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4,5-Dicyano-2-Aminoimidazole

    • Product Name 4,5-Dicyano-2-Aminoimidazole
    • Alias DCI-2AI
    • Einecs 205-705-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    497701

    Chemical Name 4,5-Dicyano-2-Aminoimidazole
    Molecular Formula C5H3N5
    Molecular Weight 133.11 g/mol
    Cas Number 94496-68-9
    Appearance Off-white to light brown powder
    Melting Point Decomposes >300°C
    Solubility Slightly soluble in water; soluble in DMSO and DMF
    Purity Typically ≥98%
    Storage Conditions Store at 2-8°C, protected from light and moisture
    Iupac Name 2-amino-1H-imidazole-4,5-dicarbonitrile
    Synonyms 2-Aminoimidazole-4,5-dicarbonitrile
    Smiles N#CC1=NC(=N[C@H]1N)C#N

    As an accredited 4,5-Dicyano-2-Aminoimidazole factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The packaging for 4,5-Dicyano-2-Aminoimidazole (5 grams) is a sealed amber glass bottle with hazard labeling and product identification.
    Shipping 4,5-Dicyano-2-Aminoimidazole is shipped in tightly sealed containers to prevent moisture ingress and contamination. Packaging complies with chemical safety regulations, typically using inert, non-reactive materials. Proper labeling, documentation, and handling instructions are included, and shipments are transported according to national and international hazardous materials guidelines to ensure safe delivery.
    Storage 4,5-Dicyano-2-Aminoimidazole should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizers. Store at room temperature and protect from moisture and light. Use only non-sparking tools and minimize dust generation to avoid inhalation. Proper labeling and secure storage are essential.
    Application of 4,5-Dicyano-2-Aminoimidazole

    Applications of 4,5-Dicyano-2-Aminoimidazole in Industrial Manufacturing

    Our production of 4,5-dicyano-2-aminoimidazole supports specialized chemical synthesis workflows across various sectors. We engage directly with manufacturers who require highly selective intermediates for complex downstream reactions, especially where purity and traceability must meet strict international standards. Below, we detail key application domains where this raw material plays a critical, process-specific role.

    1. Pharmaceutical Heterocycle Synthesis

    Pharmaceutical companies use 4,5-dicyano-2-aminoimidazole as a core building block for synthesizing advanced heterocyclic scaffolds, particularly in research and commercial routes involving anti-infectives and oncology drug APIs. Manufacturers typically introduce this intermediate in early-stage cyclization or condensation steps, benefiting from its controlled reactivity to construct target molecular frameworks while maintaining stringent impurity profiles as demanded by regulatory authorities.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practices for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.) monographs for intermediates
    • U.S. FDA 21 CFR Parts 210 & 211 for drug substance processes
    • China Pharmacopoeia (ChP) requirements for chemical APIs

    Typical usage ratio

    • 5–15 mol% relative to core reactant, optimized based on API target yield and impurity control during multi-step synthesis

    Downstream process integration

    • Added in the intermediate formation stage—often during high-pressure or high-temperature cyclization, preceding downstream functionalizations and salt formation steps

    Final product types

    • Antiviral and antibacterial active pharmaceutical ingredients (APIs)
    • Pyrimidine-based therapeutic compounds for cancer treatments
    • Advanced intermediates for new chemical entity (NCE) pipelines

    2. Agrochemical Active Ingredient Synthesis

    Producers of crop protection molecules incorporate this intermediate in the manufacture of systemic fungicides and selected insecticide actives. The unique cyano-imidazole structure enables the formation of stable heterocyclic systems, which functionalize downstream to deliver molecules with target-specific environmental resistance, essential for registered agrochemical formulations. Each manufacturing campaign requires rigorous mass balance documentation for regulatory inspections.

    Industry compliance standards

    • FAO/WHO Specification for Agricultural Pesticides
    • REACH Regulation EC No. 1907/2006 Substance Registration for agrochemicals
    • ISO 9001:2015 Quality Management for Agrochemical Intermediates
    • OECD GLP (Good Laboratory Practice) for test substance traceability

    Typical usage ratio

    • 2–8% by weight of main reactant in target synthesis pathway; increased for pilot-scale optimization, reduced in high-yield continuous processing

    Downstream process integration

    • Charged during core ring-closure or nucleophilic addition steps, before purification and final derivatization to yield active ingredients

    Final product types

    • Triazole and imidazole group fungicides
    • Pyridine- and imidazole-based systemic insecticides
    • Registered active ingredients for post-emergence herbicides

    3. Electronic Materials—Semiconductor Intermediate

    Semiconductor chemical manufacturers employ 4,5-dicyano-2-aminoimidazole for synthesizing highly conjugated organic compounds, especially precursors for electron-transport layers and advanced photoresist systems in IC fabrication. The compound’s electron-withdrawing structure imparts desirable charge-carrier mobility properties necessary for developing high-purity thin films used in OLED displays and other organic electronics. Quality assurance in these processes mandates tight control over trace metal content and residual impurities.

