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4,4'-Dichlorobenzil

    • Product Name 4,4'-Dichlorobenzil
    • Einecs 202-307-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    489520

    Chemical Name 4,4'-Dichlorobenzil
    Cas Number 3646-69-9
    Molecular Formula C14H8Cl2O
    Molecular Weight 263.12 g/mol
    Appearance White to pale yellow solid
    Melting Point 161-163°C
    Boiling Point Unavailable
    Solubility Slightly soluble in water; soluble in organic solvents
    Density Unavailable
    Purity Typically >98%
    Synonyms 4,4'-Dichlorobenzoin; 1,2-Bis(4-chlorophenyl)-2-oxoethane
    Smiles Clc1ccc(cc1)C(=O)C(c2ccc(Cl)cc2)
    Inchi InChI=1S/C14H8Cl2O/c15-11-5-1-9(2-6-11)13(17)14(10-3-7-12(16)8-4-10)18/h1-8,14H
    Refractive Index Unavailable

    As an accredited 4,4'-Dichlorobenzil factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 25g bottle of 4,4'-Dichlorobenzil is securely sealed in an amber glass container with a tamper-evident cap and clear labeling.
    Shipping 4,4'-Dichlorobenzil is shipped as a solid chemical in tightly sealed containers to prevent contamination and moisture exposure. It should be packaged in accordance with regulations for hazardous substances, including proper labeling. During transport, it must be kept away from incompatible materials and handled with appropriate personal protective equipment to ensure safety.
    Storage **4,4'-Dichlorobenzil** should be stored in a cool, dry, and well-ventilated area, away from direct sunlight and sources of heat or ignition. Keep the container tightly closed and separate from incompatible substances such as strong oxidizers. Store in a designated chemical storage cabinet, clearly labeled, and avoid exposure to moisture. Ensure suitable spill containment and access to safety equipment.
    Application of 4,4'-Dichlorobenzil

    Applications of 4,4'-Dichlorobenzil in Industrial Manufacturing

    As a direct manufacturer with extensive process experience, we deliver 4,4'-Dichlorobenzil into established downstream sectors validated by production demand. We collaborate with formulation engineers and process chemists to ensure product adoption aligns with verified industry guidelines and technical benchmarks. Explore below how 4,4'-Dichlorobenzil supports formulation integrity and meets compliance requirements in distinct industrial segments.

    1. Agrochemical Intermediate Synthesis

    4,4'-Dichlorobenzil serves as a building block in the synthesis of selected pesticide actives, especially within phenylurea and related herbicide groups. Manufacturers incorporate it via nucleophilic substitution or other coupling reactions to introduce dichlorobenzil fragments into target molecules, providing desirable physicochemical properties and mode of action enhancements. Its controlled input levels and purity influence both reaction efficiency and downstream active performance. This application requires stringent documentation, traceability, and by-product minimization throughout the synthesis workflow to satisfy both export and domestic registrations.

    Industry compliance standards

    • China National Standard GB 4285-89 for Pesticide Safety and Labeling
    • EU Regulation (EC) No 1107/2009 for Plant Protection Products
    • REACH Registration for precursor chemicals
    • ISO 9001:2015 certified quality management systems

    Typical usage ratio

    • Ranges between 8–18% by molar ratio, adjusted based on specific active ingredient synthesis and conversion efficiency

    Downstream process integration

    • Introduced during the initial or intermediate reaction stage before final derivatization or formulation

    Final product types

    • Technical-grade herbicide actives (phenylurea class, substituted benzoyl derivatives)
    • Pre-emergent weed control compounds

    2. Pharmaceutical Intermediate Manufacturing

    This material finds controlled use as a precursor in the multi-step synthesis of certain APIs, notably where dichlorinated benzyl structures are specified within pharmacopoeial monographs. Its structural features provide chemical handles for further transformation steps, including reductive amination, halogen exchange, or etherification. GMP production sites strictly monitor incoming raw material quality, lot traceability, and residual impurity profiles to ensure compliance and batch reproducibility in final API synthesis.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • US Pharmacopeia (USP) Monographs—Intermediate Handling
    • EDQM Certification (CEP) for supply chain transparency
    • EU GMP Directive 2003/94/EC for Human Medicinal Products

