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3-Phenylpropylamine

    • Product Name 3-Phenylpropylamine
    • Alias Benzylamine
    • Einecs 212-626-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    116205

    Cas Number 2148-56-3
    Molecular Formula C9H13N
    Molecular Weight 135.21 g/mol
    Iupac Name 3-phenylpropan-1-amine
    Synonyms Benzenepropanamine, 3-Phenyl-1-propanamine
    Appearance Colorless to pale yellow liquid
    Boiling Point 242-245 °C
    Density 0.964 g/cm³
    Melting Point -18 °C
    Solubility In Water Slightly soluble
    Refractive Index 1.528-1.531
    Flash Point 98 °C
    Smiles C1=CC=CC=C1CCCN
    Storage Conditions Store in a cool, dry place, tightly closed

    As an accredited 3-Phenylpropylamine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 100 grams of 3-Phenylpropylamine, tightly sealed, labeled with hazard information, product name, and batch details.
    Shipping 3-Phenylpropylamine is shipped in tightly sealed containers, protected from light and moisture. It should be stored and transported at room temperature, away from sources of ignition and incompatible substances. The container must be clearly labeled, and the chemical must comply with all relevant regulations for safe handling and transportation of hazardous materials.
    Storage 3-Phenylpropylamine should be stored in a tightly sealed container, in a cool, dry, well-ventilated area away from sources of ignition. Keep it away from strong oxidizing agents, acids, and moisture. Store at room temperature and protect from light. Label the container clearly and ensure appropriate safety equipment, such as spill containment materials, is readily accessible in the storage area.
    Application of 3-Phenylpropylamine

    Applications of 3-Phenylpropylamine in Industrial Manufacturing

    As a direct manufacturer of 3-Phenylpropylamine, we focus on its validated industrial roles within established downstream chemical synthesis. This section outlines authentic application scenarios where this specialty amine functions as a key intermediate, phrased according to real manufacturing practice, compliance requirements, and integrated process flows.

    1. Synthesis of Pharmaceutical Intermediates for Cardiovascular Actives

    Pharmaceutical companies integrate 3-Phenylpropylamine for constructing intermediates in active molecule synthesis, specifically antihypertensive and vasodilating drugs. The amine group enables efficient reductive amination or nucleophilic substitution, forming key building blocks in multi-stage synthesis. Quality control adheres to strict impurity profiles, and process validation ensures batch reproducibility during API precursor manufacturing.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice (GMP) for Active Pharmaceutical Ingredients
    • USP/NF and EP monographs for related intermediates and impurities
    • FDA 21 CFR Parts 210/211 (cGMP for finished pharmaceuticals)
    • Pharmaceutical Inspection Co-operation Scheme (PIC/S) guidelines

    Typical usage ratio

    • 0.8–1.1 molar equivalents relative to starting aldehyde or acid intermediates; empirical adjustment for yield optimization

    Downstream process integration

    • Introduced during early-stage condensation reactions or reductive amination for API precursor assembly
    • Purified by crystallization or extraction post-reaction to remove excess amine and byproducts

    Final product types

    • Pharmaceutical intermediates for calcium channel blockers and beta-adrenergic antagonists
    • Active pharmaceutical ingredients (APIs) for antihypertensive medications

    2. Fragrance Ingredient Synthesis in Aroma Chemicals

    Manufacturers in the fragrance sector use 3-Phenylpropylamine to produce odorant bases, commonly through alkylation or acylation to form musky, floral, and phenolic compounds. The amine’s structure contributes to key notes in luxury and mass-market perfumes, and process control ensures traceability of precursors according to IFRA restrictions.

