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4-(4-Chlorophenyl)-1,2,3,6-Tetrahydropyridine Hydrochloride

    • Product Name 4-(4-Chlorophenyl)-1,2,3,6-Tetrahydropyridine Hydrochloride
    • Alias CPP hydrochloride
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    817741

    Product Name 4-(4-Chlorophenyl)-1,2,3,6-Tetrahydropyridine Hydrochloride
    Cas Number 828-23-1
    Molecular Formula C11H13Cl2N
    Molecular Weight 230.14 g/mol
    Appearance White to off-white solid
    Melting Point 210-215°C
    Solubility Soluble in water and DMSO
    Purity Typically >98%
    Storage Temperature 2-8°C, protect from light
    Synonyms MPTP hydrochloride
    Iupac Name 4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride

    As an accredited 4-(4-Chlorophenyl)-1,2,3,6-Tetrahydropyridine Hydrochloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 25g quantity is packaged in a sealed, amber glass bottle with a tamper-evident cap and clearly labeled hazard warnings.
    Shipping `4-(4-Chlorophenyl)-1,2,3,6-Tetrahydropyridine Hydrochloride` should be shipped in tightly sealed, chemical-resistant containers, away from moisture and incompatible substances. Use appropriate hazard labeling, with transport in compliance with local regulations for laboratory chemicals. The package should be cushioned to avoid breakage and include a safety data sheet for emergency reference.
    Storage 4-(4-Chlorophenyl)-1,2,3,6-Tetrahydropyridine Hydrochloride should be stored in a tightly sealed container, protected from light and moisture, in a cool, dry, well-ventilated area. Keep it at room temperature, away from incompatible substances such as strong oxidizers, acids, and bases. Ensure appropriate labeling and limit access to authorized personnel, following standard chemical safety protocols.
    Application of 4-(4-Chlorophenyl)-1,2,3,6-Tetrahydropyridine Hydrochloride

    Applications of 4-(4-Chlorophenyl)-1,2,3,6-Tetrahydropyridine Hydrochloride in Industrial Manufacturing

    As a specialized manufacturer, we support global chemical and pharmaceutical partners with high-purity 4-(4-Chlorophenyl)-1,2,3,6-Tetrahydropyridine Hydrochloride for established applications in pharmaceutical active ingredient synthesis and advanced chemical research. Our expertise extends throughout the life sciences and fine chemical industry value chains, ensuring consistency and full traceability in every batch delivered for demanding industrial standards. Below, we detail the main manufacturing sectors where our material plays a critical role, including integration points, formulation details, and regulatory requirements.

    1. Intermediates in Anti-Parkinson Drug Synthesis

    This compound serves as a key precursor in the production of pharmaceutical actives, especially for anti-Parkinson agent synthesis, such as the pathway toward Selegiline and Rasagiline APIs. Downstream manufacturers depend on reliable integration into complex multi-step organic synthesis, requiring careful control of reaction profiles and impurity levels to ensure compliance with regulatory submissions. The material’s addition directly impacts titer and purity of hydrogenation and protective group removal processes central to API engineering.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • EU EudraLex, Volume 4—GMP Guidelines (Part II: Basic Requirements for Active Substances)
    • U.S. FDA 21 CFR Part 211—Current Good Manufacturing Practice (CGMP) for Finished Pharmaceuticals
    • Relevant Pharmacopeial Monographs (e.g., USP, EP for final APIs)

    Typical usage ratio

    • Exact ratios depend on the target molecule and specific synthetic route. Standard batch processes typically introduce this intermediate at a 0.9–1.2 molar equivalent relative to the limiting substrate, with adjustments based on the desired yield and purity endpoints.

    Downstream process integration

    • Added to the initial step in multi-step organic synthesis, often as the first condensation or alkylation input for nitrogen heterocycle formation. It undergoes further transformation under controlled hydrogenation, deprotection, and chiral separation steps.

    Final product types

    • Selegiline active pharmaceutical ingredient (API)
    • Rasagiline API
    • Other analogues with tetrahydropyridine structures for neurological disorder medications

    2. Chemical Reference Standards and Analytical Reagents

    Certified laboratories and pharmaceutical manufacturers employ this material as a chemical reference for method validation, calibration, and impurity profiling in analytical development. Its highly defined structure and strict batch-to-batch purity allow precise analytics, minimization of cross-lot contamination, and reliable reproducibility in research and quality control environments. Accurate mass balance, stability indication, and characterization rely on such well-defined intermediates.