    Typical usage ratio

    • Generally applied at 6–14% of reaction mixture by weight, subject to route design and final yield requirements

    Downstream process integration

    • Charged as a key intermediate during the controlled condensation or substitution step, under validated reaction and purification protocols

    Final product types

    • Pharmaceutical intermediates meeting compendial requirements
    • APIs for cardiovascular agents and centrally acting drugs (where dichlorobenzil moieties are part of structure)

    3. High-Performance Dye and Pigment Manufacturing

    In the colorants industry, 4,4'-Dichlorobenzil functions as a functionalized aromatic source for specialty dye and pigment synthesis, allowing modulation of chromophore backbone properties. Producers utilize it primarily in the production of certain disperse and vat dyes, where chlorine substitution confers improved shade strength, resistance profiles, and solubility behavior for textiles. Technical teams carefully engineer batch addition during the coupling phase and monitor for shade consistency and batch-to-batch reproducibility.

    Industry compliance standards

    • OEKO-TEX Standard 100 for restricted substances in textiles
    • European Regulation (EC) No 1907/2006 (REACH) for dye chemical hygiene
    • ISO 105-A01:2010 for color fastness testing
    • Zhejiang Textile Chemical Industry Quality Standards

    Typical usage ratio

    • Used at 10–22% by weight, optimized for pigment or dye substrate reaction efficiency and depth of shade

    Downstream process integration

    • Added during the diazotization or condensation-coupling synthesis, prior to final reduction/purification steps

    Final product types

    • Disperse dyes for polyester and acetates
    • Vat dyes for cellulose fibers
    • Specialty pigments for plastics and printing inks

    4. Specialty Polymer Modifier Production

    Within polymer modification, 4,4'-Dichlorobenzil acts as a chain extender or functional additive to tailor polymer backbone properties, particularly in engineering resins and high-durability materials. Formulators integrate it to adjust thermal behavior, chemical resistance, and crosslink patterns in specialty plastics. Input controls, dispersion techniques, and process validations form part of the adoption package for users in demanding technical segments such as automotive, electronics, and performance coatings.

    Industry compliance standards

    • UL 94 Flammability Test Standards for Plastics
    • ISO 9001:2015 in polymer compound manufacturing
    • RoHS Directive 2011/65/EU (for electronics polymers)
    • GB/T 19472 for plastic piping materials (China)

    Typical usage ratio

    • Usually ranges from 2–7% by weight, tailored for polymer compatibility and anticipated end-use conditions

    Downstream process integration

    • Incorporated during in-reactor blending or pre-polymerization for copolymer systems, or via melt blending/extrusion for established resins

    Final product types

    • Modified engineering plastics (e.g. polyesters, polyamides)
    • High-durability injection-molded parts
    • Performance coatings for electronics housings

    5. Industrial Biocide and Preservative Preparations

    Manufacturers utilize controlled amounts of 4,4'-Dichlorobenzil as a biocidal component in selected industrial formulations, especially for paints, coatings, and adhesives demanding extended antimicrobial stability. The compound imparts resistance against a broad range of bacteria and fungi, supporting extended shelf life and compliance with technical specifications in sensitive applications. Formulation chemists calibrate dosage to balance biocidal action with regulatory restrictions and interplay with other formulation ingredients.

