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4-Acetamidocinnamic Acid

    • Product Name 4-Acetamidocinnamic Acid
    • Alias 4-Acetamidocinnamate
    • Einecs 240-012-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    969239

    Cas Number 6140-22-5
    Molecular Formula C11H11NO3
    Molecular Weight 205.21
    Appearance White to off-white powder
    Melting Point 206-209°C
    Solubility In Water Slightly soluble
    Purity Typically ≥98%
    Storage Temperature Room temperature
    Synonyms N-(4-Carboxyphenyl)acetamide
    Pka 4.21 (carboxylic acid group)
    Smiles CC(=O)NC1=CC=C(C=C1)C=CC(=O)O
    Inchi InChI=1S/C11H11NO3/c1-8(13)12-10-6-4-9(5-7-10)2-3-11(14)15/h2-7H,1H3,(H,14,15)(H,12,13)

    As an accredited 4-Acetamidocinnamic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 4-Acetamidocinnamic Acid is packaged in a 25-gram amber glass bottle with a secure screw cap and detailed labeling.
    Shipping 4-Acetamidocinnamic Acid is shipped in tightly sealed, chemical-resistant containers to protect against moisture and contamination. The package is clearly labeled with hazard information and complies with regulatory standards. Shipping is arranged under ambient conditions unless otherwise specified, and compliant documentation accompanies the product to ensure safe and secure delivery.
    Storage 4-Acetamidocinnamic acid should be stored in a tightly sealed container, protected from light and moisture, in a cool, dry, and well-ventilated area. Avoid exposure to high temperatures and incompatible materials, such as strong oxidizers. Properly label the container, keep it out of reach of unauthorized personnel, and follow all relevant chemical storage regulations and safety guidelines.
    Application of 4-Acetamidocinnamic Acid

    Applications of 4-Acetamidocinnamic Acid in Industrial Manufacturing

    As a direct manufacturer, we supply 4-Acetamidocinnamic Acid widely across several specialized sectors. Below, real-world downstream industries are highlighted with focused process and compliance information important to technical and purchasing teams.

    1. Pharmaceutical Intermediate Synthesis

    4-Acetamidocinnamic Acid serves as a core intermediate for specific non-steroidal anti-inflammatory and anti-allergic APIs. It is involved in the structural modification of active scaffolds, contributing to the synthesis of targeted active pharmaceuticals. Manufacturers apply it in the amidation or condensation step, emphasizing strict reaction condition control and batch traceability. The quality of each batch must consistently meet pharmacopoeial standards and customer method validation protocols.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice (GMP) for Active Pharmaceutical Ingredients
    • USP, EP, and JP monograph guidance (where relevant to synthesized APIs)
    • FDA 21 CFR 210/211 for pharmaceutical manufacturing sites
    • Certificate of Analysis (CoA) per supplied lot, referencing customer’s validated specification

    Typical usage ratio

    • 10–25% of molar input in stepwise multi-stage formulations, adjustable by target yield and required purity level

    Downstream process integration

    • Charge as starting material or intermediate in batch reactors for amidation, acylation, or condensation reactions under controlled temperature and solvent conditions

    Final product types

    • API precursors for anti-inflammatory and anti-allergic drugs
    • Final actives produced in multi-step syntheses for branded and generic pharmaceuticals

    2. Fine Chemical Synthesis for Specialty Additives

    Our material is utilized as a building block in the production of specialty chemical additives, including UV absorbers and custom stabilizers for plastics and coatings. Its specific molecular structure introduces rigid, conjugated systems that enhance end-use performance properties. Chemical manufacturers prioritize process reproducibility and impurity profiling during reactions involving this intermediate.