    Industry compliance standards

    • ISO/IEC 17025:2017—General Requirements for Competence of Testing and Calibration Laboratories
    • USP General Chapters <621> (Chromatography), <1225> (Validation of Compendial Procedures)
    • European Pharmacopoeia General Methods for Analytical Reference Substances
    • GLP—OECD Principles of Good Laboratory Practice

    Typical usage ratio

    • For calibration and validation: 0.1–10 μg/mL concentration in analytical standards, depending on instrument sensitivity (HPLC, GC-MS, NMR). Ratio set by the required quantification limit and laboratory method validation protocol.

    Downstream process integration

    • Introduced as an analytical reference at various stages during chromatographic, spectroscopic, or mass spectrometric analysis. Employed for instrument calibration, control sample preparation, and process impurity testing racks.

    Final product types

    • Validated chemical reference standards
    • Analytical calibration mixtures
    • System suitability test samples for pharmaceutical quality assurance and laboratory proficiency testing

    3. Academic and Industry Research in Neurodegenerative Disease Models

    This material figures prominently in academic and industrial R&D when studying mechanistic models of neurodegeneration, particularly those involving dopamine pathway disruption. Research groups exploit its structural features to induce controlled neurotoxic lesions in preclinical Parkinson’s disease animal models, or as a reactant for probing receptor interactions and transporter function in CNS pharmacology. The chemical’s consistent specification supports reproducibility and comparability across multi-site collaborations under regulated research environments.

    Industry compliance standards

    • Institutional Animal Care and Use Committee (IACUC) Guidelines
    • OECD Good Laboratory Practice (GLP)
    • ISO 9001:2015 for research supply chain quality management
    • Applicable national and institutional chemical handling and ethics codes

    Typical usage ratio

    • Dose ranges reflect model design, from 10–40 mg/kg body weight in rodent models, typically administered via intraperitoneal injection or solution feed. Exact ratios require protocol adjustment based on species, route, and endpoint assays.

    Downstream process integration

    • Dissolved in saline, DMSO, or other vehicle at the chosen dosage concentration for acute or chronic neurotoxicity induction; can also enter as a reactant in in vitro receptor binding or functional transporter studies.

    Final product types

    • Established animal models of Parkinson’s disease
    • CNS pharmacological research kits
    • Study datasets for mechanistic neurodegeneration research

    4. Building Block for Advanced Heterocyclic Compound Libraries

    Chemical discovery teams use this compound as a foundation for constructing diverse libraries of nitrogen-containing heterocycles, supporting medicinal chemistry campaigns targeting CNS-related pathways. The rigid precursor chemistry provides a scaffold for regioselective functionalization and structure-activity relationship (SAR) profiling. Such libraries elevate downstream hit-to-lead optimization, screening, and potential patentable small molecule routes.

    Industry compliance standards

    • ISO 9001:2015 quality management (for custom chemical synthesis)
    • REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals)—for supply within the EU
    • Internal corporate documentation (compound registration, analytical specification management)
    • Responsible Care and laboratory safety standards (GHS, chemical risk labeling, and handling protocols)

    Typical usage ratio

    • Ranges from 1–2 molar equivalents in initial cyclization/condensation steps, with the precise amount set by desired diversification and reactivity profiles for library size and complexity.

    Downstream process integration

    • Engaged in the first or second step of parallel synthesis sequences, enabling rapid combinatorial derivatization, followed by purification and analytical verification before registration in compound libraries.

    Final product types

    • Diversified heterocyclic research libraries
    • Screening collections for CNS-related drug discovery
    • Building blocks for patent-submitted small molecule scaffolds
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    Certification & Compliance
    More Introduction

    Understanding 4-(4-Chlorophenyl)-1,2,3,6-Tetrahydropyridine Hydrochloride: A Manufacturer’s Perspective

    Direct Insights from Our Production Floor

    Years of producing 4-(4-Chlorophenyl)-1,2,3,6-Tetrahydropyridine Hydrochloride have shown us where this compound steps up to unique technical challenges. The consistency we achieve in structure, purity, and stability stems from precise control at every stage of synthesis. No batch leaves our plant without meeting analytical standards for composition and appearance, because users in chemical research, pharmaceutical development, and fine chemical synthesis expect exactness. These standards exist not to satisfy a checklist but to make sure every formulation or experiment relying on our output reads true on the data sheet and in the real-world results.

