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3-Phenylbenzaldehyde

    • Product Name 3-Phenylbenzaldehyde
    • Alias m-Phenylbenzaldehyde
    • Einecs 212-715-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    507781

    Name 3-Phenylbenzaldehyde
    Cas Number 3486-49-1
    Molecular Formula C13H10O
    Molecular Weight 182.22 g/mol
    Appearance White to off-white solid
    Melting Point 82-85°C
    Boiling Point 317°C
    Density 1.115 g/cm³
    Smiles C1=CC=C(C=C1)C2=CC=CC=C2C=O
    Purity Typically ≥98%
    Solubility Slightly soluble in water; soluble in organic solvents
    Synonyms m-Phenylbenzaldehyde, 3-Benzoylbenzaldehyde
    Refractive Index 1.626 (predicted)
    Storage Conditions Store in a cool, dry place, tightly closed

    As an accredited 3-Phenylbenzaldehyde factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 3-Phenylbenzaldehyde is supplied in a 25-gram amber glass bottle, sealed with a screw cap and labeled with safety information.
    Shipping 3-Phenylbenzaldehyde is shipped in tightly sealed containers, protected from light, moisture, and incompatible substances. Packages comply with regulations for chemical transport, including proper labeling and documentation. Handling includes safety measures to prevent leakage or exposure. Shipping is typically by ground or air, following local and international hazardous material guidelines.
    Storage 3-Phenylbenzaldehyde should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from direct sunlight and sources of ignition. Keep it away from strong oxidizing agents and moisture. The storage area should be equipped to contain spills, and access should be restricted to trained personnel. Ensure proper labeling and follow standard chemical safety protocols.
    Application of 3-Phenylbenzaldehyde

    Applications of 3-Phenylbenzaldehyde in Industrial Manufacturing

    3-Phenylbenzaldehyde serves as a key building block in fine chemical synthesis, enabling controlled structural modifications essential for high-performance end products in sectors ranging from pharmaceuticals to functional polymers. As the original manufacturer, we ensure each delivery addresses the procedural and compliance demands of advanced downstream processes.

    1. Pharmaceutical Intermediate for Anti-inflammatory APIs

    In non-steroidal anti-inflammatory drug (NSAID) production, downstream formulators use 3-Phenylbenzaldehyde for the synthesis of biphenyl central structures. The aldehyde group enables site-selective Grignard, reductive amination, or Wittig processes, facilitating efficient construction of pharmacophores present in established anti-inflammatory agents. Manufacturers rely on its purity and consistent aromatic substitution to meet batch-to-batch reproducibility requirements.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP/NF Residual Solvents and Impurities Standards
    • European Pharmacopoeia Monographs for Drug Substances
    • US FDA 21 CFR Part 210/211 Drug Manufacturing Control

    Typical usage ratio

    • Often 1.0–1.2 molar equivalents relative to amine or Grignard coupling partner
    • Adjusted based on process yield and mitigation of by-products

    Downstream process integration

    • Introduced at the initial condensation or carbon–carbon coupling stage
    • Further purified before incorporation into heterocycle-forming or side chain-elongation steps

    Final product types

    • NSAID actives (e.g., biphenyl-based anti-inflammatories)
    • Intermediates for selective cyclooxygenase inhibitors
    • Precursors for substituted benzylamines
    • API key starting material (KSM) batches for custom synthesis

    2. Synthesis of Specialty Polymer Additives

    Polymer manufacturers employ 3-Phenylbenzaldehyde as a high-performance aromatic modifier to control thermal characteristics and molecular architecture in specialty polymers. Its structural rigidity and aromatic functionality make it valuable for customizing poly(aryl ether ketone) and polyimide material properties, particularly in aerospace and electronics applications where thermal stability and processability are critical.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems
    • REACH (EC) No 1907/2006 Registration, Evaluation, Authorisation and Restriction of Chemicals
    • RoHS 2011/65/EU for Electrical/Electronic End-Use
    • UL 94 Flammability Requirements for Plastics

