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HS Code |
646271 |
| Cas Number | 89359-49-5 |
| Molecular Formula | C12H20N2O4 |
| Molecular Weight | 256.3 g/mol |
| Iupac Name | 4-acetylamino-2-[bis(2-hydroxyethyl)amino]anisole |
| Appearance | White to off-white solid |
| Melting Point | 102-106°C |
| Solubility In Water | Soluble |
| Purity | Typically >98% |
| Synonyms | N-(4-methoxy-2-[bis(2-hydroxyethyl)amino]phenyl)acetamide |
| Storage Temperature | 2-8°C |
| Uses | Hair dye intermediate |
As an accredited 4-Acetylamino-2-(Bis(2-Hydroxyethyl)Amino)Anisole factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle containing 25 grams of 4-Acetylamino-2-(Bis(2-Hydroxyethyl)Amino)Anisole, tightly sealed, labeled with hazard and handling instructions. |
| Shipping | 4-Acetylamino-2-(Bis(2-Hydroxyethyl)Amino)Anisole is shipped in tightly sealed containers, protected from light and moisture. Packages comply with chemical safety regulations, with appropriate labeling and documentation. Transport is arranged according to local and international hazardous material guidelines to ensure safe delivery and prevent contamination, leakage, or accidental exposure during transit. |
| Storage | Store 4-Acetylamino-2-(Bis(2-Hydroxyethyl)Amino)Anisole in a tightly sealed container, protected from light and moisture, at room temperature in a cool, dry, and well-ventilated area. Keep away from incompatible substances, such as strong oxidizers and acids. Ensure proper labeling, and implement safety measures to prevent accidental exposure, using chemical-resistant gloves and goggles when handling the compound. |
Applications of 4-Acetylamino-2-(Bis(2-Hydroxyethyl)Amino)Anisole in Industrial Manufacturing4-Acetylamino-2-(Bis(2-Hydroxyethyl)Amino)Anisole is mainly used as an intermediate and functional additive in advanced hair colorant formulations, specialty dye production, fine chemical synthesis, and color developer systems. We support strict traceability and documentation for every batch, ensuring process compatibility for high-value applications. Below, we outline key application scenarios with regulatory, technical, operational, and end-product aspects specific to each downstream industry. 1. Oxidative Hair Dye FormulationsThe material acts as a coupler component in permanent hair dye systems, participating in oxidative reactions to deliver stable and high-intensity color results. Its balanced hydrophilic profile supports formulation with peroxide and other amine-based agents, ensuring rapid penetration and uniform coloration. Quality control protocols demand short residence times during mixing to preserve functional group integrity for consumer safety and color performance reliability. Industry compliance standards
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2. Synthesis of Specialty Dyes for Textile PrintingThis raw material serves as a key precursor in manufacturing high-performance disperse and azo dyes tailored for synthetic and blended fabrics. In textile dye synthesis, its amino and acetyl moieties enable precision modification via acylation or azo-coupling stages. Manufacturers require trace impurity levels for batch reactivity assurance, impacting final product chromatic fastness and toxicity compliance for skin-contact uses. Industry compliance standards
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3. Color Developers in Thermal Paper ManufactureWe supply this compound to specialty paper mills as a color former component in thermal printing paper coatings. Its electron-donating structure ensures effective color image development under heat, and minimal background coloration. Paper manufacturers require strict lot uniformity for effective print head activation and shelf-stability, while maintaining compliance with global food contact guidelines for receipt and label papers. Industry compliance standards
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4. Fine Chemical Intermediates for Pharmaceutical IndustryPharmaceuticals manufacturers utilize this molecule in the synthesis of advanced API intermediates, mostly where aromatic amine functions undergo further acylation or heterocycle formation. Rigorous analytical profiling—including residual solvent and heavy metal content—is required to meet ICH and regional pharmacopoeia standards. Documented supply chain traceability directly supports regulatory filings for innovator and generic drug submissions. Industry compliance standards
Typical usage ratio
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Working on the production line of dye intermediates for decades teaches you more about chemistry than any manual ever could. At our facility, every batch of 4-Acetylamino-2-(Bis(2-Hydroxyethyl)Amino)Anisole passes through hands guided by knowledge forged in years of manufacturing. The chemical process, right down to the subtleties of temperature control and purity targets, gets constant scrutiny. We do not chase shortcuts or quick wins; instead, we invest in subtle process adjustments, equipment updates, and rigorous monitoring. The outcome is a chemical we’ve come to trust, and that trust extends to all those who rely on our product further down the value chain.