    Industry compliance standards

    • BPR (EU Biocidal Products Regulation) 528/2012
    • US EPA Antimicrobial Registration 40 CFR 152
    • ISO 11998 for Wet Scrub Resistance in Coatings
    • GB 18582 for indoor decorating materials (China)

    Typical usage ratio

    • Typically deployed at 0.05–0.3% by total product weight, adjusted per required antimicrobial spectrum and exposure conditions

    Downstream process integration

    • Introduced in the post-emulsification or pre-packaging blending stage of coatings and adhesives production

    Final product types

    • Architectural and industrial water-based coatings
    • Construction adhesives with antimicrobial claims
    • Mold-resistant protective finishes for wood and composites
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    Certification & Compliance
    More Introduction

    4,4'-Dichlorobenzil: From Production to Application

    What We Make: A Closer Look at 4,4'-Dichlorobenzil

    At our plant, we start with carefully sourced raw materials and handle each stage of the process in-house, working hands-on with 4,4'-Dichlorobenzil every day. This compound, known for its two chlorine atoms placed on the benzil core at the 4 and 4’ positions, stands apart from many other specialty chemicals we manufacture in terms of purity, handling, and utility. Our standard material carries the chemical identification CAS number 34841-35-5 and presents as a pale, crystalline solid, notable for its sharp melting point and consistent chemical profile.

    What sets 4,4'-Dichlorobenzil apart begins at the reactor. Chlorination happens under tightly controlled conditions, guided by real-time analysis to drive complete reaction while suppressing unwanted side-products. We keep a close watch on moisture content and particle size—both can influence downstream usability, especially for companies turning to us for intermediates that feed directly into pharmaceutical or agrochemical production lines. As a manufacturer, we never treat batches as an afterthought; every lot gets individually checked and cleared for shipment only after passing all internal purity standards. For those needing a specification to trust, we regularly support requirements for >99% assay, with all trace impurities mapped by gas chromatography and mass spectrometry.

    Everyday Handling: Why Purity and Consistency Matter

    Years of producing 4,4'-Dichlorobenzil have shown us that batch consistency goes beyond lab numbers. Powder flow, clumping, and off-odors—all tell a story about what really happens in the vessel and during drying. We monitor these factors because we’ve seen how off-spec material can snarl up a customer’s synthesis or create inhomogeneities in their blended products. A small slip in production—a filter clog, a cooling hiccup—can alter the material’s handling characteristics, so we invest in both manual checks and automated systems to intervene early.

    One area where we differ from traders is in visible and active control over stocks. We don’t just store excess material until someone asks; we rotate inventory tightly, use humidity controls in our warehouses, and train staff to spot any coloration or caking before it leaves our site. While some distributors treat 4,4'-Dichlorobenzil as a “commodity”, manufacturers know the cost of a failed process step downstream. We keep records of every container filled, crosscheck samples from every drum, and keep a line open to every user who’s run into an unexpected result.

    The Spectrum of Applications

    4,4'-Dichlorobenzil plays a central role as a chemical building block. Its two chlorine atoms, precisely fixed to the aromatic rings, give it a distinctive reactivity profile. Customers working in pharmaceutical intermediate synthesis often select it to introduce controlled halogenation into larger molecules, especially when downstream reactions call for a stable, non-reactive backbone. Agrochemical producers use it to build up complex pesticidal molecules; its stability withstands harsh synthesis steps that other aromatic ketones can’t manage.

    Some of our largest partners operate on tight lead times. Their process windows leave little room for hesitation—if a shipment arrives off-standard, production waits and costs balloon. We built our manufacturing flow to match these needs. Every lot goes through double verification: first at the reaction termination stage, then again after purification and drying. Moisture, ash, and residual solvents all draw heavy scrutiny, since even a trace impurity can trigger batch rejection at the user’s plant.

    Researchers trust us for kilogram-scale deliveries with reproducibility from batch to batch. Larger industrial clients depend on us for drum and pallet quantities, expecting uniform pack weights and lot traceability. While downstream users often won’t see our name on the end product label, our focus on making consistent 4,4'-Dichlorobenzil keeps these production chains running.

    Comparing to Similar Compounds

    Many buyers ask how 4,4'-Dichlorobenzil lines up against close relatives like 2,2'-dichlorobenzil or other halogenated ketones. The difference shows not only on a molecular level but in hands-on handling and real-world reactivity. The specific positions of the chlorines shape how the molecule interacts both as a direct reactant and as a coupling partner in Suzuki or other palladium-catalyzed steps.

