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4-Acetoxybenzaldehyde

    • Product Name 4-Acetoxybenzaldehyde
    • Alias p-Acetoxybenzaldehyde
    • Einecs 220-851-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry sales7@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    771045

    Chemical Name 4-Acetoxybenzaldehyde
    Cas Number 2046-07-3
    Molecular Formula C9H8O3
    Molecular Weight 164.16
    Appearance White to off-white solid
    Melting Point 112-115°C
    Boiling Point 325°C
    Solubility Slightly soluble in water, soluble in organic solvents
    Density 1.24 g/cm³
    Smiles CC(=O)OC1=CC=C(C=O)C=C1
    Iupac Name 4-(Acetyloxy)benzaldehyde
    Refractive Index 1.563 (est.)

    As an accredited 4-Acetoxybenzaldehyde factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 25 grams of 4-Acetoxybenzaldehyde, sealed with a screw cap and labeled with hazard and product information.
    Shipping 4-Acetoxybenzaldehyde is shipped in sealed, airtight containers to prevent moisture absorption and degradation. Packaging complies with chemical safety regulations, ensuring proper labeling and cushioning to avoid breakage. It is transported under ambient temperature, away from incompatible substances, with accompanying safety data sheets for secure handling and regulatory compliance during transit.
    Storage 4-Acetoxybenzaldehyde should be stored in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible materials such as strong oxidizing agents. Keep the container tightly closed when not in use to prevent moisture absorption and contamination. Store in a chemical-resistant, labeled container and protect from direct sunlight. Follow all relevant chemical storage guidelines and safety procedures.
    Application of 4-Acetoxybenzaldehyde

    Applications of 4-Acetoxybenzaldehyde in Industrial Manufacturing

    As a direct manufacturer of 4-Acetoxybenzaldehyde, we support global customers operating in specialized chemical industries with strict quality systems. Our material delivers high-purity performance in advanced synthesis, controlled formulations, and regulated environments. Below, we outline key real-world industrial applications, compliance requirements, mixing principles, and integration steps for downstream users.

    1. Pharmaceuticals: Intermediate for Active Pharmaceutical Ingredient (API) Synthesis

    Pharmaceutical manufacturers employ 4-Acetoxybenzaldehyde as a crucial intermediate in the multi-step synthesis of various APIs, such as certain non-steroidal anti-inflammatory drugs and antihypertensive agents. Application involves precise control of reaction conditions to ensure purity profiles that comply with pharmacopeial standards. Operators must monitor batch process parameters to minimize byproduct formation and maintain reproducibility. Final API quality depends on accurate input quantity and validated purification sequences.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • USP-NF (United States Pharmacopeia - National Formulary)
    • European Pharmacopoeia (Ph. Eur.) monographs as applicable
    • FDA 21 CFR Part 211

    Typical usage ratio

    • 0.3 – 1.5 molar equivalents relative to target API per batch, adjusted by specific synthesis route, reactivity with nucleophiles, and yield optimization

    Downstream process integration

    • Charged into reaction vessels as a starting material during stepwise condensation, etherification, or reduction reactions prior to main API-forming transformation

    Final product types

    • Sulindac (NSAID)
    • Furosemide precursor
    • Antihypertensive raw materials
    • Specialty pharmaceutical intermediates

    2. Agrochemical Synthesis: Herbicide and Pesticide Intermediate

    In advanced agrochemical manufacturing, downstream users implement 4-Acetoxybenzaldehyde as a selective building block for herbicides, fungicides, or insecticides. The process demands stringent control of input concentrations to meet national and international pesticide safety regulations. Careful handling during alkylation and acylation stages ensures efficient conversion and minimization of hazardous byproducts. Final product quality assurance must document the traceability of raw material in finished goods.

