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4,4'-Dichlorobenzophenone

    • Product Name 4,4'-Dichlorobenzophenone
    • Einecs 211-144-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    117798

    Iupac Name 4,4'-Dichlorobenzophenone
    Cas Number 90-98-2
    Molecular Formula C13H8Cl2O
    Molar Mass 251.11 g/mol
    Appearance White to off-white crystalline powder
    Melting Point 145-147 °C
    Boiling Point 410 °C
    Density 1.34 g/cm³
    Solubility In Water Insoluble
    Refractive Index 1.633
    Flash Point 230 °C
    Smiles Clc1ccc(cc1)C(=O)c2ccc(Cl)cc2

    As an accredited 4,4'-Dichlorobenzophenone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle labeled "4,4'-Dichlorobenzophenone, 100g," with safety symbols, lot number, and tightly sealed screw cap to prevent contamination.
    Shipping 4,4'-Dichlorobenzophenone is shipped as a solid, packaged in sealed, chemical-resistant containers to prevent contamination and moisture absorption. It is handled as a hazardous material, requiring labeling according to relevant transport regulations (such as DOT, IATA, or IMDG). Store and ship in cool, dry conditions, away from incompatible substances.
    Storage 4,4'-Dichlorobenzophenone should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from direct sunlight and incompatible substances such as strong oxidizers. Label the container clearly, and keep it protected from moisture. Store at room temperature and avoid extreme temperatures. Follow standard laboratory chemical storage protocols and ensure access is limited to trained personnel.
    Application of 4,4'-Dichlorobenzophenone

    Applications of 4,4'-Dichlorobenzophenone in Industrial Manufacturing

    As an established manufacturer of 4,4'-Dichlorobenzophenone, we supply this specialty intermediate for select downstream sectors with proven industrial-scale applications. Our technical support ensures material integration that complies with industry regulations and customer quality standards across multiple production environments.

    1. High-Performance Polymer Synthesis (Polyaryl Ether Ketones and Polyetheretherketone, PEEK)

    Polymer manufacturers rely on 4,4'-Dichlorobenzophenone as a key aromatic monomer for producing high-performance engineering resins, such as polyaryl ether ketones and PEEK. The material enters the nucleophilic aromatic substitution step, where its unique dichloro-substituted structure delivers strong thermal resistance and chemical stability to the polymer backbone. These resins support critical applications in aerospace, automotive, and electrical fields, where consistency, traceability, and regulatory compliance remain non-negotiable.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems
    • EN ISO 23936-1:2022 (Polymers for use in oil & gas pipelines)
    • ASTM D6262/D6456 (Thermoplastic Polyetheretherketone compounds)
    • REACH Regulation (EC) No 1907/2006 registration

    Typical usage ratio

    • Monomer dosing at 30–40 mol% relative to total aromatic dihalide component; final percentage adjusted to achieve target molecular weight and viscosity for polymer melt processing

    Downstream process integration

    • Feeds directly into the step-growth polymerization reactor with bisphenol monomers in basic medium under controlled temperature and vacuum; purity and moisture level directly impact final polymer performance

    Final product types

    • PEEK pelletized resins for extrusion and injection molding
    • PAEK copolymer granules for high-strength composites
    • Sheets and films meeting UL thermal endurance standards
    • High-temperature insulating tapes and wire coatings

    2. Specialty Agrochemical Intermediate

    Agrochemical synthesis plants use 4,4'-Dichlorobenzophenone as a core building block in manufacturing selective herbicides and fungicides. Its dichloroaromatic system allows for regioselective coupling and condensation reactions in multi-step synthetic routes for active pesticide ingredients, where trace impurities must be tightly controlled during each production batch to ensure efficacy and regulatory approval.

    Industry compliance standards

    • FAO/WHO Codex Alimentarius international food safety standards
    • EU Regulation No 1107/2009 (Plant Protection Products)
    • EPA 40 CFR Part 180 (Pesticide Chemicals Residues)
    • Good Manufacturing Practice (GMP) for Crop Protection Products

    Typical usage ratio

    • Intermediate concentration at 10–20% in key synthesis stages, depending on downstream yield optimization and solvent compatibility

    Downstream process integration

    • Introduced during Grignard or Friedel–Crafts acylation steps; subsequent purification and derivatization employed to isolate active ingredient precursors for final formulation

    Final product types

    • Selective herbicide technical concentrates (TCs)
    • Fungicide active ingredient intermediates
    • Formulated agrochemical sprays and dispersible granules
    • Seed treatment solutions for major crop protection

    3. Advanced Liquid Crystal Material Production

    Producers of high-specification liquid crystal materials incorporate 4,4'-Dichlorobenzophenone into syntheses of rigid-rod and calamitic mesogen units. Its electron-withdrawing and steric properties enable precise tuning of phase transition temperature and birefringence, meeting stringent requirements for panel manufacturers and device fabricators in the display industry.