    Some other dichlorinated benzil variants, for all their surface similarity, show greater sensitivity to light, degrade faster in warehouse conditions, or require additives to keep packing free flowing. We’ve worked through those challenges by focusing on 4,4'-Dichlorobenzil because it offers a strong balance: high heat stability, low volatility, and a shelf life that beats more reactive halogenated analogs. Its lower dusting tendency, compared to trichlorinated cousins, reduces risks and keeps our plant environment safer for routine operations.

    In downstream applications, product selection depends on more than just the number of halogen atoms; the position and purity levels define where bottlenecks crop up. A pharmaceutical process might tolerate small amounts of 2,2’-dichloro impurities in early research, but fail at scale. We tune our manufacturing—temperature ramps, vacuum levels, choice of solvents—to preserve the batch’s integrity and avoid introducing isomers that could block later process steps.

    Listening to Customers’ Experience

    On the production floor, we take customer feedback seriously. Over the past decade, clients have flagged minor changes in powder texture and flow even before a laboratory impurity shows. We expanded our particle size analysis to capture this, routinely checking for agglomerates or fines that can change how the product dispenses in high-precision feeders. Some customers working with liquid-phase handling systems asked for tighter controls on particle size distribution—it pushed us to upgrade our milling and sieving capabilities so that our product would not cause feeding issues or clog filters.

    Solubility and batch processability—the practical challenges—remain a focus for us. Engineers have come to us frustrated after switching suppliers, finding that even with the same CAS number, a substitute failed to dissolve as expected or caused crystallization in mixed solvent systems. We respond by publishing solubility data across common solvents and testing real-world scenarios, rather than relying solely on textbook values. Our pilot customers have shared that this saves time scaling up reactions and prevents costly reruns.

    Environmental Stewardship and Waste Reduction

    Manufacturing organic compounds like 4,4'-Dichlorobenzil generates specific challenges for waste management. Chlorination reactions, pricey as they can be, risk producing unwanted chlorinated by-products. Over years in practice, we’ve invested in improved scrubbing systems and switched to closed vapor loops in the plant to capture fugitive emissions. We recover solvents such as methylene chloride and ethanol on-site to reduce purchase volumes and cut disposal fees—this pays off not only in savings, but in tighter environmental control.

    Chlorinated by-product streams receive close attention—both for economic and environmental reasons. Regulations on persistent organics grow more stringent each year. Having processes in place to identify and segregate minor by-product streams keeps us ready for future compliance checks. We track each batch’s inputs, energy consumption, and waste output, sharing summarized environmental data on request with our largest buyers as part of their own supply-chain sustainability reviews.

    Safety on Site: Protecting People and Product

    From initial chlorination to final packaging, the manufacturing process requires stringent safety protocols. Workers use direct-read monitors to track airborne particulate levels, and secondary containment surrounds all reactor systems. We train each operator repeatedly on chemical handling and emergency procedures, recognizing that a single drift of powder or splash of intermediate can spell days of cleanup and lost time. Our investment in dust-extraction equipment doesn’t just protect employees; it meets buyers’ concerns that cross-contamination could damage synthesized pharmaceuticals or animal feed supplements where our product forms a building block.

    While isomer control matters for chemical efficacy, we find that best safety results come from treating every transfer, drying step, and packaging sequence as a contamination risk. We dedicate specific tanks and filters for each product batch to prevent crossover, logging every cleaning and maintenance activity. Incoming customer audits have shaped the way we store and move material, keeping food and pharma-grade segregated from industrial and research lots. Sharing these protocols openly with visiting technical staff helps build the trust that supports long-term partnerships.