    Industry compliance standards

    • FAO/WHO Pesticide Specifications
    • ISO 9001:2015 Quality Management
    • REACH Regulation (EC) No 1907/2006
    • China GB 2763 for Maximum Residue Limits of Pesticides in Food

    Typical usage ratio

    • 10 – 35% by weight in intermediate formation, calculated based on active compound synthesis pathway, targeted crop protection spectrum, and solvent system compatibility

    Downstream process integration

    • Introduced during stepwise amination, cyclization, or oxidation stages as a key aromatic aldehyde precursor

    Final product types

    • Herbicide actives (e.g., substituted benzaldehyde derivatives)
    • Insecticide intermediates
    • Fungicidal starter molecules
    • Plant growth regulator precursors

    3. Fragrance and Aroma Chemicals: Fine Chemical Intermediate

    Manufacturers in the fragrance sector utilize 4-Acetoxybenzaldehyde for producing complex aroma chemicals by controlled hydrolysis and condensation with alcohols or amines. Precision in input quantity, reaction temperature, and post-reaction workup are critical to achieve target aroma notes without contamination. Compliance with global fragrance ingredient inventories and allergen regulations requires documented sourcing and residual solvent control.

    Industry compliance standards

    • IFRA (International Fragrance Association) Standards
    • EU Regulation (EC) No 1223/2009 on cosmetic products
    • Cosmetic Ingredient Review (CIR) safety assessments
    • ISO 17025 testing for analytical purity

    Typical usage ratio

    • 2 – 15% by mass in blending with modifier compounds, adjusted according to desired aroma intensity and olfactory threshold of target molecules

    Downstream process integration

    • Used during early-stage synthesis of benzaldehyde-based aroma scaffolds before esterification or reduction steps

    Final product types

    • Flavor and fragrance intermediates
    • Synthetic musk and aldehyde blends
    • Perfume oil concentrates
    • Cosmetic fragrance components

    4. Dye and Pigment Manufacturing: Reactive Dye Intermediate

    Dye and pigment producers incorporate 4-Acetoxybenzaldehyde to synthesize reactive dyes for textiles and plastics. The process demands careful monitoring of feed ratios and temperature to maintain color consistency and fastness. Manufacturers must document impurity content and batch traceability in line with legislation governing colorant safety and environmental impact.

    Industry compliance standards

    • OEKO-TEX Standard 100 (Class I–IV as applicable)
    • REACH SVHC (Substances of Very High Concern) compliance
    • ISO 9001:2015 Quality Management Systems
    • ZDHC MRSL (Manufacturing Restricted Substances List)

    Typical usage ratio

    • 5 – 20% relative to total dye batch, with ratio chosen based on reactivity of chromophore assembly and depth of shade required

    Downstream process integration

    • Added as a condensation or coupling component during early-stage pigment backbone formation and extended conjugation builds

    Final product types

    • Azo dye intermediates for textile application
    • Plastic colorant masterbatches
    • Organic pigment dispersions
    • Leather and paper dyes

    5. Polymer Additive Synthesis: Monomeric Modifiers

    Polymer formulators use 4-Acetoxybenzaldehyde as a monomer-modifying agent for engineering resins and specialty polymers. The additive improves pendant group functionality, facilitating downstream crosslinking or enhancing polymer flexibility. Process parameters must comply with chemical hygiene standards and regulatory substance restrictions for advanced materials, especially when end products come in contact with food or medical equipment.

    Industry compliance standards

    • FDA 21 CFR 177 for indirect food additives in polymers
    • EU Regulation 10/2011 on plastic materials and articles intended to come into contact with food
    • ISO 10993 for medical device biocompatibility
    • USP Class VI plastics classification

    Typical usage ratio

    • 0.5 – 5% by weight in monomer blend stage, adjusted according to target polymer properties and processing environment

    Downstream process integration

    • Incorporated at the co-polymerization stage with other vinyl or acrylate monomers, followed by in-situ curing or extrusion

    Final product types

    • Functionalized polyesters
    • Specialty coatings and adhesives
    • Engineering thermoplastics
    • Medical-grade polymer components
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    Certification & Compliance
    More Introduction

    4-Acetoxybenzaldehyde: A Practical Choice Direct from Our Chemical Plant

    Real-World Manufacturing Experience with 4-Acetoxybenzaldehyde

    We have seen chemical trends come and go, but 4-Acetoxybenzaldehyde stands out as a true workhorse for seasoned manufacturers. Over two decades, as a direct producer, we pay careful attention to every kilogram leaving our plant. The value of hands-on experience shows in the reliability of our process and the properties of this compound. Over the years, we’ve adjusted our methods—never out of fashion, but because granular quality and reproducibility in each batch matter most to our clients. Others may echo generic descriptors, but from where we stand, nothing replaces crisp control and deep-rooted understanding during reaction, purification, and packaging.