    Typical usage ratio

    • Incorporated at 0.5–3% by mass as a chain terminator or branching agent
    • Varied depending on required thermal or mechanical index

    Downstream process integration

    • Added to monomer melt or solution polymerization mixture
    • Reacted via nucleophilic addition or imine formation prior to polymerization

    Final product types

    • High heat-resistant engineering plastics
    • Semicrystalline polyaryletherketone composites
    • Insulating films and sheets for microelectronic applications
    • Specialty molding compounds for automotive or aerospace

    3. Fragrance and Aroma Chemical Manufacturing

    Aroma compound producers use 3-Phenylbenzaldehyde as an intermediate for synthesizing fine fragrances and luxury perfumery bases. Its distinct aromatic-aldehyde profile enables chemoselective extensions into complex musks and floral components. Downstream, it serves in aldol condensations or selective hydrogenations, imparting refined olfactory notes to designer fragrances and aroma profiles for personal care products.

    Industry compliance standards

    • IFRA (International Fragrance Association) Standards and Guidelines
    • EU Regulation (EC) No 1223/2009 on Cosmetic Products
    • ISO 9001:2015 for Fragrance Compound Manufacture
    • FDA 21 CFR 182—Generally Recognized As Safe (GRAS) for Flavor Use

    Typical usage ratio

    • Employed at 0.1–2.0% by weight in target aroma clusters
    • Formulation level controlled to match stability and odor intensity targets

    Downstream process integration

    • Condensed with aldehydes/ketones for custom bases
    • Hydrogenated or acetalized before blending into the fragrance matrix

    Final product types

    • Fine perfumes and eau de toilette bases
    • Complex aroma compounds for soaps and personal wash liquids
    • Fragrance concentrates for luxury candles and air care
    • Specialty flavoring agents (non-edible)

    4. Fine Chemical Intermediate for Agrochemical Synthesis

    Crop protection manufacturers utilize 3-Phenylbenzaldehyde in the production of advanced aromatic agrochemical intermediates, including pre-emergent herbicide precursors and selective pesticide scaffolds. Its aromatic aldehyde moiety is essential for route-specific formylation and nucleophilic aromatic substitution, supporting scalable synthesis of high-value active molecules under tightly controlled process conditions.

    Industry compliance standards

    • FAO/WHO Technical Specification for Pesticide Active Ingredients
    • ISO 9001:2015 Certified Production Processes
    • EU Regulation (EC) No 1107/2009—Plant Protection Products
    • OECD Principles of Good Laboratory Practice (GLP)

    Typical usage ratio

    • Reacted at stoichiometric or 5–10% molar excess relative to core building block
    • Adjusted for optimum conversion and impurity control

    Downstream process integration

    • Used for the initial condensation, imine formation, or as a precursor in heterocyclization
    • Goes through successive derivatization prior to final coupling with active moieties

    Final product types

    • Herbicide intermediates for arable crops
    • Precursor substances for insecticide actives
    • Regulatory approved agrochemical intermediates
    • Custom fine chemicals for plant protection formulations

    5. Advanced Ligand Synthesis for Catalysis

    Catalyst developers incorporate 3-Phenylbenzaldehyde as a precursor to synthesize custom organic ligands, especially in applications requiring chelating ligands for transition metal complex catalysts. The aldehyde function enables selective condensation with diamines or dithiols, producing Schiff base ligands. These ligands play a critical role in industrial processes such as catalytic hydrogenation, olefin oligomerization, or fine chemical synthesis.

