Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

4-Acetamido-2-Aminobenzenesulfonic Acid

    • Product Name 4-Acetamido-2-Aminobenzenesulfonic Acid
    • Alias 4-Acetamido-2-aminobenzenesulfonic acid
    • Einecs 202-179-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    900774

    Product Name 4-Acetamido-2-Aminobenzenesulfonic Acid
    Cas Number 88-74-4
    Molecular Formula C8H10N2O4S
    Molecular Weight 230.24 g/mol
    Appearance White to light yellow crystalline powder
    Melting Point 285-287°C (dec.)
    Solubility In Water Soluble
    Ph Value Approximately 3.0 (1% solution in water)
    Boiling Point Decomposes before boiling
    Synonyms Acetosulfanilic acid, N-Acetyl-2-aminobenzenesulfonic acid
    Purity Typically ≥98%
    Storage Conditions Store at room temperature, tightly closed, in a dry place

    As an accredited 4-Acetamido-2-Aminobenzenesulfonic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Sealed in a 100g amber glass bottle, the label displays chemical name, hazard warnings, batch number, and manufacturer details.
    Shipping Shipping for 4-Acetamido-2-aminobenzenesulfonic acid should comply with all relevant chemical transport regulations. The substance must be securely packaged in a tightly sealed container, cushioned to prevent breakage. Label packages with proper hazard and handling information. Keep away from moisture and incompatible substances, ensuring temperature stability during transit.
    Storage **4-Acetamido-2-aminobenzenesulfonic acid** should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizing agents. Protect from moisture and direct sunlight. Store at room temperature, typically 15–25°C (59–77°F). Ensure proper labeling and keep away from food and drinking water. Use suitable secondary containment to prevent spills.
    Application of 4-Acetamido-2-Aminobenzenesulfonic Acid

    Applications of 4-Acetamido-2-Aminobenzenesulfonic Acid in Industrial Manufacturing

    As a manufacturer, we provide 4-acetamido-2-aminobenzenesulfonic acid for demanding industrial processes that require precise control of dye intermediates and synthetic building blocks. Our product consistently supports global producers in delivering quality and regulatory compliance across select downstream applications.

    1. Acid Dye Synthesis for Textile Colorants

    Textile manufacturers use 4-acetamido-2-aminobenzenesulfonic acid as a key sulfonated intermediate in the preparation of acid dyes, especially for wool, nylon, and silk fibers. This material enhances water solubility and influences chromophore properties in the final dye structure. Dye producers typically add the compound in the diazotization or coupling step, where exact dosing determines shade intensity and fastness. Selection of use levels depends on dye structure and targeted color shade, requiring detailed formulation adjustment based on batch yield and desired absorbance.

    Industry compliance standards

    • OEKO-TEX® Standard 100 (Annex 6 for chemical safety)
    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals Manufacturing Restricted Substances List)
    • EU REACH Registration, Evaluation, Authorisation and Restriction of Chemicals
    • GB 18401-2010 National general safety technical code for textile products (China)

    Typical usage ratio

    • Range: 0.5–2.5 mol per mol of target diazo component, adjusted to optimize coupling efficiency and final color depth

    Downstream process integration

    • Added during diazotization or azo coupling reactions for dye molecule construction pre-neutralization and spray drying

    Final product types

    • Acid dyes for wool, polyamide (nylon) fibers, silk garments, and specialty blended textiles

    2. Reactive Dye Intermediate for Printing Inks

    Printing ink formulators employ 4-acetamido-2-aminobenzenesulfonic acid to increase sulfonation and reactivity in the manufacture of water-based reactive dyes for high-definition electronic and textile printing. Specifically, this material enters reactions as a coupling agent, and its sulfonic group enables ink manufacturers to achieve migration and fixation properties required for digital textile and flexible packaging applications. Usage determination depends on ink viscosity, pigment load, and final print resolution.