    Why This Material Is Valuable Beyond Its Category

    Many of our customers hunt for intermediates that add value in targeted synthesis work, and this particular tetrahydropyridine derivative fills a gap. Its structure—featuring both the chlorine group and the tetrahydropyridine ring—sets the direction for selectivity in further transformations. The hydrochloride salt form handles well, minimizes atmospheric moisture uptake, and dissolves predictably in polar solvents, which simplifies routine lab work. Patterns in feedback highlight one trait: the way our batches support robust yield and clean conversion during reactions. Chemists see a difference when material brings less noise to their process, so we stick to validated, repeatable parameters during crystallization and drying.

    Model and Specifications from a Practical Standpoint

    No producer crafts a specification list merely for paperwork. Real stability and consistency mean controlling every detail behind the numbers: assay value, impurity threshold, appearance, melting range, and water content. Our standard model reliably falls in the high-ninety-percent assay range—frequently above 99%—backed by routinely updated chromatographic and spectroscopic data. We never rely solely on a one-off certificate; quality has to hold up as a pattern, not an exception. Discoloration, fishy odors, or unexpected melting points flag issues before any shipment goes out. From plant operators handling crystallizers to QC chemists double-checking batch samples, everyone watches for sources of deviation. In both powder and crystalline form, we maintain tight controls to make sure handling characteristics also match what downstream users expect.

    Handling Real-World Use Cases

    Most requests for this chemical don’t come from theoretical settings; they arise out of practical synthesis needs. Pharmaceutical researchers use this tetrahydropyridine for the construction of analogues with central nervous system activity. Its core structure allows for selective derivatization, and the reliability of the starting material shapes the trust in each subsequent synthetic step. Whether someone investigates neurodegenerative targets or crafts precursors for experimental compounds, the continuity we build into our product line supports study reproducibility. We also see work in specialty chemicals, where modifications of the aromatic ring or the nitrogen atom become the gateway for dyes or agrochemical agents. Each batch has to flow into these settings without gumming up production or forcing unplanned cleanup.

    What Sets Our Output Apart from Generic Sources

    The market contains several tetrahydropyridine hydrochloride options that look similar in chemical description but behave differently behind the lab bench. From experience, smaller operations sometimes let purity slip or allow batch-to-batch drift, mostly due to less investment in trained personnel and validated systems. We use analytical methods developed and tested across hundreds of deliveries and also routinely run counter-samples under high-performance liquid chromatography, mass analysis, and NMR. Customers who have trialed both ours and generic competitors report lower tailing peaks and more reliable solubilization when they use our grade. The physical properties aren’t just cosmetic; avoidance of aggregation and residual solvent means the compound responds predictably in synthesis reactions. We keep our facility dedicated to specialty aromatic chemistry to avoid cross-contamination—a variable that generic resellers or job-shoppers often overlook.

    Supporting Claims with Results, Not Just Intentions

    Quality promises mean little without figures to back them up. We log every batch release through a validated LIMS. Internal and external laboratories confirm identity and purity against reference standards. If a lot fails a routine metric, we investigate and correct, documenting deviations thoroughly. Over the past five years, customer reports have shown an out-of-specification rate of less than 0.2% for our tetrahydropyridine hydrochloride line. Repeat clients stick with us largely because they see how trouble-free their workflow becomes. Our records show that most process failures in receptor-ligand binding assays—where this product serves as a building block—have stemmed from source material used outside our specification window. People working in drug discovery don’t have time to second guess their intermediates, so they turn to consistent, traceable lots.

    Operational Know-How That Influences Quality

    There’s no shortcut to process understanding in fine chemical manufacturing. Plant operators, maintenance staff, and process engineers each bring their experience to the flow of tetrahydropyridine hydrochloride production. We rigorously track parameter stability from charge composition to agitation rate, and make continual investments to keep batch reproducibility high. Manual experience traps nuances that automation alone cannot spot: crystallization speed, filtration behavior, and even the pitch of a pump motor reveal much about a batch’s status. Final material looks and feels as clean as it tests on paper, and we keep close tabs on storage conditions from the second material leaves the reactor to time of dispatch.

