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4-Amino-2,5-Dichlorobenzenesulfonic Acid

    • Product Name 4-Amino-2,5-Dichlorobenzenesulfonic Acid
    • Alias 4-Amino-2,5-dichlorobenzenesulfonic acid
    • Einecs 216-898-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    373538

    Cas Number 88-51-7
    Molecular Formula C6H5Cl2NO3S
    Molecular Weight 258.08 g/mol
    Appearance Light brown to beige powder
    Melting Point 240-244 °C (decomposition)
    Solubility In Water Moderate
    Purity Typically ≥98%
    Synonyms 4-Amino-2,5-dichlorobenzenesulfonic acid; Sulfanilic acid, 2,5-dichloro-
    Ec Number 201-830-1
    Storage Conditions Store at room temperature, keep container tightly closed

    As an accredited 4-Amino-2,5-Dichlorobenzenesulfonic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A tightly sealed, amber glass bottle containing 100 grams of 4-Amino-2,5-Dichlorobenzenesulfonic Acid with warning and identification labels.
    Shipping 4-Amino-2,5-Dichlorobenzenesulfonic Acid is shipped in tightly sealed, chemical-resistant containers to prevent leaks and degradation. The package is clearly labeled as a hazardous material and transported according to international and local regulations, including proper documentation. Store and ship in a cool, dry place, away from incompatible substances and direct sunlight.
    Storage 4-Amino-2,5-dichlorobenzenesulfonic acid should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from incompatible substances such as strong oxidizers. Protect from moisture, heat, and direct sunlight. Use appropriate chemical storage cabinets and clearly label the container. Personal protective equipment should be worn when handling to prevent skin and eye contact.
    Application of 4-Amino-2,5-Dichlorobenzenesulfonic Acid

    Applications of 4-Amino-2,5-Dichlorobenzenesulfonic Acid in Industrial Manufacturing

    As an established manufacturer of 4-Amino-2,5-Dichlorobenzenesulfonic Acid, we ensure stringent quality controls and batch traceability for all industrial clients. This specialty intermediate plays a critical role in select downstream sectors, benefiting from high sulfonic acid group reactivity, precise amine substitution patterns, and halogen stability. Its functional properties enable precise performance in each of the following industrial processes.

    1. Azo Dye Synthesis for Synthetic Fiber Coloring

    As a diazo component, this intermediate underpins the production of water-soluble azo dyes designed for polyester, polyamide, and acrylic fiber applications. Its purity and controlled substitution pattern directly impact color fastness and shade accuracy, supporting high-performance textile dyeing. Only regulated synthetic dyes for the textile industry implement this intermediate to maintain strict color fastness and environmental requirements.

    Industry compliance standards

    • OEKO-TEX® Standard 100
    • REACH Regulation (EC) No 1907/2006—Annex XVII on azo dyes
    • ZDHC MRSL V3.1 (Zero Discharge of Hazardous Chemicals)
    • GB 18401 (National General Safety Technical Code for Textile Products, China)

    Typical usage ratio

    • 5%–28% by mass of the active dye formulation, depending on target color depth and liquor ratio

    Downstream process integration

    • Serves as a key building block in the diazotization stage, preceding azo coupling during synthesis of sulfonic azo dye series
    • Batch process adds the acid directly to diazotization reactors operating under acidic aqueous conditions (0–5°C) with sodium nitrite actuation

    Final product types

    • Direct dyes for polyester and nylon fibers
    • Reactive dyes for acrylic fibers
    • Acid dyes for wool textiles and carpets
    • Blended colorant systems for technical textiles

    2. Synthesis of Sulfonated Pharmaceutical Intermediates

    In regulated pharmaceutical manufacturing, this compound acts as a key starting reagent for sulfonated intermediates used in the downstream synthesis of certain antihypertensive, antiviral, and antibacterial drug molecules. The carefully controlled halogen and amine functionality support nucleophilic aromatic substitution and sulfonation steps important to medicinal chemistry. Manufacturers strictly monitor impurity levels to comply with global pharmacopoeia standards.

