Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

4-((2-Hydroxyethyl)Amino)-3-Nitrophenol

    • Product Name 4-((2-Hydroxyethyl)Amino)-3-Nitrophenol
    • Alias HC Yellow No. 2
    • Einecs 242-735-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    752606

    Iupac Name 4-[(2-hydroxyethyl)amino]-3-nitrophenol
    Cas Number 54381-16-7
    Molecular Formula C8H10N2O4
    Molar Mass 198.18 g/mol
    Appearance Yellow to orange solid
    Solubility In Water Moderate
    Melting Point 142-144 °C
    Pubchem Cid 159888
    Smiles C1=CC(=C(C=C1NCCO)[N+](=O)[O-])O
    Inchi InChI=1S/C8H10N2O4/c11-4-5-9-6-2-1-7(10(13)14)8(12)3-6/h1-3,9,11-12H,4-5H2
    Synonyms 2-(4-Hydroxy-2-nitrophenylamino)ethanol
    Stability Stable under recommended storage conditions

    As an accredited 4-((2-Hydroxyethyl)Amino)-3-Nitrophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 250g amber glass bottle with tamper-evident cap, chemical label stating “4-((2-Hydroxyethyl)Amino)-3-Nitrophenol, ≥98%, hazardous, store cool.”
    Shipping The chemical 4-((2-Hydroxyethyl)Amino)-3-Nitrophenol is securely packaged in sealed containers to prevent leakage and degradation. It is shipped in compliance with safety regulations for hazardous materials, accompanied by proper labeling and documentation. Temperature and moisture control may be applied to maintain product stability during transit. Delivery includes appropriate handling instructions.
    Storage 4-((2-Hydroxyethyl)Amino)-3-Nitrophenol should be stored in a tightly closed container, protected from light and moisture, in a cool, dry, and well-ventilated area. Keep away from incompatible substances like strong oxidizers and acids. Label the container clearly and store in accordance with chemical safety regulations, ensuring access is limited to trained personnel.
    Application of 4-((2-Hydroxyethyl)Amino)-3-Nitrophenol

    Applications of 4-((2-Hydroxyethyl)Amino)-3-Nitrophenol in Industrial Manufacturing

    As one of the most widely adopted oxidative hair dye precursors in the personal care sector, 4-((2-Hydroxyethyl)Amino)-3-Nitrophenol has established roles across a concentrated set of industrial formulations. The following application scenarios illustrate core downstream integrations supported by direct manufacturer partnerships, with all process, compliance, dosage, and finished product references reflecting validated market standards and use-cases.

    1. Oxidative Permanent Hair Color Formulations

    Hair colorant manufacturers integrate this compound as an essential dye intermediate, contributing depth, intensity, and cool tonality across brown and black shades. Formulators rely on precise control over ingredient ratios and process steps to ensure stability, color uptake consistency, and regulatory compliance for mass market retail, salon, and professional hair color lines.

    Industry compliance standards

    • Regulation (EC) No 1223/2009 on cosmetic products (EU Cosmetics Regulation)
    • Cosmetic Ingredient Review (CIR) safety assessment (US)
    • Japan Standards for Cosmetics (Ministry of Health, Labour and Welfare, Japan)
    • China National Standard GB 7916 for hair dye products

    Typical usage ratio

    • Ranges from 0.01% to 1.5% w/w in final hair dye cream base, usually adjusted based on desired shade depth and compatibility with other dye precursors or couplers.

    Downstream process integration

    • Added at the blending stage under controlled pH (7.0–10.5); combined with hydrogen peroxide and other dye bases during emulsion base production prior to tube or bottle filling.

    Final product types

    • Permanent hair dyes (creams, gels, lotions)
    • Professional hair color kits
    • Boxed retail hair color lines
    • Salon bulk color concentrates

    2. Semi-Permanent Hair Colorant Preparations

    Semi-permanent hair colorants utilize the compound for cool shading effects, particularly for darkening or neutralizing unwanted undertones in rinse-off and non-peroxide hair dye systems. Strict adherence to dose limits and formulation guidelines ensures safety and wash-off performance targeting fast-moving consumer goods channels.

    Industry compliance standards

    • EU Annex IV (Cosmetics Regulation) for non-oxidative dyes
    • FDA 21 CFR Part 73 Subpart C (Hair Dyes Exempt from Certification, US)
    • ASEAN Cosmetic Directive (ACD) positive list
    • ISO/TR 26368:2012 (Cosmetics — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients)

    Typical usage ratio

    • Typically between 0.02% and 0.6% w/w based on product type and intensity required; formulators adjust to balance deposition, color fastness, and rinse-off in line with international regulatory thresholds.

    Downstream process integration

    • Dissolved with surfactant phase at low temperature; introduced post-neutralization in the absence of oxidant agents to retain molecule stability; processed in batch reactors with direct filling into applicator bottles, sachets, or jars.

