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3-Propionylpyridine

    • Product Name 3-Propionylpyridine
    • Alias 3-Acetylpyridine
    • Einecs 212-118-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    758303

    Name 3-Propionylpyridine
    Cas Number 350-03-8
    Molecular Formula C8H9NO
    Molecular Weight 135.16 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 258-260 °C
    Melting Point −4 °C
    Density 1.08 g/cm³
    Refractive Index 1.537
    Solubility In Water Slightly soluble
    Synonyms 3-Acetylpyridine, 1-(3-Pyridyl)propan-1-one
    Smiles CCC(=O)C1=CN=CC=C1
    Inchi InChI=1S/C8H9NO/c1-2-8(10)7-4-3-5-9-6-7/h3-6H,2H2,1H3

    As an accredited 3-Propionylpyridine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 250 mL amber glass bottle with secure screw cap, labeled "3-Propionylpyridine, ≥98%" with safety and handling information.
    Shipping 3-Propionylpyridine is shipped in tightly sealed containers to prevent leaks and contamination. The chemical is classified as non-hazardous but should be handled in accordance with safety guidelines. Packages are typically labeled with proper identification and shipped via standard ground or air transport, avoiding extreme temperatures and moisture during transit.
    Storage 3-Propionylpyridine should be stored in a tightly closed container in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances like strong oxidizing agents. Keep it away from moisture and direct sunlight. Store at room temperature, and ensure the storage area is equipped with appropriate spill containment and firefighting measures. Handle with proper personal protective equipment.
    Application of 3-Propionylpyridine

    Applications of 3-Propionylpyridine in Industrial Manufacturing

    3-Propionylpyridine supports several specialized downstream industries, offering reliable performance as a reagent and intermediate for high-value chemical synthesis. Below, we detail its principal industrial application scenarios, emphasizing regulatory compliance, usage ratios, integration in production, and the key categories of finished goods in which it serves a critical role.

    1. Pharmaceutical Intermediate Synthesis—Third-Generation Cephalosporin APIs

    Major pharmaceutical manufacturers use 3-Propionylpyridine as a key intermediate during the synthesis of specific third-generation cephalosporin antibiotics. The compound undergoes substitution and cyclization reactions, facilitating regioselective functionalization of the pyridine moiety. Its proper handling, measured dosing, and process integration ensure both impurity control and yield consistency in delivering antibiotic final elements ready for formulation into injectable and oral drugs. Stringent in-process monitoring and detailed documentation trail the entire usage spectrum.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP–NF (United States Pharmacopeia–National Formulary) for antibiotics
    • EDQM CEP (European Pharmacopoeia Certification of Suitability)
    • China Pharmacopoeia standards (ChP, latest edition)

    Typical usage ratio

    • 0.07–0.12 molar equivalents relative to base cephalosporin nucleus; optimized based on purity control and impurity profiling
    • Process adjustments in pilot and full-scale batches based on crystallization and side reaction minimization

    Downstream process integration

    • Employed during the advanced intermediate condensation stage
    • Added in controlled-temperature reactors with closely monitored pH and solvent conditions to drive pyridyl substituent installation
    • Followed by filtration and chromatographic purification prior to API finishing

    Final product types

    • Sterile injectable cephalosporin powders
    • Oral cephalosporin tablets and capsules
    • Veterinary cephalosporin antibiotic API bulk

    2. Agrochemical Intermediate—Synthesis of Selective Fungicide Actives

    Agrochemical companies utilize 3-Propionylpyridine for the assembly of heterocyclic ring systems in pyridine-derived fungicide active ingredients. Its function as an acyl donor enables the formation of target analogs offering improvements in field persistence. Downstream applications demand tightly controlled stoichiometry, reaction temperature, and impurity removal. Each production batch requires documentation for traceability under crop protection regulations.