    Industry compliance standards

    • ICH Q7 GMP Guide for Active Pharmaceutical Ingredients
    • United States Pharmacopeia (USP) where applicable for downstream APIs
    • European Pharmacopoeia (Ph. Eur.) for sulfonated API substances
    • Chinese Pharmacopoeia (ChP) for locally registered medications

    Typical usage ratio

    • 0.8–1.2 molar equivalent relative to core ring substrate depending on synthetic step sequence and stoichiometric yield balancing

    Downstream process integration

    • Charged into glass-lined batch reactors for nucleophilic aromatic substitution or diazotization, typically under inert nitrogen purge
    • Reacts with halogen-substituted aromatic or heterocyclic cores through sulfonation or coupling
    • In-process testing ensures residual absorbable organic halides remain below pharmacopeia maximum limits

    Final product types

    • Sulfonated antihypertensive intermediates (e.g., API routes for hydrophilic variants of known medications)
    • Antiviral intermediate synthons for nucleoside analog development
    • Antibacterial ingredient intermediates utilized in parenteral or oral APIs
    • Secondary starting materials for branded and generics manufacturing

    3. High-Purity Pigment Manufacturing for Inkjet Inks

    4-Amino-2,5-Dichlorobenzenesulfonic Acid serves as a critical intermediate in the synthesis of high-purity sulfonated azo pigments used in water-based and solvent-based inkjet formulations. The derived pigments exhibit outstanding dispersion stability and low aggregation, which directly support high-resolution digital printing applications across packaging and graphic arts sectors. Downstream quality demands require the exclusion of any by-product chromophores.

    Industry compliance standards

    • EN 71-3: Safety of Toys – Migration of Certain Elements (for decorative printing)
    • ISO 2846-1:2017 (Pigments and extenders—Coloristic properties in ink jets)
    • EU Printing Ink Regulation (EC) No 1935/2004 for food-contact printing
    • AP (89)1 European Resolution on food packaging inks

    Typical usage ratio

    • 15%–22% of combined pigment precursor mass within the azo pigment synthesis batch

    Downstream process integration

    • Added during controlled azo coupling in aqueous or mixed solvent systems to generate mono- or disulfonated azo pigments
    • Pigment slurry further purified via repeated washing, microfiltration, or spray drying processes
    • Product QC includes HPLC analysis to guarantee migration-compliant purity

    Final product types

    • Water-based pigment dispersions for thermal and piezo inkjet heads
    • Solvent-based inkjet inks for coding and marking
    • Color concentrates for digital packaging printing
    • Specialty inks for wallpaper, label, and signage graphics

    4. Electroplating Additive Manufacture (Leveling Agents)

    The unique structure finds use as a functionalizing component during the downstream synthesis of sulfonated aromatic compounds deployed as grain-refining and leveling agents in nickel and copper electroplating electrolyte formulations. Its sulfonic acid group enhances the solubilization and electrochemical uniformity, while the dichloro and amino substituents modulate adsorption behavior at the cathode–electrolyte interface. Reliable end-use depends on reproducible molecular purity to avoid plating pitting or haze.

    Industry compliance standards

    • RoHS Directive 2011/65/EU for hazardous substance limits in electronics
    • IEC 61189-5-3 for assessment of PCB manufacturing process chemicals
    • ASTM B322 for cleaning metals prior to electroplating
    • ISO 14001 for environmental management of metal finishing

    Typical usage ratio

    • 0.02%–0.06% by weight of total electroplating bath volume, adjusted based on current density, desired brightness, and workpiece geometry

    Downstream process integration

    • Introduced as an intermediate during formulation blending of sulfonated aromatic leveling agents; final additive then dosed into proprietary bath solutions
    • Continuous filtration and bath monitoring maintain product performance and exclude organic bath contaminants

    Final product types

    • Nickel and copper electroplating additive concentrates
    • Leveling agent component packs for mass production lines
    • Brightener and grain-refiner additive blends tailored for electronics and automotive surface finishes

    5. Synthesis of Specialty Water-Treatment Agents

    Downstream manufacturers use this compound in the multi-step synthesis of advanced sulfonated aromatic agents, which function as scale inhibitors and dispersants in industrial water treatment, especially for high-pressure boiler and cooling water systems. Its role as an intermediate ensures high chelatability and thermal stability, serving applications where fouling resistance and ionic compatibility are crucial under variable process pH and temperature conditions.

