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HS Code |
454147 |
| Iupac Name | Ethyl [3-[(phenylcarbamoyl)oxy]phenyl]carbamate |
| Molecular Formula | C16H16N2O4 |
| Molecular Weight | 300.31 g/mol |
| Cas Number | 94158-35-3 |
| Appearance | White to off-white solid |
| Melting Point | 130-133°C |
| Solubility | Slightly soluble in water, soluble in organic solvents |
| Boiling Point | Decomposes before boiling |
| Storage Temperature | Store at 2-8°C |
| Smiles | CCOC(=O)Nc1cccc(OC(=O)Nc2ccccc2)c1 |
| Pubchem Cid | 636084 |
| Synonyms | Ethyl 3-[(phenylcarbamoyl)oxy]phenylcarbamate |
| Inchi | InChI=1S/C16H16N2O4/c1-2-22-16(21)17-12-7-5-6-11(10-12)23-15(20)18-13-8-3-4-9-14(13)19/h3-10,19H,2H2,1H3,(H2,17,21)(H,18,20) |
As an accredited [3-[[(Phenylamino)Carbonyl]Oxy]Phenyl]Carbamic Acid Ethyl Ester factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250g of `[3-[[(Phenylamino)Carbonyl]Oxy]Phenyl]Carbamic Acid Ethyl Ester` is supplied in a sealed amber glass bottle with tamper-proof cap. |
| Shipping | The shipping of `[3-[[(Phenylamino)Carbonyl]Oxy]Phenyl]Carbamic Acid Ethyl Ester` must comply with relevant hazardous materials regulations. The product is packaged securely in sealed containers, cushioned to prevent breakage, and labeled with chemical hazard information. Temperature control and proper documentation accompany all shipments to ensure safe and compliant delivery. |
| Storage | Store `[3-[[(Phenylamino)carbonyl]oxy]phenyl]carbamic acid ethyl ester` in a tightly sealed container, away from light and moisture, in a cool, dry, and well-ventilated area. Keep away from incompatible substances such as strong acids and oxidizing agents. Store at room temperature and avoid excessive heat. Ensure appropriate labeling and restrict access to trained personnel only. |
Applications of [3-[[(Phenylamino)Carbonyl]Oxy]Phenyl]Carbamic Acid Ethyl Ester in Industrial Manufacturing[3-[[(Phenylamino)Carbonyl]Oxy]Phenyl]Carbamic Acid Ethyl Ester supports specialized chemical synthesis in advanced industrial sectors. Our manufacturing expertise ensures consistent purity, targeted functional properties, and reliable scale-up for demanding downstream requirements. Below we outline primary application fields with detailed industry guidance for large-scale and niche production operations. 1. Active Pharmaceutical Ingredient (API) Intermediate SynthesisThis material serves as a key intermediate in the multi-step synthesis of certain urea-class pharmaceuticals, including selective kinase inhibitors and carbamate-protected active compounds. Pharmaceutical manufacturers require high purity specifications to sustain controlled reaction pathways and protect against cross-contamination. Downstream processes use the ester within protection–deprotection sequences for amines, ensuring robust structural control for subsequent coupling steps and API formation. Industry compliance standards
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2. Agrochemical Synthesis IntermediateManufacturers in crop protection and seed treatment rely on this ester for the synthesis of phenylcarbamate-based fungicides and growth regulators. The compound enables selective N-carbamoylation on aromatic rings, providing stable intermediates for further derivatization. Downstream processing utilizes batch or continuous flow reactors; trace impurity control ensures safe field application of agrochemical actives. Industry compliance standards
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3. Specialty Polymer Additive ManufacturingThis compound functions as a chain-modifying agent in engineering polymer production, targeting custom polyurethanes and polyureas for industrial coatings and membrane applications. Industrial users exploit its carbamate group reactivity to introduce aromatic segments and tailor the mechanical resilience and chemical resistance of finished polymer films. Control over molecular incorporation is essential for regulatory and end-use consistency. Industry compliance standards
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4. Fine Chemical and Dye Intermediate ProductionManufacturers of specialty dyes and advanced organic pigments employ this ester as a phenylcarbamate capping agent to prepare amine-functionalized chromophores with enhanced solubility and stability. Integration within multi-step dye synthesis requires strict control of reaction sequences, protecting functional groups against side reactions during coupling, diazotization, or oxidation. Downstream users depend on analytical batch tracking for color consistency and regulatory approval. Industry compliance standards
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Every batch of [3-[[(Phenylamino)Carbonyl]Oxy]Phenyl]Carbamic Acid Ethyl Ester we ship draws on decades of focused expertise in synthesis, fine purification, and tight control of the entire supply chain. From raw material procurement to crystallization and final analysis, the core of our work is reliability. Customers in pharmaceuticals, agrochemicals, and advanced materials R&D often tell us that what matters most is confidence: they want predictable quality, detailed documentation, and supply assurance. We take significant care with this compound to meet these criteria, while maintaining competitive pricing and on-schedule logistics.