    Industry compliance standards

    • FAO/WHO Joint Meeting on Pesticide Specifications (JMPS) technical equivalence guidelines
    • ISO 9001:2015 Quality Management Systems for agro-inputs
    • REACH (EC 1907/2006) registration requirements for intermediates in the EU
    • China ICAMA registration for pesticide intermediates

    Typical usage ratio

    • 5–12% by weight of total input in the acetylation or cyclization step
    • Range depends on required fungicide analog and yield after downstream purification

    Downstream process integration

    • Introduced during step-growth or cyclization stages of fungicide API synthesis
    • Monitored by in-line analytical techniques (HPLC, GC-MS) to maintain batch consistency
    • Residues removed by washing or distillation before formulation

    Final product types

    • Water-dispersible granular fungicide formulations
    • Emulsifiable concentrate fungicides for cereal and fruit protection
    • Bulk technical fungicidal actives for further blending

    3. OLED Material Synthesis—Precursor in Functionalized Pyridine Ligands

    Leading electronic materials manufacturers use 3-Propionylpyridine when constructing custom pyridine ligands for organic light emitting diode (OLED) emitters. The compound's structural properties allow for precise ligand architecture essential in color rendering and charge-carrier mobility. Processing environments require high-purity starting material, robust solvent management, and ongoing QC to meet device-grade criteria for electronic materials.

    Industry compliance standards

    • RoHS Directive (Restriction of Hazardous Substances) – Directive 2011/65/EU (EU)
    • ISO 14001 Environmental Management System for chemical production
    • SEMATECH guidelines for purity in display materials

    Typical usage ratio

    • 0.5–3.5% of total organic ligand batch, adjusted by desired emission properties and functionalization degree
    • Purity adjustments for defect-free thin film deposition

    Downstream process integration

    • Used in ligand-building block condensation or Suzuki coupling reactions
    • Solvent purification and column chromatography to achieve OLED-level purity standards
    • Integration into emitter mixture prior to vacuum deposition onto display substrates

    Final product types

    • Blue and green emitting OLED layers for display panels
    • Functionalized ligands for device research and evaluation
    • OLED lighting module materials

    4. Fragrance Ingredient Intermediate—Synthesis of Pyridine-based Aroma Compounds

    Fragrance and flavor manufacturers rely on 3-Propionylpyridine to create proprietary aroma chemicals featuring a unique, warm, nutty or tobacco note. The compound is transformed through controlled acylation and subsequent hydrogenation, enabling the manufacture of high-value flavors and perfumes used in luxury consumer goods. Processing stages emphasize residue control and adherence to food safety norms for direct food contact components.

    Industry compliance standards

    • IFRA (International Fragrance Association) standards for allowed aroma ingredients
    • EU Regulation (EC) 1223/2009—Cosmetic safety rules
    • FDA 21 CFR parts 172/173 (for food contact flavor bases, US)
    • ISO 9001:2015 certified flavor manufacturing facility guidelines

    Typical usage ratio

    • 0.2–2.5% by mass in aroma intermediate synthesis
    • Adjustment made for target concentration in final blend and compliance with olfactory thresholds

    Downstream process integration

    • Acylation reaction with controlled temperature and solvent choice to prevent side aroma notes
    • Post-reaction distillation ensures removal of high-boiling fractions unsuitable for fragrance applications
    • Hydrogenation or esterification for final aroma enhancement

    Final product types

    • Tobacco, nutty, and chocolate aroma molecules for luxury perfumes
    • Flavor bases for confectionery and baked goods
    • Pyridine-derived accords for fine fragrance mixing

    5. Fine Chemical Building Block—Custom Synthesis and Research Chemicals

    Specialty and research chemical firms utilize 3-Propionylpyridine as a modular building block for small-molecule synthesis, including heterocyclic switches, chelating agents, and molecular probes. High reactivity of the propionyl function makes it valuable in controlled condensation, reductive amination, and Grignard-type transformations essential in research pipelines. Batch consistency and trace analysis ensure reproducibility during scale-up and method validation.

