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4-Amino-2,6-Diphenylphenol

    • Product Name 4-Amino-2,6-Diphenylphenol
    • Alias 4-ADP
    • Einecs 629-021-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    857422

    Iupac Name 4-amino-2,6-diphenylphenol
    Molecular Formula C18H15NO
    Molecular Weight 261.32 g/mol
    Cas Number 4329-39-1
    Appearance White to off-white solid
    Melting Point 180-183°C
    Solubility In Water Slightly soluble
    Purity Typically ≥98%
    Storage Temperature 2-8°C
    Synonyms 4-Amino-2,6-diphenyl-1-hydroxybenzene
    Smiles c1ccccc1C2=C(C=C(N)C(=C2)O)c3ccccc3
    Inchikey HVUAMBUEFLSOFS-UHFFFAOYSA-N
    Hazard Statements May cause eye and skin irritation

    As an accredited 4-Amino-2,6-Diphenylphenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 4-Amino-2,6-Diphenylphenol is supplied in a 25-gram amber glass bottle with tamper-evident cap and clear labeling.
    Shipping 4-Amino-2,6-Diphenylphenol should be shipped in tightly sealed containers, protected from light and moisture. Transport should comply with all local, national, and international regulations for chemicals, using appropriate hazard labeling. Avoid extreme temperatures and rough handling. Shipping documentation must include the substance's chemical name, hazard classification, and relevant safety information.
    Storage 4-Amino-2,6-diphenylphenol should be stored in a tightly sealed container, protected from light, moisture, and incompatible materials such as strong oxidizing agents. Store it in a cool, dry, and well-ventilated area, away from sources of ignition and direct sunlight. Proper labeling and access control are recommended, and appropriate personal protective equipment (PPE) should be used when handling.
    Application of 4-Amino-2,6-Diphenylphenol

    Applications of 4-Amino-2,6-Diphenylphenol in Industrial Manufacturing

    We specialize in the production of 4-Amino-2,6-Diphenylphenol, supplying global manufacturers in specialty chemical sectors. Our product supports high-value chemical synthesis and material production, finding use in multiple advanced applications. We focus on supporting real-world downstream industries with technical formulation details and compliance integration.

    1. Pharmaceutical Intermediate Synthesis

    4-Amino-2,6-Diphenylphenol serves as a key building block in the synthesis of select pharmaceutical compounds such as non-steroidal anti-inflammatory drugs (NSAIDs) and central nervous system agents. It participates in advanced condensation and amidation steps where high-purity performance is critical. Pharmaceutical manufacturers source this raw material for formulation of intermediates under controlled batch reaction conditions, requiring precise quality and traceability throughout the process.

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP), ICH Q7 and Q11
    • European Pharmacopoeia, USP/NF monographs for related intermediates
    • ICH guidelines for impurity profiles and process validation
    • FDA DMF (Drug Master File) optional support

    Typical usage ratio

    • Ranges from 0.5% to 3.2% by molar ratio in multi-step syntheses, based on reaction stoichiometry; adjustments depend on targeted yield and purity profile in final API intermediate.

    Downstream process integration

    • Added during the initial condensation or amidation stage under inert atmosphere.
    • Reaction temperature and solvent system selected according to downstream sensitivity to hydrolysis or oxidation.
    • QC sampling at each stage to confirm molecular integrity and absence of by-products.
    • Packed in lined drums to prevent cross-contamination before blending into reaction vessels.

    Final product types

    • Pharmaceutical intermediates for NSAIDs
    • Precursor compounds for antiepileptic drugs
    • Active pharmaceutical ingredient (API) building blocks

    2. Liquid Crystal Materials Manufacturing

    The compound is used as a functional additive and structural modifier in the production of specialty liquid crystal mixtures for display technologies. Its unique diphenyl structure enhances rigidity and thermal stability in the resulting nematic and smectic liquid crystal formulations, vital for performance in flat-panel displays and advanced optics.

    Industry compliance standards

    • RoHS Directive (2011/65/EU) for electronics materials
    • IEC 61249-2-21 for halogen-free requirements in display manufacturing
    • ISO 9001:2015 for material management and traceability
    • Supplier declarations for SVHC (Substances of Very High Concern, REACH)

    Typical usage ratio

    • 0.1%-1.0% by total mass of the liquid crystal blend, carefully adjusted to avoid phase separation and maintain electro-optical properties.

