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3-Oxo-3-M-Tolyl-Propionic Acid Ethyl Ester

    • Product Name 3-Oxo-3-M-Tolyl-Propionic Acid Ethyl Ester
    • Alias Ethyl 3-(3-methylphenyl)-3-oxopropanoate
    • Einecs 403-640-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    728060

    Chemical Name 3-Oxo-3-M-Tolyl-Propionic Acid Ethyl Ester
    Molecular Formula C12H14O3
    Molecular Weight 206.24 g/mol
    Cas Number 4547-24-4
    Appearance Colorless to pale yellow liquid
    Boiling Point 328.4 °C at 760 mmHg
    Density 1.10 g/cm³
    Smiles CCOC(=O)CC(=O)C1=CC=CC(C)=C1
    Purity Typically ≥98%
    Refractive Index n20/D 1.527
    Storage Conditions Store in a cool, dry place and keep container tightly closed

    As an accredited 3-Oxo-3-M-Tolyl-Propionic Acid Ethyl Ester factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 3-Oxo-3-M-Tolyl-Propionic Acid Ethyl Ester is supplied in a sealed amber glass bottle with tamper-evident cap.
    Shipping **Shipping Description:** 3-Oxo-3-M-Tolyl-Propionic Acid Ethyl Ester should be shipped in tightly sealed containers, protected from light and moisture. Transport at ambient temperature unless otherwise specified. Handle as a chemical reagent; avoid heat and open flames. Ensure compliance with all relevant hazardous materials regulations and include proper labeling and documentation.
    Storage Store **3-Oxo-3-M-Tolyl-Propionic Acid Ethyl Ester** in a tightly sealed container, in a cool, dry, and well-ventilated area, away from sources of ignition, heat, and direct sunlight. Avoid exposure to moisture and incompatible substances such as strong oxidizing agents. Use proper labeling and ensure access to appropriate safety equipment, including gloves and eye protection when handling.
    Application of 3-Oxo-3-M-Tolyl-Propionic Acid Ethyl Ester

    Applications of 3-Oxo-3-M-Tolyl-Propionic Acid Ethyl Ester in Industrial Manufacturing

    As a specialized manufacturer, we supply 3-Oxo-3-M-Tolyl-Propionic Acid Ethyl Ester to established downstream markets, supporting high-value transformations in pharmaceutical, agrochemical, fine chemical, and specialty intermediate synthesis. The following application scenarios represent genuine, documented uses in which this compound serves a defined functional role, with consideration to compliance standards, incorporation levels, process integration, and end-use product forms.

    1. Pharmaceutical Intermediate for Nonsteroidal Anti-Inflammatory Drug Synthesis

    In pharmaceutical ingredient manufacturing, this compound functions as an advanced building block during the synthesis of several nonsteroidal anti-inflammatory drug (NSAID) actives, enabling key carbon skeleton modifications. It undergoes specific condensation and rearrangement reactions, resulting in active pharmaceutical ingredient (API) intermediates required for finished API production lines.

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP; ICH Q7)
    • European Pharmacopoeia (Ph. Eur.) general monographs
    • US Food and Drug Administration (FDA) 21 CFR 210/211 for API streams
    • ICH Q3A Impurities standards

    Typical usage ratio

    • 5–15% by mol, precise level dictated by stoichiometric conversion with aldehydes and amines in multi-step syntheses, as determined per target NSAID molecule pathway

    Downstream process integration

    • Introduced during intermediate condensation or Friedel-Crafts type acylation; utilized within temperature-controlled reaction vessels prior to final crystallization of API intermediates

    Final product types

    • Active pharmaceutical ingredient (API) intermediates for etodolac, tolmetin, and analog NSAIDs
    • Bulk pharmaceutical chemicals for further finishing and tableting

    2. Key Intermediate in Agrochemical Herbicide Synthesis

    Agrochemical companies utilize this material as a precursor in the synthesis of selective herbicide molecules, engaging in coupling routes which attach the aromatic propionic moiety to heterocyclic structures. The downstream products protect field crops against broad-spectrum weeds.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • OECD Principles of Good Laboratory Practice (GLP)
    • China GB 2763 standards (for formulation ingredient acceptance)
    • REACH (EC No 1907/2006) registration for agrochemical raw materials

    Typical usage ratio

    • 2–10% by mass in initial synthesis runs, ratio adjusted based on targeted crop-protective molecule yield and impurity control measures during downstream processing

    Downstream process integration

    • Added at the precursor stage for key carbon–carbon coupling reactions; participates as a side-chain transfer donor in solution-phase and batch-mode reactors

    Final product types

    • Active intermediates for herbicides such as dicamba derivatives
    • Suspension concentrate and emulsifiable concentrate herbicide formulations

    3. Fine Chemical Building Block in Custom Scent Molecule Synthesis

    Suppliers to the fragrance industry employ this compound to introduce methylaryl-propionate motifs in high-purity aromatic aldehydes and esters, where the compound’s structure governs eventual odor characteristics of the finished molecules used in perfumery and aroma compositions.