    Industry compliance standards

    • ISO 17025 General requirements for competence of testing and calibration laboratories
    • GLP (Good Laboratory Practice) for custom synthesis operations
    • IUPAC purity and identity criteria for research grade compounds

    Typical usage ratio

    • Typically 1.0 equivalent per targeted moiety; adjusted for stepwise or combinatorial synthesis
    • Purification and dosage refined for end-use in analytical protocols

    Downstream process integration

    • Fed as a primary reagent in solution-phase synthetic routes
    • Intermediate purification by crystallization, chromatography, or distillation for subsequent steps
    • Documentation maintained for batch traceability and regulatory reporting in customer audits

    Final product types

    • Pyridine-functionalized chelating agents
    • Custom heterocycle research molecules
    • Reference standards and analytical probes for laboratory R&D
    Free Quote

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    Certification & Compliance
    More Introduction

    3-Propionylpyridine: Straight from Our Reactor to Your Lab

    Understanding the Real Value of 3-Propionylpyridine

    Producing 3-Propionylpyridine has never felt like a routine job around here. Over the years, the requests for this fine chemical have arrived from teams looking to advance pharmaceutical synthesis, universities hunting for new catalyst precursors, and specialty coatings companies after unique molecular tweaks. These projects always need a consistent and clean supply—not a mixed bag with batch-to-batch quirks. That matters because the chemical’s main roles rarely make the news, yet the quality can make or break a critical process.

    In our reactor halls, 3-Propionylpyridine follows a tried-and-true route that balances high conversion rates and minimal side-product contamination. Fitting a pyridine ring with a propionyl group at the 3-position sounds simple in textbooks. On the ground, it calls for sharp temperature control, careful pH monitoring, and decent patience. Controlling the hydration at each stage goes a long way. There are plenty of routes, but the difference between a half-hearted batch and a reliable chemical stream becomes clear out in use cases, not just in our QC notebooks.

    What Sets Our 3-Propionylpyridine Apart

    Each producer follows their own synthesis path for 3-Propionylpyridine. We’ve found that sticking close to the raw material source—not relying on outside intermediates—gives us room to adjust for process shifts quickly, especially when slight changes in impurity profiles start showing up. This hands-on approach means end users can count on similar purity each batch, whether they ordered a drum or a dedicated bulk campaign.

    Our plant works at a scale large enough to handle industrial demand, but small enough to keep the process nimble. Staff take pride in tuning the batch parameters and digging into micro-impurity profiles. There’s no farmed-out “general purpose” chemistry here; we produce for serious project requirements, and the difference shows up every time your analytics lab scours a certificate of analysis.

    Specifications That Really Matter on the Floor

    3-Propionylpyridine leaves our facility in clear, tightly-sealed containers with a purity going beyond the 99% mark measured by GC—because we know even trace pyridine byproducts can throw off sensitive steps. Moisture sits low, and our in-house high-throughput driers keep the product free-flowing and clear. The team goes beyond ticking off purity; we look at isomer presence, polar impurity traces, and run additional detection for aldehyde contaminants if customer specs require it.

    For teams using 3-Propionylpyridine in scale-up or pilot plant work, each delivery matches chromatograms run on previous shipments. Reliable melting points and reproducible spectral confirmation back every lot. Shelf stability figures get tracked through controlled storage studies; any shift in physical or analytical character triggers an investigation, and customers never get product that hasn't passed our internal review.

    On the Shoulders of Real Experience—Not Marketing Lines

    Years back, we fielded a call from a pharmaceutical researcher frustrated with supplier variability. They couldn’t afford a single synthetic intermediate that drifted from spec mid-project. So, we invited their team to watch a full campaign, talk to operators in real time, and run parallel lab checks. After seeing our operation, they changed upstream process assumptions and saved weeks of troubleshooting.