    Industry compliance standards

    • ANSI/NSF Standard 60: Drinking Water Treatment Chemicals—Health Effects
    • EU Biocidal Products Regulation (BPR, Regulation (EU) 528/2012) for non-biological inhibitors
    • ISO 9001 for chemical process quality control
    • GB/T 19001 for Chinese water treatment chemical manufacturing

    Typical usage ratio

    • Intermediate is consumed stoichiometrically at 1–1.2 equivalents for each mole of condensation agent in the initial synthesis step; finished scale inhibitor applied at 2–25 ppm in treated water

    Downstream process integration

    • Enters multi-step batch reactors for sulfonation and aromatic condensation, followed by neutralization and filtration to achieve high-purity active ingredient
    • End-use application via automated chemical dosing units into plant recirculation systems

    Final product types

    • Sulfonated aromatic polymeric scale inhibitors
    • High-performance dispersant blends for industrial cooling towers
    • Boiler water treatment formulations for process industries
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    Certification & Compliance
    More Introduction

    4-Amino-2,5-Dichlorobenzenesulfonic Acid: Experience from the Factory Floor

    Introducing Our Process for 4-Amino-2,5-Dichlorobenzenesulfonic Acid

    Every year, our production lines transform raw aromatics into specialized intermediates relied upon by dyestuff and pigment makers across industries. Among these, 4-Amino-2,5-Dichlorobenzenesulfonic Acid stands out for its consistent application in reactive dyestuff synthesis. Our team has spent years controlling the reaction profiles, impurity thresholds, and crystalline profile for this sulfonic acid. We understand firsthand that it’s not just about producing a chemical—it’s about delivering reproducibility and confidence when our partners rely on downstream performance.

    This compound, often discussed by its chemical shorthand or model, comes out of our reactors as a solid, light yellow to beige crystalline powder. Users notice its high water-solubility and tendency to form clear solutions, traits that influence how color yields develop in subsequent dye formulations. Our team places focus on granulation and purity from the earliest sulfonation steps, knowing that small process changes can impact batch-to-batch coloring strengths or filterability.

    Product Details Shaped by Real-World Application

    In our main production hall, our product typically satisfies strict minimum purity targets. Analysts in our own labs use established HPLC methods to verify the content. We see requests for material ranging from several metric tons for multinational dye groups, down to smaller kilogram batches for research institutes refining next-generation colorants. These clients are rarely concerned with generalized claims—they want reliable wetting, filtration, and solubility behaviors that do not shift from drum to drum.

    Physical properties matter more than a simple purity figure. Experienced operators at our plant know that moisture must be managed across every packing job, since traces above 1% can lead to inconsistent formulation performance. Over the years, we have experimented with different drying strategies—vacuum, fluidized bed, or simple oven drying—to hit the right balance between energy input and desirable flow characteristics in the finished acid. Technical customers want to pour the powder directly into formulations without fighting clumps or variances. So, close monitoring of particle size distribution on every lot has become routine for our QA team.

    Decades of Process Tuning: What Makes This Acid Different?

    Many companies offer benzenesulfonic acids with various halogen or amino group placements. Our specific 4-Amino-2,5-Dichlorobenzenesulfonic Acid holds a consistent profile of both halogen atoms and amine group placement that is tailored for coupling reactions in the dye and pigment sectors. Through years spent in the aisles with pigment techs and R&D chemists, we’ve heard over and over that some alternatives, such as 2,4-dichloro analogs, are less forgiving in certain dye builds. Some competitors may cut corners or ship products blended for price competition. From the factory standpoint, we refuse to mix waste streams or blend lower-grade intermediates for cost reasons.

    As the actual manufacturer, we’ve also learned the importance of the ortho and para positionings on the benzene ring—not simply as an academic distinction, but as a trait influencing reactivity in coupling chemistries and the purity of final pigments. Minor traces of structural isomers or side-products can cascade into unpredictable color strength or wash fastness failures in finished goods. For this reason, our internal procedures emphasize stage-by-stage impurity tracking. Each time we receive feedback on minor off-colorations, we convene plant reviews and make adjustments, rather than rationalize the deviation away.