    Industry compliance standards

    • International Fragrance Association (IFRA) Code of Practice
    • ISO 9235: Aromatic Natural Raw Materials for the Production of Fragrances
    • REACH Regulation (EC) No 1907/2006 for chemical safety
    • EU Regulation 1223/2009 on Cosmetic Products

    Typical usage ratio

    • 0.5–2.0% by weight relative to total substrate, based on target aromatic profile or downstream esterification needs

    Downstream process integration

    • Reacted via amidation or carboxyalkylation to produce musk bases or fixatives
    • Formulation blending into bulk fragrance oils post-reaction

    Final product types

    • Fine fragrance concentrates for perfumes
    • Functional aromas for detergents, personal care, and cosmetics

    3. Agrochemical Intermediate in Selective Herbicide Production

    Agrochemical firms employ 3-Phenylpropylamine to construct amide or imine intermediates during selective herbicide synthesis. The primary amine reacts in controlled conditions to deliver functionalized ring systems with improved biodegradation profiles. Adherence to multinational standards for residual amine and impurity content is mandatory to support registration dossiers and environmental safety requirements.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products (FAO/WHO JMPR)
    • ISO 9001:2015 Quality Management for Agrochemical Production
    • EPA 40 CFR part 180: Tolerances and Exemptions for Pesticide Chemical Residues
    • REACH Regulation (EC) No 1907/2006

    Typical usage ratio

    • 5–12% w/w of the amine in targeted condensation and cyclization steps; adjust based on structure and required crop selectivity

    Downstream process integration

    • Feeding into batch reactors for stepwise synthesis of imidazolinone, triazine, or pyridine herbicide precursors
    • Purification via aqueous extraction and distillation to reduce unreacted species

    Final product types

    • Technical-grade selective herbicides
    • Formulated crop protection agents (EC, SC, WG forms)

    4. Precursor for Cationic Surfactant Synthesis in Industrial Cleaners

    Chemical formulators utilize 3-Phenylpropylamine as a starting molecule to synthesize quaternary ammonium surfactants, vital for industrial and institutional cleaners. The amine undergoes quaternization or alkylation reactions, introducing cationic head groups that enable unique antimicrobial and surface-active properties. Batch traceability and formulation alignment with industrial and food contact regulations are crucial in downstream workflow.

    Industry compliance standards

    • Regulation (EC) No. 648/2004 on Detergents
    • US EPA Safer Choice Standard (applicable to surfactant components)
    • ISO 14001:2015 Environmental Management for surfactant plants
    • FDA 21 CFR 178.1010 for sanitizing solutions (food contact surface cleaners)

    Typical usage ratio

    • 18–25% as a molar fraction in quaternization reactors, selected for the desired chain length and target microbiological performance

    Downstream process integration

    • Input into methylation or alkyl halide quaternization processes
    • Post-synthesis blending with solvents or additional surfactant classes before final packaging

    Final product types

    • Cationic surfactants for industrial and institutional cleaning agents
    • Biocidal active blends for food processing and healthcare sanitation
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    Certification & Compliance
    More Introduction

    Introducing 3-Phenylpropylamine: Our Perspective from the Manufacturing Floor

    Understanding 3-Phenylpropylamine Through Direct Handling

    Walking through the production lines, you learn to distinguish materials not just by their chemical names but by their quirks, their reactions, their strengths. 3-Phenylpropylamine is one of those chemicals you come to appreciate for its versatility and reliability. In our experience, its role extends beyond being just another specialty amine. Packing this product every day, we see demand coming from more than one direction: small labs, major pharmaceutical makers, fragrance houses, and even research startups finding new synthetic purposes for its stable, accessible structure. We produce it with a focus on clarity—clear liquid, stable purity, near neutral odor, holding up in storage and handling.

    Chemists and process engineers often highlight 3-Phenylpropylamine’s C9 backbone, which sets it apart in aromatic amines. As manufacturers, we work with this structure in mind, paying close attention during distillation and purification to deliver a product that supports consistent downstream chemistry. You can tell when a batch is right by both analytical data and experience: colorless, low impurity, and free of residual solvents. Our typical material offers a purity of not less than 99% by GC, with only a trace level of water and minimal secondary amines. While these numbers might look like the everyday minimums, we know every decimal point holds meaning for those running scale-up reactions or regulatory submissions.

    Day-to-Day Manufacturing Decisions Shape the End Use

    3-Phenylpropylamine isn’t just “produced”—it’s coaxed into its ideal form by a series of choices at every stage. Operators manage reactor temperature ramps carefully, since aniline derivatives can develop color and byproducts if things run too hot. We run repeated crystallizations and distillations, not just because a spec sheet demands it, but because subtle changes in product state can cause trouble for our downstream customers. Having direct control over each step lets us support not only current bulk orders, but also projects needing unusual grades or tight impurity profiles.