    Industry compliance standards

    • REACH (EC 1907/2006) for registration, evaluation, and authorization
    • ISO 9001:2015-certified production and QC systems
    • Customer-specific MSDS and Technical Data Sheet (TDS) provision

    Typical usage ratio

    • 2–8% by weight for synthesis of specialty additives; can be optimized based on desired molecular modifications and final performance specification

    Downstream process integration

    • Utilization in controlled condensation or polymer grafting steps, usually within small- to medium-volume reactors designed for specialty fine chemicals

    Final product types

    • UV stabilizers for coatings
    • Performance additives for engineering plastics
    • Functionalized specialty resins

    3. Aroma and Fragrance Intermediate

    Fragrance and aroma compound producers incorporate this acid as a precursor during the synthesis of aromatic derivatives. Its cinnamic backbone provides a base for further acylation or esterification, allowing tailored scent profiles for high-value fragrance bases. Production adheres to international standards for ingredient purity and traceability due to the direct or indirect application in cosmetic formulations.

    Industry compliance standards

    • IFRA (International Fragrance Association) Code of Practice
    • EU Regulation (EC) No 1223/2009 for cosmetic products
    • ISO 22716:2007 (GMP for cosmetics manufacturing)

    Typical usage ratio

    • 1–6% of total batch mass, depending on the fragrance’s targeted finished profile

    Downstream process integration

    • Direct introduction into esterification reactors or as an intermediate for aldehyde derivative reactions under anhydrous conditions

    Final product types

    • Fragrance bases for perfumery
    • Aroma chemicals for personal care products
    • Essential oil blends for premium applications

    4. Agrochemical Active Intermediate

    Specialty agrochemical producers source our material for use as a functional intermediate in the synthesis of selective fungicide and herbicide active ingredients. It offers defined reactivity for ring closure and side-chain modification steps, supporting new-generation agrochemical development. Production protocols require comprehensive impurity control and trace documentation for each lot used in downstream plant protection chemicals.

    Industry compliance standards

    • FAO/WHO specifications for agricultural active ingredients
    • Chemical Facility Anti-Terrorism Standards (CFATS)
    • ISO 14001:2015 environmental management system (as applicable for downstream plants)

    Typical usage ratio

    • 5–15%, calculated based on targeted active content and desired conversion rates within the synthesis process

    Downstream process integration

    • Charged in batch synthesis or semi-continuous production for cyclization and acylation during preparation of new active compounds

    Final product types

    • Active ingredients for fungicides
    • Precursors for herbicides in seed treatment and crop protection
    • Adjuvant intermediates for agrochemical blends

    5. Research and Specialty Chemicals Development

    University labs, contract research organizations (CROs), and specialty R&D manufacturers acquire this acid for targeted synthesis work, method development, and structure-activity relationship (SAR) studies. Product consistency and availability in research-grade specification are priorities for projects requiring reproducible data and regulatory-compliant lab records.

    Industry compliance standards

    • Good Laboratory Practice (GLP) per OECD guidelines
    • ISO 17025 accreditation for analytical testing
    • Traceable batch documentation for scientific research

    Typical usage ratio

    • Variable, typically in the 20 mg–100 g per experiment range, defined per project or reaction scale

    Downstream process integration

    • Sampled into research-scale glassware for reaction screening, catalyst studies, or model compound preparation

    Final product types

    • Reference standards for analytical method development
    • Custom compounds for SAR screening
    • Non-commercial synthesis samples for internal validation

    6. Dye and Pigment Intermediate Manufacturing

    Producers of organic dyes and pigments implement this compound for synthesis of advanced colorant molecules, especially those requiring aromatic or amide functionality. It enters the reaction chain as a precursor for coupling steps, influencing final hue stability and fastness properties in the resulting pigment. Supply chain traceability and batch homogeneity are critical to maintaining color quality in downstream dispersions or formulations.

    Industry compliance standards

    • EN 71-3 (Safety requirements for migration of certain elements in toys, where applicable)
    • GADSL (Global Automotive Declarable Substance List) reporting for automotive pigment use
    • ISO 1248 quality test for pigment applications

    Typical usage ratio

    • 3–10% by mass, optimized per pigment type and purity requirements in final dispersions

    Downstream process integration

    • Introduced as a reactant during diazotization or coupling steps in pigment synthesis; can be isolated or further functionalized as needed

    Final product types

    • Synthetic organic dyes
    • Color pigments for coatings and inks
    • Special effect pigments for plastic masterbatch
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    Competitive 4-Acetamidocinnamic Acid prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Introducing 4-Acetamidocinnamic Acid: Reliable Quality from a Trusted Source

    Rooted in Experience and Expertise

    Years spent on the production floor shape every batch of 4-Acetamidocinnamic Acid that leaves our site. The synthesis doesn’t just involve a catalogue reaction; it calls on the careful, hands-on refinement that comes from real trial and error. The chemists overseeing the process have run hundreds of small and large batches, dealt with the quirks and variables not covered in textbooks, and honed a method that brings consistency—not just on paper, but in every drum or bag we deliver to researchers and manufacturers.