    Avoiding the Pitfalls That Plague Commodity Production

    Not every manufacturer faces the scale or operational challenges that come with intermediary chemicals. Frequently, the root cause of quality drift ties back to lapses in process verification. Outsourcing production or operating on small-batch lines might seem to cut costs. In our direct experience, these shortcuts multiply risk: higher impurity levels, residue from contact with non-dedicated equipment, increased byproduct traces, and unreported changes in operating conditions. For high-purity chemicals like 4-(4-Chlorophenyl)-1,2,3,6-Tetrahydropyridine Hydrochloride, small inconsistencies surface big downstream. With direct in-house production, the feedback loop remains short—any blip in yield or purity gets immediate attention and does not roll into the next batch.

    Evaluating Market Alternatives: What Users Tell Us

    Across a range of technical users—process chemists, medicinal chemists, R&D teams—typical feedback about alternatives echoes the same concern. People looking for cheaper, shortcut intermediates complain of subtle batch drift, poor storage stability, and outsize effort spent on purification or process adaptation. The physical presentation of the product—whether caking, clumping, or inconsistent flow—makes a daily difference in bench work and scaleup alike. Our commitment to transparency gives users peace of mind. Every shipment includes complete analytical files, not just a sheet of numbers. Over the years, we’ve observed that this approach builds more long-term partnerships than offers based on speculative price cuts.

    The Science Behind Our Approach: Not All Synthesis Routes Give Equal Results

    Each synthesis pathway offers trade-offs between yield, selectivity, and impurity profile. During years of tweaking and process improvement, we singled out a method that produces a high assay product with minimal colored impurity and manageable exotherm control. Our route gives not only clean conversion but also makes scaling safer and allows better ergonomics for the operators. That means less downtime, greater batch traceability, and fewer surprises for our customers at the receiving dock. Maintaining detailed process knowledge and investing in incremental improvements pay off: reduced solvent waste, sharper melting profiles, and smaller deviations across lots. When the market floods with products made by non-optimized processes, customers see the difference in their own troubleshooting burden and the long-term reliability of their results.

    Storage and Handling Insights Learned on the Factory Floor

    The nuances of storage show up far clearer behind the warehouse door than on a typical datasheet. Hydrochloride salts can clump or deliquesce if moisture finds its way into packaging. Using multi-layer barriers and controlling ambient storage humidity keeps product flowable. Our staff learned that minor packaging leaks, ignored by shippers chasing lower costs, become sources of frustration during product sampling and weighing. We track every environmental variable and teach our warehouse crew to spot early warning signs, which keeps complaints to a minimum and ensures stable delivery to customer benches.

    Supporting the Modern Laboratory Environment

    Research settings now run with less tolerance for batch variability or missed delivery windows. By keeping everything—from compliance documentation to packaging formats—under one roof, we cut out delays and smooth out the supply chain jitters seen with indirect sourcing. Ordering direct from our facility, users notice reliable turnaround and fewer missing shipment details. We enable custom lot reservation and can adapt packing size to match consumption rates, which holds down waste and simplifies inventory management for end-users. Our technical support teams, with decades on the factory floor, remain only a phone call away for any troubleshooting, application advice, or custom purification request.

    Why Downstream Results Should Matter to Us as Manufacturers

    Materials like 4-(4-Chlorophenyl)-1,2,3,6-Tetrahydropyridine Hydrochloride operate far upstream from the breakthroughs in drug discovery or agrochemical research. Still, firsthand accounts from researchers point to one certainty: inconsistent or contaminated intermediates slow down everything. While the temptation in the chemical industry is to maximize output with the least attention to minute details, genuine customer progress depends on invisible features: absence of trace metal, stability to oxidation, controlled packaging atmospheres, and absence of extraneous byproducts. Our staff hears these stories and knows every step counts—right down to how the powder pours or how clearly it dissolves.