    Downstream process integration

    • Introduced in the blend tank after initial base LC components are prepared and filtered.
    • Dissolved at controlled temperature under nitrogen; agitation ensures molecular dispersion.
    • Monitored via HPLC and birefringence measurements at blend completion.
    • Transferred to inert packaging to prevent moisture ingress before cell assembly.

    Final product types

    • STN, TFT, and OLED display liquid crystal mixtures
    • Light modulation films and retarders
    • Automotive and industrial monitor panels

    3. High-Performance Polymer Additive

    4-Amino-2,6-Diphenylphenol is integrated as a monomeric component or a chain extender in the preparation of specialty polyamides, polyesters, and thermosetting resins, especially where increased rigidity and thermal endurance are required. Polymer industry leaders use this material to boost glass transition temperature and maintain dimensional stability under stress, primarily in high-demand electronic, aerospace, and automotive applications.

    Industry compliance standards

    • ISO 9001:2015 and ISO/TS 16949 for automotive plastic production
    • UL 94 for flammability of polymer components
    • EU REACH Regulation for pre-registration and safety evaluation
    • ASTM D638 and D3418 for mechanical/thermal property testing

    Typical usage ratio

    • From 0.5% to 3.5% of total monomer weight in copolymer blends; adjusted based on required glass transition and modulus properties.

    Downstream process integration

    • Fed into a closed reactor after base resin components preheat; co-reacted under nitrogen at set pressure.
    • Melt-profile or solid-state polymerization process applies, depending on target polymer type.
    • QC controls molecular weight distribution post-polymerization by GPC analysis.
    • Material compounded with relevant flame retardants or colorants before pelletizing.

    Final product types

    • High-performance engineering plastics (polyamides, polyesters)
    • Industrial adhesives and encapsulants
    • Molded components for automotive and aerospace uses

    4. Specialty Dye and Pigment Intermediate

    The chemical serves as a primary amine and phenolic precursor in the production of specialty azo dyes, high-durability organic pigments, and colorant intermediates. Dye manufacturers select it to achieve unique chromatic properties and lightfastness, integrating it into complex diazotization or coupling reactions under controlled conditions. End uses span advanced printing inks, plastics coloration, and coatings for electronics.

    Industry compliance standards

    • EN 71-3:2019 (Toy Safety Standard) for pigments in children’s products
    • ISO 105 series for fastness properties in dyehouses
    • Oeko-Tex Standard 100 for textile and leather colorants
    • REACH Annex XVII regarding azo dye restrictions and reporting

    Typical usage ratio

    • Typically 1.0%-2.5% by reaction mass in azo coupling syntheses; varies according to pigment shade and concentration discipline in final application batch size.

    Downstream process integration

    • Added to aqueous or organic phase first, followed by controlled addition of coupling partners and oxidant or acid as required.
    • Reaction temperature and pH strictly monitored for consistent pigment quality.
    • Pigment slurry filtered, washed, and dried for downstream blending or dispersion.
    • Sampled per lot for colorimetric and purity validation.

    Final product types

    • Specialty azo dyes for textiles and leathers
    • High-end organic pigments for paints and coatings
    • Custom colorants for plastics and electronic device housings

    5. Corrosion Inhibitor Formulations

    Manufacturers of industrial treatment chemicals use 4-Amino-2,6-Diphenylphenol as a key functional component in the formulation of anti-corrosion agents for metal protection. Its chemical composition enables the material to adsorb onto metal surfaces, especially in oilfield, water treatment, and pipeline maintenance systems. It is selected for its ability to form stable, hydrophobic protective layers that minimize both oxidation and acid attack in aggressive industrial environments.

    Industry compliance standards

    • ASTM G31 (Laboratory Immersion Corrosion Testing)
    • API RP 682 (Pumps - Shaft Sealing Systems in Petroleum Industries)
    • ISO 8044:2020 (Corrosion of metals and alloys – Vocabulary)
    • OECD Testing Guidelines for water solubility and environmental safety parameters

    Typical usage ratio

    • Used at 0.05%-0.20% by total inhibitor concentrate, adjusted for brine composition, pH, and exposure temperature.