4-Acetylamino-2-(Bis(2-Hydroxyethyl)Amino)Anisole has unique features honed through practice. Our standard material presents as a fine light tan powder, flowing smoothly because we guard against excess moisture through specialized drying. With years of handling shipments in humid climates, this matters more than paperwork suggests. Most material ships with a purity above 99%, as repeatedly measured with HPLC and independent third-party analysis. Each batch records water content and residual solvents. This habit grew out of customer requests to see less drift in endpoint color, especially in pigment manufacturing. Our quality benchmarks never aim for the theoretical average. They rest on the absolute values that users at the end of the process need.
The value of 4-Acetylamino-2-(Bis(2-Hydroxyethyl)Amino)Anisole comes out during formulation. Most commonly, this product goes into permanent and semi-permanent hair dye systems. A chemist needs a dye intermediate that dissolves cleanly in water, tolerates oxidation with hydrogen peroxide, and does not add excess background yellowing or off-odors. We learned over years supplying both the big names and boutique operations in the personal care sector. Users come back to this molecule because of the reliable batch-to-batch color shade and compatibility with a wide pH range. The structure, featuring bis(2-hydroxyethyl)amino groups, helps it withstand typical hair dye processes that apply alkaline or oxidative conditions. Through feedback and real-world test blends, we confirmed that the product achieves the right degree of penetration in fiber and holds up after multiple washes.
Unlike traders or blenders, our expertise centers on the process chemistry. Every production campaign starts with reviewing reaction kinetics and adapting to raw material variability. We keep traceability logs on every lot of starting material, so any drift in physical properties gets flagged before reaction scale-up. The nuance here is not a listed spec — it is the quiet consistency that comes only from direct control at every stage. Our team keeps analytics running constantly, not only on the end batch but also at critical stages in the process, helping us target tighter cut-off points for byproducts and unreacted amines. The burden of proof sits on us, not the customer, as performance in their formulation depends on what we deliver. In practice, this means real response to customer batch feedback: color drifts, odor changes, solubility issues. Every modest improvement in purification or waste reduction ripples forward into a more predictable, stable ingredient.
Direct experience in both upstream synthesis and customer formulation lets us spot the subtle advantages of this intermediate. Many dyes and related p-phenylenediamine derivatives can taint formulations with metal content, unpredictable color shifts, or long-term stability failures. The acetyl group in our product acts as a stabilizer, curbing side reactions that produce unwanted color bodies under oxidative conditions. The bis(2-hydroxyethyl)amino groups trade off some reactivity for much better water solubility and safer handling. This combination — stability during oxidation, high solubility, and low odor — makes it preferred over more reactive analogs, such as 4-aminophenol or simple parabens, which may create unpredictable side products. Feedback from end-users indicates far fewer color variations from batch to batch, and their environmental, health, and safety teams appreciate the reduced volatility and easier cleanup.
We see our product’s true strengths during site visits and troubleshooting at customer plants. Process engineers often call us to discuss anomalies that occur only during full-scale production, not lab tests. Solutions frequently come down not just to spec sheets but to a practical understanding of why our intermediate behaves a certain way. One customer found their traditional supplier’s batches leaving residues in mixing kettles. Shared data and side-by-side trial runs pinpointed that slight increases in bulk density and lower chloride content in our batches allowed a smoother dispersion, saving hours of clean-up and downtime every week. Another client, experimenting with eco-friendlier hair dye kits, praised the absence of heavy metals and low formation of quinone impurities during oxidation. These details appear only when manufacturers lead their product from factory gate all the way to end-use application.
Many alternatives on the market, including mono- and di-substituted aminophenols, appeal to buyers due to initial low cost or wide availability. From our own experience, these options invite more rework and troubleshooting. Higher impurity profiles, inconsistent solubility, and reactivity under alkaline or oxidative conditions force end-users to adapt their formulations repeatedly. Our intermediate, in contrast, presents as a predictable performer across production runs and formulation changes. The molecular structure better resists oxidative degradation and forms a more stable precursor for color development, providing a more consistent and longer-lasting tone. By managing the process from raw input to shipment, we make it easier for dye and cosmetic processors to maintain high quality without having to compensate for hidden variables.
We respond to what customers value most: not just a high-assay product, but one that solves problems at scale. Technical support from our team leans on first-hand troubleshooting in factories, not just phone calls from a distant sales desk. Whether it’s an unplanned shutdown, unforeseen batch color drift, or regulatory inquiry about product traceability, our team tracks every aspect back to actual production data. We commit to transparency — full formulation disclosure, stability data, and fresh Certificates of Analysis with every batch. Our records reach back years, documenting how adjustments in impurity levels, packaging, or analytical calibration affected both shelf life and product performance. Thanks to this level of attentiveness, the hair color and pigment manufacturers using our product report far less downtime along with fewer end-user complaints related to batch variation.
