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3-Phenylphenol

    • Product Name 3-Phenylphenol
    • Alias m-Phenylphenol
    • Einecs 201-993-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    315576

    Cas Number 486-19-1
    Molecular Formula C12H10O
    Molar Mass 170.21 g/mol
    Appearance White to light yellow crystalline powder
    Melting Point 122-124 °C
    Boiling Point 319 °C
    Density 1.17 g/cm³
    Solubility In Water Slightly soluble
    Synonyms m-Phenylphenol, m-Biphenylol, 3-Hydroxybiphenyl
    Smiles C1=CC=C(C=C1)C2=CC=CC=C2O

    As an accredited 3-Phenylphenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White plastic bottle with a secure screw cap, labeled "3-Phenylphenol, 100g." Includes hazard symbols, product details, and manufacturer's information.
    Shipping 3-Phenylphenol is typically shipped in tightly sealed, chemical-resistant containers to prevent contamination or moisture ingress. During transport, it is classified as a hazardous material and must comply with relevant regulatory guidelines. Proper labeling, documentation, and placement in a cool, dry area away from incompatible substances are essential to ensure safe shipping.
    Storage 3-Phenylphenol should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from incompatible substances such as strong oxidizing agents and acids. Protect it from light and moisture. Segregate from food and drink. Clearly label the storage area and ensure appropriate safety signage. Use appropriate personal protective equipment when handling the chemical.
    Application of 3-Phenylphenol

    Applications of 3-Phenylphenol in Industrial Manufacturing

    As an established chemical raw material manufacturer, we supply 3-Phenylphenol to a range of specialized downstream sectors that require performance-focused intermediates for high-value applications. The following scenarios highlight diverse, real-world industrial integrations, covering regulatory standards, recommended formulation ratios, exact process insertion points, and the nature of finished products derived from 3-Phenylphenol.

    1. Synthesis of Pharmaceutical Intermediates

    3-Phenylphenol serves as a critical intermediate in multi-step syntheses within pharmaceutical manufacturing, particularly in the preparation of active pharmaceutical ingredients (APIs) such as selective estrogen receptor modulators (SERMs), anti-inflammatory agents, and certain antihistamines. Its phenolic structure permits downstream modifications through etherification, sulfonation, or acylation, supporting medicinal chemists in assembling complex molecular scaffolds. Entry points for material addition are governed by stringent industry protocols, with process chemists specifying batch-wise dosing based on reaction stoichiometry and impurity control requirements.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP Pharmacopeial standards for residual solvents and impurities
    • European Pharmacopoeia specifications for intermediates
    • FDA cGMP 21 CFR Part 211 for quality control

    Typical usage ratio

    • Utilized at 0.5–3.5 molar equivalents in target synthesis reactions, tailored according to API synthesis route and the desired conversion yield; process engineers optimize the precursor ratio based on analytical yield and upstream supply chain constraints.

    Downstream process integration

    • Introduced during the initial stages of batch or flow synthesis, prior to heterocyclic ring assembly or halogenation steps; typically handled in oxygen-limited reactors to prevent overoxidation.

    Final product types

    • API intermediates for SERMs and other hormone modulators
    • Active ingredients for anti-inflammatory and anti-allergy medications
    • Specialized compound libraries for pharmaceutical R&D
    • Proprietary fine chemical intermediates for drug discovery

    2. High-Performance Polymer Additives

    In the production of specialty polymers and engineering plastics, 3-Phenylphenol functions as a monomer modifier or chain terminator. Its aromatic and sterically hindered structure influences the thermal resistance, mechanical strength, and UV stability of end polymers, such as polycarbonates and specialty polyesters. Process operators incorporate the additive at calibrated points in polymerization, targeting formulation footprints compliant with downstream mechanical property specifications.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006 for monomer safety
    • ISO 9001:2015 Quality Management for process traceability
    • UL 94 flammability ratings for engineered plastics
    • RoHS Directive 2011/65/EU for electronic polymer applications

    Typical usage ratio

    • 0.2–1.2% by weight of total monomer feed; functionalization level is optimized according to targeted glass transition temperature (Tg) and flame-retardant properties as confirmed by batch-to-batch QC analytics.

    Downstream process integration

    • Blended directly into monomer melt streams during reactive extrusion or bulk polymerization; dosing systems apply in-line verification of incorporation efficiency and residual monomer analysis as per QC protocols.