    Every drum that bears our name reflects countless hours of refinement. We keep an open dialogue with users in pharmaceuticals, fragrance, and specialty chemistry labs. Teams in synthesis and scale-up regularly discuss outcomes with our chemists. The feedback distills into our production floors, changing details like acetate feed rates or refining the distillation stages. In the end, the aldehyde’s bright clarity and its chemical integrity remain unwavering—no surprises, no shortcuts, just chemistry you can rely on from the moment you pop the lid.

    Specifications, Quality, and Why Purity Means More Than a Number

    Not everyone appreciates why a half-percent difference in assay means so much until a downstream reaction stalls or an impurity co-elutes on a chromatogram. In our facility, we shoot for a final purity of at least 99%. That is not a sticker for marketing—it’s a reflection of strict fractional distillation on purpose-built glassware, calibrated every month to catch drift before a faulty batch disrupts a whole production run. The main technical characteristics include:

    Labs often ask whether our 4-Acetoxybenzaldehyde comes from recycled sources. We keep production starting from fresh phenol derivatives using catalytic acylations, not reclaimed streams. This isn’t a hollow boast; spent reagent residues from industrial byproducts skew reactions, which is not something to hide under a technicality if you care about process stability. Side-products like hydroxybenzaldehyde or mixed esters can trouble chromatography in research, so we maintain robust separation at every step. That dedication wins repeat buyers who have had disappointing runs with imports and want a domestic supplier who talks specifics, not slogans.

    Manufacturing Consistency and Batch Control

    Astute buyers probe beyond brochures—they check for batch records, consistency checks, traceability to source, and the calibrations behind the numbers. We welcome those questions. In our manufacturing environment, release testing isn’t an afterthought. Analytical data, from nuclear magnetic resonance (NMR) to high-performance liquid chromatography (HPLC), are checked against internal references. Real people pull samples from each batch, not robots. Sight, smell, and sometimes simple melting points provide clues that don’t show up in spreadsheets.

    We never treat 4-Acetoxybenzaldehyde as just another SKU. Instead, every operator runs through the motion of weighing, filling, and sealing by hand. Human eyes check clarity and color on glass sheets in daylight, not only under sterile lamps. The point is simple—if you’re making intermediates for something as valuable as an active pharmaceutical ingredient (API), every hand along the supply chain needs to know the compound’s quirks. We encourage partners to request production logs, impurity profiles, or to schedule a virtual plant tour. It builds trust. Nobody needs a mystery drum at the back of their process bay.

    Performance in Application: Linking Theory and Practice

    People who just resell don’t see what’s at stake for your technical team. On application, 4-Acetoxybenzaldehyde runs as an essential building block for downstream chemistry. Chemists prize its activated aromatic ring. Fewer interfering groups mean improved yields for researchers pressing for new condensation reactions, ligands, or crystalline intermediates. The acetate moiety offers synthetic leeway—remove it in mild base, or exploit it in acetylation cascades. That flexibility draws both the university bench-top crowd and industrial processors looking for speed with predictable isolation yields.

    We follow where our product goes, not to track sales but because our own scientists want to see the outcomes. In pharmaceutical development, our clients often couple it in Suzuki couplings and nucleophilic substitutions. The aldehyde’s reactivity holds up batch after batch, and we check in for any reports of byproduct issues. In fragrances, its formyl group carries notes for designer scents. The acetate makes it easier to isolate compared to hydroxy analogs, which darken or resinify with time.

    Working together with R&D clients, we often adapt gram-to-kilogram protocols. We’ve sent technical notes on how to strip residual acetic acid in pilot reactors or on the safest order of reagent addition. That’s not extra service; it’s what we’d expect if we were on the receiving end. We know a failed batch wastes more than money—it costs credibility and time to innovation.

    Comparing to Derivatives: Differences from Hydroxybenzaldehyde, Vanillin, and Others

    Sometimes, we talk with researchers considering whether to swap 4-Acetoxybenzaldehyde for close cousins like 4-hydroxybenzaldehyde or even vanillin. From a synthetic standpoint, these compounds look similar in structure and share chemical roots, but real differences define how each performs.