    Industry compliance standards

    • EN 71-3: Safety of Toys – Part 3: Migration of certain elements (for children’s textiles and paper products)
    • GMP EU 2023/2006 (Good Manufacturing Practice for ink manufacture for food contact)
    • ISO 2846-1: Pigments and Extenders — Spectral and Colorimetric Properties of Printed Ink Set

    Typical usage ratio

    • 0.3–1.8 wt% of total dye intermediate mass; precision adjusted based on ink system fluidity and end substrate requirements

    Downstream process integration

    • Introduced during aqueous coupling stages before inklet filtration and blending, ensuring full sulfonation prior to pigment grinding

    Final product types

    • Textile printing inks for digital and screen applications
    • Inkjet inks for flexible packaging films and coated papers

    3. Pharmaceutical Intermediate for Sulfonamide Synthesis

    The pharmaceutical industry applies 4-acetamido-2-aminobenzenesulfonic acid for the targeted synthesis of sulfonamide antimicrobial intermediates. Process engineers rely on its controlled reactivity for selective coupling with heterocyclic amides, where the compound’s sulfonic and amino functionality supports downstream reactions in the formulation of specific active pharmaceutical ingredients (APIs). Use concentration varies in line with route yield, impurity profiles, and pharmacopoeia assay requirements.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • USP–NF: United States Pharmacopeia – National Formulary
    • European Pharmacopoeia (Ph. Eur.) monographs for sulfonamide APIs

    Typical usage ratio

    • 0.7–1.3 equivalents per target sulfonamide moiety; fine-tuned by route optimization and analytical control strategies

    Downstream process integration

    • Reacted during early amidation or condensation synthesis, upstream of crystallization and purification for API isolation

    Final product types

    • Sulfonamide antibiotic intermediates and finished bulk drug substances (e.g., sulfadiazine derivatives)

    4. Electroplating Additive for Conductive Polymers

    Producers in the electronics sector use 4-acetamido-2-aminobenzenesulfonic acid as an electrolyte additive in the synthesis of sulfonated conductive polymers for electroplating processes. This compound enhances solubility and ionic conductivity, enabling uniform deposition on substrates such as printed circuit boards and connectors. Addition rates depend on polymerization kinetics and the electrical performance required by end-use application, defined during pilot scale trials and validated by in-process electrical testing.

    Industry compliance standards

    • IEC 61249-2-21: Halogen-Free Base Materials for Printed Boards
    • IEC 60068 Environmental testing — test for circuit reliability
    • RoHS Directive 2011/65/EU (Restriction of Hazardous Substances in Electrical and Electronic Equipment)

    Typical usage ratio

    • 0.1–0.6 mol per mol of aniline monomer, adjusted for desired film thickness and substrate coverage

    Downstream process integration

    • Dosed into electrochemical baths as a co-monomer or dopant precursor prior to electrodeposition of polymers

    Final product types

    • Electro-conductive polymer films for multilayer printed circuit boards
    • Protective coatings on electronic components and connectors

    5. Diagnostic Reagent Intermediate in Clinical Chemistry

    Diagnostic reagent manufacturers leverage 4-acetamido-2-aminobenzenesulfonic acid to synthesize chromogenic substrates used in clinical laboratory assays, particularly in colorimetric enzyme tests and protein quantification kits. Its presence as a sulfonated building block imparts water solubility and stability, ensuring consistent signal generation for analytical applications. Amounts introduced depend on test kit sensitivity calibrations and substrate throughput performance.

    Industry compliance standards

    • ISO 13485:2016 Quality management systems for medical devices
    • CLSI GP42-A6: Procedures for the Collection Of Diagnostic Blood Specimens by Venipuncture
    • FDA 21 CFR Part 820 Quality system regulation for in vitro diagnostic (IVD) device manufacture

    Typical usage ratio

    • 0.2–2.5 wt% in chromogenic substrate matrix, modulated for target absorbance and detection limits

    Downstream process integration

    • Incorporated during substrate synthesis and purification steps before lyophilization or kit blending

    Final product types

    • Chromogenic reagents for clinical biochemical assays
    • Ready-to-use liquid and dry test kits for hospital and laboratory diagnostics
    Free Quote

    Competitive 4-Acetamido-2-Aminobenzenesulfonic Acid prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    4-Acetamido-2-Aminobenzenesulfonic Acid: Delivering Quality at Its Core

    Understanding What Sets 4-Acetamido-2-Aminobenzenesulfonic Acid Apart

    In our years producing specialty chemicals for the dye and pigment markets, few intermediates play as steady a role as 4-Acetamido-2-Aminobenzenesulfonic Acid. Chemists know it by various names, but the chemical structure—C8H10N2O3S—remains a staple in sulfonated intermediates. Out of the hundreds of aromatic sulfonic acids cycling through a modern dye facility, this compound stands out for its stability, clarity in solution, and reliability batch after batch.