    Our Model: A Product Grown from Consistent Results

    We don’t treat 4-Acetamidocinnamic Acid as another box on a supply list. The model our team uses grew out of requests directly from customers working in pharmaceuticals, specialty chemicals, and academic research. With a molecular formula of C11H11NO3 and a clear structure based on the cinnamic acid backbone modified by an acetamido group at the para position, the product sets itself apart right from the molecular level.

    Lab teams often deal with compounds of similar classes. Cinnamic acid derivatives can be fussy; the addition of the acetamido group changes solubility, reactivity, and stability properties. Our 4-Acetamidocinnamic Acid passes purity tests by HPLC and NMR, leaving no room for guesswork in downstream reactions. Our focus tracks the analytical details: melting point in the 198-201°C range, consistent crystalline morphology, negligible byproducts detectable on TLC, and tightly controlled moisture content. Each of these characteristics matters for end users optimizing synthesis steps or scaling up reaction volumes.

    Known Uses and Real-World Value

    Working directly with R&D teams, we see just how versatile our product can be. 4-Acetamidocinnamic Acid surfaces as a key intermediate in the synthesis of pharmaceuticals—especially non-steroidal anti-inflammatory drugs—and in some situations serves as a scaffold for modification in drug discovery. Small-molecule chemists value it for its aromatic system and modifiable amide functionality. The compound can also step in for educational use in advanced organic chemistry courses, offering students an opportunity to handle a stable, well-characterized substance with real-world connections.

    Practical feedback from long-term users tells us that our version lets them run reactions with greater confidence. In scale-up, purity becomes crucial; even a stray impurity can throw off reaction yields, cause color changes, or show up as ghost peaks on chromatograms. Our technical staff review each batch’s analytical data before shipping. It’s not a token gesture; it’s done because we’ve seen what happens to downstream steps when a batch falls short.

    Comparing with Other Aromatic Acid Derivatives

    Many of our contacts ask why they shouldn’t simply use more available derivatives, such as cinnamic acid or p-methoxycinnamic acid. Our team has run detailed side-by-side comparisons in our labs. The acetamido substitution makes a pronounced difference in both chemical behavior and practical usage. While simple cinnamic acid may display broader solubility in some solvents, 4-Acetamidocinnamic Acid holds up under reaction conditions that degrade less robust analogues. The modified amide group also enables distinct reactivity, allowing for selective transformations not possible with other derivatives.

    For instance, in amide coupling or selective reduction protocols, our product’s moiety resists unwanted side reactions common with more reactive or less stable analogues. In polymer research, labs use it to introduce rigid segments into custom polyester chains, exploiting the amide’s hydrogen bonding and the cinnamoyl unit’s stiffness. Each step in its use calls for reliable batch-to-batch performance, which can’t just be faked with off-grade material or resold surplus.

    Standards Set by Real-World Use

    Having worked with chemists at the bench and managers planning multi-ton campaigns, we don’t batch out a product unless it meets the level of scrutiny we’d demand ourselves. Small discrepancies in analysis appear quickly under fine-tuned QC. Our 4-Acetamidocinnamic Acid stays free of yellowing, polymerization, or cross-contamination with related acids and amides. That consistent quality owes much to decades of refinement in solvent recovery, reaction purification, and downstream handling.

    The difference goes beyond numbers on a spec sheet. In industrial settings—where solvents, temperatures, and scale introduce noise and opportunity for things to go wrong—we’ve seen poorly-made material create costly downtime. Teams using our product report far fewer deviations, faster reaction setups, and lower failure rates on scale-up validation. The reason is simple: the conditions under which each batch is made closely parallel the reality of how the product is actually used, not just how it’s described in a chemical database.