    Industry compliance standards

    • ISO 17025:2017 Laboratory Testing Accreditation
    • REACH/CLP Regulation for Handling Catalyst Components
    • GMP for Catalysts in Food Contact or Pharma Synthesis
    • ISO 14001:2015 Environmental Management in Catalyst Manufacturing

    Typical usage ratio

    • Reacted at 1:1 molar ratio with chelating component
    • Adjusted for desired selectivity and stability of the final catalyst

    Downstream process integration

    • Condensed with polyamines or dithiols in solvent phase
    • Ligand complexes isolated before downstream metalation and catalyst activation

    Final product types

    • Custom metal-complex catalysts for batch and flow reactors
    • Fine chemical process catalysts
    • Specialty ligand libraries for screening
    • Homogeneous catalytic systems for selective transformations
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    Certification & Compliance
    More Introduction

    3-Phenylbenzaldehyde — Practical Insights from Decades of Manufacturing Excellence

    The Real Work Behind Reliable 3-Phenylbenzaldehyde Supply

    Years in chemical manufacturing have shown us that quality counts most once our products enter a customer’s process. 3-Phenylbenzaldehyde stands as one of the most reliable aromatic aldehydes in our portfolio, rooted in the nuanced chemistry of aromatic ring transformations. Every batch comes from oxidation of 3-phenyltoluene or selective functionalization of biphenyl systems, processes we have refined over years in-house to maintain tight control over purity, yield, and byproduct content. Consistent performance requires understanding how raw materials behave across yearly crop cycles and recognizing shifts when new solvent systems or catalysts impact product outcomes.

    Product Overview: What Sets 3-Phenylbenzaldehyde Apart

    3-Phenylbenzaldehyde (CAS No. 3958-56-5) delivers more than a distinctive aromatic presence. Behind the clear to pale yellow liquid, there's a core aldehyde function joined to a phenyl ring at the meta position. This position on the benzene core determines its chemical behavior in both lab-scale and bulk synthesis, separating it from isomers like 2- or 4-phenylbenzaldehyde. We’ve found that its structure gives a balance between reactivity and stability, which broadens its use in fine chemicals, pharmaceutical intermediates, and advanced materials. That blend minimizes undesired side reactions, especially in multistep synthesis where precise selectivity saves both cost and time.

    Our lots are offered with GC purity above 99%, typically accompanied by moisture analysis and assay for residual solvents based on each customer’s downstream requirements. Crystallization points and color index are both closely monitored, since even slight deviations may hint at wartime chemical discoloration from early-stage raw material variation. Chemists in our team check against archived spectra to trace even minor changes from kettle to kettle, so users can pick up our material with confidence for reproducible R&D or production runs.

    Manufacturing Details: Beyond the Standard Aldehyde

    Each lot of 3-Phenylbenzaldehyde follows batch protocols honed from years of pilot and full-scale work. High-performance catalysts and carefully controlled reactor temperatures govern how the benzyl group is activated, then converted, to prevent over-oxidation. We work in closed stainless-steel vessels to block air ingress and moisture pickup, which can otherwise trigger polymerization or yellowing. Every load of raw phenyltoluene travels through filtration and pre-drying systems, minimizing unknowns before the main reaction.

    No two reactors are identical, but over the years, our engineers have isolated those small technical differences that can transform the product’s performance in the customer’s hands. For example, agitation rate and stoichiometry sometimes get overlooked at pilot scale but drive packed column performance for finished product color and purity. Consistently, harmonizing these physical and chemical conditions keeps batch variations low between runs. Many buyers count on us because their own process windows are tighter than what generalized industry specs allow.

    Key Specifications — From Chemists to Chemists

    We walk through batch data at a molecular level because our customers do, too. Each drum leaves inspection only after passing:

    Those numbers came from hundreds of customer audits, synthetic trials, and feedback loops where minor unknowns derailed downstream reactions. We record the full chromatograms so emerging peaks can be flagged before release, not after customer complaint.

    Consistent Sourcing, Ethical Production

    Modern chemical manufacturing keeps us more accountable than ever. Every precursor reaching our gates comes traceable to established suppliers, each batch matched by analytical report for hydrocarbons, metals, and regulated impurities. Waste reduction isn’t just rhetoric; each process node is mapped so vent streams can be minimized and residues repurposed. Years ago, aromatic aldehyde streams often wound up burned or dumped. Now, much of the side fraction is reprocessed or sold into adjacent markets, cutting both waste output and uncontrolled emissions.