    Quality in this market means more than just assay numbers. Partners expect our processes to deliver sharp, reproducible color and clean reaction flow downstream. Over years of continuous operation, we developed our current model grade for this acid, balancing purity, flow properties, and solubility based on feedback from dyestuff makers themselves. We tested tolerance in both batch and continuous systems, because plant managers want to keep lines humming with the minimum of downtime or filter swaps. Bringing together experience from years of troubleshooting lets us save customers time on the production floor.

    How Our Grade Delivers Results for Applications

    Customers who approach us for 4-Acetamido-2-Aminobenzenesulfonic Acid often manufacture azo and reactive dyes. They look for a bright, consistent source material to ensure color shades meet customer expectation with little deviation. In dye synthesis, small differences in sulfonic acid content or side-product tail can create a headache down the line—resulting in patchy coloration or reduced yield. We’ve seen clients struggle with poorly defined intermediates from third-party sources that don’t dissolve smoothly, don’t pass filtration, or slowly clog autoclaves with unknown particulates. Our production line focuses on clarity and filtration yield for a reason; a solid upstream material improves customers’ output and cost control.

    Lab trials at our end have given us essential data about what customers see. Our team tracks particle size distribution, dissolves a sample in neutral water, and runs every lot through real-world dye synthesis—sometimes with our clients present. For example, batches produced with our improved process typically display less than 0.1% insoluble matter, a figure we stand by. Our quality department checks each drum for off-color, off-smell, and unexpected residue, as these signal process hitches that could throw off a dye synthesis run. Even a slight deviation in condensation product might reduce dye strength by several percent—something we work to avoid.

    Industrial clients make direct black, acid yellow, and reactive orange dyes using this acid. Many have run the synthesis on our grade side-by-side with grades from local producers or large trading houses. Consistent feedback circles back to three main points: easy dissolution, bright end-product tone, and low waste during intermediate purification. This repeatability comes from years spent refining our filtration, crystallization, and drying stages. On a practical level, fewer filter changes and higher yields in the dye step improve output and minimize materials sent to waste treatment.

    Inside Our Production Approach: What Matters in Practice

    Efficient production involves real-world choices between starting materials, waste management, and batch consistency. We source raw aniline and sulfonating agents from vetted suppliers, using in-house pre-cleaned lines and a staged purification process after reaction. By focusing on monitored cooling curves and pH control, we've achieved a greener, more predictable process. We invested heavily in analytics, installing HPLC and UV-vis systems on each batch to pick up trace impurities before final release.

    Waste stream management is a daily reality for every chemical maker; sulfonic acids can bring issues with high COD and difficult-to-breakdown byproducts. Our facility channels spent acid to an in-house neutralization plant, capturing as much sulfate as possible for re-use, then sends clarified water to a local environmental bureau-monitored discharge. Over the years, stricter government limits pushed our team to rethink solvents and drying cycles, aiming to avoid residual dimethylformamide or similar traces in the final product. The drive for cleaner output started as a regulatory matter, but we've found customers appreciate the consistently low odor and residue it brings.

    Handling this acid in bulk presents challenges. Some operations store in drums or bags in humid climates, and caking once led to real headaches on the customer side. In response, our R&D upgraded anti-cake coatings and changed granulation size to cut slumping and firming during storage. Our in-house shipping team advises clients on best practices—shipping only in lined, moisture-proof bags and limiting exposure to open air. It’s these day-to-day details, gathered from field experience, that truly separate one producer's output from another’s.

    How Specifications Affect Actual Performance

    Most buyers start with assay and moisture numbers, but experienced dyers know that batch-to-batch performance counts more than a certificate. To this day, we run duplicate tests for iron, copper, and heavy metals down to 5ppm, knowing even trace contamination could shift color or introduce catalyst poisoning in sensitive syntheses. Over years supplying to export and domestic firms, every client has their own quirks—some need ultra-low calcium, others want an extra filtration step for micron-scale solids. We’re upfront about what our process can achieve, rather than promising theoretical minimums. Open communication upfront saves everyone time and trouble.

    Particle size influences not just dissolution speed, but also handling ease during transfer and dosing. Our granule size distribution aims to balance dust control (for cleaner plant environments) with rapid solution formation. For specialty uses outside dyes—such as pharmaceutical intermediates or certain advanced materials—precise size control might play a critical role. We can accommodate requests for tighter sizing by adjusting crystallization or milling parameters, based on real feedback from end users.

