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4-[(2-Cyanoethyl)Methylamino]Benzaldehyde

    • Product Name 4-[(2-Cyanoethyl)Methylamino]Benzaldehyde
    • Alias 4CEMABAL
    • Einecs 629-785-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    277086

    Product Name 4-[(2-Cyanoethyl)Methylamino]Benzaldehyde
    Cas Number 214776-31-9
    Molecular Formula C11H12N2O
    Molecular Weight 188.23 g/mol
    Appearance Light yellow to brown solid
    Purity Typically ≥98%
    Melting Point 53-56°C
    Boiling Point No data available
    Solubility Soluble in organic solvents such as DMSO and methanol
    Structure Contains a benzaldehyde core with a para-substituted (2-cyanoethyl)methylamino group
    Smiles CC(C#N)N(C)C1=CC=C(C=C1)C=O
    Storage Temperature Store at 2-8°C, protected from light and moisture

    As an accredited 4-[(2-Cyanoethyl)Methylamino]Benzaldehyde factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 4-[(2-Cyanoethyl)Methylamino]Benzaldehyde is supplied in a sealed 25g amber glass bottle with tamper-evident cap and labeling.
    Shipping `4-[(2-Cyanoethyl)Methylamino]Benzaldehyde` is shipped in tightly sealed containers, protected from moisture and light. Packaging complies with chemical safety regulations. Transport is arranged via recognized carriers, following hazardous material guidelines if applicable, and includes appropriate labeling, documentation, and temperature control to ensure product stability and safe delivery to the recipient.
    Storage 4-[(2-Cyanoethyl)Methylamino]Benzaldehyde should be stored in a tightly sealed container, away from direct sunlight, moisture, and incompatible substances such as strong acids and oxidizers. Keep it in a cool, dry, well-ventilated area, preferably in a chemical storage cabinet. Proper labeling and secondary containment are recommended to prevent accidental release or contamination. Always follow local regulations and safety guidelines.
    Application of 4-[(2-Cyanoethyl)Methylamino]Benzaldehyde

    Applications of 4-[(2-Cyanoethyl)Methylamino]Benzaldehyde in Industrial Manufacturing

    As the direct manufacturer of 4-[(2-Cyanoethyl)Methylamino]Benzaldehyde, we support a precise range of specialized downstream production routes. Our partnerships with leading industrial clients are built on a foundation of compliance, technical transparency, and process-focused delivery at scale. Below, we outline verified application scenarios reflecting the integration of this intermediate in high-value chemical syntheses.

    1. Pharmaceutical Intermediate for Active Pharmaceutical Ingredient (API) Synthesis

    Pharmaceutical manufacturers incorporate this compound as a scaffold for the preparation of CNS-active drug intermediates through nucleophilic addition and condensation routes. Its aromatic aldehyde structure enables efficient downstream elaborations, supporting the synthesis of select psychoactive therapeutics and related molecules. Extensive documentation is maintained for audits, batch traceability, and regulatory submission purposes in line with global API production protocols.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • United States Pharmacopeia (USP) requirements (when used for USP monograph APIs)
    • European Directorate for the Quality of Medicines (EDQM) CEP system
    • China Drug Master File (DMF) and registration regulations

    Typical usage ratio

    • 15–25 mol% of total batch input for targeted condensation reactions, adjustable depending on purity demands, substrate sensitivity, and downstream steps

    Downstream process integration

    • Alkylation and reductive amination process steps for precursor assembly
    • Sequential condensation performed under controlled pH and solvent recovery
    • Product isolation often followed by recrystallization prior to further derivatization

    Final product types

    • Finished CNS drug actives (e.g., antipsychotic API intermediates)
    • Specialty generic API intermediates with custom side-chain modifications

    2. Synthesis of Liquid Crystal Intermediates for Electronics

    Producers of liquid crystal materials for display panel manufacturing leverage this chemical to build anisotropic aromatic components through stepwise Suzuki or Heck coupling reactions. Its electron-withdrawing cyanoethyl group is specifically valued for modulating dielectric properties in nematic and smectic phase liquid crystals. Material qualification is performed according to electronic grade trace impurity specs.