    A fresher batch can make all the difference in certain hydrogenation or alkylation steps. Some of our clients want the product shipped out as soon as it clears QC, so we schedule extra pickups. In-house glassware and stainless reactors scale up from a few kilos to multi-ton batches, depending on market pulse. Each time a chemist or operations manager calls us to talk through how things actually go on the floor, it adds to our insight and lets us adapt—sometimes by tweaking purification techniques, sometimes by adjusting logistics for better shelf life.

    Where 3-Phenylpropylamine Makes a Clear Impact

    Over the years, our 3-Phenylpropylamine has served applications across the map. In medicinal chemistry, it’s a recurring motif in intermediate libraries or target leads; you see requests spike ahead of certain regulatory cycles as teams look to secure material for filing. The chemical’s aromatic ring linked to a straight three-carbon amine chain offers both reactivity and selectivity, which process engineers put to work in several catalyst and ligand manufacturing schemes. In our lab, we’ve seen it pulled for aromatic substitution, reductive amination, and even specialty surfactant formulation.

    Fragrance and flavor developers reach out for similar reasons—its structure fits well in notes meant to bridge natural and engineered scent profiles. Handling requirements in these industries focus less on chemical reactivity and more on minimizing off-odors and guaranteeing batch-to-batch sensory consistency. Recognizing that, we keep an extra tight rein on distillation conditions and prepack everything in low-permeability drums, catching requests before seasonal runs in the field begin.

    Beyond established fields, we’ve seen an uptick in pilot-scale work leveraging 3-Phenylpropylamine in emerging areas: advanced polymers, surface treatments, and specialty coatings. These clients often seek multiple drum lots with rapid turnaround, and the only way to keep up is by holding steady on QA standards that allow us to sign off new customer profiles and guarantee ongoing reproducibility.

    How This Amine Differs from Competing Aromatic Amines

    You hear questions about how 3-Phenylpropylamine stacks up against other similar amines. We’re hands-on with structures like benzylamine, phenethylamine, aniline, or meta- and para-substituted phenyl derivatives. The biggest difference lies in the side chain: with three carbons between the amino group and the phenyl ring, the molecule avoids some of the issues seen with shorter chains. Phenethylamine and benzylamine, for example, come with different boiling points and reactivity— our material is less volatile and less prone to decomposition under thermal load, which brings handling and storage benefits.

    Operators report fewer emissions and easier temperature management in our reactors when working with 3-Phenylpropylamine, compared to its two-carbon cousin (phenethylamine). Physical handling improves as well—high purity means predictable melting/freezing behavior, less tendency to oxidize or darken, and consistent pH control without erratic acid-base balance. Chemists interested in substituent introduction or heterocycle formation often prefer this amine’s lower reactivity toward direct electrophilic attack on the core, which opens more reaction doors, especially in scale-up.

    Transparency Through the Entire Supply Chain

    As manufacturers, we never discount the value of visibility. We carry out every stage—from sourcing and hydrogenation to purification and final QC—in our own facilities. Every batch reaches signoff only after a final round in our in-house analytical lab, which runs not only purity checks but also stress tests under simulated shipping conditions. Our chemists pay attention to trace component profiles, using NMR and GC-MS to document every lot and ensure customer records line up with regulatory expectations worldwide.

    Product stewardship means staying in close contact with our key suppliers, maintaining full-chain audit trails, and tracking changing rules across markets. We keep safety data up to date, and provide transport documentation stating clear origin. For international clients, clear labeling, tamperproof containers, and full tracking remove much of the guesswork associated with bulk specialty chemicals.

    Perspective on Product Consistency and Problem Solving

    Our direct involvement on the floor has taught us that no two lots are ever identical without intervention. Process variables—reactor workload, catalyst activity, raw material age—each play a part. We monitor these in real time, adjusting as batches run, because small inconsistencies in precursor purity or moisture can cascade unpredictably. Within our plant, early detection comes from regular inline sampling, and quick corrections mean less offgrade product heading to reprocessing.