    The acetoxy group protects the para position, making the molecule less reactive in undesired side reactions than its hydroxy counterpart. For those designing selective transformations, this means cleaner work-ups—no polymerization or resorcinol byproducts muddying the mass balance. Vanillin brings added methoxy groups that can throw off delicate catalysis or lead to fouling downstream when residual flavor lingers in solvent lines. Aromatic systems with unprotected hydroxy groups soak up moisture from air, browning and thickening over weeks. Our acetoxybeznaldehyde outlasts these, as packaging and storage get simpler: color holds, powders pour freely, and flask clean-up doesn’t become a wrestling match.

    We field constant questions from process chemists aiming to scale up. Most realize soon enough that swapping in or out functional groups on paper never matches outcomes in the reactor. Acetoxybenzaldehyde, thanks to its resistance to quick hydrolysis and oxidative changes, aligns best for longer campaigns. We share this openly since it benefits everyone—no need to fix problems that could have been sidestepped at the start.

    Shelf Life, Handling, and Transport – Practical Manufacturing Insights

    As manufacturers, we have a real stake in how long our product lasts and how easily it moves from plant to customer. At our facility, storage conditions get weekly checks. The compound holds stable for years under dry, cool, and sealed conditions. Standard packaging includes double-lined bags in tight-head drums. We select this setup because a single puncture or poor lining can ruin a shipment after weeks at sea. If a customer needs a bulk tote or smaller container, we have packaging options ready at short notice.

    Teams regularly document how the product fares across climates and months. Last winter, a shipment crossed three continents, arriving as bright and crisp in Mumbai as it left our line in northern Europe. Issues with condensate, static build, and container sweating get solved with real adjustments—desiccant packs, dry-air flushing, and tamper-proof tampons. Manufacturing isn’t a theoretical field here; it’s tight coordination among production, QA, and shipping crews.

    Should something go wrong, our plant supports expedited replacements, not drawn-out claims. Root-cause investigation takes priority. Once, a micro-leak in a liner threatened a large project for a client. Our team replaced the lot and altered packing protocols in the following weeks, so our own lessons ripple outward. We believe transparency earns more trust than flawless shipping stats can.

    Regulatory and Compliance Confidence from a Manufacturer’s Perspective

    Know-how with compliance doesn’t grow from reading regulations on a screen. Our experience includes years of audits, surprise inspections, and document reviews by authorities and client quality teams. 4-Acetoxybenzaldehyde, produced on our line, follows the most up-to-date practices for traceability and material safety. Every batch file and lot registration meets ISO-backed protocols. Our chemists keep records in real-time, not as an afterthought stitched together for inspectors at the last minute.

    We understand hands-on what pharmaceutical and fine chemical buyers expect. Certificates of analysis detail not only purity but also impurity profiles: chlorinated residues, phenol carryover, and traces of mineral acid—real data from direct HPLC, NMR, and titration, not just cut-and-paste certificates. Our safety sheets are reviewed at least twice yearly by a team linking production with compliance officers—each update anchors on ongoing feedback from users and shippers in actual transport and lab situations.

    Buyers trust us because we anticipate—not only react to—changes in global regulations. As a direct manufacturer, we’re invested in clean supply chains, safe working environments, and up-to-date hazard information, so partners can focus on use, not uncertainty about origin or compliance. CNSC, REACH, and GHS documents stay current, thanks to an in-house team that can trace every raw material to its producer, with digital backups for every shipment. It may sound bureaucratic, but it prevents headaches decades down the road.

    Supporting R&D, Customization, and Quick Problem-Solving

    Every process chemist, research leader, or purchasing agent who reaches out faces unique questions that won’t fit a fill-in-the-blank order system. We’ve learned to listen, then adapt in real time. Sometimes this means producing a smaller, ultra-dry lot for a spectral analysis project or shifting purity to 99.5%+ for an advanced synthesis route. Our crew had a case last year working with a biotech client needing 4-Acetoxybenzaldehyde at a scale not offered elsewhere, and we retooled not just the batch size but also logistical supports, like bulk-bin shipment schedules and just-in-time packaging.

    As a team grounded in the day-to-day of a chemical plant, we know R&D seldom follows a linear script. Variable yields, unexplained side reactions, or color shifts often emerge regardless of planning. We step in, discuss with your technical staff, and pivot together. Sometimes, this means pulling older campaign data and reanalyzing chromatograms; other times, it involves rapid reformulation and new pilot runs. Our plant doesn’t hide behind generic customer service portals. You reach experienced chemists because we know the material by touch, smell, and structure.