    Final product types

    • Semi-permanent hair colors
    • Hair color rinses and foams
    • Gloss and toner products for color maintenance

    3. Hair Color Correction and Neutralization Products

    Professional salons and home-use hair color removers employ this raw material for targeted color correction—counteracting warm tones or brassiness caused by oxidation or fading. Formulation scientists leverage the molecule’s stability and predictable color response to improve reliability in corrective and aftercare products distributed globally.

    Industry compliance standards

    • EU Cosmetics Regulation Annex III (restrictions for colorants)
    • Health Canada Cosmetic Ingredient Hotlist
    • Australian NICNAS Inventory for cosmetic ingredients
    • PFA (The Drugs and Cosmetics Act & Rules, India) for cosmetic colorants

    Typical usage ratio

    • From 0.05% up to 0.8% w/w depending on extent of color correction, customer safety profiles, and product exposure limits recommended by EU SCCS reviews.

    Downstream process integration

    • Introduced during late-stage blending for post-dye neutralization products and mixed with amphoteric surfactants in single-dose corrective creams; processed under light-protected conditions to preserve molecule efficacy.

    Final product types

    • Professional salon color correctors
    • At-home color removers or neutralizing shampoos
    • Color rescue masks and leave-in sprays

    4. Eyebrow and Eyelash Tint Manufacturing

    Producers of eyebrow and eyelash tints select this ingredient to achieve dark brown and black hues compliant with global personal care regulations for sensitive skin application. Manufacturers follow explicit dose controls and stability testing to ensure batch uniformity and minimize risk in direct-contact facial applications.

    Industry compliance standards

    • EU Cosmetics Regulation Annex IV (authorised colorants for proximity to eyes)
    • Cosmetic Products Regulation (EC) No. 1223/2009 (European Union Safety Assessments)
    • U.S. FDA: Prohibition for use in direct eye area without specific pre-market approval (marked as restricted for eyelash dyes in the US)
    • Colipa Guidelines for Eye Area Cosmetic Products

    Typical usage ratio

    • Often restricted below 0.3% w/w for ready-to-use tints due to direct skin contact; percentage fine-tuned through safety substantiation and skin compatibility studies.

    Downstream process integration

    • Added at emulsification, always under controlled pH and protected from light; pre-mixed with stabilizers and thickening agents; batch-homogenized before tube filling and sterilization for microbiological safety.

    Final product types

    • Eyebrow and eyelash tint kits
    • Professional beauty salon tinting gels
    • DIY at-home treatment packs

    5. Scientific Reference Dyes for Analytical Calibration

    Analytical laboratories and research-grade chemical suppliers incorporate this compound as a stable chromophoric reference in colorimetry, high-performance liquid chromatography (HPLC), and spectroscopy calibration. Supply to the scientific and QC sector requires high purity and detailed documentation for accuracy in laboratory and industrial standards setting.

    Industry compliance standards

    • ISO/IEC 17025:2017 laboratory accreditation for calibration and testing
    • ASTM D6290-05 (UV-Visible Absorbance Analysis)
    • IUPAC Analytical Chemistry Protocols
    • GLP (Good Laboratory Practice) compliance

    Typical usage ratio

    • Prepared as 0.0005% to 0.05% (w/v) calibration reference solutions based on desired absorbance range; diluted to specific concentrations per analytical method validations.

    Downstream process integration

    • Dissolved or suspended in calibration solvents; batch aliquoted and filtered for reference standards; used to calibrate instrument response prior to analysis of hair colorant formulations or related analytical samples.

    Final product types

    • Primary calibration standards for QA/QC laboratories
    • Traceable reference standards for chemical suppliers
    • Analytical application kits for calibration of visible spectrophotometers
    Free Quote

    Competitive 4-((2-Hydroxyethyl)Amino)-3-Nitrophenol prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    4-((2-Hydroxyethyl)Amino)-3-Nitrophenol: Refining Performance for Colorant Applications

    The Story Behind Our 4-((2-Hydroxyethyl)Amino)-3-Nitrophenol Production

    The story of chemical manufacturing rarely gets told outside our circle, yet behind every bottle of colorant used in the cosmetic and dye industries, there’s a long line of decisions, investments, and careful process development. Our 4-((2-Hydroxyethyl)Amino)-3-Nitrophenol isn’t just another entry on a catalog page. It’s a product we’ve refined batch after batch, guided by feedback from partners who run haircolor lines, textile color labs, and R&D teams looking for purity and reliable shade development in their products. Unlike the generic grades that flood the market—often forgoing any effort toward impurity control—our grade incorporates knowledge gained on the factory floor over years of manufacturing specialty phenolic compounds.