    Downstream process integration

    • Dosed directly into blending tanks with base components and surface-active agents.
    • Emulsified under agitation before QC assessment for active content and stability.
    • Packaged in corrosion-resistant containers, followed by deployment to field service teams.
    • Monitored for performance through on-site metal coupon testing during use.

    Final product types

    • Oilfield and pipeline corrosion inhibitors
    • Chemical treatment blends for cooling towers
    • Anti-rust additives for metalworking fluids
    Free Quote

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    Certification & Compliance
    More Introduction

    4-Amino-2,6-Diphenylphenol: A Perspective from Our Manufacturing Floor

    Our Commitment Behind the Chemistry

    Here on the plant floor, the daily pulse of production keeps us grounded in the real meaning of quality chemicals. Our team spends hours checking every step of the process, not just for regulatory compliance, but because we believe craft matters. We take the making of 4-Amino-2,6-Diphenylphenol seriously. As producers, we see the insides of its manufacturing, monitor batches from the first charge until final packaging, and track every QC report by hand and heart. That’s how we understand this compound's strengths and see its role in research, manufacturing, and fine synthesis daily.

    What Sets 4-Amino-2,6-Diphenylphenol Apart?

    In our lab, the pale, crystalline powder of 4-Amino-2,6-Diphenylphenol reflects a distinct molecular profile — clear ring systems, a para-positioned amino group, and robust phenol core. Hands-on experience shows that this combination impacts both its chemical reactivity and the way it builds bonds in more complex molecules. Many clients working in pharmaceutical research, pigment preparation or advanced material synthesis turn to us specifically for this structure. Unlike similar phenolic chemicals, ours offers less steric hindrance, providing a more accessible reaction point, especially during coupling or cyclization steps.

    Through the years, repeat feedback from formulation chemists points out that this compound’s double phenyl groups improve overall stability far beyond what single-ring analogs manage. It resists oxidation and harsh process steps where more basic aminophenols break down. Soil scientists, pigment makers, and intermediate manufacturers keep choosing it for these reasons. For those needing subtlety in electron distribution, this structure delivers, producing finer controlled yields during downstream transformations.

    Model, Specifications, and Real-World Consistency

    In production we maintain a high bar for purity, typically above 99%. Every crystalline batch gets tested for ash content, melt range, and a full panel of residual solvents. Variability remains very low compared to off-the-shelf or barrel-packed material circulating from distributors. Continuous process monitoring with automated analytics and manual spot verification lead to homogeneity across lots, minimizing quality swings. Some products might promise a similar peak area on chromatography, but our retention time drift is negligible thanks to process controls that never leave a batch alone.

    The particle texture makes a difference for blending and dissolution. Fine, dust-free powder flows cleanly through feeders and resists lumping during storage. This pays off for customers loading the compound into automated reactors, saving cleanup and downtime.

    We always check each shipment for heavy metal content. Lab records show our product holds lead and cadmium readings below widely recognized regulatory limits, which gives peace of mind to those developing medical or food-adjacent catalysts and coatings. We pay attention to water content too. Our process keeps moisture levels low, avoiding hydrolysis risks in client applications. No batch leaves the site unless it matches spec for appearance, analytical purity, and residual moisture — not just what shows up on a datasheet.

    Direct Usage in Diverse Industries

    Research teams in pharmaceutical synthesis often call us for 4-Amino-2,6-Diphenylphenol. This molecule helps create key intermediates, especially in building blocks for anti-inflammatory and oncology pipelines. Its amino group opens numerous derivatization pathways, from sulfonation to acylation, which streamlines route scouting. Our partners in agrochemicals use it to bridge complex aromatic compounds, enhancing biologically relevant scaffolds.

    In pigment manufacture, the dual phenyl nature gives formulations stronger color fastness. Technical documentation from color labs testing our product notes how it stands up to repeated wash and light cycles far better than untouched mono-aminophenols. Polymer researchers add it as a specialty modifier, seeking to craft plastics with higher thermal resistance or targeted reactivity with other functional groups. Material scientists working on advanced coatings and laminates also look for a molecular design that stays stable under processing — double phenyls give that edge.