    Ethics applies to labor as well. Our site teams train on chemical handling and PPE every quarter, learning not just what standards require, but how minor lapses can lead to bigger environmental or safety failures. The pressure to cut corners never outweighs the need to send out safe, specification-conforming aldehyde.

    Understanding 3-Phenylbenzaldehyde in Real Processes

    End users take our 3-Phenylbenzaldehyde across a spectrum of industries. In fragrance R&D labs, its aromatic core brings a note distinct from bulk benzaldehydes, lending resinous richness where simple benzoic derived aldehydes fall short. Chemists investigating pharmaceutical building blocks value its specificity — the meta linkage avoids metabolic hot spots seen in ortho or para isomers, and clean handling minimizes risk of unwanted side products.

    We’ve seen dyestuff developers exploit its resonance effects to push color performance in organic pigment design. Where reactive positions on the ring count, the meta arrangement of the phenyl group blocks certain undesired substitutions, guiding downstream transformations with better predictability.

    Compared to Benzaldehyde, and Isomer Challenges

    Some customers new to the meta-phenylbenzaldehyde family expect it to behave like simple benzaldehyde. Instead, that extra phenyl group changes the electron density and reactivity profile across the aromatic system. For reduction or condensation steps, we see a higher selectivity against overreaction, while protecting group chemistry often goes cleaner due to steric effects.

    Differences show up most clearly in Grignard additions and imine formations, where isolation of the desired addition product proves easier than with less hindered isomers or mixed-ring aldehydes. Customers accustomed to para-phenylbenzaldehyde find different solubility and melting characteristics, so solvent selection and product handling protocols get tweaked on their end. Each year brings practical questions on how to swap one isomer for another, and our technical support often addresses issues not spelled out in standard organic reference texts.

    Analytical Control — Assurance Beyond Purity Specs

    Modern quality management digs much deeper than labeling a drum “>99% pure.” Our team runs full spectrometric analysis — 1H and 13C NMR, FT-IR, plus elemental microanalysis — for both inhouse tracing and to help customer new process scaling. Sulfur or phosphorus impurities, even in low ppm, can poison downstream catalysts or alter reaction yields. In many routes, GP or research users test foul-smelling aldehyde mixtures due to stray byproducts not visible in bulk assay — we trap and analyze these before shipping, not just as a matter of compliance, but because our own chemists need those answers on a bench.

    Supply Security and Lot Scalability

    2020’s global logistics crunch taught even the largest chemical buyers that reliable supply partners outlast last-minute traders. In every market downturn, buyers turn to original manufacturers who back up their material with full-source documentation, sample retention, and predictable lead times. Tight relationships with regional feedstock suppliers anchor lot scheduling, and site infrastructure investments secure capacity for base demand plus seasonal surges from dyes, API intermediates, and specialty polymer developers.

    Customer Experience: Lessons from Field Collaboration

    We learn the most from customers running their chemistry under non-standard circumstances. Once, a fine chemicals group flagged unexpected polymer buildup in a Mannich base reaction. After examining side product profiles, our team pinpointed a low-level impurity from a minor solvent change at our plant, traced it backward, and rebuilt the batching protocol. Follow-ups not only satisfied that customer, but improved processing on our own end, tightening purity specs for everyone downstream.

    Another case involved a specialty pigment plant switching from a competitor’s para isomer material, which kept fouling equipment. Our process chemists worked directly with their production team to adjust solvent, agitation rate, and work-up conditions, finding that our more tightly run fractionation cut problematic residues in half. Cases like these reinforce what we’ve always known: transparency, fast support, and knowing the ins-and-outs of our own manufacturing lets us add direct value beyond the literal drum of chemical provided.