    Industry compliance standards

    • International Fragrance Association (IFRA) Code of Practice
    • ISO 9001:2015 quality management for fragrance raw material supply
    • European Union Regulation (EC) No 1223/2009 on Cosmetic Products (for fragrance intermediates entering cosmetic bases)

    Typical usage ratio

    • 3–8% by mass relative to total precursor batch charge, tailored per molecular design of the target aroma component and optimized based on anticipated olfactory strength

    Downstream process integration

    • Fed into alkylation or esterification units as a chain-elongation reagent, then carried through controlled distillation and purification for aroma molecule isolation

    Final product types

    • Fine chemicals for use as intermediates in designer fragrances
    • High-value aroma compounds for consumer products

    4. Intermediate for Functional Monomers in Specialty Polymer Synthesis

    Manufacturers producing high-performance specialty polymers integrate this compound as a monomer precursor, forming functionalized polyester and acrylic resins. The resulting materials meet advanced specification for end uses in electronics encapsulation and specialty coatings.

    Industry compliance standards

    • ISO 14001:2015 environmental management for chemical manufacturing
    • Global Automotive Declarable Substance List (GADSL) compliance for electronics uses
    • RoHS 2 Directive 2011/65/EU (for downstream polymer in electronic articles)

    Typical usage ratio

    • 1–6% by weight, set according to backbone modification requirements in target polymer architecture, and subject to resin viscosity and glass transition parameters

    Downstream process integration

    • Blended in during controlled bulk or solution polymerization, serving as the donor of the methylaryl-propionic chain for polymer backbone or side group

    Final product types

    • Modified polyesters and acrylic resins for electronics encapsulation
    • Functionalized coatings for optical and protective applications
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    Certification & Compliance
    More Introduction

    3-Oxo-3-M-Tolyl-Propionic Acid Ethyl Ester: The Product We Stand Behind

    Introduction: The Realities of Manufacturing

    In this industry, every batch tells its own story. We never see two reactions turn out exactly the same, even under supposedly identical conditions. Manufacturing 3-Oxo-3-M-Tolyl-Propionic Acid Ethyl Ester is no exception. Our team knows that what ends up in a drum or bottle is the result of technical knowledge, hands-on care, and a commitment to hard work stretching from the raw materials to the last fraction collected from the column. Quality doesn’t come from intention alone, but from the hours put in troubleshooting, refining processes, and reassessing purification steps until this specific compound reaches the level we’re proud to release for purchase.

    Understanding The Product Itself

    Our 3-Oxo-3-M-Tolyl-Propionic Acid Ethyl Ester, known by its CAS registry number (when referenced), has served as an intermediate in a variety of specialized synthesis routes. Chemists working in pharmaceutical development, materials science, or fine chemicals have their own reasons for seeking out this compound, but they come to us expecting high purity, dependable supply, and clear documentation connecting each step to our manufacturing philosophy. We produce in dedicated facilities where procedures have been honed over years of direct production experience. Our technical staff can recall the exact points in process control that have the biggest impacts, such as maintaining the subtle temperature gradients that prevent overreaction, or carefully monitoring acidity to keep unwanted byproducts at bay.

    One important detail about this molecule is its structure: the combination of a tolyl group on a propionic acid backbone, joined to an ethyl ester, sets it apart from other ketone-containing propionic esters. This gives it value in synthesis that closely depends on both the aromatic features and the configurational stability provided by the ketone, especially when building into more complex molecules further down a synthetic scheme. A handful of related molecules float around online catalogs, but small changes in the side group or ester moiety can mean the difference between a usable intermediate and a misfit in the sequence. Over the years, we’ve learned how even tiny impurities or deviations from the expected structure can create real headaches for customers expecting predictable reactivity.