    Final product types

    • High-performance polycarbonate sheets for automotive glazing
    • Protective housings for electronic components
    • Flame-retardant specialty polyesters for industrial laminates
    • Glass fiber reinforced composites for aerospace parts

    3. Industrial Biocide and Antimicrobial Agents

    Manufacturers use 3-Phenylphenol as a precursor for synthesizing phenolic-based disinfectants and preservatives, particularly in formulations where broad-spectrum antimicrobial activity is required. Its unique substitution pattern enhances both bactericidal efficacy and environmental persistence, making it suitable for industrial formulations in water treatment and surface disinfection. Compliance with hazard and residue level standards is strictly managed throughout every stage from raw material dosing to final product release.

    Industry compliance standards

    • BPR (EU Biocidal Products Regulation) (EU) No 528/2012
    • US EPA FIFRA regulations for antimicrobial products
    • ISO 11930:2019 Microbiological quality of finished products
    • OECD guidelines for biocide environmental safety

    Typical usage ratio

    • Concentration in biocidal formulations ranges from 0.05–0.2% by weight, adjusted per minimum inhibitory concentration (MIC) testing against targeted microorganisms and in accordance with maximum residue limits set by local authorities.

    Downstream process integration

    • Added during the post-neutralization blending step in biocide concentrate and before final dilution in finished formulations; monitored for purity and residual active fraction by HPLC or GC to ensure regulatory thresholds are not exceeded.

    Final product types

    • Industrial surface and equipment disinfectants
    • Preservative systems for water-based coolant fluids
    • Algaecide and bactericide agents in industrial water treatment
    • Antimicrobial coatings for infrastructure

    4. Color Developer in Thermal Paper Coatings

    3-Phenylphenol serves a core function as a color developer in thermal paper coatings for high-durability tags, tickets, and receipt rolls. Its role is to facilitate fast dye development upon heat activation, offering enhanced image stability and resistance to background fading even under prolonged exposure to light or contaminants. Material addition is coordinated tightly with coating thickness and controlled by automated dispensing units aligned to online colorimetric feedback systems.

    Industry compliance standards

    • US FDA 21 CFR 176.170 and 176.180 for food-contact compliant paper coatings
    • EN 12281:2017 for thermal paper quality requirements
    • ISO 186 Paper and Board Sampling standards
    • RoHS and REACH for chemical ingredient restrictions

    Typical usage ratio

    • Developer is incorporated at 2.5–8.0% by weight of the dry coating composition; formulation chemists fine-tune the proportion based on print intensity requirements and compatibility with selected leuco dyes.

    Downstream process integration

    • Dispersed into the aqueous or solvent-based coating matrix prior to high-speed gravure or blade coating onto paper substrate; process control systems ensure developer dispersion homogeneity and prevent agglomerate formation throughout drying and calendering.

    Final product types

    • Thermal POS receipt papers
    • Barcode labels and logistics tags
    • Lottery tickets with thermal print layers
    • Transit fare cards with heat-activated markings

    5. Organic Synthesis Intermediate for Agrochemical Actives

    In agrochemical manufacturing, 3-Phenylphenol is applied as an intermediate for synthesizing specific herbicide and fungicide active ingredients, where its aromatic framework supports targeted halogenation and etherification reactions. The resultant actives benefit from robust stability and selective mode of action required for modern crop protection applications. Downstream integration within multi-step synthesis is subject to traceability and impurity control systems to meet market registration requirements.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • ISO 17025 Laboratory Accreditation for residue analysis
    • AGROSTEP Quality Control Protocols for formulation consistency
    • National pesticide regulatory agencies (e.g., US EPA, EU EFSA)

    Typical usage ratio

    • Implemented at 1.0–4.5 molar equivalents in the synthesis sequence, based on structural requirements of the target active and conversion efficiency as monitored by in-process analytical methods.

    Downstream process integration

    • Charged during the initial reaction sequence for precursor aryl ether or phenol-ester formation, prior to final purification and crystallization of the crop protection active; custom synthesis protocols minimize carryover of residual starting material in final products.

    Final product types

    • Active intermediates for selective herbicide and fungicide classes
    • Ready-to-formulate agrochemical technical concentrates
    • Bulk actives for seed treatment products
    • Co-formulated crop protection agents for integrated pest management systems
    Free Quote

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    Certification & Compliance
    More Introduction

    Introducing 3-Phenylphenol: From Core Synthesis to End-Use Solutions

    Understanding 3-Phenylphenol Production

    At our site, we put years of hands-on experience behind every batch of 3-Phenylphenol we bring to market. You find it listed in the trade as meta-phenylphenol or 3-Hydroxybiphenyl, but the chemical backbone is consistent: a biphenyl ring system with a single hydroxy group at the 3-position. Chemists value this structure for a reason—it links the best of reactivity and stability, forming a reliable platform for downstream synthesis.