    Addressing the Long-Term Needs of Science and Industry

    Shaping a specialty chemical to advance scientific discovery requires an approach based on measured improvement, not just price or theoretical yield. Users report back to us when a process runs more smoothly or when a reaction meets a target yield because of a cleaner, more predictable starting material. These reports guide our ongoing process upgrades. We encourage open dialogue with teams in pharma and academia—not just to troubleshoot issues, but to gather data on process behavior, anomaly causes, and usage trends. This relationship keeps us tuned to the frontlines of technical progress and puts real substance behind our efforts to improve.

    Differences That Matter in a Crowded Marketplace

    With more iterations of tetrahydropyridine hydrochloride cropping up worldwide, users face decision fatigue. Naming protocols, claimed specifications, and certificate formats may look interchangeable across suppliers, yet hands-on work uncovers distinctions. With our chemical, no sharp odors, odd colors, or gritty solids turn up in the drum. Customers rarely send an item back or pause their pilot line due to our product. These facts don’t show up in comparison tables, but they define the real user experience. Over the years, product reliability has built reputational capital that no pricing strategy can outdo. As a manufacturer, we continue to put these tangible qualities at the center of our production philosophy.

    Innovation as Ongoing Practice, Not Buzzword

    Baking real technical expertise into every kilogram means devoting time to routine batch review, staying ahead of regulatory changes, and pressing for lower process variation year on year. We keep up with the literature, run pilot tests against updated methods, and collaborate with researchers testing novel applications for this tetrahydropyridine hydrochloride. Improvements in yield rarely come from monumentally disruptive shifts, but by layering small, smart changes—updated reactor liners, finer grade silica for final purification, or real-time solvent monitoring. The effect accumulates: less loss, more consistency, better customer reports, and a product that proves its worth in tough synthesis scenarios.

    Environmental and Safety Considerations Built-In, From Raw Material to Shipment

    Processing chlorinated intermediates demands respect for safety data and environmental risks. Shielding the workforce and surrounding area from volatile fumes, employing proper waste traps, and carrying out end-of-line inspections show up as priorities, not afterthoughts. Green chemistry tweaks help us pare down the waste load with every campaign. Real progress is measured in fewer solvent drums to dispose of and tighter emissions logs, not just regulatory compliance but also operator well-being and planet impact. These measures keep us sustainable and ready to serve rigorous industries that scrutinize sourcing credentials with a fine-toothed comb.

    Relationships Over Transactions: What Repeat Buyers Reveal

    Long-term business doesn’t flourish on single-shot sales or always chasing the lowest list price. Our most loyal buyers keep returning because we talk about real pain points with them and respond meaningfully. If a process hit a snag in a final hydrogenation, or if a new analytical method flagged something unexpected, we dive in and help track down the cause. Over time, these shared troubleshooting sessions bring win-win improvements. This approach—open discussion, prompt feedback, tweaks as needed—writes our difference into every order and shipment.

    Looking Forward: Anticipating the Next Challenge in Tetrahydropyridine Chemistry

    Sustained experience with this chlorophenyl tetrahydropyridine points to new application trends and tighter purity demands. Teams designing CNS-active pharmaceuticals look for ever-purer intermediates, while custom fine chemical makers adopt stricter impurity profiles. The call from industry heads is clear: keep innovating, keep control standards sharp, and build in responsiveness to new regulatory needs. We invest in people, plant infrastructure, and local analytical partnerships to keep growing with that need.

    Direct Engagement: Why Sourcing Directly from Us Delivers Value Beyond Price

    Each transaction brings direct lines to our production, analytics, and technical support teams. We field phone consults, answer in-depth technical questions, and provide tailored documentation with every shipment. By cutting out indirect channels, users get speedier problem resolution, more reliable scheduling, and less hassle if anything needs adjustment. Our open-door policy remains; feedback always shapes our next production run.

    Summary of an Ethos Built on Knowledge, Precision, and Listening

    Continuous improvement defines how we manufacture 4-(4-Chlorophenyl)-1,2,3,6-Tetrahydropyridine Hydrochloride. By holding product quality, plant safety, and customer relationships as top priorities, we offer something more than a commodity item. We remain committed to supporting valuable advances in research and industry, sustaining the improvement loop with every shipment. Years of direct engagement with critical users guide how we produce, package, and innovate around this compound, ensuring that people relying on our product can do their best work.