    Industry compliance standards

    • JEITA ED-7302 Electronic Material Standards
    • RoHS Directive 2011/65/EU for hazardous substance limits in electrical equipment
    • International Electrotechnical Commission (IEC) purity test methods for display materials
    • Customer-specific ultrapure screening protocols (sub-ppm metals/residual solvents)

    Typical usage ratio

    • 5–12 wt% in precursor blend, dependent on target mesogen type and final phase behavior

    Downstream process integration

    • Introduction at the aromatic aldehyde stage for cross-coupling reactions
    • Purification by high-vacuum distillation to meet optical-grade requirements
    • Subsequent assembly of rigid core structures for liquid crystal alignment

    Final product types

    • TFT-LCD display panel liquid crystal mixtures
    • Specialty organic LED display precursor compounds

    3. Advanced Dye and Pigment Precursor for Colorants

    Manufacturers of specialty dyes and organic pigments rely on this material as a reactive aldehyde donor in the synthesis of azo and Schiff base dyes for textiles and inkjet formulations. The presence of the cyanoethyl group allows tailored reactivity, driving vibrancy and fastness in the final pigment molecules. All stages are documented to maintain eco-compliance and batch performance reproducibility.

    Industry compliance standards

    • REACH (EC 1907/2006) registration for dye intermediates
    • OEKO-TEX Standard 100 compliance for textile colorants
    • EN 71-3 Toy Safety Directive (heavy metal content in inks)
    • ZDHC (Zero Discharge of Hazardous Chemicals) Manufacturing Restricted Substances List (MRSL)

    Typical usage ratio

    • 8–16 mol% in diazotization or condensation formulation, subject to chromophore structure and dye route

    Downstream process integration

    • Charge to diazo-coupling reactors after initial substrate diazotization
    • Condensation under acidic or basic aqueous phase control
    • Isolation of pigment base followed by spray drying and milling for dispersion

    Final product types

    • Fiber-reactive and acid dyes for textile dyeing
    • Aqueous organic pigments for digital inkjet printing
    • Colorant intermediates for plastic masterbatches

    4. Fine Chemical Intermediate for Agrochemical Synthesis

    Crop protection chemical manufacturers utilize this intermediate at scale in the multi-step synthesis of selective herbicides and fungicides, especially compounds featuring substituted benzaldehyde cores. Its chemical structure supports nitrile and imine functionality introduction via downstream modifications, helping formulators optimize crop safety and regulatory compliance in the final actives.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products (JMPS)
    • ISO 9001-certified quality assurance systems for agrochemical production
    • OECD Guidelines for Testing of Chemicals (residual assessment in actives)
    • US EPA 40 CFR Parts 150–180 (registration and technical grade requirements)

    Typical usage ratio

    • 10–20 mol% depending on target pesticide synthesis route and conversion efficiency, commonly optimized after pilot-scale trials

    Downstream process integration

    • Condensation and cyclization steps for lead compound assembly
    • Reactive nitrile group transformation in intermediate formation
    • Final purification through crystallization or chromatographic purification for technical grade

    Final product types

    • Precursor for triazole or benzimidazole fungicides
    • Key intermediates in selective broadleaf herbicide production
    • Process chemicals for new molecule development (R&D scale)
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    Certification & Compliance
    More Introduction

    Introducing 4-[(2-Cyanoethyl)Methylamino]Benzaldehyde: Fine Chemicals Built on Experience

    Our Perspective on Manufacturing 4-[(2-Cyanoethyl)Methylamino]Benzaldehyde

    In the world of fine chemical manufacturing, reliability and consistency matter just as much as purity. At our plant, 4-[(2-Cyanoethyl)Methylamino]Benzaldehyde represents both a technical benchmark and a story of hands-on production experience. Long before this product landed in catalog listings, it moved from one reactor to another under our own roof, supervised by technicians who have spent entire careers producing specialty aromatic intermediates. We have seen our own process for this compound evolve through careful engineering, batch after batch.

    Understanding the Chemical and Its Role in Industry

    This compound, recognized in our trade by its structural formula, brings together a benzaldehyde core modified with a 2-cyanoethyl methylamino group. The resulting molecular profile supports a range of applications. Most end users seek this intermediate for use in pharmaceutical research, pigment synthesis, and specialty materials, drawn by its combination of reactivity and functional selectivity. A significant portion delivers chemical value thanks to the presence of the formyl group combined with the electron-rich aromatic ring, providing a useful handle for subsequent coupling or derivatization.

    In practice, chemists have turned to 4-[(2-Cyanoethyl)Methylamino]Benzaldehyde as a platform to build more complex structures — often using its aldehyde function in key condensation reactions, or leveraging the cyanoethyl chain as a masked amine source. Synthetic routes benefit from this dual-function, which streamlines workflow and releases lab teams from juggling multiple starting materials or complicated protecting group strategies.

    Production Process Builds Trust

    Having processed high-purity batches in varying scales, we know that product quality comes from attentive process control, not hope or wishful thinking. Our manufacturing department takes each batch from controlled raw material selection through reaction, work-up, crystallization, and analytical verification. Unlike upstream traders, we lay our eyes on the material at every step: we have learned to spot lot variability through both data and sight, and we treat deviations as opportunities to improve rather than signs to ignore.