    We routinely produce this compound under controlled atmospheric conditions to ensure both purity and yield meet real-world manufacturing needs. Temperatures and pressure ranges are tightly managed throughout the formation and subsequent purification stages. Rigorous monitoring during each batch keeps overhead low and quality high.

    What Sets Our 3-Phenylphenol Apart

    Every manufacturer claims purity, but actual results show the difference. Our line offers material with 99% minimum assay by gas chromatography. Hard experience taught us that minor impurities, especially residual biphenyl, compromise downstream reactions. For that reason, we invest in batch-specific analytical tests. Each drum gets its own certificate, backed by HPLC and NMR, giving customers the confidence that only true 3-phenylphenol makes it through our process.

    Consistency goes beyond testing. We source all raw materials with full traceability, working with partners willing to meet our strict entry controls. Each solvent, acid, and base used reaches our minimum LOD (limit of detection) threshold, and logistics operate on a just-in-time model to guarantee fresh stock and stable pricing. This tight control means repeatable performance in every order, no matter the volume.

    Physical Specifications and Handling

    Finished 3-phenylphenol appears as an off-white crystalline solid, sometimes picking up faint polish from residual solvents, though always within limits set by downstream handling expectations. Melting point ranges hold steady above 160°C, which suits most industrial demands for high-temperature synthesis. Although the powder carries a slight phenolic odor, standard PPE and good ventilation keep the work environment comfortable. We always recommend sealed transfer for bulk handling, using flanged drums and lined packaging to prevent cross-contamination or moisture uptake.

    Chemists who need to weigh out small lots appreciate our commitment to anti-static packaging and tamper-resistant seals. The product flows freely through most feeding and weighing equipment at ambient lab temperatures. For larger plants aiming for automated dispensing, we offer bulk totes supplied with vented linings to keep dust and static at bay.

    Application in Industrial and Laboratory Contexts

    3-Phenylphenol acts as a versatile intermediate. In the agrochemical and pharmaceutical sectors, it forms the core structure for a range of downstream products. Manufacturers who make veterinary additives frequently choose our material as the building block for advanced phenolic compounds. Classic Suzuki-Miyaura coupling reactions prove especially efficient with our product, thanks to the high para-selectivity and minimal residual water content.

    Our clients in the polymer industry see different advantages. The biphenyl core resists oxidation, giving end products longer shelf life and higher mechanical durability. When formulated into epoxy systems or advanced thermoplastic matrices, the hydroxy group allows controlled cross-linking, raising glass transition temperatures or adding flexibility, depending on requirements.

    Colorant producers working on dyes and pigments benefit from reproducible UV absorbance profiles, which stem directly from our strict control of the biphenyl substitution pattern. We work closely with these customers, offering technical support to tune lot sizes, grain sizes, and purity so that downstream chromatographic separations run clean from trial scale to full production.

    Comparing 3-Phenylphenol to Similar Compounds

    Many ask about the difference between 3-phenylphenol and its close relatives, like 4-phenylphenol and pure biphenyl. Here’s what stands out. With biphenyl, there’s no hydroxy group. For every application that needs reactivity—polymer cross-linking, further functionalization, or strong hydrogen bonding—plain biphenyl just falls short. In contrast, 3-phenylphenol supports these, opening a wide set of chemical pathways.

    Some customers look to 4-phenylphenol or 2-phenylphenol, both of which carry the hydroxy group at different points on the ring system. While each isomer finds its niche, subtle changes in reactivity crop up during large-scale synthesis. We’ve seen yields drop and color bodies increase when switching among isomers without proper process validation. 3-phenylphenol’s meta-position ensures balanced reactivity and less steric hindrance in standard coupling or etherification reactions. Where selectivity matters—especially in pharmaceutical intermediate synthesis—the differences mean real-world performance, not just academic distinctions.

    Cost factors also come into play. Sourcing high grades of 2-phenylphenol increasingly runs into price volatility, as global suppliers divert raw material for use in fungicides and wood treatments. 3-Phenylphenol keeps a steady supply and more predictable cost curves, matching budget expectations for both routine and specialty production.

    Practicalities of Scaling and Integration

    Integration at larger sites takes more than a spreadsheet. Engineers setting up new lines put process utility first. Our high-purity 3-phenylphenol flows easily through standard piped systems and feeding hoppers, keeping transfer times short and clean. In-line filters and segregated pumping zones keep the workspace productive and the product reliable.

    Controlled venting and dust suppression have proved essential during scale-up and repeated cycles. We saw early on that minor static build-up could trigger flow interruptions or, in rare cases, trace contamination in sensitive reactor loads. After pilot tests, we adjusted packaging strategies to focus on lined, grounded containers, sharply reducing these risks for our customers.