    Industry compliance standards

    • IEC 61249-2-7 (Materials for printed boards: Halogen-free requirements)
    • JEITA EM-3509 (Quality requirements for advanced display chemicals)
    • RoHS Directive 2011/65/EU
    • ISO 14001:2015 (Environmental Management Systems)

    Typical usage ratio

    • 2–8% as a structural mesogen precursor in final liquid crystal formulation; concentration tuned for clearing point adjustment and alignment stability

    Downstream process integration

    • Enters during the condensation or etherification reaction prior to final mixture purification; after column purification, blended with proprietary additives under controlled atmospheric conditions

    Final product types

    • Twisted nematic (TN) and in-plane switching (IPS) liquid crystal mixtures
    • Thin-film transistor (TFT) panel-grade LC materials
    • Alignment layer additives for glass substrate coating
    • Specialized optical films for high-contrast LCDs

    4. Photoinitiator and UV-Curable Resin Synthesis

    Manufacturers of advanced UV-curable coatings and inks utilize 4,4'-Dichlorobenzophenone as a core intermediate when synthesizing photoinitiators based on benzophenone skeletons. The raw material’s controlled incorporation impacts light absorption properties and radical generation, determining curing speed and final film hardness in high-throughput applications such as printed circuit board (PCB) solder masks and industrial overprint varnishes.

    Industry compliance standards

    • ISO 27668 (Requirements for UV ink & coating)
    • EN 71-3 (Printing and surface coating for toy safety)
    • GB/T 21822-2008 (Photoinitiators for UV-curable systems)
    • UL 94 (Flammability of plastic materials for parts in devices)

    Typical usage ratio

    • Intermediate level at 5–12% in photoinitiator synthesis; final UV resin formula typically contains 1–5% photoinitiator based on substrate and curing method

    Downstream process integration

    • Integrated during Friedel–Crafts acylation and subsequent chlorination; downstream blending into defined photoinitiator molecules, then incorporated into resin or ink bases

    Final product types

    • Industrial UV-cure adhesives and coatings (clear and pigmented)
    • PCB solder mask formulations
    • Overprint varnishes for packaging
    • High-speed printing inks and flood coating agents

    5. Pharmaceutical Intermediate for Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

    Active pharmaceutical ingredient (API) synthesis for NSAID families makes use of 4,4'-Dichlorobenzophenone as a key intermediate during multi-step synthetic schemes. Its reactivity and purification behavior under GMP conditions allow manufacturers to ensure reproducible batch quality, strict impurity control, and regulatory document traceability for later clinical and commercial production phases.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for APIs
    • United States Pharmacopeia (USP, where relevant in intermediate stages)
    • EU GMP EudraLex Volume 4
    • 21 CFR Parts 210 and 211 (US FDA)

    Typical usage ratio

    • Used at 8–15% depending on target molecular architecture and optimization of subsequent coupling or reduction yields

    Downstream process integration

    • Introduced during early or mid-stage acylation and condensation reactions; followed by multi-step purification using crystallization and chromatography to assure pharmacopoeial purity specs

    Final product types

    • Key registered NSAID intermediates
    • Bulk API for tablet and injectable dosage forms (after subsequent synthesis)
    • Clinical phase research chemicals for development
    • Regulated substance side-chains for generic drug synthesis
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    Certification & Compliance
    More Introduction

    Introducing 4,4'-Dichlorobenzophenone: Practical Insights from Manufacturing

    Understanding the Value Behind 4,4'-Dichlorobenzophenone

    As direct manufacturers of 4,4'-Dichlorobenzophenone, we work with this compound each day, overseeing every batch from raw material selection to the final packaging. This environment keeps us connected to the core of our product's properties and its relevance across industries. Our model typically features a white to pale yellow crystalline powder with a reliable melting point and consistent assay, crucial qualities for users needing predictability in chemical reactions.

    Our clients most often seek our 4,4'-Dichlorobenzophenone for its central role in specialty polymer synthesis, pharmaceutical intermediates, and certain fine chemical transformations. We've seen strong demand from resin formulators and research labs developing next-generation plastics. The dichloro functionalization on the benzophenone backbone offers key reactivity for crosslinking and structure building, leading to improved polymer thermal stability and resistance.

    Why Purity and Specification Matter

    In our experience, attention to purity distinguishes a high-functioning product from unreliable alternatives. Our standard grade repeatedly exceeds 99% assay, confirmed by in-house HPLC and GC systems. Color, moisture content, and residual solvents are tightly controlled, minimizing unforeseen influences on downstream synthesis. These controls don't just look good on paper. They reflect our regular audits and test runs, which often reveal that batches outside our spec will perform less efficiently in polymerization or may bring unwanted side products in pharmaceuticals.