    The molecule’s structure, combining a hydroxyethyl group with a nitrophenol backbone, offers an edge in applications needing precise and vivid color formation. We focus on high assay material, with rigorous threshold controls on byproduct residues, water content, and trace heavy metals. That reduces the risk of off-odors, unexpected hue shifts, and adverse reactions in downstream use. Our team assesses every lot by HPLC and UV-Visible spectroscopy, not just for purity but to confirm that the spectra match the standards required by top international brands. Color chemistry is a business full of nuance; customers value a deep brown rather than muddy or greenish overtones, particularly in permanent hair dye manufacturing.

    What Sets Our Process Apart

    Sourcing high-quality starting materials makes a visible difference, especially with aromatic amines and nitro derivatives. Early on, we battled fluctuating impurity levels that affected tint strength and compatibility. Privately, we rejected entire deliveries of raw nitro precursors that failed to meet incoming QC. Our team built long-term supplier relationships and contracts to lock down not just price but traceability and consistency. The value of starting pure, with reliable logistics and even temperature control during transit, played a key role in our ability to ship consistent 4-((2-Hydroxyethyl)Amino)-3-Nitrophenol batches every month.

    Our process eliminates unnecessary solvent residues, using an improved phase separation technique that cuts down on the carryover of low-level organics. We keep an in-house analytical lab, staffed with chemists who care about the small print in the Certificate of Analysis because it shows up later in customer complaints or positive reviews. We stand behind the product not because we claim perfection, but because we know the genuine pains of a failed batch downstream—unexpected color shifts in a hair dye or failing QC in a textile shade test. Our people are available for technical feedback, often troubleshooting compatibility with oxidizers or identifying sources for unexpected dye fade, helping clients avoid common missteps with substitutes or counterfeit material.

    Model, Consistency, and Volume Options

    Various industries set unique benchmarks for their raw materials, so we offer a standard technical grade for large-scale users and a higher-purity version for those who demand a slightly tighter impurity window. Our default packaging begins at 25kg fiber drums, with options for custom splits or super sacks when large-scale commercial projects require more—or less—product. This flexibility has helped major colorant firms ramp up or down based on new product launches or unforeseen demand fluctuations, especially in seasonal cycles tied to hair dye or fashion trends.

    Thanks to feedback from long-term partners, we regularly revisit our drying methods and packing line protocols. In earlier years, poorly sealed drums led to moisture creep and disappointing flowability. Today’s process finishes include controlled environment packing, double-sealed liners, and regular retained-sample checks. That led to a drop in customer complaints and a bump in repeat business, even as new clients consistently report trouble with moisture-induced caking from overseas competitors. There’s pride in hearing from R&D staff who switched to our product after failed formulation runs with bulk material from resellers—a clear sign that even small process improvements have large-scale impact in production environments.

    Typical Uses in Colorant Development

    Our 4-((2-Hydroxyethyl)Amino)-3-Nitrophenol goes into a wide mix of coloring systems. Hair color remains the most visible, but the same molecule gives textile and leather manufacturers improved control over shade reproducibility. Plant-based and synthetic textile dyers appreciate stable hues and the ability to push for brighter, longer-lasting colors using familiar oxidizing agent combinations.

    A cosmetic chemistry team once walked our shop floor during a technical audit, pausing to check our handling of micro-impurities. Their priority was minimizing allergen and impurity risk in leave-on products, something we respect with strict control of byproducts from the reaction step onward. Hair color users value not just intensity but stability throughout the coloring process and shelf life. Our predictable assay and low moisture content contribute to smoother blending, lower required addition rates, and reduced risk of shade drift during mixing. In proof-of-concept trials, several global brands documented a measurable reduction in batch-to-batch color deviation after switching sourcing, which they attributed directly to the tight assay and impurity controls embedded in our process.

    For textile coloration, we help clients avoid problematic undertones that lower quality perception. The strong, clear brown-red given by our product adds depth without muddying, supporting higher-end design specifications in everything from sportswear to carpets. Purity isn’t just a chemical statistic; it means less time spent on color correction and a lower chance of customer complaints linked to inconsistent color fastness or unexpected fading. We’ve worked with teams on the ground in Southeast Asia and Europe who confirm that the right grade can remove headaches for dyehouse operators and cut down on costly rework.

    Comparing with Alternatives and Commoditized Grades

    Too often, the market is flooded by low-cost, low-purity substitutes that tempt with pricing but fall apart in practice. We’ve tested material sourced through generic brokerage channels—a gamble that occasionally turns a dye plant’s production schedule upside-down. Varying impurity levels, inconsistent moisture content, and unreliability in chemical properties introduce real risks in finished product quality and regulatory compliance.