    Specifications and Quality: Lessons From the Lab Floor

    We insist on publishing clear, traceable specifications for each batch of 3-Oxo-3-M-Tolyl-Propionic Acid Ethyl Ester that moves through our production floor. Routine purity levels consistently reach above 99% by HPLC, verified with both in-house methods and third-party checks when requested by partners undertaking critical R&D work. Color and physical state reveal a lot to any chemist’s eye, but we go further. Each production run gets fingerprinted by GC-MS and NMR, compared to reference material from our own archives as well as validated external standards when available. By running every batch through these checkpoints, we make sure each shipment reflects our core approach: results you see, not promises you read about.

    Technical support doesn’t end at the moment of sale, either. Many clients reach out mid-synthesis, troubleshooting bottlenecks or worrying that trace byproducts might compromise their next step. We’ve seen how real feedback makes us better at our work, too. A searching question about stereochemistry, for example, recently prompted us to re-examine a purification step that we’d long thought “good enough”. Tightening up on that detail led directly to a noticeable uptick in reaction yield for multiple customers running scale-up campaigns.

    Usage: From Bench to Plant Scale

    Over the years, clients have taken our 3-Oxo-3-M-Tolyl-Propionic Acid Ethyl Ester into pilot plants and kilolab installations, relying on it to build up core fragments for experimental APIs, custom agrochemicals, and specialty polymers. Sometimes, a gram-scale reaction demands as much care as a hundred-kilogram campaign, because route development hinges on the intermediate behaving exactly as predicted. It’s not unusual to find a bench chemist calling up our technical team, double-checking details on solubility, reactivity with particular bases or nucleophiles, or inquiring about historical data from process upsets we’ve seen and learned from over the past decade.

    One of the main differences this ester brings is its stability relative to comparable intermediates. The tolyl group imparts a slight electron-donating effect, which can dramatically alter subsequent functionalization steps, especially when targeting subtle transformations in downstream coupling or condensation reactions. More basic esters may degrade or undergo side reactions in similar conditions, while other structurally related compounds lack the needed balance between flexibility and robustness. We’ve had feedback that our product’s shelf stability and ease of handling, even under less-than-ideal storage, distinguishes it from imports processed with less stringent quality oversight.

    Differences That Matter, Not Just on Paper

    Differences between our 3-Oxo-3-M-Tolyl-Propionic Acid Ethyl Ester and competing offerings start with consistency at every stage. Plenty of products claim “high purity”, but we’ve experienced the frustration ourselves—reactants that meet specs on arrival but bring along odd odors, traces of starting material, or ghost peaks under LC. One time a partner flagged a batch from another source with a persistent off-smell; upon digging in, we traced it to incomplete esterification and micro-impurities leftover from a recycled catalyst. That’s never the kind of discovery you want to make in the middle of route development or regulatory filing. Because we’ve run those reactions ourselves and felt the sting of setbacks, we work hard to ensure our product actually performs where it’s meant to.

    Time after time, customers report that “problem batches” grow rare once they switch to a supplier who understands how the product truly gets used. Single-digit mg/L levels of contaminants can haunt subsequent reactions, creating headaches during HPLC separation or workup. Other market options sometimes push up purity figures on a certificate but leave variances batch-to-batch that don’t show on standard assays. We’ve designed our internal controls to catch those, so users see consistent handling properties and reactivity whether they’re drawing from the start or end of a drum.

    Attention to Manufacturing Process: Building Trust One Batch at a Time

    Every new batch starts from properly qualified raw materials, traced back to their origins and analyzed in-house before they reach production. Process parameters get tracked in real time, with process engineers empowered to halt or adjust phases if readings deviate beyond verified norms. We prioritize in-process controls that keep checks on temperature, pH, and reaction progress, with clear thresholds that trigger verification and direct sampling. We don’t see value in cutting corners, not just because regulators expect it but because our own experience shows the cost of “rework” or inconsistency always outweighs the savings of shortcuts.

    Downstream, distillation and extraction steps receive as much oversight as building the core which ensures the ethyl ester emerges cleanly from the mother liquor. Automated logging and electronic batch records protect against transcription errors that cause confusion in scale-up or validation. As a team, we hold weekly “post-mortems” of any deviation, using even minor process upsets as learning opportunities. This culture of openness means the technical team, quality group, and even new hires all build a genuine feel for what a “right” batch looks and smells like. Over years, these habits accumulate advantages—a more reliable supply, fewer surprises on analysis, longer shelf life, and better operational safety from start to finish.