    Environmental Responsibility and Worker Safety

    Chemical manufacture brings real hazards: toxic vapor, pressurized reactors, and liquid waste all need vigilant control. Over time, we replaced open-system batch handling with closed transfer and vapor recovery, investing in scrubber systems that allowed our site to cut emissions while recycling valuable byproducts. We built regular product slurry testing to catch residue build-up trends, preventing the kind of environmental mishaps that haunted the bad old days of uncontrolled aldehyde synthesis.

    Safety isn’t just about compliance. On-the-ground operators are encouraged to speak up about design changes or routine that create risk points — a leaky valve, a missed gasket, a strange scent in the reactor bay. Regular walk-throughs by mixed teams of management and chemical technicians spot issues before they cascade into safety incidents. Many of our improvements in 3-Phenylbenzaldehyde handling came from these discussions, not just regulatory audits.

    Looking Forward — Meeting the Changing Demands of Industry

    As new downstream markets appear, particularly in OLED materials and high-performance polymers, precise isomer composition and batch-to-batch reproducibility matter more than ever. Customers from advanced materials call for absolute traceability and data packages, especially to meet ever-evolving international regulatory standards. Our supply chain teams have grown adept at assembling all necessary compliance records on short notice — from RoHS to REACH, and detailed impurity profiles for FDA-driven drug applications.

    Our in-house R&D keeps watching for greener synthetic routes: recent years saw rollout of waste-minimizing batch workups and catalyst recycling approaches, cutting both footprint and raw material demand. Collaborations with academic and technology partners speed up new process trials. User requests for cleaner byproduct removal or safer odor profile drive us to revisit legacy protocols — proof that sustained manufacturer engagement leads product evolution.

    Supporting Chemists with Practical Knowledge

    Beyond product in a bottle, we back up every shipment with real-world guidance — from sample solubility tips to advice on work-up and storage for scale-up users. Chemical buyers contact us because our teams have spent time on the bench or in production plants themselves. We flag possible shipment holdups, suggest workaround formulas, and adjust blending options if downstream requirements shift. That’s born not from generic customer-service training, but decades confronting and solving practical scale-up and process headaches.

    We share protocols and safety data not just for compliance, but because, as chemists, we understand how surprises can break batch performance and cost time. Known issues — like light sensitivity, polymerization tendency, or residual peroxide formation — get communicated upfront, with recommended supplier-side QC checks and mitigation strategies. We supply cold-flow specs for users in northern zones, and advise warm-storage precautions when shipping to tropical ports. The technical backup fits the practical, not the textbook ideal.

    Perspectives on Product Evolution

    In our experience, the mark of a good manufacturer is willingness to change. Over the years, routine customer feedback revealed several improvements: modern drum lining prevents aldehyde-metal reaction, daily maintenance of filtration equipment drops particulate leftovers, and continuous operator training reduces error rates at critical batch steps. We innovate as much to satisfy our internal quality expectations as to pass external audits. By keeping batch data transparent and sharing best practices, we aim for every customer to achieve more with our material than with anonymous, warehouse-stored alternatives.

    Economic pressures, regulatory changes, and customer process evolution drive us to reassess both raw material inputs and batch parameters annually. Price trends on phenyl intermediates, global shipping delays, or newly listed environmental restrictions all change how we plan and supply. Long-term buyers appreciate our willingness to offer advance notice of process or source shifts so they can plan accordingly — predictability often matters more than lowest price in their own cost models.

    Continuous Improvement and End-Use Support

    Our approach holds that the best chemical product delivers on its promise in the hands of working chemists, not just on a spec sheet. New analytical technology, more sophisticated batch operations, and direct feedback from thousands of runs help us refine control strategies at every step. Improvements are measured not only at the gatehouse, but in the field trials and pilot plants of those we supply.

    3-Phenylbenzaldehyde will continue to play a central role for both specialty and large-scale chemical producers. Our focus on reproducibility, end-use support, and sustainable manufacturing grounds every decision behind its supply. Success grows from sharing what we learn, listening to user experience, and keeping quality control a hands-on occupation. We welcome input from any user willing to share their process — the better we all understand the challenges, the better each lot of product serves its role in new chemistry.