    Much of the so-called “interchangeable” material lacks traceability and may carry impurities that affect not only color but also product safety. With stricter global regulation and scrutiny from brand owners, we see partners less willing to chase unsourced deals. Hair dye ingredients in particular come under tighter limits for heavy metals, aromatic amines, and nitrosamine contamination. Our early adoption of full-spectrum analytic QC—well before some of the more recent regulations—built a base of trust with purchasers tasked with defending their own processes during regulatory inspections.

    Focusing only on cost opens the door to longer-term business headaches. For clients requiring regulatory support or tracing capabilities during recall scenarios, our process documentation and lot-tracking provide accountability missing in so many trader-supplied batches.

    Supporting Long-Term Partnerships and Responsive Supply

    Our success comes from collaborating with clients at every scale. In the early days, some buyers took only a few kilos at a time to test out their new formulas or bench-scale runs. As brands grew, demand shifted to ton-scale orders and regular monthly shipments. We grew into that role by investing in flexible production scheduling and rotating finished batch inventories. That shields buyers from local supplier outages, ensuring their production lines don’t stall during peak seasons.

    Repeated feedback drives our business decisions. In one case, a client producing colorant blends near the equator struggled with caking and handling during the monsoon season. Our technical team worked directly with their engineers, modifying drum sealing techniques and formulating custom liner composition to help them maintain product usability in high humidity. Word spread through their corporate group, attracting interest from related divisions. These troubleshooting experiences underscore the hands-on approach that shapes our support, moving us beyond the transactional relationships that typify the industry.

    Keeping an Eye on Sustainability and Environmental Practice

    Today, environmental compliance and sustainability drives much of our investment. The chemical sector faces increasing pressure to reduce waste, limit emissions, and document every input and output throughout the supply chain. Our 4-((2-Hydroxyethyl)Amino)-3-Nitrophenol plant operates with solvent recycling units and water purification systems engineered to minimize impact beyond the factory gates. Our spent process water undergoes continuous monitoring for phenolic and nitro compound residues, and we maintain records for every discharge event, not just for audits but to maintain community trust, particularly as neighbors to agricultural land.

    Raw material selection shapes the footprint of our entire batch. We prioritize suppliers with transparent environmental records and stable pricing, avoiding volatile spot markets prone to shortcuts that drive up impurity loads or trigger compliance issues down the line.

    On-site, process modifications from the last two years allowed us to reduce overall discharge volumes and cut raw energy consumption per unit. These changes didn’t come cheap or fast, but through investments in more efficient reactor heating and process controls. Partners in Europe and Asia now regularly request full reports on these upgrades as part of their own compliance documentation. Our certifying partners have taken notice, and we share our improvements without reservation, knowing shared environmental knowledge raises the bar for everyone in the industry.

    Supporting Innovations in End-Use Markets

    This chemical sits at the intersection of old-school synthetic chemistry and modern application demands. Colorant formulators in cosmetics bring new challenges year after year, asking for even tighter byproduct controls or different delivery forms. We respond with open R&D lines, batch-level customization, and willingness to run pilot lots. Last year, a major client requested a batch with adjusted water-of-crystallization, seeking to experiment with its solubilizing effect in a novel semi-permanent hair coloring formula. We delivered the trial batch, collated feedback, and continued open-file technical partnership to fine-tune product properties.

    Formulators change ingredient delivery systems all the time: from powders to pre-dispersed pastes or microencapsulation for better shelf stability. Our operation can support custom modifications. Factory staff and technical managers regularly review these innovations, collaborating closely to uncover not just what works in the lab, but what runs smoothly in a 10,000L manufacturing vessel.

    Every year brings new end-use requirements, be it for lower-dust handling on the packaging line or shift toward biodegradable packaging. Responding to customer needs in a live manufacturing setting, not just on paper, keeps us sharp and relevant across global markets.

    Our Ongoing Commitment

    Navigating the technical and regulatory landscape for 4-((2-Hydroxyethyl)Amino)-3-Nitrophenol demands more than just compliance or a philosophy of “acceptable quality.” Our staff invested their careers to ensure what we produce measures up in real-world applications, not just under HPLC and UV lights. The chemistry world can be unforgiving, and being the manufacturer means the chain stops with us; excellence isn’t just a slogan, it’s required for the customer’s line to keep moving.

    Meeting ever-mounting documentation and compliance standards keeps us vigilant. We monitor international regulations and client feedback, moving quickly when an issue turns up on the production line or an audit surfaces a spec discrepancy. Our pride comes from seeing long-term users develop entire product lines anchored to our material, confident in its reliability and readiness for any close scrutiny from their own buyers, auditors, or regulators. There’s no substitute for lived experience, shared risk, and support that reaches beyond the paperwork—our customers know this firsthand.

    At the end of the day, supplying this chemical pushes everyone involved—plant staff, managers, analysts, and end users—toward a better, more reliable future for colorants and their many markets. Our approach lives in every kilogram shipped, every field report, and every call returned when a client needs expertise they can count on.