    We’ve lost count of how many times troubleshooting with a customer brought us to the realization that a small off-spec impurity caused entire batches of polymer to fall apart or caused test reactions to show inconsistent yields. Reliable 4,4'-Dichlorobenzophenone means fewer reworks, streamlined process validation, and lower long-term costs — all realized through careful, direct control of each manufacturing step.

    What Sets 4,4'-Dichlorobenzophenone Apart from Similar Chemicals

    4,4'-Dichlorobenzophenone often gets confused with its mono-chloro, tri-chloro, or unsubstituted relatives. Yet, in real-world applications, the two para-chloro groups bring unique functionality. This compound resists unwanted oxidation and hydrolysis better than some singly-chlorinated or unsubstituted benzophenones, allowing manufacturers to extend product shelf life and operate under challenging reaction conditions. We’ve worked with resin labs needing this stability for their high-performance thermoplastics, where substitutions at different positions simply didn’t hold up to required specifications.

    Compared with 4-chlorobenzophenone or pure benzophenone, the symmetrical dichloro substitution increases melting point and changes solubility — properties essential to predict during compounding or scale-up. If a user opts for less-chlorinated versions, they often trade off some of the thermal properties and may run into unpredictable polymerization kinetics. Direct comparison in our test batches reveals the tighter molecular packing and resulting heat resistance of the dichloro version, which many specialized polyarylate and polyether ketone chemistries demand.

    Production Experience: Controlling Consistency Batch after Batch

    In practice, the synthesis of 4,4'-Dichlorobenzophenone demands precise reaction condition control. We’ve faced challenges ranging from maintaining temperature gradients in larger reactors to mitigating minor chlorination byproducts. Consistent filtration, recrystallization, and drying cycles shape our approach. For any batch that strays from color or melting point standard, adjustments happen in real-time, giving us a track record our downstream users rely on.

    Our testing routine includes sampling at multiple production stages, not just final material analysis. This lets us catch issues early, before they scale into wasted product or costly downtime. Feedback loops with our longtime clients, especially polymer makers, drove us to refine not just purity but also bulk density and flow properties for smoother process integration. It’s a reflection of our relationship-based approach; every technical inquiry or troubleshooting request feeds back into better process control on our end.

    Not Just Chemistry: Safety and Handling at the Source

    It’s easy to glance at a data sheet and forget the practicalities of daily use. Handling chlorinated aromatic ketones brings operational considerations — from dust management in large transfer systems to the right selection of packaging materials. Our facility uses lined drums and robust sealing to stop moisture ingress and dust escape. These details matter when workers open containers or transfer weights into synthesis tanks. Early on, customers flagged problems with caking or airborne dust, so we invested in modified drying and sieving processes, achieving a free-flowing, manageable product that reduces worker exposure.

    We pay attention to the logistics chain, ensuring each shipment remains uncompromised from door to dock. Our trained staff prioritize worker safety not just in our own factory, but in preparing guidance for partners and customers. This hands-on experience means we don’t just see numbers; we see the whole lifecycle, from our reactor halls all the way to your finished application.

    Reliable Sourcing in a Volatile World

    Recent years saw many disruptions in chemical supply chains. Here, making 4,4'-Dichlorobenzophenone in-house shields our customers from swings due to third-party shortages or sudden quality lapses. Unlike traders or resellers who scramble at the last moment, our vertical integration lets us source core raw materials, monitor availability, and anticipate trouble. We’ve weathered storms in global logistics, ensuring backup raw material channels and redundancy in our production lines.

    This direct model supports our clients who place a high value on steady supply and transparent communication. Whether demand surges, or global shipment lanes tighten, holding manufacturing onsite gives us enough flexibility to ramp up, maintain safety stock, and communicate honest lead times. Our buyers often note the absence of batch-to-batch variation and recall how competitors, relying on repacked or mixed-supplier stocks, faced delays, losses, or outright failures.

    Environmental Considerations and Responsible Manufacturing

    We treat chemical stewardship seriously, knowing the impact extends beyond our plant boundaries. Chlorinated aromatics have waste and emissions challenges; that’s no secret in the business. We limit environmental impact by capturing and neutralizing chlorinated off-gas, investing in closed-loop solvent recovery, and working with licensed hazardous waste partners for all residues and wash streams. Some early challenges with regulatory changes around chlorinated compounds led us to redesign some waste capture technologies, now standard at our site.

    Recent upgrades reduced total organic and halogenated emissions, documented through annual third-party audits and compliance checks. Our customers in healthcare or electronics require documentation proving these steps; we provide full transparency, tracking and reporting environmental metrics at the batch level. This effort not only meets international standards but reassures customers their supply comes from a responsible source.