    Key process parameters have been mapped and refined over time, from solvent exchange rates to purification protocols. Our team has met challenges such as efficient capture of intermediates, minimization of residual amines, and protection from byproduct aldehyde condensation. Lab teams collaborate with production, swapping context around small-scale runs and plant-scale reality. This has grounded our approach, teaching us how to avoid impurities that can dog the finishing or downstream reactivity of our product. Because our product rarely leaves our hands until batch records are cross-checked, customers get a compound free from surprise residuals.

    Specifications and Analytical Rigor

    4-[(2-Cyanoethyl)Methylamino]Benzaldehyde from our lines is typically provided as an off-white crystalline powder, with purity confirmed by comprehensive in-house analytical testing. We use both HPLC and NMR (proton and carbon) as mainstays for structural and purity assessment, isolating potential isomers and side products that could complicate downstream chemistry. Our typical batches achieve purity not less than 98%, with water content and residual solvents measured to match actual end-user process needs.

    Customers often want to know if our product differs from the market’s generic offerings. Many sources operate as brokers, sourcing from contract plants or bulk chemical warehouses. Having handled our own material from start to finish, we identify and suppress residuals at levels lower than third-party supply would guarantee. Some buyers have told us that our material performs more predictably in high-sensitivity coupling reactions, or yields cleaner conversion in pharmaceutical syntheses where uncontrolled imines or polymeric byproducts from poorly washed material have spoiled runs. There is no magic trick to this — it comes from informed selection at every manufacturing phase.

    Why Specifications Matter: Real-World Examples

    A developmental chemist working in dye synthesis may depend on this molecule for an initial scaffold. Dull or off-hue coloration has, in our experience, often been traced back to subvisible impurities — particularly lingering residues from incomplete work-ups or oxidized fragments left from inadequate handling. Achieving the required pigment hue means starting with material untouched by oxidizing agents or foreign stabilizers.

    In another application, a research lab exploring CNS-active pharmaceutical leads needed consistently low biogenic amine content below 0.1%. With other sources, uncontrolled amine remnants have contributed to product degradation or off-path condensation during downstream steps. Our plant’s tight attention to stripping and QA testing meant fewer failed syntheses — less downtime in screening rounds, fewer lost weeks redoing multi-step sequences.

    These examples highlight the gap between simple assay numbers and process-deep quality. Industry success is not measured at the purity column alone; it’s measured by the absence of headaches across dozens of users with different end-uses and sensitivities.

    Key Features Shaped by Daily Manufacturing

    We shipped our first orders of 4-[(2-Cyanoethyl)Methylamino]Benzaldehyde more than a decade ago, back when scale-up required handmade glassware and patience. Over time, the process started revealing practical truths still valid today. Stable packaging matters as much as batch variation. Moisture migration, poorly purged solvents, or caked powder can all affect user experience. We moved from glass bottles to lined drums, built-in desiccants, and tamper-proof seals. Once, a delayed customs shipment sat exposed on the tarmac in humidity. That single event led to an upgrade in our container closure practices and a company-wide focus on robust packaging.

    We keep a small team responsible for final packing. They are trained to recognize visual or olfactory cues hinting at compromised product, and to re-test if anything seems “off.” No one here lets a shipment go without personal inspection. In smaller shops, mistakes or accidental cross-contamination can wipe out weeks of customer work. We know this from the calls we have fielded and the corrective actions we have supplied.

    Comparison With Alternative Materials

    Chemists sometimes ask what makes 4-[(2-Cyanoethyl)Methylamino]Benzaldehyde the preferred building block over similar benzaldehydes or other N-alkyl amine derivatives. What we have witnessed in the market is that the positional chemistry — the combination of the aldehyde and cyanoethyl-methylamino functions — speeds up subsequent steps, simplifies protection/deprotection schemes, and enables certain selectivity regimes unachievable with less substituted analogs.

    Contrast this with other substituted benzaldehydes or N-ethylaminobenzaldehydes. These analogs often offer only a single point of reactivity, which pushes chemists to perform more steps, deal with less stable intermediates, or tolerate lower yields. For example, switching to a simple N-methylaminobenzaldehyde removes the cyano handle, cutting off downstream functionalization options. Using only unsubstituted benzaldehyde offers little value for those who need controlled basicity in the ring and orthogonal handles for diversity-oriented synthesis. In direct customer feedback, the message has always been consistent: reducing time in the flask with better starting materials matters more than a theoretical cost-per-kilogram saving.

    Supporting Facts and Industry Context

    Fine chemical manufacturing demands more than announcements or product numbers. Any chemist prepping for multi-step synthesis wants proof, not promises. Over recent years, notification obligations and quality requirements have evolved, but the heart of the conversation still comes down to: what is in the drum, how was it made, and what evidence can users trust?