The product itself originated from core principles of carbamate design, offering a unique profile compared to common derivatives. The ethyl ester group, coupled with a phenylcarbamate backbone, brings solubility advantages and stability that support rigorous downstream chemistry. We manage each synthesis run in controlled conditions, targeting minimal side product formation and maximum product consistency. Typical output purity consistently exceeds 98% by HPLC or GC, with single-batch variances monitored and documented. Each lot includes a full spectrum of analytical results. Batch records, spectra, and impurity data remain available for clients with traceability reaching back through all precursor lots.
We have handled many carbamate intermediates over the years. Most possess similar parent skeletons, but subtle modifications reshape their compatibility, reactivity, and usability. For chemistries that demand a delicate balance—stability in the bottle and fast reaction kinetics at the bench—[3-[[(Phenylamino)Carbonyl]Oxy]Phenyl]Carbamic Acid Ethyl Ester brings a clear advantage. Its molecular conformation allows selective downstream derivatization and coupling steps, supporting both scale-up for manufacturing and flexibility for research applications.
Clients using older methyl or isopropyl carbamate esters have reported issues: lower process yields, more challenging work-ups, and inconsistent melting points. We routinely see our ethyl ester outperform those analogues, both in reactivity for subsequent transformations and resistance to undesired hydrolysis under standard handling. Its phenylamino group remains a robust anchor, tolerating conditions unfavorable to less stable motifs. Over time, we have optimized both the esterification and purification regimes to minimize trace contaminants, especially those known to interfere with common coupling agents or cause streaking during chromatography.
Most requests focus on two general models: small-scale, research-grade and multi-kilogram, process-validated lots. For each, the key specifications remain tightly defined—minimum 98% purity, low moisture content, and total ash content of less than 0.1%. Typical physical appearance is a fine off-white crystalline powder. As the actual manufacturer, we always have control over granulometry. For clients using the compound in automated systems or preparing it for tablets or coating solutions, we have tuned our crystallization to deliver uniform particle size and rapid dissolution.
We run full organoleptic, melting point, and chemical identity checks for every delivery. Our LC-MS and NMR labs screen each lot to confirm structure and check for any potentially reactive byproducts, including isomeric impurities. Stability studies have shown minimal degradation over a year in sealed original packaging under standard temperature and humidity. This reliability further distinguishes our product from similar compounds that may degrade quickly. If customers require further milling or special packaging, our facility can calibrate both without exposing the material to external contaminants.
In life sciences, [3-[[(Phenylamino)Carbonyl]Oxy]Phenyl]Carbamic Acid Ethyl Ester is often selected as a protected intermediate for synthesizing complex heterocycles, bioactive small molecules, or as an activated building block for linking or functionalizing aromatic systems. Contract researchers and industrial scientists choose it for its smooth downstream deprotection profiles and minimal risk of transferring residual color or impurities to finished products. Its ethyl group often accelerates subsequent transesterification or amidation steps, reducing reaction times and allowing for softer conditions that protect sensitive payloads in multi-step syntheses.
Beyond pharmaceuticals, advanced material labs utilize this compound in surface modification chemistries, especially where selective functional group transformations on rigid aromatic frameworks bring competitive advantage. As manufacturers, we have partnered with multiple universities and pilot-scale facilities, observing that its reactivity profile provides versatility not seen in older carbamate intermediates. One collaboration sought to optimize the yield of a new photocatalyst array; our product’s stability under both acidic and basic conditions let their team speed up screening and cut down on batch-to-batch troubleshooting.
Environmental compatibility and safety occupy a major place in how we think about usage. We support customers’ environmental reporting goals with full trace element profiles and waste stream documentation. Our compounds avoid persistent solvents in the production process, and we field requests to replace legacy intermediates that require riskier reagents, especially in high-volume manufacturing.
Our reactors and purification lines have seen nearly every challenge these carbamates can pose. Early on, moisture and oxygen sensitivity presented barriers to maintaining yield throughout scale-up. We invested in modern inert-atmosphere reactors and vacuum systems, monitored in real time. By maintaining strict batch records, we learned to tune pressure, temperature, and concentration profiles throughout the process. Years of analytical feedback drove us to tweak specific parameters in reflux, crystallization, and purification, minimizing risk of impurity introduction and loss of volatile esters.
Many customers approach us after previous suppliers delivered inconsistent quality, often tied to uncontrolled parameters or lack of in-house instrumentation. We have seen cases where off-specification color, odor, or melt point led to hours of troubleshooting for downstream users. That feedback guided us toward an approach defined by root-cause analysis, not patchwork correction. Analytical transparency is not just a slogan: our standard documentation package includes all relevant test data, spectra, synthetic batch records, and impurity profiles. We work with open lines of technical support so issues get resolved quickly, without looping through intermediaries. This model provides the level of technical trust that contract researchers, production chemists, and regulatory teams require.