    Supporting Advanced Applications in Polymers and Pharma

    Our 4,4'-Dichlorobenzophenone forms the backbone for demanding specialty polymers, often as a monomer or functional seed for further substitution. Customers synthesize polyetherketones or novel thermoplastics needing this very specific dichloro structure. In the pharma sector, fine chemical houses employ it as a key intermediate for analgesic and anti-inflammatory drug precursors. The direct feedback from their process chemists drove us to streamline purity and moisture content, since even slight impurities could halt an entire process validation.

    Having a direct line with process development teams means we adapt to process evolution. As they experiment with greener reactions or tighter impurity specs, we respond by investing in additional purification and real-time analytical controls. Our longtime clients in polymers often bring us novel requirements, such as particular particle size for melt blends, or custom packaging for clean-room loading. These are real-world hurdles that generic materials rarely meet, but with manufacturing control, we tune each batch accordingly.

    Avoiding Common Pitfalls: Lessons Learned

    Looking back, some of our strongest relationships started with trouble: off-brand materials that clumped, altered color post-storage, or brought persistent downstream headaches. Fixing those issues meant more than simply swapping a material. We dug into user process data, ran comparative trials, and customized our drying or milling steps to match their needs. Some customers faced major production costs before switching to our consistent quality, reporting fewer failed runs and lower waste.

    We keep routine communication lines open, not waiting for problems to arise. Monthly performance meetings with our main users feed process data back into R&D and plant operations. These steps close the feedback loop — ensuring new issues get detected early, and our product evolves with industry trends. Forward-thinking clients shape our process controls as much as internal engineering.

    Technical Support Rooted in Experience

    Being a manufacturer gives us a deeper insight into troubleshooting and adaptation. When clients want to scale reactions from lab to plant, our technical support team, staffed by engineers and chemists familiar with our own production, can advise based on real-world outcomes, not just literature. For example, when transitioning from small flask to kilo tanks, mixing speed, addition rate, and solubility limits become clear sticking points — we guide this with our own production notes.

    Sometimes, service means anticipating seasonal or regional logistics. High-humidity climates spark clumping in transit; for these cases, we preemptively adjust our dehydration cycles or recommend double-bagged inner packaging. With pharmaceutical end-users, support also covers detailed impurity profiles and guidance on regulatory documentation. Having boots on the ground makes all the difference in fielding regulatory or validation questions directly, with the insights of those who make the product daily.

    Customization: More Than Just Particle Size

    Every now and then, a project demands characteristics just outside the standard catalog. Whether it’s micronized formats for high-speed extrusion, or specific bulk densities for automated powder feeders, our plant adapts production lines to suit these requirements. Changing variables at scale brings its own challenges — balancing crystallization solvent ratios or tweaking drying curves — but the end result is a product tailored to the process, not compromised by generic offerings.

    Many of these custom requests started as side conversations between engineers. Engineers from both sides discuss not only what the process needs now, but what improvements could look like in future years. This collaborative approach sets direct manufacturing apart from third-party vendors focused mostly on price, not process. Our lab teams relish these challenges, and more often than not, the gains in productivity or final product performance far outweigh the modest added development time.

    Future Trends: Demands for Traceability and Digital Integration

    Regulatory agencies and consumer brands both push for more visibility in supply chains. Responding to these needs, our facility upgraded digital batch tracking, integrating each lot of 4,4'-Dichlorobenzophenone to unique codes tracking source, process parameters, and shipping events. End-users, especially those producing food-contact polymers or pharma APIs, need digital records and rapid traceability for audits and compliance. Investing in this infrastructure came from years of hands-on requests from customer quality teams — a true partnership bringing benefits to both sides.

    Beyond traceability, we increasingly encounter clients with sustainability initiatives. LCA calculations, waste minimization, energy accounting — these are no longer just buzzwords but process parameters we build into every production run. Upgrades in heat recovery, solvent recycling, and smart process analytics all started as pain points uncovered in plant audits, now standard parts of our daily routines. By acting more like a process team member than a faceless supplier, we learn and evolve alongside the engineers using our product.

    Final Thoughts: The Human Element in Every Batch

    Years in this field taught us that no chemical is just a commodity when your own name stands behind each lot. Every sample we dispatch reflects the hard lessons learned through direct innovation, customer feedback, and hands-on troubleshooting. The difference a good batch of 4,4'-Dichlorobenzophenone makes in a polymer chain or pharma intermediate becomes clear out on the line, not just on the specification sheet. Every day, we see people — not just clients — putting trust in the bottle they open, and for us, that's the real motivation to get every detail right.