    Seasoned operators notice the little things—an unusual coloration in a distillate, a slight shift in odor profile, or a minor viscosity change. These don’t show up in standard endpoint testing, but they could signal trouble for an end user. Our intervention shuts off lots that “look right” on paper but don’t pass nose and eye checks familiar only to those who have filled, sealed, and shipped this compound for years.

    The hands-on approach allows for rapid troubleshooting: filter upgrades, updated base washing steps, even custom glassware setups. These are tweaks we can implement by walking from the control room to the line, not by sending slow emails through a supply chain maze. Keeping these controls inside the factory lets us respond directly to urgency—whether triggered by a sudden spike in demand, a customer technical question, or a new formulation emerging from R&D.

    Meeting Regulatory Expectations Through Direct Oversight

    Experienced chemical buyers know the headaches that come with documentation and compliance. Our compliance teams sit in the same buildings as our production managers, so questions about, say, REACH registration numbers or US import codes get resolved fast. We manage each regulatory filing and keep supporting records for at least a decade—far beyond the legal mandate—because old reference samples have solved more than one customer dispute. Each outgoing drum or container ships with batch analytics, stability data, and declaration of conformance, reflecting hands-on confirmation rather than theoretical extrapolation.

    We regard adherence to global and regional standards as a core part of our role: customers receiving 3-Phenylpropylamine know that their storage and usage instructions reflect practical conditions, proven in our own facilities. From container selection to truck scheduling, we don’t cut corners—both for the safety of our workers and for your peace of mind.

    Supporting Sustainable Sourcing and Waste Reduction

    The chemical industry has faced a renewed spotlight on sustainability. Direct production gives us room to optimize reactions for lower energy draw and less waste generation. For years, we’ve invested in closed-system reactions and vapor recovery—but the push toward green chemistry has us working on even longer solvent recycling loops. Operators track how much off-spec product and rinse waste leaves our gates monthly, and real efforts go into minimizing unnecessary drumming, repackaging, and short-dated batches.

    Our commitment means using less hazardous feedstocks, choosing routes that avoid persistent byproducts, and redirecting spent process waters to in-plant treatment. Off-site, we search for routes to supply 3-Phenylpropylamine using greener precursors; our partners develop biobased benzene alternatives, which (though early) help us measure real long-term improvement against traditional petrochemical benchmarks. By controlling production from the front end, we guarantee our customers’ material comes with traceable sustainability records and meaningful carbon accounting.

    Responding to Customer Feedback and Innovation Trends

    Feedback from users on the ground has shaped our approach from the start. A request for a more controlled amine acidity, for instance, led to a tweak in our purification cascade that now delivers material with a narrower pH range upon shipping. A customer targeting high-throughput pharmaceutical screening asked us to minimize particulate generation; our response was to swap filter media and update our final drip points, ensuring a cleaner product with each run.

    We keep close ties with formulators who bring back stories of product performance in the real world—chemical compatibility issues, unforeseen side reactions, longevity in storage, and ease of blending with exotic polymers. Each of these interactions sharpens our approach and leads to new QA checkpoints or subtle tweaks in our standard operating procedures.

    Consistency, Supply Assurance, and Long-Term Relationships

    Being a manufacturer, we’re responsible for the complete journey of 3-Phenylpropylamine from raw material to your plant door. Each production run feeds into a system of continuous improvement, shaped by years of practical experience and daily audits. Our customers expect each drum or flask to perform as the last; meeting that expectation comes from strict controls, not luck or supplier “trust.”

    Product reliability is never taken for granted. Downstream projects in high-pressure research or regulated industries rely on upstream suppliers who can keep material steady through market swings, weather disruptions, or feedstock price crunches. Our approach means planned capacity buffers, robust inventory planning, and established redundancy across critical production stages.

    Conclusion: Value Beyond the Drum

    Handling 3-Phenylpropylamine from synthesis to shipping underscores a simple truth—only the manufacturer can truly guarantee the character of what leaves the plant floor. Each batch, each container, holds thousands of small decisions and adjustments, each made with the end user’s needs in mind. The pride we take comes from a job done with care, an open line to every buyer, and the confidence that every drum reflects our direct input, our technical expertise, and our persistent drive for improvement.