    Manufacturing 4-[(2-Cyanoethyl)Methylamino]Benzaldehyde at scale combines reaction engineering with safe handling of intermediates and finished product. We have invested in continuous environmental monitoring of our process area to keep residue levels, fume emissions, and material losses below industry health and safety guidelines. Each lot passes through trace-level analysis for restricted byproducts as a routine, not an exception. This is our way of converting regulatory requirements into real value for chemists, so downstream products can move smoothly through trials, QA, and regulatory submission.

    Our product has supported diverse teams: custom synthesis shops, university spin-outs, and multinational formulators. A stream of regular customers has seen their own results published and patented using our material. Once, a project in agricultural chemical research required scaled-up availability on short notice due to an unforeseen grant success. We arranged just-in-time production, supporting their research effort through more than scheduling — the batch consistency made their workflow more efficient, reducing the risk of variable data and questionable reproducibility.

    Solutions Developed Through Direct Feedback

    Years of cumulative experience have made it clear that solving real-world challenges means listening to the chemists and engineers using our materials. Early on, recurring issues reported by customers drove us to re-engineer purification, washing out stubborn residues that otherwise spoil longer synthetic sequences. Customer input shapes our process — from particle sizing and flowability to shelf-life improvements and QA reporting formats, our methods always evolve to reflect stakeholder concerns.

    While some industry players treat chemical markets as commodity spaces, our experience proves otherwise for specialty intermediates. We have often partnered with R&D teams needing tailored support — for instance, providing custom analytical certification, working with customers on chromatographic separation obstacles, or troubleshooting minor impurity tails in spectral data. This feedback loop runs both ways: we routinely gather batch samples after long shipping routes to validate that product stability meets intended shelf-lives in geographically distinct climates.

    These partnerships create a cycle of improvement that strengthens all parties, translating raw synthesis knowledge into a practical, real-world solution for challenging synthetic chemistry needs.

    Risks Addressed By Transparent Manufacturing

    One of the constant worries in fine chemicals is reliability of supply. It is common for markets to experience fluctuations in availability, especially if raw materials for key intermediates tighten. Our approach is to manage these risk factors in-house: maintaining backup inventories, qualifying multiple sources of starting reagents, and staying in close communication with customers when market shifts loom.

    During global logistics disruptions, some buyers found themselves left with uncertain stocks from unfamiliar suppliers. We received more inquiries for records of origin, batch history, and analytical support than ever before. These experiences reinforced our belief that open communication and real documentation matter more than boosted marketing claims. By tracing every batch back to its source and by maintaining an open book on testing, we helped customers manage their risk exposure and avoid the headaches of variable supply.

    Trust in a specialty manufacturer comes from the sum of open, verifiable process control and consistent delivery. Our operations are always on display for technical audits and customer visits, because only deep visibility builds durable buyer confidence.

    Continuous Improvement Driven by Real Experience

    Processes never stand still. Environmental standards tighten. Analytical methods evolve. Downstream user needs change as regulation, patent landscapes, and chemistry itself march forward. Our staff regularly participates in industry learning: keeping up with analytical instrumentation, re-validating material handling protocols, and studying emerging synthetic trends. Routine upgrades in chemical process safety, waste minimization, and inventory control help us meet, and sometimes surpass, new regulatory expectations. Our on-site QA lab supports method upgrades, integrating technological advances in chromatography, spectroscopy, and moisture analysis to provide greater assurance.

    We foster a culture where improvement suggestions can come from the control room, the warehouse, or our longtime delivery drivers. Small changes — such as switching to higher-grade desiccant or redesigning the fill-port on containers — often arise from lived, day-to-day experience, not just managerial initiatives. This attention to detail, drawn from real manufacturing life, protects each batch as it moves from reactor to drum, to dock, to customer.

    Conclusion: A Manufacturer’s Commitment

    No long-term supplier can rest on today’s success or past performance. For manufacturers like us, building a reputation for reliable, high-purity 4-[(2-Cyanoethyl)Methylamino]Benzaldehyde means doing the hard work: investing in both process and people, recognizing challenges as sources of learning, and maintaining open lines with everyone who uses our products.

    Each shipment represents more than a chemical — it’s proof of rigor, teamwork, and adaptability. Chemists across industries know that better starting material translates to smoother projects and dependable results. Our collective daily experience, drawn from the lab, the production line, and our customers’ own hands, shapes how we make and deliver 4-[(2-Cyanoethyl)Methylamino]Benzaldehyde, and will continue to drive us as the market and the science continue to evolve.