Several process improvements arose directly from customer collaboration. The move from batch to continuous-flow reactors for key intermediates reduced reaction time, cut waste solvent generation, and actually tightened the purity distribution lot-to-lot. Our current process incorporates mild conditions and emphasizes scalable green chemistry with viable solvent recycling. As a result, turnaround time on multi-kg orders dropped by half while maintaining or exceeding the purity and physical consistency critical for regulated industry use.
Not every challenge in chemical manufacturing revolves around purity or documentation. Many buyers in regulated industries face issues around unpredictable lead times, handling risks, and regulatory hurdles for new substances. Fluctuating raw material prices have made long-term supply contracts trickier to manage. To counter this, we maintain direct material sourcing relationships and safety stocks of key inputs. That ensures supply chain stability and insulates our clients from international market swings. Over years of hard-won experience, we built redundancy into our plant so bottlenecks elsewhere rarely disrupt final product delivery.
Carbamate-based materials also confront increased scrutiny for toxicity and residual solvent profiles. By implementing closed-system reactors and solvent condensation lines, our plant minimizes worker exposure and product contamination. We use non-chlorinated solvents whenever possible and provide full transparency about any chemical auxiliaries that touch the process stream. Independent audits, both internal and customer-driven, keep our compliance at a level above standard industry baselines.
One recurrent challenge in the R&D pipeline involves intermediates sensitive to moisture or excessive handling. As manufacturers, we invest in packaging designed for transport resilience, barrier protection, and customer convenience. Moisture-absorbing liners, tamper-proof seals, and small-batch packaging mean that whether a client processes a single gram or a full tote, the contents retain original strength, appearance, and downstream suitability. As supply partners learn to trust this reliability, their teams waste less time troubleshooting and gain more time for what really counts in synthesis—getting to a final, validated product.
Most off-the-shelf carbamate esters—especially low-cost imports—use simplified routes that cut purification steps to maximize throughput. That trade-off invites inconsistent purity, color drift, and reactivity issues. Competing methyl or isopropyl carbamates come with different acid sensitivities and hydrolysis rates, often creating difficulties in storage and multi-step syntheses. We have studied these effects side by side using controlled, blinded batch trials. Staff chemists reported the ethyl ester version consistently held up to a broader range of solvents, and survived longer on the shelf without caking or visible breakdown. That translates to less troubleshooting and higher effective yields in multi-step routes.
Our production process allows us to respond to custom requests—be it for scale, tighter impurity thresholds, or alternate salt forms—without lengthening lead times. Many competitors lack this flexibility. For certain applications, clients need non-standard grades and we batch custom lots on demand. As customers move toward continuous manufacturing or real-time analytics, they value our ability to integrate directly into their testing and traceability needs. This level of customization, combined with the technical insight only direct manufacturing brings, distinguishes our offering in both niche research use and ready-to-scale commercial manufacturing.
Every technical sheet can claim purity and reliability, but only hands-on manufacturers recognize the importance of seamless troubleshooting, root-cause support, and real transparency in the relationship with customers. We recognize that every batch not only reflects our technical acumen, but also represents someone else’s important project, clinical target, or growing business. By focusing on interactive support, real-time problem-solving, and honest communication, we build the trust that labs—big or small—depend on to reduce project risk and speed up their innovation timelines.
Feedback from our partners often shapes our next process improvements. Whether tackling new regulatory filings, ramping up to pilot quantities, or qualifying a new analytical endpoint, our hands-on approach ensures fewer surprises for our clients. That trust is earned, not issued as a certificate. Full auditability, continuous process refinement, and clear communication continue to drive our service ethos—making us more than just a supplier.
Our story with [3-[[(Phenylamino)Carbonyl]Oxy]Phenyl]Carbamic Acid Ethyl Ester is not static. Customer requests for greener packaging, trace element reporting, and product customizations shape our ongoing improvements. Industry trends move quickly: new coupling agents, process intensification, and further regulatory oversight now sit center stage. By actively engaging in these developments and remaining connected to frontline users, we keep the product and our manufacturing philosophy current and competitive.
We commit technical and R&D resources every year to investigate better raw materials, cleaner routes, and more sustainable recycling techniques. Technicians train annually in best practices for personal safety, analytical operation, and spill management. Internal analytical reviews, process retrospectives, and cross-disciplinary troubleshooting ensure that each year’s batches reflect not just consistency, but actual learning from the past. The result isn’t just a product ready for today’s chemistry, but a commitment to meet tomorrow’s challenges in supply chain reliability, regulatory requirements, and process greening.
Throughout our history with this compound, we have learned that the best results stem not from routine repetition, but from listening carefully to the scientists and engineers who use our materials, acting on their feedback, and adapting to their emerging needs. Our journey with [3-[[(Phenylamino)Carbonyl]Oxy]Phenyl]Carbamic Acid Ethyl Ester reflects this belief. We take seriously the responsibility—and satisfaction—of delivering a product reliable enough for regulated industries, robust enough for daily research, and innovative enough for chemists charting new ground in synthesis and new product development.