    Our job doesn’t end at shipping drums; we stay involved when users want to discuss batch differences or compare notes with our lab. The trust comes from experience—not just posters and bullet points. We listen to researchers who can spot tiny shifts by how their reactions behave, and we make adjustments for custom requirements when standard specs don’t fit.

    Where 3-Propionylpyridine Fits—and Where It Doesn’t

    Most requests for 3-Propionylpyridine come from chemists building scaffolds for active pharmaceutical ingredients. The propionyl group on the 3-position opens up reactivity different from 2- or 4-substituted cousins. Some clients want cleaner alkylation chemistry, others chase high-yield cross-coupling routes. The compound appears in condensation chemistry, heterocycle formation, and tweaking UV-response polymers. Sometimes it shows promise as a ligand core, influencing how metals coordinate in experimental catalysts.

    But we’ve seen it all, including misunderstandings. On a few occasions, customers have run into unexpected reactivity while using alternatives—say, 2- or 4-Propionylpyridine—only to switch back and notice cleaner yields. Our team can talk users through those differences, showing how small changes on the pyridine ring completely re-map downstream chemistry. We’ve watched this knowledge spread across research clusters and into real-world processes, where margins and product safety depend on the right position.

    Comparing with Other Products We Make

    A customer once asked why we don’t just push out more generic pyridine derivatives, instead of focusing on 3-substituted compounds. The market demands variety, but manufacturing these molecules takes a lot more than changing a reagent or turning a knob. Each isomer pays off in different potency, reactivity, and toxicity if you’re looking at specialty pharma or crop protection agents. 3-Propionylpyridine, by virtue of its structure, balances ring activation and steric hindrance in a way that’s absent in its siblings.

    Our experience running large-scale 2- and 4-Propionylpyridine campaigns has proven the main differences right at the crystallization stage. The yields drop or side product formation increases if the process doesn’t match the unique behavior of the 3-position variant. Cheaper products often cut corners with a one-size-fits-all process, but our reactors get tuned specifically for each isomer. For R&D teams chasing narrowed reaction windows, these details save months of optimization.

    Usage Across Industries: Not Just a Lab Curiosity

    Although 3-Propionylpyridine gets its name dropped in synthetic chemistry journals, the real utility stretches across several industries. Our bulk shipments go to API plants, where every intermediate run must keep pace with strict regulatory guidelines, traceability, and documentation. If a batch doesn’t match the analytical fingerprint, the investigations ripple up and down supply chains.

    Smaller lots move to research parks, crafting new classes of antimicrobials. In fragrance chemistry, the precise positioning makes specific notes in complex blends possible. In electronics, modified versions influence the assembly of special polymers, tightening control over dielectric constants or other functional properties. More than once, a customer has looped us back in with performance data, tying the batch quality right to end-application behavior.

    Not everyone outside the field sees the link between the purity of a single intermediate like 3-Propionylpyridine and the reliability of modern medical or material products. But decades in the plant have taught us every technical advantage stacks up over time, whether it’s a tiny impurity or a shipment that skips a QC step.

    Troubleshooting: Where Deep Knowledge Outranks “Standard” Service

    We’ve had batches from outside producers come in with yellow tints, elevated moisture, or odd GC signals. In some cases, switching back to our 3-Propionylpyridine cleared up customer production bottlenecks. Sometimes, tweaks in end-user purification saved resources, while other times, a focused conversation about adjusting a reaction workup unlocked better results.

    Customers have brought us samples riddled with side-products, cloudy solutions, or batch-to-batch microvariances no one at the distributor level caught. We examine these under the same protocols used in our own operation. If needed, we flex the synthesis to minimize specific contaminants, from acid traces to unreacted pyridine. Because we keep tabs on every input and process lever, we’re in a position to solve problems before they snowball into regulatory or manufacturing headaches.