Hair dye isn’t the only industry where 4-Acetylamino-2-(Bis(2-Hydroxyethyl)Amino)Anisole proves its worth. The paper and textile dyeing fields also benefit from its stability and compatibility with existing processing standards. Its clean solubility profile minimizes the risk of dye speckling and uneven distribution — a recurring problem with some lower-grade alternatives. Users working in high-speed coating and inkjet formulations cite the rapid dissolution and stable coloration under both acidic and alkaline environments. The product’s resistance to photodegradation also serves well in specialty coatings and high-performance inks meant for outdoor or high-light environments. Across every use case, technical input from our experienced operations team helps users optimize not just on paper, but in real-world, continuous-run equipment. Our research team remains ready to support further expansions to new sectors needing a clean, reliable, and safe dye intermediate.
Our entire approach to making and supplying 4-Acetylamino-2-(Bis(2-Hydroxyethyl)Amino)Anisole grows from the conviction that good chemistry is repeatable, honest, and built on feedback. Every investment in reactor upgrades, waste handling, analytical controls, and packaging materials comes from listening to partners using our material day in and day out. Long-term cooperation with raw material suppliers, including strict vetting for byproduct formation and consistency, cuts supply chain surprises. We refuse to accept off-spec batches, no matter the short-term costs; reputation with customers and regulators rests on decades of diligence. The technical knowledge in our senior team, drawn from hands-on lab and plant floor experience, feeds directly back into how we tweak or validate our process.
Pressure to cut environmental impact keeps the industry evolving. Our own operations have advanced through investment in closed-loop solvent recovery and treatment. This cuts both emissions and total impurity load in finished goods, which means a safer product down the line. The stability of the acetylamino and bis(hydroxyethyl) groups also helps reduce formation of hazardous byproducts during end-use. On employee safety, training programs go beyond compliance. Plant personnel carry deep knowledge of the safe handling of all intermediates. Accidents or unexpected emissions drop when the line workers and supervisors understand the process, not just the paperwork. Frontline diligence, not slogans, keeps the product consistent and the workplace safe.
Dye intermediate chemistry never stands still. We keep regular contact with scientific publications, industry conferences, and regulatory updates to ensure the product always meets the evolving standards in cosmetics and specialty colorants. For instance, tracking trace contaminants — even below regulatory reporting thresholds — helps end-users avoid surprise recalls or issues during audits. Where local requirements differ, we tap into our internal database of batch results and adapt shipping or packaging accordingly. Years of compliance work support every customer’s registration and regulatory documentation, taking pressure off their technical and legal staff. As new studies emerge on safety or environmental risk, we test proactively — not just to tick a box, but to give users a full and honest assessment of how the product performs against the latest standards.
Partnerships with our customers mean more than fulfilling orders. Joint development projects have improved yield, shelf life, and color fastness. A customer in the U.S. wanted to roll out a lower VOC dye product, and we adjusted our purification process to dramatically lower residual solvents in their final batches. This hands-on approach spells the difference between guessing and knowing what works in scale-up and real factory conditions. Our R&D team regularly collaborates on pilot-scale tests, providing guidance on ideal storage, blending practices, and compatibility with new complementary ingredients. Customer feedback during these trials shapes both our next round of production and improvements in analytical controls.
Providing 4-Acetylamino-2-(Bis(2-Hydroxyethyl)Amino)Anisole as a true manufacturer means full accountability throughout the product lifecycle. We see firsthand how variations in starting material, utility interruptions, or a simple tweak in pH shift product performance. Our commitment runs from the plant floor, through the final check of logistics, and into the ongoing support for customer process engineers and quality teams. Unlike trading houses and intermediaries, we don’t outsource troubleshooting; our responsibility to product quality begins and ends within our own facilities. For the end user, this means peace of mind. Problems rarely spiral out of control because we possess both the authority and means to respond directly and quickly.
The market for specialty colorants and dye intermediates grows more complex each year. We keep pace by sharpening our process controls, updating documentation, and keeping open channels with customers. Every report of a process hiccup, shade drift, or unexpected side reaction invites us to dig deeper and refine our product further. Younger chemists joining our team learn not only the science but the importance of listening to user feedback and translating those lessons into process changes. This ongoing education, both inside our plant and in our customers’ facilities, maintains our reputation for producing a dye intermediate that meets the demands of a fast-evolving field.
4-Acetylamino-2-(Bis(2-Hydroxyethyl)Amino)Anisole represents more than a chemical structure on a label. For us, it embodies a long-standing dedication to manufacturing that makes life easier for real people: the dye chemists, plant operators, QA managers, and end customers relying on uniform performance. Every innovation we add, every adjustment we make, and every call we answer feeds into the next improvement. We approach our craft as a responsibility: to provide not only consistent quality but also industry leadership and technical integrity. Producing and shipping this intermediate forms only the start. Supporting success downstream, learning from user experience, and always pushing for better outcomes complete the story. That’s how value grows — batch after batch, year after year.