    Supporting Color Science and Market Development

    4-Amino-2,5-Dichlorobenzenesulfonic Acid lives at the intersection of industrial chemistry and color science. Factory workers on our crews know that finished dyestuff quality hinges heavily on each intermediate. Since color is evaluated visually and quantitatively, unexpected tints or dullness can point directly back to slip-ups in the early stages of manufacture. We have been called to troubleshoot color points across global production chains—every time, the discipline starts in properly managing reactant flowrates, sulfonation kinetics, and cleanup protocols that go beyond compliance-driven checklists.

    Unlike general-purpose sulfonic acids, this molecule’s dichloro groups add significant selectivity in downstream azo and anthraquinone dyestuff synthesis. Customers involved in high-purity dyestuff projects facing regulatory audits often rely on us to explain the absence of certain byproducts or to provide extended certificates of analysis tracing each reagent batch. This context shapes decisions in our process plant about whether extra washes or recrystallization runs are worthwhile—not merely for quality claims, but because trace contaminants can risk customer business or regulatory clearances.

    From Laboratory Bench to Full-Scale Drums

    We get few questions from experienced dyestuff chemists about the abstract definition of this acid—they focus on granular questions: Will it form uniform cakes during their own filtration? Is batch-to-batch acidity reproducible, so that they won’t need to re-optimize formulation each quarter? Over years of technical support and site visits, our engineers run stress tests on each new production campaign to see how the acid will perform under diverse plant conditions, such as varying temperature, water purity, or mixing speeds typical in Asian, European, and US pigment factories.

    Those lessons feed back into our process improvement cycles. For example, technicians noticed that some customers fighting fine particulate issues benefited from a coarser grain, while users employing inline dissolution tanks requested a finer mesh for faster dissolution rates. Instead of providing “one powder fits all,” we’ve invested in adjustable milling and screening technology, always anchored by the chemistries needed for azo coupling or direct dye manufacturing. Our engineers regularly revisit SOPs alongside new client requests, knowing that laboratory conditions rarely match scaled factory operations.

    Environmental and Safety Considerations from Inside the Plant

    Our experience tells us that handling sulfonic acids demands careful attention during every step from synthesis to packaging. Operators suit up well before we open tanks, even though the end product is not classified as extremely hazardous. Inadequate dust management can trigger unnecessary exposure and drive up cleanup costs—years of running lines have taught us that every open hopper invites both safety risks and product loss. For that reason, packing stations now use semi-automated filling systems and closed transfer piping.

    Environmental rules vary by country; we commit to water treatment and in-house neutralization installations for effluent streams. As a factory, we process every spent solution until regulatory bodies sign off on discharge levels. Customers should be confident that residual chlorinated organics or unused sulfonating agents do not slip out into municipal streams, because every phase of our process is audited and results logged for traceability back to raw receipt. We also limit employee exposure by ventilating workspaces and rotating duties, lowering cumulative contact risk beyond what standard compliance dictates. These investments help prevent health incidents and conserve product at the same time.

    Understanding the Global Demands for This Product

    Many purchasing managers and formulators have asked whether there is much variation regionally on this product. Based on direct export experience, certain Asian markets prefer acid forms specifically tailored for local water chemistry and indigenous dye builds. In contrast, European buyers expect granular documentation about contaminant profiles, especially for eco-label dye production. Some North American partners prioritize packaging convenience—bags versus drums—when planning warehouse and plant space. We adjust packing specifications and labeling language to fit regulatory norms and warehouse requirements worldwide, always confirming with users before finalizing shipment details.

    Alongside performance, we’ve watched as markets transition toward stricter environmental certifications. Dye customers now face demands for traceability, low salt content, and reduced hazardous breakdown products. Since our own inputs are audited, we cut out recycled or mixed-stream feedstocks from our supply chain. Lab teams periodically pull random old stock for retesting, maintaining full shelf-life transparency. If a lot falls below standard after long storage or through mishandling, it gets reworked or scrapped, not rebagged and resold. Listening to user pain points—filter blockages, color strength dips, unexpected emissions in dyeing vats—taught us to hold higher reserves and select only established reagent suppliers.

    Technical Dialogues: Beyond Specification Sheets

    Production staff and account managers often invite customer requests for direct plant visits or online audits. Many clients send their chemists or buyers for on-site quality checks, asking for walk-throughs of batch records, sampling protocols, or even live monitoring of product as it moves from reactor to packout. We leave sampling open and traceable; our factory offers not just facility tours but sampling splits at each phase, so partners see for themselves what ends up in their drums. Questions about off-profile color, extra fines, or moisture spikes are met with data-backed lab runs and open access to retained batch samples.