    Trusted Data, Not Just Promises

    We only release batches that clear both our internal standards and independent third-party analysis. Analytical figures, such as residual solvent content, melting point spread, and heavy metal traces fall well within established purity guidelines. We remain transparent with all data, not only because compliance matters, but because we’ve seen how much trust can mean to a formulation chemist or process engineer relying on precise inputs.

    Reports from academic collaboration partners confirm that research outcomes run more smoothly with our 4-Acetamidocinnamic Acid compared to samples sourced from bulk traders. For synthetic organic labs, where small synthetic errors can derail an entire campaign, this attention to detail makes the difference between publishing new work and repeating last year’s experiments.

    Why Process Control Matters

    On the shop floor, much can go wrong that buyers never see. Handling the synthesis from raw material reception down to packaging, we control traceability across the production log. Process deviations—like temperature spikes, trace moisture, or batch timing errors—manifest quickly in the final product’s color and purity. Our operators draw from hundreds of past runs, so they catch deviations before they become an issue. By catching and fixing these challenges at their source, rather than after-the-fact, we can guarantee the product heads to user labs in the right condition for hands-on work.

    No off-the-shelf approach can replace the value of built-in checks. Our setup includes modern reactor monitoring, real-time analytics, and hands-on review by staff who know what to look for. Each improvement emerges from practical feedback. We listen to formulation chemists needing less dusting, production managers wanting larger packaged units, and researchers requiring more detailed impurity analyses.

    Upholding Reliability Across Sectors

    Years of fulfilling repeated orders for the pharmaceutical, fine chemical, and academic sectors have taught us the necessity of reliability. Our largest partners operate in environments where a failed reaction doesn’t just waste money—it delays months of effort and throws project schedules into uncertainty. Being a manufacturer, we get immediate feedback from these users; the value of a consistently high-purity 4-Acetamidocinnamic Acid echoes across research reports and production logs.

    Over the years, our product has become the backbone of certain custom syntheses, like the production of specialty amide-linked polymers and candidate molecules for drug-discovery screening. Every batch leaving our site carries a unique code, with all QC records available on request—reflecting our ongoing commitment to transparency and traceability. This isn’t just an exercise in paperwork; undocumented changes in process can compromise product consistency and ultimately affect user results.

    Reducing Risk in Your Supply Chain

    Unplanned surprises in the supply chain arise more often from inconsistent fine chemical sources than from any other factor. Since we synthesize 4-Acetamidocinnamic Acid in-house, we can manage strategic raw material sourcing, double down on quality checks, and keep lead times short. Changing suppliers mid-project almost always creates worry for chemists and project managers, since purity, performance, and even physical characteristics can shift overnight.

    We maintain open channels with our customers; early warnings about scheduling, formulation adjustments, or upcoming compliance requirements are standard. Major end users frequently visit our facility—not just for audits, but for collaborative troubleshooting and sharing ideas for improvement. This on-the-ground interaction shapes how we package and document our product.

    Sustainable Practices in the Manufacturing Process

    Our team has spent years refining a greener workflow for 4-Acetamidocinnamic Acid. We focus on solvent recycling, waste minimization, and energy efficiency. High-purity solvents are recovered and reused through careful distillation, while catalysis steps have been altered to lower emissions and hazards. Local environmental regulations have only grown stricter, so we design our processes to meet both today’s compliance burden and future requirements.

    What sometimes sets us apart is our willingness to field calls from environmental managers at client sites. We offer detailed environmental and safety data and work with customers developing greener downstream processes. The manufacturer’s responsibility goes past shipping a product—we ensure our methods won’t complicate their environmental compliance or workplace safety procedures. Generating less hazardous waste has direct, visible benefits for both our operation and our partners’ bottom lines.

    Customers’ Realities Guide Production

    Companies using 4-Acetamidocinnamic Acid include everything from small, privately held research groups to globally recognized pharma firms. Their needs differ, and our flexibility meets that challenge. One project might demand ultrapure material for a pilot API campaign, while another focuses on fast delivery for production scale-up. Our technical sales and support staff bridge the gap, sharing technical details directly with end user labs and offering guidance based on both supplier and manufacturer experience.