    Industry compliance standards

    • JEITA Standard for Organic Electronic Materials
    • ANSI/ESD S20.20 ESD Control in Microelectronics Production
    • ISO 14001:2015 Environmental Management for Semiconductor Materials
    • RoHS Directive 2011/65/EU for restricted hazardous substances

    Typical usage ratio

    • 0.5–3% of total organic formulation mass, adjusted according to film thickness targets and electronic property requirements

    Downstream process integration

    • Dispensed into monomer or oligomer coupling reactions before vacuum deposition or spin coating of functional layers

    Final product types

    • Organic light-emitting diode (OLED) transport layer precursors
    • Advanced photoresist components for semiconductor lithography
    • Printed circuit board dielectric materials

    4. Fine Chemical Intermediate for Colorant Manufacturing

    Manufacturers specializing in dye and pigment synthesis use 4,5-dicyano-2-aminoimidazole in the production of high-performance pigment molecules and specialty dyes. Its reactivity supports the formation of nitrogen-rich chromophores, with downstream products widely used in textile coloring, inkjet cartridges, and performance coatings. Strict batch-to-batch consistency and regulatory documentation on trace impurities are essential throughout scale-up and commercial production.

    Industry compliance standards

    • OEKO-TEX® Standard for textile colorants
    • EN 71-3 Safety of Toys: Migration of certain elements (for inks and coatings)
    • ISO 9001/14001 Management Systems for Fine Chemical Plants
    • EU REACH Regulation for industrial pigments and dyes

    Typical usage ratio

    • 1–10% of primary aromatic feedstock, tuned in R&D based on target hue intensity and chroma in the final pigment

    Downstream process integration

    • Introduced during azo-coupling or condensation polymerization, preceding pigment precipitation and surface treatment steps

    Final product types

    • Nitrogen-containing organic pigments for high-temperature applications
    • Performance dyes for digital printing and textile dyeing
    • Specialty colorants for industrial coatings and plastics

    5. Specialty Polymer Monomer Synthesis

    Specialty polymer manufacturers incorporate this intermediate when designing copolymer systems requiring tailored electronic or thermal performance, such as in advanced engineering plastics or membrane technologies. The molecule’s unique functional groups enable controlled copolymerization and site-specific backbone modifications, which are critical for applications involving precise mechanical or filtration properties. Entire process batches undergo documented traceability and monomer conversion efficiency testing prior to product release.

    Industry compliance standards

    • ISO 9001:2015 for Polymer Production Facilities
    • ASTM D883 Terminology for Plastics and Polymers
    • Food Contact Material Regulations (when relevant, e.g., 21 CFR 174–178)
    • ISO 10993-5 for biocompatibility testing of polymers used in medical devices

    Typical usage ratio

    • 2–6 mol% introduced in copolymerization feedstock; ranges adjusted according to molecular weight targets and property thresholds

    Downstream process integration

    • Used as a comonomer or cross-linking agent in solution or suspension polymerization, prior to granulation or extrusion of final polymer

    Final product types

    • High-performance engineering resins for automotive or electronics
    • Specialty filtration membrane matrices
    • Functional coatings for industrial processing lines
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    Certification & Compliance
    More Introduction

    4,5-Dicyano-2-Aminoimidazole: Practical Value from the Factory Floor

    A Look at 4,5-Dicyano-2-Aminoimidazole

    We have been engaged in the manufacture of specialty imidazoles for years, and 4,5-Dicyano-2-Aminoimidazole stands out in our range. Chemistry is never a field that rewards shortcuts, and this compound takes skillful hands and patient processing. Our line, marked by consistency from batch to batch, shows both the reliability and flexibility that continuous production brings. In the laboratory and on the production floor, workers and chemists prioritize material purity and repeatable behavior, both of which we have refined through thousands of hours of feedback and adjustment around actual customer usage.

    From Basic Chemistry to Ready Material: How We Make Differences Count

    4,5-Dicyano-2-Aminoimidazole isn’t a commodity. Its molecular structure, with cyano groups at positions 4 and 5 and an amino at position 2, creates unique electron patterns. That’s something you notice straight away during synthetic work. It demands precision in temperature control and the handling of reactive intermediates. Years ago, our early production had to contend with variable yields and unpredictable side reactions. Through process improvements and stubborn attention to the details that matter, we brought yields up and lowered the noise in the chromatograms.