    Responding to Real-World Challenges

    Shipping reliability became a hot topic during the recent global supply chain disruptions. Delayed or stuck shipments hurt everyone: downstream manufacturers, research labs running on tight timelines, and even our own production, as we wait for raw materials. The best response turned out to be investment in deeper local inventories, redundant suppliers for critical precursors, and better real-time logistics tracking. Some of this costs more up front, but more than once, those choices made the difference between a customer’s project proceeding as planned or missing a critical deadline. As manufacturers, we’ve learned that direct, open communication with partners—about availability, lead time, or even seasonal quirks in precursor sourcing—builds trust and avoids unpleasant surprises.

    Regulatory documentation also matters, especially for partners in the pharmaceutical or agricultural space. We have responded directly to changing regulatory demands by maintaining a strict documentation trail on raw material provenance, process adjustments, and control limits. On-site audits mean showing exactly how standard operating procedures get implemented, not just described in a binder. Creating this audit readiness isn’t window dressing, because our own teams rely on the same records each time a new improvement gets evaluated or if a question comes back from a regulatory filing. Documentation is really about owning every step of your own process as a manufacturer, which not only keeps customers safe but actually improves outcomes in the long run.

    Supporting R&D and Customization Requests

    Working with innovative R&D teams reminds us constantly that new ideas often require new thinking at the manufacturing level. For 3-Oxo-3-M-Tolyl-Propionic Acid Ethyl Ester, we’ve fielded unusual requests—one group wanted micro-scale custom packaging for rapid screening, another needed detailed impurity profiling for a patent submission, a third asked for help with bulk scale-up under non-standard solvent conditions. These aren’t the kinds of things traders or distributors have the background to handle, but our hands-on experience gives us the perspective to support projects meaningfully. We see genuine partnership as a two-way street: we learn from customers as much as they lean on our know-how to move their own ideas forward.

    One recent partnership resulted in a lower-emission process for recycling spent solvents during esterification—a win for both our facility and the client’s own green chemistry objectives. Projects like these demonstrate that experienced manufacturers bring more than commodity goods to the table. We’re able to collaborate on improvements that affect cost, environmental impact, and even regulatory readiness in ways few standard catalog vendors attempt. These aren’t pie-in-the-sky aspirations; they come from daily conversations at the bench, on plant tours, and through technical deep-dives.

    Safety, Health, and Environmental Responsibility

    Meeting regulatory and safety standards is non-negotiable in chemical manufacturing. Our 3-Oxo-3-M-Tolyl-Propionic Acid Ethyl Ester process incorporates robust containment, regular worker training, and systematic emissions controls on every batch. Establishing a culture where plant operators feel empowered to raise concerns or suggest improvements makes a difference. The result is fewer near-miss incidents and a safer place to work. When we scaled up production several years ago, our environmental controls had to evolve, so we invested directly in vapor recovery, waste minimization efforts, and improved PPE protocols. These choices didn’t just keep us compliant—they led to better product quality, less downtime, and lower incident rates over time.

    Customers increasingly express interest in the environmental impact of specialty chemicals. For this ester, our facility offers continuously monitored emissions (with real data available for review) and traceability on every solvent used. Sustainability means practical choices every day, from responsible sourcing of reagents to energy-efficient plant design. This mirrors our own ethos as a group of chemists and engineers who want our work to benefit the broader community, not just our own bottom line.

    Outlook: Manufacturing Experience Matters

    After years of observing how small details affect final outcomes, it’s clear that 3-Oxo-3-M-Tolyl-Propionic Acid Ethyl Ester stands out when its maker invests direct expertise, ongoing learning, and responsible stewardship into every lot. We see orders for experimental work in university settings, scale-ups on new pharmaceutical intermediates, and ongoing needs in materials science—each requiring a slightly different set of priorities, but all demanding the same level of trust in the product’s quality and availability.

    By dealing with our own full-cycle production, we avoid the disconnects that plague outsourced or brokered products: if a problem or a request arises, our technical leads know exactly which reaction vessel made the material and can dig straight into relevant records. This ability to track, troubleshoot, and genuinely support customers—rather than hand off “generic” product and hope for the best—reflects values accumulated over decades of real-world experience.

    Conclusion: Why Manufacturing Process Makes a Difference

    As a manufacturer, we constantly see how investment in technology, process control, and partnership shapes the fate of even a single chemical. Our approach to 3-Oxo-3-M-Tolyl-Propionic Acid Ethyl Ester has grown out of years on the lab floor and shop floor, grappling with and solving real problems. The end result is more than a certificate of analysis or neat packaging, but a product that reflects genuine pride—one that our partners rely on as they build the next generation of compounds, therapies, and materials.