    Environmental Responsibility and Waste Management: On-the-Ground Changes

    Sustainability is not a label to us—it guides choices in solvents, energy use, and handling of byproducts. The synthesis of 4-Acetoxybenzaldehyde, like many fine chemicals, can leave persistent residues. Our facility anchors waste minimization in every step. Spent acetic acid, for example, gets neutralized and recovered onsite. We rigorously batch and treat chlorinated waste using closed-loop systems and regular third-party audits.

    We pursue emissions and water discharge limits beyond what law strictly requires. This springs from pride in craft and the belief that responsible manufacturing strengthens long-term partnerships. Our engineers pilot new condensation reactors aimed at cutting solvent use by twenty percent over the next two years. If there’s an opportunity for greener inputs or more efficient workups, we take it seriously—not as part of a glossy Corporate Social Responsibility slide deck, but because the next generation of chemists on our production floor deserve better.

    Our clients share these priorities, and many bring tailored waste and recycling guidelines for their projects. We work side-by-side, building solutions into each purchase and being candid about process limits. If regulations shift, or if alternative greener routes become viable, we collaborate openly and welcome peer reviews of our sustainability metrics. Precision doesn’t need to come at the cost of environmental health.

    What We Really Offer: An Open Channel for Chemistry

    From a manufacturer’s perspective, the difference between a commodity and a partnership grows sharper by the year. Supplying 4-Acetoxybenzaldehyde is not just filling orders. It means listening for subtle shifts in customer demand, keeping old-fashioned pride in lab craft, and investing in people, both ours and yours. Our teams stand ready not just for technical questions, but for honest conversation—processing headaches, scheduling snags, or even outlier purity targets that don’t fit a catalog listing.

    Our work doesn’t stop with the departure of a truck or ocean container. We track outcomes, check up months later, and fold feedback into real adjustments on our line. Chemistry, at its best, runs on openness and shared standards. 4-Acetoxybenzaldehyde has been a core product from our floors for years, and its story, like ours, grows with every shipment and conversation. We stick to what works and improve where we can. Buyers returning after a decade, sometimes switching back after a competing trial, prove the case for substance over slogan and experience over abstraction.

    Facing Industry Challenges: Reliability in Unpredictable Times

    Recent supply chain disruptions have reshaped expectations across chemical manufacturing. Raw material delays, shipping bottlenecks, and evolving safety standards put strain everywhere. We’ve learned resilience by doubling up supplier vetting, expanding our on-site raw materials stock, and training a flexible workforce. On-the-ground agility lets us handle last-minute changes without dimming quality or extending lead times out of reach.

    Technical progress isn’t an abstract aim for us. Over years, tweaks to process controls, operator training, and real-time batch analytics have shrunk rejection rates close to zero. Even through unexpected plant downtime or regional raw material shortages, customers count on delivery and batch uniformity. Those affected by sudden loss of suppliers, or stock-outs by traders selling off-the-shelf unknowns, know deeply how much quiet dependability matters.

    We see every batch not only as a transaction but also as a reflection of people doing careful, invisible labor behind the scenes. 4-Acetoxybenzaldehyde supplies critical links in advancement—whether new drug building blocks, improved fragrances, or electronics research. Keeping the pipeline clear, safe, and on time isn’t a footnote in our daily work—it’s the core job. Real expertise comes from sticking it out through changing regulations, evolving benchmarks, and the daily unpredictability of manufacturing on scale.

    Conclusion: Expertise Rooted in Experience, Delivered with Every Batch

    From plant to client, our approach to 4-Acetoxybenzaldehyde is never casual. Every drum started as a dozen conversations: on process, purity, and practical hurdles. Every delivery reflects the rigor of plant crews, analysts, and technical liaisons who feel responsible for making another person’s chemistry flow. Locally grounded, globally connected—we keep processes open, details honest, and guarantees clear.

    Buyers looking for more than a label find in us a capable partner, ready to dive deep, adjust to new needs, and back claims with facts and collective long-term knowledge. For 4-Acetoxybenzaldehyde, expect nothing less. That’s a promise only a producer with skin in the game and hands on the equipment can make, batch after batch, year after year.