    The compound’s appearance—fine, free-flowing powder, white or pale off-white—signals successful exclusion of degradation products. Some competitors accept higher levels of colored impurities due to shortcut purifications. We saw customers run into quenching or reproducibility issues. Our technicians applied staged crystallization and adjusted solvent ratios to address that. Today, the difference comes through in end product performance, especially in highly sensitive synthetic steps or assays.

    Batch Consistency: No Mystery, Just Diligence

    Purity is a measurement of professional pride on the factory line. For 4,5-Dicyano-2-Aminoimidazole, we target minimum purity levels over 98%. Routine batch analytics include HPLC, NMR, and elemental analysis. ‘Routine’ doesn’t mean mindless – each test is an active crosscheck on both method and material. We support analytical transparency, providing traceable batch data to partners. These details matter because small variations in reactivity cost more than a rework: they can ruin week-long syntheses in the hands of customers. Chemists who rely on our 4,5-Dicyano-2-Aminoimidazole to function as a robust building block get precise control over downstream N-alkylation, ring formation, or pharmaceutical intermediate steps.

    Some orders demand tighter controls, where residual solvent or water content drops to below 0.5%. We handle that with post-drying and in-line checks, not just spot checks at dispatch. These procedures result from customer requests and real process headaches—not from standard manuals.

    Usage in Synthesis, Medicine, and Materials

    Not every molecule has true versatility, but 4,5-Dicyano-2-Aminoimidazole covers a lot of bases in chemical industries. Its cyano groups make it receptive to further modification—essential in medicinal chemistry where stepwise synthesis wins out over one-pot attempts. End-users turn to this compound to build imidazole-based heterocycles, often integrated into pharmaceutical candidates targeting antiviral or anticancer effects. Our ongoing conversations with researchers tell us most value purity and straightforward scale-up over low price. They want to trust outcomes, not gamble on variable quality.

    Lab notebooks fill up with its function as a precursor to fused and substituted imidazoles, especially in research around bioactive small molecules. Peptide mimics, kinase inhibitors, and assorted bioassays run on the backbone our compound provides. In specialty polymers and material science, that electron-withdrawing effect from the cyano groups builds performance into dielectric layers and molecular electronics. Some of our largest orders come from material research teams looking to push imidazole derivatives into new functional films.

    We also see steady demand from contract research firms and pharmaceutical scale-up facilities. They need kilogram-lot consistency, not gram-scale curiosity. Our plant infrastructure, designed around process safety and dust containment, lets us offer this at practical lead times.

    Specification: Grounded in Experience

    Customers rarely want columns of raw numbers—they want context and trust. 4,5-Dicyano-2-Aminoimidazole leaves our line with moisture and heavy metal levels below the tough standards set by pharmaceutical applications. Packing lines track temperature and exposure; sealed bags reach the loading dock without risk of humidity pickup or cross-contamination. Supply teams deal directly with technical questions about solubility, stability during shipping, and blending for downstream synthesis. We learned years back that answering chemistry questions with fact, not jargon, builds real partnerships.

    We keep particle size within tight bands, since users blending this compound for solid-phase reactions run into trouble with fines or clumps. Standard mesh readings and bulk density checks make their work easier down the line.

    Real-World Lessons: How 4,5-Dicyano-2-Aminoimidazole Compares

    Many companies supply related imidazoles and nitriles. Our customers have told us direct comparisons matter, not specification sheets. 4,5-Dicyano-2-Aminoimidazole stands apart from similar-looking materials such as 2-Aminoimidazole or dicyanoimidazole isomers, both in reactivity and in the way it behaves in multistep syntheses. The double cyano substitution changes more than shelf stability; it shifts both nucleophilicity and the activation energy required for downstream reactions. Chemical process teams who tried less-substituted or mixed isomer imidazoles often ran into yield plateaus or unexpected byproducts. Our conversations with process engineers pointed to the need for uniformity, low side-product profiles, and robust scale-up support.

    We deliver a product ready for either bench-top proof-of-concept or pilot-scale optimization. Older sources, especially from single-step or batch importers, can show high variability or lack detailed analytical support. Our controlled environment and history of ‘living in the trenches’ of plant-scale chemistry led us to rule out shortcuts. This lets process chemists rely on set stoichiometry and avoid re-developed workups from lot to lot.

    Process Safety and Integrity: What Years of Production Have Taught Us

    Chemical production always raises questions about safety and repeatability, and 4,5-Dicyano-2-Aminoimidazole is no exception. This compound, with its cyano groups, asks for experienced containment and exhaust protocols. Years back, we experienced fugitive emission problems during a process scaleup; that lesson burned in procedures for granular dust control, tailored ventilation, and regular re-training. We work with regulators, not just for compliance but because trust falls apart if downstream users face exposure or cross-contamination.

    We also invested in closed-loop waste management for water and spent solvents. Every kilo produced reflects the feedback loop between what plants need, what regulators demand, and what operators learn by doing the work. Our own teams carry out ongoing risk analyses not as an annual box to tick but as a weekly review, often response to user questions or production surprises.