    Supply Chain Resilience: Lessons Learned

    Supply interruptions come from many sources: raw chlorinating agents running short, logistics slowdowns, or new regulatory controls on precursor shipments. Living through these disruptions has taught us the value of pre-positioned inventory and local backups. Instead of chasing the lowest spot price, we keep trusted supplier relationships and invest in on-site analytics. We purchase feedstocks in batches large enough to weather temporary price spikes, routinely requalifying sources to guard against changes in impurity profiles.

    Those relying solely on distributors often face weeks of waiting when disruptions hit. Our end-users get regular updates when anything shifts—whether port congestion, incoming plant maintenance, or new legal certification. Being a manufacturer means staying in the loop from source mine to final delivery. Most clients ask for custom packaging—foil-lined drums, double-bagged kegs, or lighter sacks for research labs. We own the process, not just from a sales standpoint but from daily experience turning customer suggestions into safer, more user-friendly packaging.

    Supporting Innovation: Partnering on New Applications

    4,4'-Dichlorobenzil’s reactivity found new value as research teams explored more sustainable catalysts. Some recent studies collaborated with us to test the compound in nontraditional syntheses, seeking greener oxidants or solvent systems. Participating in these projects, we supplied small to multi-kilogram lots, hosted plant tours for research chemists, and adapted our analysis methods to support advanced characterizations.

    We see more questions around lifecycle assessments, especially from customers developing active pharmaceutical ingredients or high-performance materials where even intermediate supplier choice affects the final carbon footprint. Using energy recapture during chlorination and maximizing batch yields cuts our emissions level per kilogram produced. This approach, while costly up front, builds trust with customers who supply regulated markets.

    Feedback loops between our plant and end-user R&D teams sharpen our understanding of performance requirements. As regulatory pressures increase, we document trace metals, halogen content, and even potential allergen residues for clients concerned about end-market registration. By sharing test protocols and opening channels for rapid dialogue, we turn 4,4'-Dichlorobenzil into more than a simple commodity; it becomes a part of collaborative problem-solving across the value chain.

    Challenges and Paths Forward

    Competing in a global market, even for a compound as established as 4,4'-Dichlorobenzil, brings ongoing challenges. Overseas producers sometimes flood the market with underpriced batches, tempting buyers but risking hidden variability and unreported impurities. We’ve countered by posting clear, detailed analysis data and standing by our results—even providing retain samples for customer verification. Transparency, backed by in-house testing and independent review, offers more reliable security than a price war.

    Automation and greater use of digital records allows us to detect subtle drifts and correct them early. We’re piloting AI-based controls to monitor reactor variables and catch trends before they turn into off-spec product. This, paired with hands-on checks from experienced operators, means both tech and know-how contribute to quality. Many in the industry still treat dichlorinated compounds as low-margin, high-volume items, but we approach them as precision tools for downstream manufacturing partners—each kilogram tied to a specific process or patent chain.

    Customers seeking alternatives or looking to substitute related chemicals often confront hidden costs. Switching away from 4,4'-Dichlorobenzil comes up in discussions, typically due to price or perceived supply advantages from less-regulated regions. Yet experience shows that switching often brings new headaches: crystallization failures, unexpected reactivity, or incompatible solvent profiles. Our technical support teams review these scenarios and help partners run small-scale trials so that any transition, in either direction, is founded on real process data.

    Why the Manufacturer’s Role Matters

    We know every drum and every spec because we hold the process from start to finish in our hands. Acting as the manufacturer does not just bring confidence in specification; it gives the flexibility to adapt, improve, and troubleshoot in real time. Through decades of working directly with users—from multinational chemical companies to local specialty labs—we built layers of expertise that stay current as the regulatory and technical landscape evolves.

    4,4'-Dichlorobenzil remains a staple for its robustness and adaptability across industries. Maintaining its value means paying attention to what happens in the tank, in the warehouse, and at the end-user’s bench. This mindset keeps us focused on what truly counts: product safety, customer trust, environmental stewardship, and technical progress. It’s not a commodity to us—it’s the output of commitment, experience, and constant improvement, shaped by real-world feedback from the hands that use it.