    Most importantly, the interaction goes two ways. R&D staff on the customer end sometimes propose adjustment to final moisture or suggest slight modifications in grain size. Any new process potential is tested first on pilot lines and checked for multi-batch reproducibility. We openly share test results instead of simply pushing products out the door. Over the long term, this transparency reduces surprise downstream—users get a closer match to their process needs, and we avoid unexpected inventory returns or quality complaints.

    Comparing with Other Aromatic Sulfonic Acids

    Within the aromatic sulfonic acid family, subtle structure differences can make or break a formulation. This particular acid, with two chlorines and one amino group, outperforms standard monosulfonated or monohalogenated variants in dye builds calling for high color depth and fastness. The double chloride presence gives it a more controlled reactivity profile when forming azo and anthraquinone products, crucial for modern textile and ink applications. We’ve handled requests for other isomers and variants, such as 2,4-dichloro, 2,5-dichloro without the amino, and others. Each time, downstream color response and coupling consistency guide our recommendations. Over years of manufacturing, we’ve seen a clear preference migrate towards this specific acid in advanced dye formulations, particularly those striving for higher wash, light, or perspiration fastness grades.

    By running direct post-reaction tests on each isomer, our analysts can share compositional tables and color performance results. Some differences are invisible to the casual user but register immediately in textile or ink color lab trials. For instance, incorrect ring substitutions or excess impurities can trigger undesired shade drift, metamerism, or slow reaction rates in batch dyeing. We have been called in to troubleshoot batch failures where users switched between suppliers or substituted in isomers hoping for quick fixes—those efforts often cost both time and raw material, emphasizing why a long-term relationship with an original producer leads to more predictable outcomes.

    Challenges, Solutions, and Industry Evolution

    Consistent production poses its own set of operational hurdles. Temperature swings across seasons influence batch crystallization, so our teams run extra viscosity and purity checks year-round, catching deviations before shipping. Longshore transport and variable customs delay certain shipments; for these, QA holds retention samples for customer review in case product arrives off-spec. Internal traceability allows us to resolve any doubts about what rolled off the production line weeks earlier.

    Cutting waste and improving process yield remain vital topics every year. Investment in real-time process analysis, from inline sensors to NIR color checks, has paid off by slashing off-spec output. By minimizing reject lots at source, we keep both costs and resource use under control, sharing those gains with customers via pricing consistency and faster responsiveness to rush orders. Throughout each upgrade, we keep the lines running with trained plant staff—those familiar hands who spot and head off bottleneck risks before they spike costs or compromise supply.

    Looking across the market, the demand for precise, well-characterized intermediates appears set to grow. Textile supply chains want traceability and low residual impurity footprints. Color technology evolves but rarely forgets the core tenets of reproducibility and reliable upstream intermediates. That’s why our process includes constant technical exchange—industry and lab experts visiting our site, sending reference standards, running parallel pilot syntheses, and sharing detailed field results both covering success and highlighting weak points. Every comment and data point from our partners prompts another review of our own protocols. The aim is simple: reduce friction, build process trust, shrink surprises in end-use applications.

    Trusted Quality, Direct from the Source

    Longevity in this business teaches respect for detail. The commitment starts with raw material checks, verified as they arrive on site, and continues through each reactor, filter press, dryer, and packaging station. Only direct production—a model that allows real control over every variable—has enabled us to supply the same acid to multinationals and small-batch developers alike. As other players come and go, or as market preferences shift between powder, granular, or pre-slurried forms, our team adapts but never abandons core process vigilance.

    Working with this acid has shown us that stability and openness win out. End-users recognize when quality drifts or shipments contain off-cuts. They share news of color yield drops, slow washes, or new regulatory constraints. By focusing on process transparency—and by respecting both seasoned procurement specialists and first-time technical buyers—we stay attuned to what matters most in 4-Amino-2,5-Dichlorobenzenesulfonic Acid for the industries that count on it. Partners new and old benefit from a supplier who knows not just the specification sheet, but the real-world context and feedback that transforms a fine chemical from a commodity to a trusted link in the color chemistry chain.