    Global Logistics, Schedules, and Customer Support

    We learned early on that the best compound in the world is useless if it doesn’t arrive when and where it’s needed. Over the years, we adapted our shipping and storage for 4,5-Dicyano-2-Aminoimidazole to address actual pain points: temperature variation, customs holds, and long-haul transits. Sealed pouches inside hard drums, long shelf-life at ambient conditions, and custom labeling all came from customer feedback rather than from generic guidelines.

    Lead times matter to chemists running high-throughput or scheduled scale-ups. Our order system ties plant output directly to scheduling, so we give honest lead times and live updates. Teams at universities, pharmaceutical companies, and industrial research centers want a single batch to last through an entire series. We keep track of repeating orders at the batch level, so each lot matches or improves on the last.

    The Value of Traceability and Technical Transparency

    We rarely see two customers with identical applications, but consistency in raw material remains a shared requirement. Every batch receives a unique identification string linked to production logs and analytics. Over the years, our experience showed that hidden batch blending or off-shore tolling creates more customer headaches than it solves. Aligning technical documentation with actual material, not just paperwork structure, builds confidence for audits, regulatory reporting, and in-lab troubleshooting.

    Raw data—chromatograms, certificates, analytical spectra—arrive with shipments. Some buyers run confirmation tests; others trust our record. Quality control personnel and regulatory teams have come to rely on full disclosure of trace contaminants as new rules around genotoxic impurities grow stricter. Both large and small firms push for transparency, and we support them from the plant level up.

    The Path Forward Through Problem Solving

    No process or compound, no matter how refined, escapes ongoing improvement. As analytical expectations rise, so do requests for new grades—chromatography-grade, enhanced stability for long-term storage, or customized particle sizes. Even with many years’ experience, we still run into new questions from the field. Prompt technical support, batch-specific consultation, and follow-up testing close the loop between what goes out the door and how the compound performs in actual use.

    In recent years, as more synthetic chemists tackle demanding cross-coupling and ring extension protocols involving 4,5-Dicyano-2-Aminoimidazole, we found that adjustments in bulk density and granulation method could cut downtimes and manual corrections in customer plants. This happened because we listened—not just to procurement teams, but to the chemists who run the reactions. Small improvements, like re-engineering desiccant packs in shipment or changing bag liners, emerged from problem reports, not design committees.

    Listening to the Daily Realities of Chemists

    No sales brochure replaces steady, reliable product performance. Researchers and production chemists open bags and load materials with expectations set by years of both good and bad supply experiences. 4,5-Dicyano-2-Aminoimidazole is one of those specialty intermediates that carries disproportionate impact for its size. If it doesn’t meet expectations, whole synthesis flows back up. We take enormous pride in the fact that repeat customers quote yields, track impurities, and note the absence of failed scale-ups directly to our production records, not just catalog entries.

    Change in process chemistry is constant. Today’s hot candidate or workflow often shifts seasonally. Because of our long track record supplying 4,5-Dicyano-2-Aminoimidazole, we support discussions around new uses—such as its integration in high-throughput screening or adaptive chemistry platforms. Our technical support does not end at the invoice; every batch delivers a chance to reinforce partnerships by troubleshooting unusual outcomes or tuning parameters for project-specific workflows.

    What Experience Tells Us About the Market

    Competition in specialty chemical manufacturing can create pressure for cost-cutting, shortcuts, or imprecise marketing. From years watching the cycles of buyouts, rebranding, and reformulation, we stuck to direct production control for 4,5-Dicyano-2-Aminoimidazole. Process improvements occur in-house, allowing us to update or adapt as both regulatory demands and actual usage shift. Customers feel the difference, not only in product performance but also in the willingness to address questions and act on feedback.

    Emerging environmental standards continue to challenge all producers. We integrate waste minimization, solvent recycling, and responsible sourcing of upstream precursors as integral parts of our strategy. This direct engagement with sustainability is not just “greenwashing”—it prevents supply interruptions and earns preferences from buyers facing internal audit.

    Looking Ahead

    4,5-Dicyano-2-Aminoimidazole reflects the intersection of technical expertise, persistent improvement, and open communication with end-users. Over years and through thousands of kilograms produced, refined, packaged, and shipped worldwide, we have found that mastery of detail—down to solubility curves, impurity profiles, and shelf life—anchors trust with customers doing demanding research, manufacturing, or product development. The pathway from plant to customer is neither quick nor mechanical, but shaped by operators and chemists committed to material excellence. As technology pushes research into new frontiers, from molecular electronics to innovative medicinal chemistry, we continue strengthening both our process rigor and our engagement with those who rely on our materials to make each new breakthrough possible.