    For those involved in specialty adhesives or epoxy resins, the molecule handles cross-linking without runaway side reactions. This tight control isn’t just theoretical: production technicians see faster line speeds and fewer defect logs when they switch from generic aminophenols to our carefully fractionated compound. The ease of batch blending and lack of dust carryover into the customer environment, yielding cleaner tanks and less lost product.

    The Role of Sourcing from Actual Manufacturers

    Anyone who’s done real-world synthesis knows the frustration of batch variability. We have seen customers who relied on traders or third-party repackagers only to run into gels, inconsistent reactivity, or off-colored reaction masses. That’s usually a question of material sitting too long in storage, poor QC, or blend-downs with marginal stock. We stamp each drum directly on-site, never relabel, and ship on demand. Our storage protocols keep every lot in climate-controlled spaces, watched by in-house staff. Shipment timing is always aligned to keep freshness intact and chemical reactivity at its best.

    This may seem obvious, but the difference becomes clear once a downstream batch or synthesis campaign finally runs smoothly. Our closest partners tell us that sourcing directly cuts skips, re-dos, and back-and-forth troubleshooting by a wide margin. People who control the actual process will always have a deeper understanding of what the product does, and how it should behave. We answer technical inquiries with confidence because the knowledge comes from lived experience, not from secondhand notes.

    The Comparison with Other Phenolic and Aminoaromatic Compounds

    We have manufactured a range of aminophenol derivatives, and every production shift knows their quirks. Standard para-aminophenols, for example, tend to oxidize faster, leaving residual iron oxide stains in distillation columns and filters. They often need extra antioxidants or careful blanketing with nitrogen to perform in sensitive manufacturing. By contrast, 4-Amino-2,6-Diphenylphenol stands up to oxygen and acid exposure, maintaining a consistent blush-white color in solution and pellet form. The bulk and rigidity of its structure mean it holds up to stress throughout diverse process conditions.

    Some would ask if 2,6-diphenyl substitution blocks derivatization, or complicates solubility. In practice, we have found most polar and aromatic solvents produce clean dissolution. Performance in protic or polar aprotic systems matches or even exceeds standard aminophenols at comparable loadings. End-users cite simplicity of workup — fewer extraction and isolation steps, higher yields, and less need for column cleanup.

    On the cost side, straightforward single-ring aminophenols look attractive upfront, but we’ve seen customers spend more chasing impurities, wrangling inconsistent yields, and managing safety incidents. In contrast, the reliability and processability of our diphenyl analog save labor and raw materials, offsetting any premium. The time-saving quickly justifies the switch, especially in pilot and scale-up environments.

    Addressing Regulatory and Safety Expectations

    Safety oversight continues to tighten in the chemical industry. Every operator here learns about cradle-to-gate tracking for raw materials and products. Our traceability logs go back years, serving as documentation for REACH, TSCA, and other frameworks. With 4-Amino-2,6-Diphenylphenol, frequent inquiries come from regulatory affairs teams needing proof of compliance and confirmation of clean handling. We hear the need for low residual metals, phthalate-free processing, and high batch reproducibility. Our protocols grew alongside those expectations.

    We brought in extra screening steps for volatile organic contaminants, enhanced our effluent management, and lent technical support for end-users facing audits. For downstream formulators working in sensitive fields like food-contact materials or specialty coatings, trace contamination makes or breaks qualification. We run our processes and sampling plans with those users in mind. The significant investment in equipment and training stems from seeing what non-conformance can do to trusted industry relations.

    Handling of 4-Amino-2,6-Diphenylphenol remains safe with normal PPE, good ventilation, and standard material transfer discipline. Production techs routinely share handling tips, and our on-site safety program cuts preventable incidents to zero internal recordables this past year. Regular updates go out to partners with application-specific safety findings, and we make every SOP available upon request.

    Crafting Solutions for Advanced Applications

    Customers driving new active ingredient synthesis or next-generation polymer research often start with a demanding target profile. These innovators push required purity, customized particle sizes, or special impurity profiles not found in generalized products. We listen and adjust. For projects needing tailored features, our R&D and pilot teams adjust purification, crystallization time, and drying parameters. Some found success with an ultra-fine grind; others worked with us to minimize specific aromatic byproducts.