    Technical teams often request custom specifications, such as altered particle size, solvent-free batches, or special packaging to fit automated handling systems. We don't just take orders; we collaborate on formulation problems, advise on potential impurity effects, and follow shipments through to application. If customers report unexpected results or analytic deviations, we dig into root causes and trace the product’s journey from batch mixing to delivery.

    Setting a Benchmark for Fine Chemical Manufacturing

    Supplying a specialty product like 4-Acetamidocinnamic Acid means competing against traders, resellers, and low-cost bulk sources. Many buyers discover quickly that price doesn’t reflect total cost; failed syntheses, compliance risks, and troubleshooting eat up savings overnight. We rarely see repeat business for these imported “off-grade” alternatives. The market pressures every supplier to deliver quickly, but speed without attention to quality breeds long-term customer frustration. Our approach—born out of decades of practical challenges—focuses on clear communication, steady improvement, and willingness to adapt to users’ shifting requirements.

    Years of refining our craft, building analytical expertise, and responding to end user needs allows our 4-Acetamidocinnamic Acid to perform in high-stakes, high-visibility projects worldwide. We report findings, new application notes, and advances transparently so that science-driven buyers aren’t left guessing about critical specifications. Whether you’re running structure-activity relationship studies or optimizing a fine-chemical process, our team stands ready to offer technical support based on first-hand troubleshooting and collaborative problem-solving.

    Continual Improvement in Product and Process

    Complacency in chemical manufacturing spells trouble. Feedback from leading researchers and process developers brought to light numerous incremental changes over the years—finer crystallization control for batch-to-batch uniformity, smarter in-line purity detectors, and enhanced packaging that stands up to real field transport conditions. Not every improvement shows up in a price list, but they pay dividends in reduced mishaps, fewer delays, and happier project shareholders.

    We regularly review and upgrade plant equipment to keep up with the tighter tolerances demanded by next-generation applications. In an era when trace impurities can tank a clinical trial or introduce toxic limits in a new product, our in-house labs constantly hunt for new ways to sharpen analysis and trim away potential risks. No batch moves forward until both machine and human checks clear every data point. Our customers know what they are getting—because we know what we have made, inside and out.

    Practical Solutions for End User Challenges

    Projects don’t always go according to plan. A customer facing a stuck reaction found a trace impurity in an old stock sample—our technical team triangulated the issue with side-by-side re-sampling and delivered a fresh batch in days, keeping their project on track. In another case, a process team needed a modified delivery schedule to match an unexpected production surge; we reallocated resources and kept their synthesis uninterrupted.

    Time and again, feedback loops between supplier and user have improved both our process and the compound itself. Customer suggestions have driven everything from new packaging sizes to the addition of QR-coded data sheets for lot traceability. Our culture values partnership and takes an open-door view of both complaints and praise. Each improvement, no matter how small, reflects real-world challenges faced by the chemists and engineers who put 4-Acetamidocinnamic Acid to work.

    Not Just a Product—A Complete Support System

    Modern chemical manufacturing doesn't succeed by making a standard product and walking away. Delivering 4-Acetamidocinnamic Acid has meant becoming a technical partner, not just a supplier. We invest in training and growing expertise along the whole line—production workers, QC analysts, technical support engineers, and field users. When a user calls us with a challenge, they speak with people familiar with making and using the compound, not call center reps or hands-off salespeople reading a script.

    We aim for clear, honest exchanges, and share both strengths and weaknesses openly with clients so that together, more reliable results follow. Supporting innovation in fine chemicals demands a living connection between manufacturer and user, not a static product pushed out the door. Every bottle and drum reflects that commitment—and keeps our team responsive to the fast pace of discovery and process change in today’s marketplace.

    A Product Built on Experience, Delivered with Care

    Throughout our history, attention to process, willingness to innovate, and partnership with users have marked the growth of our 4-Acetamidocinnamic Acid offering. While specifications and models describe the substance, the lived experience of producing, refining, and supporting its use tells the fuller story. The next time a synthesis or research project calls for a trusted source of this valuable compound, our team stands ready—not just to fill an order, but to share decades of practical knowledge and real-world insight.