only after years of hands-on production and troubleshooting batch after batch. Many clients ask about the difference between our product and alternatives sourced from trading companies or secondary processors. The real distinction becomes clear when examining critical specifications such as assay, moisture content, and impurity profile. Reliable repeatability and this rare degree of transparency matter, especially for customers scaling up their own synthesis or feeding the compound into a manufacturing process that tolerates little deviation.

    Understanding the Compound

    The chemical structure of 4-Amino-5-Imidazolecarboxamide Hydrochloride offers much more than an academic interest. Its imidazole ring and amino substitution make it a building block for a variety of applications. In our experience, this product serves as a foundation for synthesizing nucleoside analogues, which underpin essential biomedical research. Scientists rely on its stability and purity, whether they are working on antiviral drugs, exploring cellular energy transfer mechanisms, or supporting the development of emerging classes of therapeutic molecules.

    Unlike some bulk chemicals, this compound invites attention to detail. The hydrochloride salt brings enhanced solubility and makes handling during formulation more practical, particularly under the conditions faced in both R&D and full-scale manufacturing. Over the years, we have reached a specification for crystal habit, particle size, and residual solvent limits—each driven by feedback from formulation chemists and process scientists who do real work with the material. What sets our lots apart stems from an ongoing, often quiet dialogue with these end users.

    Batch Consistency and Real-World Impact

    If you ask a bench chemist, a lot goes into determining whether a batch is “good.” A clean analytical profile matters, but even more so, how the material behaves in actual use tells the real story. Through thousands of kilograms produced, we have honed upstream purification techniques that strip away starting material residues and clamp down on trace organic impurities. Most customers notice that our product consistently meets purity targets above 98% HPLC, with many batches pushing above 99%. That’s not luck. We achieve these figures through a mix of conscientious process monitoring, regular maintenance, and investing in robust analytical tools.

    Differences show up not just in numbers, but in routine handling and application. Solubility, for example, becomes less of a headache thanks to well-controlled crystallization steps and careful drying. Researchers working with downstream transformations or sensitive couplings report fewer failures linked to unexpected byproducts. Time lost to redissolving, filtering, or troubleshooting impure feedstock drops, which lets teams focus resources on actual innovation.

    Production Know-How and Traceability

    Years of manufacturing experience with 4-Amino-5-Imidazolecarboxamide Hydrochloride reveal all kinds of variables that don’t appear in textbooks. Operators quickly notice that batch yield, mother liquor handling, and even tank age can nudge impurity levels. For us, no production lot is ever truly routine. Our QA and QC teams check each step: from temperature mapping in reactors to particle analysis before packaging. We keep batch records comprehensive and accessible, so clients in regulated industries can verify traceability without the runaround.

    Nothing gets omitted or glossed over. Full transparency and document control are part of our workflow, not only for compliance but for practical benefit. If a trend appears—maybe a subtle uptick in solvent residue—we go straight to the source and correct it before it becomes a pattern. Customers who return year after year say that kind of diligence saves them both time and reputation.

    Differentiation from Other Producers

    Comparisons occasionally crop up in the market, sometimes pitched as all suppliers being interchangeable. Our team knows firsthand this isn’t the case. We routinely reprocess “off” material purchased from intermediaries who claim to match our specifications. These batches nearly always show higher side product inclusions, off-white coloration, or moisture pickup—evidence of cutting corners during their isolation or packaging steps. Instead of passing that burden downstream, we choose to reject or upgrade such lots. It costs us more, but the assurance pays dividends for chemists burning through deadlines or trying to meet strict regulatory reviews.

    Capacity and responsiveness make a difference, too. Having our own synthesis lines and crystalline isolation equipment means faster turnaround and flexible-scale manufacturing. If a customer suddenly jumps from kilogram to multi-ton demand, we avoid delays pegged to importing intermediates or seeking permission from brokers. Control over the supply chain matters deeply in uncertain times. We guarantee reserve lots for key partners, which means research doesn’t come to a halt because of supply snags.

    Handling and Storage Experience

    This compound, like others in its class, absorbs moisture from the air. Users often comment on caking or clumping from alternative sources. Our team minimizes these issues by employing low-dew-point packaging and immediate bottling after drying. Repeated customer feedback suggests this routine makes material handling far less stressful in real-world laboratory or production settings. If an application calls for weighing low-milligram portions or preparing concentrated solutions, the lot behaves as expected—no concealed water, no sudden static cling, and no lost compound to bottlenecked dispensers.

    Proper shelf management plays a role, too. We recommend cool, dry conditions—not because it’s easy, but because it is crucial to extending usable life. End users have told us more than once that a sealed container from our factory remains free-flowing and uncompromised long past initial opening, provided storage follows standard protocols. Product wastage sinks costs and introduces variability; long-lasting stability aligns with customer interests as much as ours.

    Supporting Scale-Up and Downstream Processes

    Research groups and contract manufacturing partners increasingly demand a product that keeps pace with shifting project needs. Our experience in technology transfer, pilot-scale expansion, and strict batch reproducibility offers real practical value. When a customer moves from gram to kilogram scale, our documentation includes specifics on lot behavior, mixing times, and any required conditioning steps. Beyond the lab, we’ve worked with commercial API manufacturers who count on trouble-free feeding into multi-step syntheses, where one batch hiccup can disrupt weeks of scheduled activity.