    The feedback loop never ends. There’s always a need for tighter analytical cutoff, improved flow, or better batch documentation. Over years, these adjustments become part of the process, not just one-off accommodations. Our open-door attitude gives rise to partnerships where industrial chemists, formulation leads, and QC managers shape how the product evolves.

    Our approach keeps project managers, bench chemists, and end-users at the center. Failures become rare, and those that do occur lead to direct conversations for rapid fix, not finger-pointing. We see opportunity in these challenges—it pushes us to innovate in small, practical steps without compromise to safety, quality, or delivery.

    Sustainability and Environmental Stewardship in Production

    History has not always been kind to the chemical manufacturing world. Waste, emissions, and inefficient resource use have dogged the industry for decades. On our floor, we invest in greener approaches for 4-Amino-2,6-Diphenylphenol production. Water recycling runs in parallel to product filtration. Solvent recovery brings down both cost and environmental impact. Every energy audit uncovers spots for process optimization, with new heat exchangers and insulation cutting overhead and bringing long-term stability to operations.

    Improved plant hygiene reduces the load on effluent treatment. We partnered with waste handling specialists who provide new technologies for safer disposal, converting old waste streams into usable inputs wherever workable. Scrutiny by auditors and customers ensures we keep raising our standards, and this improves accountability across every shift.

    Transparency is critical. Our team responds to inbound sustainability questionnaires, provides carbon footprint data for regulatory and internal programs, and commits to eliminating hazardous process aids by developing better alternatives through our own labs or through supplier partnerships. We think of this as more than compliance: it’s a means to make a more resilient organization and serve a market that demands both product reliability and responsible citizenship.

    Connectivity with R&D and Downstream Innovation

    In-house chemists, engineers, and pilot-plant techs work closely, sharing insights with process partners outside our own walls. The datasets we generate feed directly into both daily logs and long-term process improvements. Take for example a pigment application looking for better resistance to photobleaching; our R&D facility trialed ring modifications that eventually made it through to full production, directly benefiting the customer’s end-use. No process exists in a vacuum, and our advice is colored by years of engagement with downstream research.

    Across disciplines — pharmaceuticals, polymers, dyes, coatings — the most creative work often emerges from shared knowledge. Our team maintains relationships with academic laboratories, trade organizations, and customer-facing chemists. We supply samples for early-stage work and scale as research progresses. The loop stays open so that specification changes or unexpected hurdles get solved together, not in isolation.

    For the global market, we enforce strict material authentication routines to combat counterfeiting. Customers receive full chain-of-custody documentation, all tied to our lot numbers and integrity checks. Every positive or negative review comes back to us — and shapes future process improvements. Our operations team uses these lessons to help minimize bottlenecks for our customers and keep their supply chains humming.

    Moving the Needle: Perspectives on the Future

    Innovation keeps the chemical industry moving. We look ahead at challenges the next decade will bring. Tighter environmental controls, renewed scrutiny on health impacts, and customer demand for both performance and traceability are growing. Our plan stays simple — build trust one batch at a time, take every improvement seriously, and keep customer engagement front and center.

    For 4-Amino-2,6-Diphenylphenol, possibilities continue to open in pharmaceutical platforms, novel agricultural tools, and multifunctional materials. Material science grows ever more demanding in its purity and compliance requirements. Production technologies change, and we adapt. Our passion for this work comes from years on concrete floors, problem-solving chemistry in real time, and a dedication to making things right when the unexpected arises.

    Each shipment carries this ethos forward: honest documentation, robust process control, and a willingness to listen when a partner needs a customized run or a faster response. Product satisfaction matters, but it plays out daily because we stand behind the craft.

    We care about the real-world uses, the technical challenges, and the people who trust our work. The lessons learned from every process adjustment, client conversation, and quality check fuel how we produce 4-Amino-2,6-Diphenylphenol — not as a commodity, but as a craft. That’s the perspective from our manufacturing floor, and we’re proud to share it with teams pushing chemistry further every day.