    Scaling Up Without Cutting Corners

    As requests for 3-Propionylpyridine increased year-on-year, we invested in scalable, closed-system reactors equipped with advanced controls for parameters like jacket temperature and agitation speed. Real-time analytical measurement across each step keeps the output on target and prevents surprises. By sourcing key starting materials directly, we keep quality tight and trace any variability to its source.

    There’s no shortcutting supplier audits or internal process reviews. We keep direct lines to our logistics partners to minimize storage time and avoid risk of contamination during long transit. Every container carries documentation that flows up through our digital batch records to match compliance demands. We’ve seen how a single out-of-spec drum can bog down a customer’s integrated process, and we go beyond what’s on a standard COA to prevent that.

    Why Our Approach Builds Lasting Partnerships

    We live in an era where partners want more than price lists or catalog entries. Consistency, clear technical backup, and the option for process customization often tip the scale. Our technical contacts share data, respond fast to troubleshooting calls, and join in customer conferences when unusual questions arise—none of this happens in the abstract. It grows from years of developing mutual respect and a reputation for standing behind our chemistry.

    Sometimes, that means halting a shipment if tests flag an unexpected profile. More often, it means working with customers in real-time to fine-tune downstream uses—sometimes even shipping out alternative spec samples at our own expense, or switching up process solvents to reduce residual odours or oxidative risk.

    Knowledge Transfer: Serving Those Who Rely on Details

    Younger chemists often ask what separates a reliable 3-Propionylpyridine supply from the bulk intermediates stacked on lab shelves. The answer rarely boils down to paperwork or price per kilo. Instead, ongoing technical records, batch correlations, and process data mean the compound arrives as expected—and catches the eye of those who troubleshoot every blip in a reaction scheme.

    We provide more than analytical data; teams can get insight into synthesis history, batch trends, and even observed downstream outcomes with particular substrates. We share stories from previous scale-ups and help with regulatory prep. The conversations run both ways: users tell us about bottlenecks and process holes, and we adapt routines to fit real-world use, not hypothetical grade sheets.

    Sustainable Practice, Real Accountability

    We know that large-scale chemical synthesis carries environmental and social responsibilities. For every batch of 3-Propionylpyridine, waste streams are monitored and minimized. Installations for solvent recovery and emission control operate on strict cycles. Each operator understands the impact of overlooked steps—environmental, legal, and reputational. And we keep regular audits, sharing performance stats with downstream customers.

    Supply resilience matters, too. When global logistics run into snags, we hold safety stock and offer upstream suppliers feedback to prevent shortages. Customers who’ve weathered raw material crises with us understand that supply chain partnerships matter just as much as technical accuracy.

    Looking Ahead: Supporting Chemistry’s Next Steps

    The field of fine and specialty chemicals keeps moving, and so do our processes for 3-Propionylpyridine. Teams are working on process intensification, smarter waste minimization, and better raw material traceability. Customers leaning into digital QC integrations now get faster feedback on lot matching, with real-time data flowing both ways. Supplier traceability matters for every kilogram, which is why our system keeps batch genealogy accessible, especially under regulatory review.

    We continue to consult with researchers about alternative synthetic routes if shortages or new regulatory hurdles appear. Sometimes, we pre-invest in process changes so potential needs are met before they become bottlenecks. Because people rely on this compound in high-value projects, we support both present and future requirements by investing right alongside our partners.

    Bringing Depth to Your Project, Not Just Another Product Listing

    Choosing 3-Propionylpyridine becomes a partnership that stretches well beyond a shipment date. Our approach, built on direct manufacturing and continual technical conversation, brings knowledge into your project pipeline at each step. From analytics to hands-on troubleshooting, you get insight, flexibility, and the reassurance that comes from decades of focused chemical manufacturing—not just a series of online listings with stock statements.

    If you carry the process forward to novel chemical entities or regulatory filings, you need a supply line that keeps pace with technical developments and process adjustments. That’s a promise built from years on the line and in the lab—one we keep batch after batch, from our reactor floor to your experiments or production runs.