    Soluble, stable, and easy to work with, our hydrochloride form avoids complications tied to alternative salts or free bases. We provide granulation or custom-milling to tightly match a targeted bulk density or mesh size—pulling from lessons learned through direct feedback rather than what looks best on a certificate of analysis. Over time, supporting these kinds of custom requests actually trims waste and supports client productivity. No two applications are the same, which is why we avoid a cookie-cutter approach.

    Regulatory Readiness and Analytical Data

    Many customers buy 4-Amino-5-Imidazolecarboxamide Hydrochloride for pharmaceutical or diagnostic research, which brings regulatory obligations. Our analysis covers more than the routine: each delivery includes a detailed COA, plus, when needed, identity confirmation by NMR, melting point range, and heavy-metal analysis by ICP-MS. We have built this analytical rigor into daily operations simply because we also benefit. Problems solved early shield everyone from last-minute questions or regulatory rejections.

    We store batch retains and full manufacturing records for all ship dates, which has helped countless clients complete audits or support regulatory filings without headache. Repeat orders come not from one-off promises but from a demonstrated culture of openness and reliability. Contract auditors and regulatory visitors have full access and direct insight into our protocols, and we view this not as a hurdle but as a point of pride.

    Environmental Responsibility and Worker Safety

    Making 4-Amino-5-Imidazolecarboxamide Hydrochloride safely and responsibly always remains top priority. Our plant managers and EH&S teams keep a sharp eye on both emissions and worker exposure. We’ve invested in advanced closed-system reactors and modern solvent recovery units to shrink our environmental footprint. The solvents entering our recovery line re-enter circulation; waste minimization is no longer an afterthought.

    Operators who manage the day-to-day processing get extensive safety training. Gloves, goggles, and on-call ventilation measures are simply part of the fabric. Working with fine powders means dust control is essential—for our team as well as for end users. Our procedures get written by those closest to the process, and management values every suggestion for improved safety or sustainability. This continuous loop between production and safety teams prevents near-misses from repeating. No batch leaves the plant without passing both chemical quality and personal safety checks.

    Current Applications and Customer Feedback

    Every use case for our 4-Amino-5-Imidazolecarboxamide Hydrochloride teaches us something new. Customers span R&D labs, large-scale pharmaceutical companies, and specialty chemical producers. Feedback has ranged from requests for ultra-low endotoxin levels for sensitive biological assays to bulk volume shipments for established process flows. Many users highlight a simpler purification process downstream, thanks to the low baseline impurity profile we achieve. Others appreciate the fast and consistent response from our technical team, particularly when troubleshooting or adapting to late-stage process modifications.

    Some report using it as the core for synthesizing adenosine analogues; several request custom packing or handling documentation to suit specific regulatory submissions. Our response grows out of understanding the science as much as the logistical challenges that go with it. No batch leaves without double-checking against the agreed specs. Persistent quality keeps dozens of regular clients from shopping around.

    Research, Collaboration, and Innovation

    Working alongside research partners, our staff sometimes joins early discovery programs or scale-up trials. Helping customers walk through a process optimization, or offering advice based on firsthand manufacturing snags, creates mutual understanding. New uses in nucleic acid chemistry or metabolic studies pop up regularly. Internal investment in pilot equipment and analytical capacity means our knowledge grows as fast as the markets we supply.

    This back-and-forth with innovators feeds directly into better products and more responsive technical service. Our “open door” approach means labs tackling tough syntheses or regulatory queries can get a direct answer from someone who’s actually handled hundreds of similar lots. Over time, these partnerships have sparked some of the most meaningful upgrades to our production protocols—ranging from shorter processing times to revised packaging options and improved documentation.

    Challenges and Solutions in Manufacturing

    Problems develop without warning in chemical manufacturing. Sometimes a supplier tweaks the input material spec, resulting in yield drift or a subtle impurity increase. Sometimes a routine process adjustment disrupts a long-standing equilibrium. Staff learn quickly that the best solution comes from careful logging, rapid QA checks, and a willingness to act on small changes before they spiral. Equipment upgrades, raw material vetting, and careful process validation all contribute to steady product quality.

    Technical staff stay engaged with customers not just to take orders, but to ask the difficult questions about what causes workflow slowdowns, contaminated outputs, or regulatory head-scratchers. By building out our own analytical and pilot capabilities, we help partners solve puzzles faster. If a batch misses a spec, immediate root-cause analysis takes priority, followed by a concrete solution rather than vague assurances. This in-house troubleshooting pays off in real reduction of wasted time and project risk.

    Looking Ahead: How Customer Experience Shapes the Product

    What distinguishes our production and support of 4-Amino-5-Imidazolecarboxamide Hydrochloride comes down to listening as much as making. Year-over-year consistency, direct answers, and open communication—these traits foster trust with chemists and buyers from a variety of fields. Being the actual manufacturer imparts a flexibility no third-party can mirror. Whether it’s fine-tuning a process step to accommodate new regulatory changes or reshaping packaging based on end user input, we act with practical urgency.

    All our experience rolls into every kilogram we ship. Decades of trial, error, and iterative improvement have shaped this product and the team producing it. For anyone advancing synthesis chemistry, exploring pharmaceutical applications, or just seeking a quality-driven partnership with a manufacturer who cares, our 4-Amino-5-Imidazolecarboxamide Hydrochloride is more than a product code. It’s a commitment. What leaves our facility isn’t simply a chemical; it’s the result of focus, experience, and a willingness to stand behind what we make.