    Downtime and downtime risk remain at the forefront of most production managers’ worries. Our logistics and production teams coordinate on fixed lead times and batch sizes, preventing backlog in the upstream supply chain. Emergency shipments occasionally matter for customers running critical paths, so we maintain buffer stock and validated logistics partners to step up supply as needed. For clients running smaller-batch or just-in-time lines, our drum-sized units mean they can take what they need without locking up capital in excess inventory.

    Environmental Responsibility and Safety Commitments

    Producers today face more scrutiny than ever around chemical stewardship. We meet this head-on by implementing closed-loop solvent recovery throughout the manufacturing stages. This not only conserves resources but also keeps our workplace safer for operators, as they avoid exposure to unnecessary emissions. Scrubbers and vapor treatment installations in our plants cut down on atmospheric release, keeping our environmental impact low.

    Waste minimization requires practical steps, not just slogans. Each lot is tracked for off-specification material. Any residues go into in-house blending, serving secondary applications in controlled settings. Local authorities regularly audit our waste handling, verifying that our operations remain within guidelines and best practices.

    We treat worker safety as more than a formality. Training covers the correct donning of PPE, best practice for contact avoidance, and site-specific emergency drills. Our experience has shown that even veteran technicians need reminders and refreshers. Built-in shower and eyewash stations appear at every active packaging line, and periodic drills keep everyone ready.

    Customer Support, Collaboration, and Technical Solutions

    We rely on more than automated systems to keep customers satisfied. Technical support teams draw from our manufacturing floor, where supervisors and production engineers collaborate on deeper problem-solving. Questions on impurity profiles, reactivity, solvent compatibility, or filtering methods get real answers grounded in day-to-day experience, not just generic advice.

    Our labs handle custom requests, whether for tighter impurity specs or bespoke packaging. We have scaled custom grades to suit specific polymer blend or pharmaceutical syntheses, building up documentation for traceability. Customers frequently invite us to troubleshoot line productivity, and we dispatch experienced chemists who have faced similar hurdles in our own operations.

    We take pride in our order reproducibility, and that means more than just lab work. We offer sample lots and pilot-scale shipments before ramping to full volume, reducing scale-up surprises and trimming wasted effort. Communication lines stay open from proposal to delivery, and post-delivery follow-up ensures that everything meets real-world need, not just technical spec sheets.

    Pursuing Innovation and Continuous Improvement

    Markets evolve, and so do our methods. Feedback from industry partners has pushed us to refine our reaction conditions, looking for ways to cut down on byproduct formation and waste. Our R&D team recently validated continuous flow production at pilot scale, showing both lower energy use and tighter control over reaction kinetics. This makes high-purity batches accessible at capacities that were unthinkable a decade ago. We monitor and document the impact of these adjustments, sharing data with stakeholders.

    Our lab and plant teams participate in professional forums, exchanging ideas and teaching others what we have learned. New routes get tested for both energy efficiency and compatibility with downstream equipment. Small tweaks—a shift in catalyst loading or a fresh approach to quenching—result in big improvements at the production line. We see ourselves not just as suppliers, but as partners in pushing new solutions to long-established chemical hurdles.

    Partnering for Reliability in an Unpredictable World

    Supply chains can swing fast, and chemical producers have to plan for rough patches and surges alike. We saw this during the COVID-19 pandemic, when freight routes tightened and raw material inventories fluctuated overnight. Our response involved more than just stockpiling: we worked closely with trusted suppliers, kept raw materials at regional depots, and adapted production schedules within hours, not weeks. The result: our customers experienced minimal disruption, even in chaotic markets.

    Learning from these episodes means designing ever more resilient systems. We invest in staff training, cross-plant coordination, and digital monitoring of key inventories. Our customers count on our readiness to adapt and keep their operations going, regardless of upstream events. Flexibility—grounded in logistics planning and real-time communication—means peace of mind for anyone relying on 3-phenylphenol as an input to their own products.

    Moving Forward: Why Choice of Supplier Matters

    Selecting the right source of 3-phenylphenol shapes both short-term output and long-term business outcomes. Producers who cut corners or accept uneven quality often deal with more rework, returns, and lost productivity down the line. Our track record, built on years of steady partnership and technical insight, stands as proof of what tested processes can deliver.

    With our blend of thorough quality checks, constant process refinement, and active technical collaboration, customers get more than a chemical—they gain a partner in keeping their own reputations for quality and reliability solid. We welcome new partners to see for themselves what dependable 3-phenylphenol production and support can make possible.