    In our facility, rigor translates to actionable control points. Each step, from sulfonation to neutralization, gets monitored. Random sampling occurs not just at the end of the batch but at key process breaks. Blending and homogenization steps guard against localized over-acetylation and give every shipment the same performance, not just matching a spec sheet but delivering the result the application needs. We’ve learned over time that consistency matters much more to real production lines than a chase after ultra-high-purity benchmarks that mean little in practical use.

    Comparisons: What Really Makes This Product Different?

    Some competing products claim higher assay or fancy "ultra-low" trace content across the board. While high numbers look good on a sheet, operational reliability tells the full story. Batches we’ve reviewed from unknown sources sometimes lack full conversion, leaving unreacted aniline or byproducts that slip by routine checks. In a customer’s real-world tank, these show up as off-color, persistent foam, or residues that settle in expensive equipment. We run regular bake-off batches in our test lab to compare dissolution, filtration, and end-dye shade against competitor samples. Clients benefit from this side-by-side, real-data approach, instead of relying only on paper specs.

    We don’t overstate "multi-purpose" claims. In fact, our product gets tailored for use primarily in azo and reactive dye synthesis, as confirmed by decades of market experience. Certain pharmaceutical syntheses use this acid as a minor intermediate, and we work on a case-by-case basis with formulators. Each user group cares about different parameters—so we listen and share what our process can achieve, rather than forcing a universal claim.

    Unlike resellers or traders who merely pass along drums sourced from decentral suppliers, as a manufacturer we have day-to-day oversight—knowing each stage’s temperature fluctuations, pH corrections, and filtration adjustments. Having an in-house team, from production line to QA, provides traceability and allows for real tracking and improvement based on plant incidents or customer feedback.

    Some non-integrated sources offer similar products but can’t match the transparency over raw material origin or control over byproduct management. This difference shows itself during regulatory audits or incident reporting. With growing international oversight and concern for supply chain transparency, buyers increasingly value material produced with defined, documentable steps all the way from core chemical precursors to final drum loading.

    Supporting Sustainable Manufacturing in Practice

    Direct dialogue with clients revealed another significant criterion: environmental stewardship. Over the years, regulations on effluent, emissions, and total organic load have only gotten stricter. In response, our team invested in process redesign—recovery of mother liquor, tighter controls on organic solvent use, and minimization of washwater volumes. We recycle water where it meets analytical guidelines, sending controlled loads to a modern onsite treatment plant. Colored and acidic wastewater only exits after multi-stage adjustment; records are open for inspection by authorities and auditing customers alike.

    We also respond to customer requests for sustainability documentation—disclosing every raw material source, quantifying carbon footprint where possible, and documenting safe handling steps for all parties in the supply chain. Over time, this culture of openness cut down on misunderstandings and helped customers see what they're actually getting, not what someone merely promises on a glossy catalog.

    Our production approach doesn’t ignore challenges either. Maintaining a low-waste process sometimes slows throughput, but in a field crowded by quick-turn brokers and one-off offers, the result pays off in customer loyalty and lower long-term cost. Supporting clients in their own "green chemistry" initiatives makes us a more reliable partner, not just a supplier.

    Lessons Learned From Years in Direct Manufacturing

    Producing 4-Acetamido-2-Aminobenzenesulfonic Acid on a fixed site puts responsibility—and power—directly in our hands. This lets us resolve upstream bottlenecks before they affect partners. For example, years back, seasonal humidity swings caused product caking in southeast storage. Fixing that came not just from a tweak in packaging, but also deeper process changes—controlling moisture in the final dryer, adjusting cooling rates, and integrating a double-layer liner right on packing line. Changes like these emerge from close work with actual end users, rather than a distant sales channel.

    Over time, we’ve found that sharing process insights with customers isn’t a competitive disadvantage, but a foundation for trust. Explaining any off-batch or rare deviation, or even walking a client through an onsite trial, cements long-term partnerships. Several clients began with small, trial lots for pilot lines, scaling up only after seeing consistent results over time and season. For many, it’s not marketing talk, but the ability to back up claims under real production conditions that leads to repeat orders.

