Applications of 4-[4-(2-Hydroxy-Ethyl)-Piperazin-1-Yl]-4-Oxo-Butyric Acid in Industrial Manufacturing

As the direct producer, we supply 4-[4-(2-Hydroxy-Ethyl)-Piperazin-1-Yl]-4-Oxo-Butyric Acid to multiple precision downstream fields, where it supports strict compliance, unique formula requirements, specialized process flows, and the production of high-value finished goods. Each application below details its specific industrial role.

1. Pharmaceutical Intermediate for Antitumor Agent Synthesis

Leading oncology API manufacturers use this compound as a core intermediate in the multi-stage synthesis of targeted kinase inhibitors. The structure allows for selective modification during post-piperazine coupling steps, ensuring high purity in the critical path for small molecule APIs. Strict handling of the intermediate's acidity and hydroxyl reactivity is required throughout API purification by high-performance chromatography.

Industry compliance standards

• ICH Q7 GMP for Active Pharmaceutical Ingredients
• FDA 21 CFR Part 211 (Finished Pharmaceuticals)
• EU GMP Volume 4, Part II
• USP/NF specifications for pharmaceutical intermediates

Typical usage ratio

• 0.15–0.28 molar equivalents relative to piperazinyl base, adjusted according to targeted yield and reaction sequence

Downstream process integration

• Charged to reaction vessel post-protection step; reacts with activated acids to form extended heterocyclic intermediates
• Enter purification train prior to final deprotection in API synthesis

Final product types

• Active Pharmaceutical Ingredients (e.g., kinase inhibitors, DNA-interacting agents)
• Reference listed drugs (RLDs) for oncology
• Pharmaceutical patent intermediates

2. Custom Synthesis Building Block in Medicinal Chemistry Research

Pharmaceutical R&D divisions and contract research organizations incorporate this acid in the exploration of new heterocyclic scaffolds due to its modifiable hydroxyethyl and carbonyl functionalities. Research chemists leverage it in combinatorial libraries for preclinical screening, supporting hit-to-lead compound development. Sensitive process optimization enables high reproducibility across small-scale parallel syntheses.

Industry compliance standards

• ISO 9001:2015 (Quality Management in Research Labs)
• European Pharmacopoeia guidelines for research chemicals
• OECD Principles of Good Laboratory Practice (GLP)

Typical usage ratio

• 0.03–0.12 mmol per 1 mmol of library scaffold; varies based on the number of diversification points

Downstream process integration

• Used in solution-phase or solid-phase synthesis protocols as a chain extender
• Enters high-throughput parallel synthesis robots for multiple analog creation

Final product types

• Combinatorial library compounds
• Lead candidate molecules for in vitro and in vivo screening
• Preclinical substance libraries

3. Advanced Intermediate for Diagnostic Reagents and Biomedical Imaging Agents

IVD manufacturers and biomedical imaging solution providers employ this molecule in the synthesis of targeted tracer compounds. Its functional groups serve as anchor points for radiolabel or fluorescent tag attachment, with tight specification control over impurities to prevent signal noise. Downstream coupling routines integrate the acid into bifunctional chelators for use in imaging probe formulations.

Industry compliance standards

• ISO 13485 (Quality Management for Medical Devices and IVDs)
• FDA 21 CFR Part 820 (Quality System Regulation)
• CLSI Guidelines for Clinical Diagnostic Reagents

Typical usage ratio

• 0.02–0.06 equivalents per labeling reagent batch; ratio depends on probe payload requirements and conjugation method

Downstream process integration

• Introduced during bifunctional linker assembly for chelator or probe synthesis
• Processed through controlled labeling and purification steps in medical reagent manufacturing

Final product types

• Fluorescent tracer reagents for in vitro diagnostics (IVD)
• Radiolabeled probes for PET/SPECT imaging
• Affinity-binder diagnostic reagents

4. Functional Monomer for Specialty Polymer Synthesis in Coating Applications

Manufacturers of high-performance industrial coatings and biomedical films utilize this monomer as part of functionalized copolymer systems. The hydroxyethyl side chain and tertiary amide structure enable the formation of hydrophilic, crosslinkable coatings with controlled degradation or solubility profiles. Precise feeding rates ensure batch consistency for automotive, electronic, and medical device coatings.

Industry compliance standards

• REACH Registration (EC 1907/2006) for Manufacturing and Import
• ISO 10993 for biocompatibility of medical polymers
• ASTM D790 for polymer mechanical properties testing

Typical usage ratio

• 2–6 wt% in acrylic or polyurethane resin formulations; adjusted to achieve target film thickness and water interaction parameters

Downstream process integration

• Fed into polymerization reactor during co-monomer addition
• Mixed with catalyst and chain transfer agents prior to film casting or spray application

Final product types

• Hydrophilic surface coatings for medical catheters
• Waterborne industrial anticorrosion coatings
• Functional printing inks for electronics substrates

5. Chelating Ligand Intermediate for Metal Ion Capture in Water Treatment

Water treatment technology providers integrate this compound as an intermediate for synthesizing selective chelating agents. The piperazine core and adjacent carboxyl group impart high affinity for transition metal ions, aiding downstream manufacturers in producing chelators for heavy metal removal from municipal and industrial wastewater streams.

Industry compliance standards

• ISO 14001 (Environmental Management Systems)
• EN 13443-1 for equipment in water treatment
• Standard Methods for the Examination of Water and Wastewater, APHA/AWWA/WEF

Typical usage ratio

• 0.7–1.8 wt% as a monomeric unit in chelating polymer synthesis; adjusted for target binding capacity per application

Downstream process integration

• Enters reaction during the condensation stage of chelating resin production
• Integrated into functional group grafting setups for ion exchange bead manufacturing

Final product types

• Ion exchange resins for heavy metal removal
• Polymeric chelators for water purification
• Industrial effluent treatment polymers

6. Fine Chemical Intermediate for Crop Protection Agent Production

Plant protection product manufacturers utilize this piperazine acid as a coupling unit in the synthesis of advanced agrochemical actives. Its chemical framework supports stable attachment of activity enhancers and improves water dispersibility of finished products, with formulations tailored to meet strict residue and leaching control requirements.

Industry compliance standards

• FAO/WHO Specification for Pesticides
• EU Regulation (EC) No 1107/2009 for Plant Protection Products
• China National Standard GB 2763 for pesticide residues in food

Typical usage ratio

• 0.9–2.3 wt% in final technical concentrate; depends on active ingredient and formulation route

Downstream process integration

• Introduced during the final coupling reaction of the synthetic route
• Added to formulation tanks for stabilized dispersion concentrate production

Final product types

• Water-dispersible granules (WDG) of crop protection agents
• Emulsifiable concentrate pesticides
• Stabilized agrochemical actives for foliar application