    Even with well-controlled lines, we see new uses pop up from innovative developers—sometimes for fine chemicals, sometimes for advanced material lines. Instead of giving a blanket "yes" or generic literature, our technical team engages directly, running test syntheses where possible. If a client comes with a unique challenge—such as an ultra-low impurity threshold or specialized granulation requirement—we aren't afraid to share where our process fits and where it may need adjustment. Open, realistic dialogue helps both sides plan more efficiently, saving time rather than leading clients down an uncertain path.

    Practical Solutions to Production and Usage Challenges

    Challenges can include off-spec batches, unexpected color deviation, or handling issues in transit. We track every batch by lot, with full documentation down to operator logs and temperature records. This traceability means that in rare events of customer complaint, resolution is prompt and concrete—pulling retain samples, checking process logs, and sharing exact findings openly. Over time, rapid, data-based problem solving has set us apart, especially for clients who manage sensitive cost or quality control themselves.

    Real-world use rarely follows textbook paths. For example, in a busy dyehouse, minor trace contaminants in the intermediate may deposit over months, slowly reducing filter lifespans or causing mid-season shade drift. Addressing that means not just matching a purity spec, but also understanding each client's process and collaborating on workable tweaks—whether it be lot selection, blending, or even introducing filtration aids. In these scenarios, blanketing a customer with broad, catch-all claims doesn’t help; only practical, shared approach yields improvement.

    Continuously investing in analytics and real batch review cycles, we've reconsidered each production bottleneck—trialing new filter aids, adjusted sulfonation time for higher yield, and dialed in crystallization controls. Field feedback from users, not just internal lab testing, drives these changes. This unique feedback loop ensures our process evolves in parallel to customer challenges.

    The Role of Direct Feedback in Improving Product and Service

    We see client partnerships evolve beyond mere transactions. Many customers update us on color development challenges or new process routes, leading to dialogue that often yields tweaks in our standard grade. Through seasonal reviews, we measure not just sales numbers, but actual process KPIs: yield, waste load, filter run time, and finished shade variance. Some of our largest clients even visit for joint root-cause reviews, building confidence and transparency.

    Nothing substitutes direct on-site dialogue. On numerous occasions, clients have traced an anomaly in their process not to product quality, but to unexpected interactions with their own system water, pH correction method, or auxiliary feed. By sharing insights between teams, both sides become more efficient—and new production challenges turn into sustainable solutions. Our approach evolved not from a top-down directive, but from real trial, error, and course correction with open lines of communication.

    Why Process Control and Experience Matter

    Not every producer offers the same depth of process experience. Making 4-Acetamido-2-Aminobenzenesulfonic Acid consistently—with the same level of control, cleanliness, and accountability—takes real hands-on operation. One-off traders or decentralized resellers rarely maintain that quality from batch to batch, and seldom offer support post-sale. For us, manufacturing doesn’t end at shipping; it continues through follow-up, technical sharing, and troubleshooting as needs arise.

    Product specification sheets matter, but winning long-term trust depends on showing results in real operations. Over years of scaling output and refining process flow, we've seen how real-life performance shapes client loyalty. The value translates not in lowest cost per kilo, but in smooth-running dye plants or advanced material labs—times when product reliability prevents costly stops or rework.

    Direct manufacturing brings another edge—end-to-end visibility. We know the charge batch, drying cycle, and even packing crew on every outgoing drum. For clients navigating increasingly complicated logistics and compliance landscapes, this direct accountability brings peace of mind. Large, global buyers sometimes need documented assurance of product origin, batch history, and environmental compliance—demands we’re ready to support with full access to process records and compliance logs.

    Looking Forward: Where We Go Next

    Quality requirements and industry regulations evolve each year. Our approach must keep pace, whether this means advanced analytics or on-the-ground process change. Moving forward, we plan to continue investing in both equipment and staff training—because adaptable, skilled operators are as vital as automation. Our history proves that attention to process, client feedback, and a willingness to share challenges as well as successes leads to deeper trust on all sides.

    As global dye, pigment, and fine chemical markets continue to shift, end-users increasingly demand more than certificates or single-point prices. They expect traceability, technical support, responsible production, and real-world results. As a direct producer of 4-Acetamido-2-Aminobenzenesulfonic Acid, we hold responsibility for every drum leaving our plant—not just on paper, but in every customer's daily operation. This ongoing partnership—built on sharing data, solving problems, and steady improvement—remains our core value and the surest way forward in a changing market.